TY  - JOUR
AU  - Raković, Dejan
AU  - Dugić, Miroljub
AU  - Jeknić-Dugić, Jasmina
AU  - Plavšić, Milenko
AU  - Jaćimovski, Stevo
AU  - Šetrajčić, Jovan
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5781
AB  - In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi)classically intractable. To illuminate it, we applied quantum-chemical and quantum decoherence approaches to conformational transitions. Our analyses imply the existence of novel macroscopic quantum biomolecular phenomena, with biomolecular chain folding in an open environment considered as a subtle interplay between energy and conformation eigenstates of this biomolecule, governed by quantum-chemical and quantum decoherence laws. On the other hand, within an open biological cell, a system of all identical (noninteracting and dynamically noncoupled) biomolecular proteins might be considered as corresponding spatial quantum ensemble of these identical biomolecular processors, providing spatially distributed quantum solution to a single corresponding biomolecular chain folding, whose density of conformational states might be represented as Hopfield-like quantum-holographic associative neural network too (providing an equivalent global quantum-informational alternative to standard molecular-biology local biochemical approach in biomolecules and cells and higher hierarchical levels of organism, as well).
PB  - Hindawi Publishing Corporation
T2  - BioMed Research International
T1  - On macroscopic quantum phenomena in biomolecules and cells: From levinthal to hopfield
SP  - 580491
VL  - 2014
DO  - 10.1155/2014/580491
ER  - 

@article{
author = "Raković, Dejan and Dugić, Miroljub and Jeknić-Dugić, Jasmina and Plavšić, Milenko and Jaćimovski, Stevo and Šetrajčić, Jovan",
year = "2014",
abstract = "In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi)classically intractable. To illuminate it, we applied quantum-chemical and quantum decoherence approaches to conformational transitions. Our analyses imply the existence of novel macroscopic quantum biomolecular phenomena, with biomolecular chain folding in an open environment considered as a subtle interplay between energy and conformation eigenstates of this biomolecule, governed by quantum-chemical and quantum decoherence laws. On the other hand, within an open biological cell, a system of all identical (noninteracting and dynamically noncoupled) biomolecular proteins might be considered as corresponding spatial quantum ensemble of these identical biomolecular processors, providing spatially distributed quantum solution to a single corresponding biomolecular chain folding, whose density of conformational states might be represented as Hopfield-like quantum-holographic associative neural network too (providing an equivalent global quantum-informational alternative to standard molecular-biology local biochemical approach in biomolecules and cells and higher hierarchical levels of organism, as well).",
publisher = "Hindawi Publishing Corporation",
journal = "BioMed Research International",
title = "On macroscopic quantum phenomena in biomolecules and cells: From levinthal to hopfield",
pages = "580491",
volume = "2014",
doi = "10.1155/2014/580491"
}

Raković, D., Dugić, M., Jeknić-Dugić, J., Plavšić, M., Jaćimovski, S.,& Šetrajčić, J.. (2014). On macroscopic quantum phenomena in biomolecules and cells: From levinthal to hopfield. in BioMed Research International
Hindawi Publishing Corporation., 2014, 580491.
https://doi.org/10.1155/2014/580491

Raković D, Dugić M, Jeknić-Dugić J, Plavšić M, Jaćimovski S, Šetrajčić J. On macroscopic quantum phenomena in biomolecules and cells: From levinthal to hopfield. in BioMed Research International. 2014;2014:580491.
doi:10.1155/2014/580491 .

Raković, Dejan, Dugić, Miroljub, Jeknić-Dugić, Jasmina, Plavšić, Milenko, Jaćimovski, Stevo, Šetrajčić, Jovan, "On macroscopic quantum phenomena in biomolecules and cells: From levinthal to hopfield" in BioMed Research International, 2014 (2014):580491,
https://doi.org/10.1155/2014/580491 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2137
PB  - Dove Medical Press Ltd, Albany
T2  - International Journal of Nanomedicine
T1  - Influence of microenvironment on cell adhesion, polarization, and migration
EP  - 3474
SP  - 3473
VL  - 7
DO  - 10.2147/IJN.S33433
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Plavšić, Milenko B.",
year = "2012",
publisher = "Dove Medical Press Ltd, Albany",
journal = "International Journal of Nanomedicine",
title = "Influence of microenvironment on cell adhesion, polarization, and migration",
pages = "3474-3473",
volume = "7",
doi = "10.2147/IJN.S33433"
}

Pajić-Lijaković, I.,& Plavšić, M. B.. (2012). Influence of microenvironment on cell adhesion, polarization, and migration. in International Journal of Nanomedicine
Dove Medical Press Ltd, Albany., 7, 3473-3474.
https://doi.org/10.2147/IJN.S33433

Pajić-Lijaković I, Plavšić MB. Influence of microenvironment on cell adhesion, polarization, and migration. in International Journal of Nanomedicine. 2012;7:3473-3474.
doi:10.2147/IJN.S33433 .

Pajić-Lijaković, Ivana, Plavšić, Milenko B., "Influence of microenvironment on cell adhesion, polarization, and migration" in International Journal of Nanomedicine, 7 (2012):3473-3474,
https://doi.org/10.2147/IJN.S33433 . .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
AU  - Bugarski, Branko
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1955
AB  - The system of living cells closed in a polymer matrix and self-organized into clusters is considered, extending free volume concept developed for complex system interactions quantification in statistical mechanics of jammed state of matter. Possibility of extension of Edwards concept of compactivity and angorisity developed for hard irregular grains with friction to living cell systems, is considered. Existences of scaling laws for cell colony grow, related to their self assembling and response to polymer hydrogel micro-environment constrains, is analyzed as function of rate of cluster density increase. Based on the theory proposed are developed relations, connecting cluster properties that are difficult to measure, to data from standard cell cultivation experiments. The model also provides possibilities of incorporation data on single cell behavior, available from modern nano- rheology measurements, into cluster
PB  - Polish Acad Sciences Inst Physics, Warsaw
T2  - Acta Physica Polonica A
T1  - Network Theory of Living Cell Clusters and Rheological Applications at Nano-Level
EP  - 271
IS  - 2
SP  - 266
VL  - 120
DO  - 10.12693/APhysPolA.120.266
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Plavšić, Milenko B. and Bugarski, Branko",
year = "2011",
abstract = "The system of living cells closed in a polymer matrix and self-organized into clusters is considered, extending free volume concept developed for complex system interactions quantification in statistical mechanics of jammed state of matter. Possibility of extension of Edwards concept of compactivity and angorisity developed for hard irregular grains with friction to living cell systems, is considered. Existences of scaling laws for cell colony grow, related to their self assembling and response to polymer hydrogel micro-environment constrains, is analyzed as function of rate of cluster density increase. Based on the theory proposed are developed relations, connecting cluster properties that are difficult to measure, to data from standard cell cultivation experiments. The model also provides possibilities of incorporation data on single cell behavior, available from modern nano- rheology measurements, into cluster",
publisher = "Polish Acad Sciences Inst Physics, Warsaw",
journal = "Acta Physica Polonica A",
title = "Network Theory of Living Cell Clusters and Rheological Applications at Nano-Level",
pages = "271-266",
number = "2",
volume = "120",
doi = "10.12693/APhysPolA.120.266"
}

Plavšić, M. B., Pajić-Lijaković, I., Plavšić, M. B.,& Bugarski, B.. (2011). Network Theory of Living Cell Clusters and Rheological Applications at Nano-Level. in Acta Physica Polonica A
Polish Acad Sciences Inst Physics, Warsaw., 120(2), 266-271.
https://doi.org/10.12693/APhysPolA.120.266

Plavšić MB, Pajić-Lijaković I, Plavšić MB, Bugarski B. Network Theory of Living Cell Clusters and Rheological Applications at Nano-Level. in Acta Physica Polonica A. 2011;120(2):266-271.
doi:10.12693/APhysPolA.120.266 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Plavšić, Milenko B., Bugarski, Branko, "Network Theory of Living Cell Clusters and Rheological Applications at Nano-Level" in Acta Physica Polonica A, 120, no. 2 (2011):266-271,
https://doi.org/10.12693/APhysPolA.120.266 . .

TY  - BOOK
AU  - Balać, Igor
AU  - Bugarski, Branko
AU  - Ćosić, Irena
AU  - Dramićanin, Miroslav
AU  - Đorđević, Drago
AU  - Filipović, Nenad D.
AU  - Ignjatović, Nenad
AU  - Janaćković, Đorđe
AU  - Kojić, Miloš
AU  - Manojlović, Verica
AU  - Marković, Zoran
AU  - Obradović, Bojana
AU  - Pajić-Lijaković, Ivana
AU  - Pavlović, Miodrag
AU  - Plavšić, Milenko B.
AU  - Raković, Dejan
AU  - Ranković, Vladimir
AU  - Stojanović, Boban
AU  - Trajković, Vladimir
AU  - Uskoković, Dragan
AU  - Uskoković, Petar
AU  - Veljković, Dejan
AU  - Vlastelica, Ivo
AU  - Vunjak-Novaković, Gordana
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1535
AB  - Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi. Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci. Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti. Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.
PB  - Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala
T1  - Biomaterijali
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7344
ER  - 

@book{
author = "Balać, Igor and Bugarski, Branko and Ćosić, Irena and Dramićanin, Miroslav and Đorđević, Drago and Filipović, Nenad D. and Ignjatović, Nenad and Janaćković, Đorđe and Kojić, Miloš and Manojlović, Verica and Marković, Zoran and Obradović, Bojana and Pajić-Lijaković, Ivana and Pavlović, Miodrag and Plavšić, Milenko B. and Raković, Dejan and Ranković, Vladimir and Stojanović, Boban and Trajković, Vladimir and Uskoković, Dragan and Uskoković, Petar and Veljković, Dejan and Vlastelica, Ivo and Vunjak-Novaković, Gordana",
year = "2010",
abstract = "Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi. Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci. Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti. Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.",
publisher = "Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala",
title = "Biomaterijali",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7344"
}

Balać, I., Bugarski, B., Ćosić, I., Dramićanin, M., Đorđević, D., Filipović, N. D., Ignjatović, N., Janaćković, Đ., Kojić, M., Manojlović, V., Marković, Z., Obradović, B., Pajić-Lijaković, I., Pavlović, M., Plavšić, M. B., Raković, D., Ranković, V., Stojanović, B., Trajković, V., Uskoković, D., Uskoković, P., Veljković, D., Vlastelica, I.,& Vunjak-Novaković, G.. (2010). Biomaterijali. 
Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala..
https://hdl.handle.net/21.15107/rcub_vinar_7344

Balać I, Bugarski B, Ćosić I, Dramićanin M, Đorđević D, Filipović ND, Ignjatović N, Janaćković Đ, Kojić M, Manojlović V, Marković Z, Obradović B, Pajić-Lijaković I, Pavlović M, Plavšić MB, Raković D, Ranković V, Stojanović B, Trajković V, Uskoković D, Uskoković P, Veljković D, Vlastelica I, Vunjak-Novaković G. Biomaterijali. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_7344 .

Balać, Igor, Bugarski, Branko, Ćosić, Irena, Dramićanin, Miroslav, Đorđević, Drago, Filipović, Nenad D., Ignjatović, Nenad, Janaćković, Đorđe, Kojić, Miloš, Manojlović, Verica, Marković, Zoran, Obradović, Bojana, Pajić-Lijaković, Ivana, Pavlović, Miodrag, Plavšić, Milenko B., Raković, Dejan, Ranković, Vladimir, Stojanović, Boban, Trajković, Vladimir, Uskoković, Dragan, Uskoković, Petar, Veljković, Dejan, Vlastelica, Ivo, Vunjak-Novaković, Gordana, "Biomaterijali" (2010),
https://hdl.handle.net/21.15107/rcub_vinar_7344 .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1709
AB  - The system of living cells closed in a polymer bead as a matrix is considered in formalism of lattice model extended with compactivity concept developed for complex systems in statistical mechanics of jammed state of matter. Possibility of extension of Edwards concept of compactivity developed for hard irregular grains with friction to living cell systems, is considered if function of cell interactions and properties. Existence of critical points in the course of cell colony grow related to their self assembling and response to polymer hydrogel micro-environment resistance, is analyzed in function of cell volume fraction growth. Based on the theory and experiments it is related to characteristic values of compactivity in analogy to phase transition temperatures.. Interpretation of data from literature on cancer cell cluster growth suppression under pressure of microenvironment on the base of model proposed is offered
PB  - World Scientific Publ Co Pte Ltd, Singapore
T2  - International Journal of Modern Physics B
T1  - Compactivity of cell colonies-relations between living cells inside polymer hydrogel beads
EP  - 824
IS  - 6-7
SP  - 813
VL  - 24
DO  - 10.1142/S0217979210064459
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Plavšić, Milenko B.",
year = "2010",
abstract = "The system of living cells closed in a polymer bead as a matrix is considered in formalism of lattice model extended with compactivity concept developed for complex systems in statistical mechanics of jammed state of matter. Possibility of extension of Edwards concept of compactivity developed for hard irregular grains with friction to living cell systems, is considered if function of cell interactions and properties. Existence of critical points in the course of cell colony grow related to their self assembling and response to polymer hydrogel micro-environment resistance, is analyzed in function of cell volume fraction growth. Based on the theory and experiments it is related to characteristic values of compactivity in analogy to phase transition temperatures.. Interpretation of data from literature on cancer cell cluster growth suppression under pressure of microenvironment on the base of model proposed is offered",
publisher = "World Scientific Publ Co Pte Ltd, Singapore",
journal = "International Journal of Modern Physics B",
title = "Compactivity of cell colonies-relations between living cells inside polymer hydrogel beads",
pages = "824-813",
number = "6-7",
volume = "24",
doi = "10.1142/S0217979210064459"
}

Plavšić, M. B., Pajić-Lijaković, I.,& Plavšić, M. B.. (2010). Compactivity of cell colonies-relations between living cells inside polymer hydrogel beads. in International Journal of Modern Physics B
World Scientific Publ Co Pte Ltd, Singapore., 24(6-7), 813-824.
https://doi.org/10.1142/S0217979210064459

Plavšić MB, Pajić-Lijaković I, Plavšić MB. Compactivity of cell colonies-relations between living cells inside polymer hydrogel beads. in International Journal of Modern Physics B. 2010;24(6-7):813-824.
doi:10.1142/S0217979210064459 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Plavšić, Milenko B., "Compactivity of cell colonies-relations between living cells inside polymer hydrogel beads" in International Journal of Modern Physics B, 24, no. 6-7 (2010):813-824,
https://doi.org/10.1142/S0217979210064459 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Ilić, Vesna Lj.
AU  - Bugarski, Branko
AU  - Plavšić, Milenko B.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1706
AB  - The complex phenomenon of rearrangement of band 3 molecules after erythrocyte swelling under hypotonic condition is considered. The rearrangement includes the increase of the mobile fraction and clustering of band 3. The self-associative tendency and the action of the elastic field generated within the lipid membrane after erythrocyte swelling result in equilibration of the number of molecules per cluster and the number of clusters. The local perturbation of the elastic field induces excitation of the cluster in the nearest neighbor and changes its packing state generating changes in the free volume within the cluster. The local perturbation could result in the reversible formation of osmotic hole. We formulated a model to predict changes of the cluster packing states generated by rearrangement of band 3 molecules on two time-scales. The phenomenon is examined on the basis of two experimental sets, i.e. low (5.2 mM Na3PO4 solution) and high (46.0 mM Na3PO4 solution) hypotonicities at 21A degrees C, from Golan and Veatch (Proc Natl Acad Sci 77(5):2537-2541, 1980). Modeling considerations suggested that lower hypotonic conditions resulted in higher values of: the driving force of agglomeration of band 3 as a measure of self-associative tendency, the specific rate of cluster breaking, the specific rate of increase of the mobile fraction of band 3, and the dispersion of cluster sizes. Lower hypotonic conditions ensure the generation of a higher average value of the free energy within the membrane after erythrocyte swelling, which enables more intensive rearrangement of band 3 molecules.
PB  - Springer, New York
T2  - European Biophysics Journal with Biophysics Letters
T1  - Rearrangement of erythrocyte band 3 molecules and reversible formation of osmotic holes under hypotonic conditions
EP  - 800
IS  - 5
SP  - 789
VL  - 39
DO  - 10.1007/s00249-009-0554-6
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Ilić, Vesna Lj. and Bugarski, Branko and Plavšić, Milenko B.",
year = "2010",
abstract = "The complex phenomenon of rearrangement of band 3 molecules after erythrocyte swelling under hypotonic condition is considered. The rearrangement includes the increase of the mobile fraction and clustering of band 3. The self-associative tendency and the action of the elastic field generated within the lipid membrane after erythrocyte swelling result in equilibration of the number of molecules per cluster and the number of clusters. The local perturbation of the elastic field induces excitation of the cluster in the nearest neighbor and changes its packing state generating changes in the free volume within the cluster. The local perturbation could result in the reversible formation of osmotic hole. We formulated a model to predict changes of the cluster packing states generated by rearrangement of band 3 molecules on two time-scales. The phenomenon is examined on the basis of two experimental sets, i.e. low (5.2 mM Na3PO4 solution) and high (46.0 mM Na3PO4 solution) hypotonicities at 21A degrees C, from Golan and Veatch (Proc Natl Acad Sci 77(5):2537-2541, 1980). Modeling considerations suggested that lower hypotonic conditions resulted in higher values of: the driving force of agglomeration of band 3 as a measure of self-associative tendency, the specific rate of cluster breaking, the specific rate of increase of the mobile fraction of band 3, and the dispersion of cluster sizes. Lower hypotonic conditions ensure the generation of a higher average value of the free energy within the membrane after erythrocyte swelling, which enables more intensive rearrangement of band 3 molecules.",
publisher = "Springer, New York",
journal = "European Biophysics Journal with Biophysics Letters",
title = "Rearrangement of erythrocyte band 3 molecules and reversible formation of osmotic holes under hypotonic conditions",
pages = "800-789",
number = "5",
volume = "39",
doi = "10.1007/s00249-009-0554-6"
}

Pajić-Lijaković, I., Ilić, V. Lj., Bugarski, B.,& Plavšić, M. B.. (2010). Rearrangement of erythrocyte band 3 molecules and reversible formation of osmotic holes under hypotonic conditions. in European Biophysics Journal with Biophysics Letters
Springer, New York., 39(5), 789-800.
https://doi.org/10.1007/s00249-009-0554-6

Pajić-Lijaković I, Ilić VL, Bugarski B, Plavšić MB. Rearrangement of erythrocyte band 3 molecules and reversible formation of osmotic holes under hypotonic conditions. in European Biophysics Journal with Biophysics Letters. 2010;39(5):789-800.
doi:10.1007/s00249-009-0554-6 .

Pajić-Lijaković, Ivana, Ilić, Vesna Lj., Bugarski, Branko, Plavšić, Milenko B., "Rearrangement of erythrocyte band 3 molecules and reversible formation of osmotic holes under hypotonic conditions" in European Biophysics Journal with Biophysics Letters, 39, no. 5 (2010):789-800,
https://doi.org/10.1007/s00249-009-0554-6 . .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Bugarski, Branko
AU  - Budinski-Simendić, Jaroslava
AU  - Nedović, Viktor
AU  - Putanov, P.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1568
AB  - Living cell organization in clusters is considered in terms of cell-cells and cells-microenvironment interactions as important factor in fundamental understanding of cell behavior in formation and grow of living tissues, wound heeling and development some serious illness, but also in present tissue engineering, immobilization of cells in polymer matrices and culture grow. Significant importance of parameters as compacivity and compressibility for quantification of cell behavior is found as well as possibility for modeling cell organization in terms of classical models of polymer structure as blends. The theory of Karasz and coworkers on miscibility widows in polymer blends is used for interpretation of some polymer-cell relations.
PB  - Amer Chemical Soc, Washington
T2  - ACS Symposium Series
T1  - Pseudo-Blend Model of Hydrogel Immobilized Living Cells
EP  - 229
SP  - 215
VL  - 1061
DO  - 10.1021/bk-2010-1061.ch014
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Bugarski, Branko and Budinski-Simendić, Jaroslava and Nedović, Viktor and Putanov, P.",
year = "2010",
abstract = "Living cell organization in clusters is considered in terms of cell-cells and cells-microenvironment interactions as important factor in fundamental understanding of cell behavior in formation and grow of living tissues, wound heeling and development some serious illness, but also in present tissue engineering, immobilization of cells in polymer matrices and culture grow. Significant importance of parameters as compacivity and compressibility for quantification of cell behavior is found as well as possibility for modeling cell organization in terms of classical models of polymer structure as blends. The theory of Karasz and coworkers on miscibility widows in polymer blends is used for interpretation of some polymer-cell relations.",
publisher = "Amer Chemical Soc, Washington",
journal = "ACS Symposium Series",
title = "Pseudo-Blend Model of Hydrogel Immobilized Living Cells",
pages = "229-215",
volume = "1061",
doi = "10.1021/bk-2010-1061.ch014"
}

Plavšić, M. B., Pajić-Lijaković, I., Bugarski, B., Budinski-Simendić, J., Nedović, V.,& Putanov, P.. (2010). Pseudo-Blend Model of Hydrogel Immobilized Living Cells. in ACS Symposium Series
Amer Chemical Soc, Washington., 1061, 215-229.
https://doi.org/10.1021/bk-2010-1061.ch014

Plavšić MB, Pajić-Lijaković I, Bugarski B, Budinski-Simendić J, Nedović V, Putanov P. Pseudo-Blend Model of Hydrogel Immobilized Living Cells. in ACS Symposium Series. 2010;1061:215-229.
doi:10.1021/bk-2010-1061.ch014 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Bugarski, Branko, Budinski-Simendić, Jaroslava, Nedović, Viktor, Putanov, P., "Pseudo-Blend Model of Hydrogel Immobilized Living Cells" in ACS Symposium Series, 1061 (2010):215-229,
https://doi.org/10.1021/bk-2010-1061.ch014 . .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Lazić, N.
AU  - Bugarski, Branko
AU  - Putanov, P.
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1528
AB  - Interaction of cells with polymer networks in nanostructured devices as alginate beads for cell immobilization are considered. Influence of process parameters as oxygen concentration inside a bead on changes of alginate material structure is experimentally investigated. Significant swelling of alginate beads during process is observed and ascribed to combined action of chemical components in the reactor and of growing cells, causing expansion of beads and degradation of their networks. The culture of mouse/mouse hybridoma cells secreting a monoclonal antibody (IgG) specific to human chorionic gonadotropin (beta-hCG) was used. A kinetic model of catalytic alginate degradation is developed for controlling the process. The model provides possibilities to analyze conditions for suppressing large swelling and influence of oxidative agents. Moreover, it provides some deeper insights into mechanism of polymer network-cell interactions and dynamics during the process. It is based on separation of contributions of reactants in the system from contributions of cells to degradation of the network and in that way to effective swelling of the bead.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Materials and Manufacturing Processes
T1  - Catalytic Degradation Processes and Swelling of Alginate Bio-Medical Gels under Influence of Oxygen
EP  - 1196
IS  - 10-11
SP  - 1190
VL  - 24
DO  - 10.1080/10426910903031727
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Lazić, N. and Bugarski, Branko and Putanov, P.",
year = "2009",
abstract = "Interaction of cells with polymer networks in nanostructured devices as alginate beads for cell immobilization are considered. Influence of process parameters as oxygen concentration inside a bead on changes of alginate material structure is experimentally investigated. Significant swelling of alginate beads during process is observed and ascribed to combined action of chemical components in the reactor and of growing cells, causing expansion of beads and degradation of their networks. The culture of mouse/mouse hybridoma cells secreting a monoclonal antibody (IgG) specific to human chorionic gonadotropin (beta-hCG) was used. A kinetic model of catalytic alginate degradation is developed for controlling the process. The model provides possibilities to analyze conditions for suppressing large swelling and influence of oxidative agents. Moreover, it provides some deeper insights into mechanism of polymer network-cell interactions and dynamics during the process. It is based on separation of contributions of reactants in the system from contributions of cells to degradation of the network and in that way to effective swelling of the bead.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Materials and Manufacturing Processes",
title = "Catalytic Degradation Processes and Swelling of Alginate Bio-Medical Gels under Influence of Oxygen",
pages = "1196-1190",
number = "10-11",
volume = "24",
doi = "10.1080/10426910903031727"
}

Plavšić, M. B., Pajić-Lijaković, I., Lazić, N., Bugarski, B.,& Putanov, P.. (2009). Catalytic Degradation Processes and Swelling of Alginate Bio-Medical Gels under Influence of Oxygen. in Materials and Manufacturing Processes
Taylor & Francis Inc, Philadelphia., 24(10-11), 1190-1196.
https://doi.org/10.1080/10426910903031727

Plavšić MB, Pajić-Lijaković I, Lazić N, Bugarski B, Putanov P. Catalytic Degradation Processes and Swelling of Alginate Bio-Medical Gels under Influence of Oxygen. in Materials and Manufacturing Processes. 2009;24(10-11):1190-1196.
doi:10.1080/10426910903031727 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Lazić, N., Bugarski, Branko, Putanov, P., "Catalytic Degradation Processes and Swelling of Alginate Bio-Medical Gels under Influence of Oxygen" in Materials and Manufacturing Processes, 24, no. 10-11 (2009):1190-1196,
https://doi.org/10.1080/10426910903031727 . .

TY  - JOUR
AU  - Jokanović, Vukoman
AU  - Dramićanin, Miroslav
AU  - Andrić, Z.
AU  - Dramićanin, Tatjana
AU  - Plavšić, Milenko B.
AU  - Pašalić, Snežana
AU  - Miljković, Miroslav
PY  - 2008
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1321
AB  - A new approach to the two-level design and self-assembling of MexSiOy (Me = Gd, Y and Ca or their mixtures) nano-powders from SiO2 sols is described. The nanostructure design of various optical active materials based on different compounds of Me(x)Sio(y) is discussed. These particles were formed by the combination of hydrothermal synthesis and ultrasound spray pyrolysis. The morphology and structural design of the particles and sub-particles are defined by their synthesis procedure and processing parameters. The mean particle size and size distribution of all the MexSiOy based compounds were determined by SEM analysis. These results were compared with the particle diameter evaluated from the theoretical model of the breaking-up of capillary waves. For all the synthesized powders, the obtained results indicate the possibility of a rigorous design of the structure of the particles throughout their entire hierarchy.
PB  - Elsevier, Amsterdam
T2  - Optical Materials
T1  - Nanostructure designed powders of optical active materials MexSiOy obtained by ultrasonic spray pyrolysis
EP  - 1172
IS  - 7
SP  - 1168
VL  - 30
DO  - 10.1016/j.optmat.2007.05.043
ER  - 

@article{
author = "Jokanović, Vukoman and Dramićanin, Miroslav and Andrić, Z. and Dramićanin, Tatjana and Plavšić, Milenko B. and Pašalić, Snežana and Miljković, Miroslav",
year = "2008",
abstract = "A new approach to the two-level design and self-assembling of MexSiOy (Me = Gd, Y and Ca or their mixtures) nano-powders from SiO2 sols is described. The nanostructure design of various optical active materials based on different compounds of Me(x)Sio(y) is discussed. These particles were formed by the combination of hydrothermal synthesis and ultrasound spray pyrolysis. The morphology and structural design of the particles and sub-particles are defined by their synthesis procedure and processing parameters. The mean particle size and size distribution of all the MexSiOy based compounds were determined by SEM analysis. These results were compared with the particle diameter evaluated from the theoretical model of the breaking-up of capillary waves. For all the synthesized powders, the obtained results indicate the possibility of a rigorous design of the structure of the particles throughout their entire hierarchy.",
publisher = "Elsevier, Amsterdam",
journal = "Optical Materials",
title = "Nanostructure designed powders of optical active materials MexSiOy obtained by ultrasonic spray pyrolysis",
pages = "1172-1168",
number = "7",
volume = "30",
doi = "10.1016/j.optmat.2007.05.043"
}

Jokanović, V., Dramićanin, M., Andrić, Z., Dramićanin, T., Plavšić, M. B., Pašalić, S.,& Miljković, M.. (2008). Nanostructure designed powders of optical active materials MexSiOy obtained by ultrasonic spray pyrolysis. in Optical Materials
Elsevier, Amsterdam., 30(7), 1168-1172.
https://doi.org/10.1016/j.optmat.2007.05.043

Jokanović V, Dramićanin M, Andrić Z, Dramićanin T, Plavšić MB, Pašalić S, Miljković M. Nanostructure designed powders of optical active materials MexSiOy obtained by ultrasonic spray pyrolysis. in Optical Materials. 2008;30(7):1168-1172.
doi:10.1016/j.optmat.2007.05.043 .

Jokanović, Vukoman, Dramićanin, Miroslav, Andrić, Z., Dramićanin, Tatjana, Plavšić, Milenko B., Pašalić, Snežana, Miljković, Miroslav, "Nanostructure designed powders of optical active materials MexSiOy obtained by ultrasonic spray pyrolysis" in Optical Materials, 30, no. 7 (2008):1168-1172,
https://doi.org/10.1016/j.optmat.2007.05.043 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2008
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1221
AB  - Aim. A phase-field mathematical model was formulated to describe yeast cell growth within the Ca-alginate microbead during air-lift bioreactor cultivation. Model development was based on experimentally obtained data for the intra-bead yeast cell volume fraction profile within the microbead after reaching the equilibrium state for cells (150 h), as well as, total yeast cell volume fraction per microbead and microbead volume as functions time. Microbead with growing yeast cells is treated as a two-phase system. one phase represents the cell agglomerates, while the other is the alginate hydrogel matrices. The interactions between phases are simulated using the Langevin class, non-conservative phasefield model based on the reduction of the modeling resolution. The model considered the growth of small domains of one phase (cell agglomerates) as nucleation. Methods. Total yeast cell volume fraction in the beads was estimated by using Thoma counting chamber after dissolution of beads. Local cell volume fraction per microbead layers is calculated from experimentally determined surface fraction of cells for various microbead cross sections by image analysis. Microbead volume is estimated by measuring the microbead diameter. Diameters of microbeads were measured using the optical microscope equipped with a micrometric device. Results. The proposed model offered the only one model parameter, which represents the specific measure of microenvironmental restrictive action to the cell growth dynamics. The optimal value of this model parameter is obtained by comparison analysis between experimental data and model predictions. Conclusion. Besides giving useful insights into the dynamics of restrictive cell growth within the Ca-alginate microbead, the model can be used as a tool to design/optimize the performance of microbead and studying the microenvironmental restrictive mechanism action of the cell growth.
T2  - Minerva Biotecnologica
T1  - Modeling of microenvironmetal restricted yeast cell growth within Ca-alginate microbead
EP  - 102
IS  - 2
SP  - 99
VL  - 20
UR  - https://hdl.handle.net/21.15107/rcub_technorep_1221
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Plavšić, Milenko B. and Nedović, Viktor and Bugarski, Branko",
year = "2008",
abstract = "Aim. A phase-field mathematical model was formulated to describe yeast cell growth within the Ca-alginate microbead during air-lift bioreactor cultivation. Model development was based on experimentally obtained data for the intra-bead yeast cell volume fraction profile within the microbead after reaching the equilibrium state for cells (150 h), as well as, total yeast cell volume fraction per microbead and microbead volume as functions time. Microbead with growing yeast cells is treated as a two-phase system. one phase represents the cell agglomerates, while the other is the alginate hydrogel matrices. The interactions between phases are simulated using the Langevin class, non-conservative phasefield model based on the reduction of the modeling resolution. The model considered the growth of small domains of one phase (cell agglomerates) as nucleation. Methods. Total yeast cell volume fraction in the beads was estimated by using Thoma counting chamber after dissolution of beads. Local cell volume fraction per microbead layers is calculated from experimentally determined surface fraction of cells for various microbead cross sections by image analysis. Microbead volume is estimated by measuring the microbead diameter. Diameters of microbeads were measured using the optical microscope equipped with a micrometric device. Results. The proposed model offered the only one model parameter, which represents the specific measure of microenvironmental restrictive action to the cell growth dynamics. The optimal value of this model parameter is obtained by comparison analysis between experimental data and model predictions. Conclusion. Besides giving useful insights into the dynamics of restrictive cell growth within the Ca-alginate microbead, the model can be used as a tool to design/optimize the performance of microbead and studying the microenvironmental restrictive mechanism action of the cell growth.",
journal = "Minerva Biotecnologica",
title = "Modeling of microenvironmetal restricted yeast cell growth within Ca-alginate microbead",
pages = "102-99",
number = "2",
volume = "20",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1221"
}

Pajić-Lijaković, I., Plavšić, M. B., Nedović, V.,& Bugarski, B.. (2008). Modeling of microenvironmetal restricted yeast cell growth within Ca-alginate microbead. in Minerva Biotecnologica, 20(2), 99-102.
https://hdl.handle.net/21.15107/rcub_technorep_1221

Pajić-Lijaković I, Plavšić MB, Nedović V, Bugarski B. Modeling of microenvironmetal restricted yeast cell growth within Ca-alginate microbead. in Minerva Biotecnologica. 2008;20(2):99-102.
https://hdl.handle.net/21.15107/rcub_technorep_1221 .

Pajić-Lijaković, Ivana, Plavšić, Milenko B., Nedović, Viktor, Bugarski, Branko, "Modeling of microenvironmetal restricted yeast cell growth within Ca-alginate microbead" in Minerva Biotecnologica, 20, no. 2 (2008):99-102,
https://hdl.handle.net/21.15107/rcub_technorep_1221 .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Bugarski, Diana
AU  - Plavšić, Milenko B.
AU  - Bugarski, Branko
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1088
AB  - A mathematical model was formulated to describe hybridoma cell growth within the alginate-poly-L-lysine (alginate-PLL) microcapsules during air-lift bioreactor cultivation. Model development was based on experimentally obtained data concerning the hybridoma cell counts, monoclonal antibody (mAb) production and the distribution of hybridoma cell growth within the microcapsules. The cell growth was modeled using a mean field approach expressed as Langevin class of equations for two different regions of alginate-PLL microcapsules, the alginate microcapsule core and the annular region between microcapsule core and membrane. In this paper we propose an influence of microenvironmental conditions on cell growth. The osmotic pressure changes in the Na-alginate liquefied annular region, as well as, the resistance effects of Ca-alginate hydrogel in the core region during the cell growth were incorporated into the model. Good agreement between the experimental data and model prediction values was obtained. The proposed model successfully predicted the impact of various microenvironmental restriction effects on the dynamics of cell growth and appears useful for further optimization of microcapsule design in order to achieve higher intra-capsule cell concentrations resulting in higher amounts of mAb produced.
PB  - Elsevier Sci Ltd, Oxford
T2  - Process Biochemistry
T1  - Influence of microenvironmental conditions on hybridoma cell growth inside the alginate-poly-L-lysine microcapsule
EP  - 174
IS  - 2
SP  - 167
VL  - 42
DO  - 10.1016/j.procbio.2006.07.023
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Bugarski, Diana and Plavšić, Milenko B. and Bugarski, Branko",
year = "2007",
abstract = "A mathematical model was formulated to describe hybridoma cell growth within the alginate-poly-L-lysine (alginate-PLL) microcapsules during air-lift bioreactor cultivation. Model development was based on experimentally obtained data concerning the hybridoma cell counts, monoclonal antibody (mAb) production and the distribution of hybridoma cell growth within the microcapsules. The cell growth was modeled using a mean field approach expressed as Langevin class of equations for two different regions of alginate-PLL microcapsules, the alginate microcapsule core and the annular region between microcapsule core and membrane. In this paper we propose an influence of microenvironmental conditions on cell growth. The osmotic pressure changes in the Na-alginate liquefied annular region, as well as, the resistance effects of Ca-alginate hydrogel in the core region during the cell growth were incorporated into the model. Good agreement between the experimental data and model prediction values was obtained. The proposed model successfully predicted the impact of various microenvironmental restriction effects on the dynamics of cell growth and appears useful for further optimization of microcapsule design in order to achieve higher intra-capsule cell concentrations resulting in higher amounts of mAb produced.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Process Biochemistry",
title = "Influence of microenvironmental conditions on hybridoma cell growth inside the alginate-poly-L-lysine microcapsule",
pages = "174-167",
number = "2",
volume = "42",
doi = "10.1016/j.procbio.2006.07.023"
}

Pajić-Lijaković, I., Bugarski, D., Plavšić, M. B.,& Bugarski, B.. (2007). Influence of microenvironmental conditions on hybridoma cell growth inside the alginate-poly-L-lysine microcapsule. in Process Biochemistry
Elsevier Sci Ltd, Oxford., 42(2), 167-174.
https://doi.org/10.1016/j.procbio.2006.07.023

Pajić-Lijaković I, Bugarski D, Plavšić MB, Bugarski B. Influence of microenvironmental conditions on hybridoma cell growth inside the alginate-poly-L-lysine microcapsule. in Process Biochemistry. 2007;42(2):167-174.
doi:10.1016/j.procbio.2006.07.023 .

Pajić-Lijaković, Ivana, Bugarski, Diana, Plavšić, Milenko B., Bugarski, Branko, "Influence of microenvironmental conditions on hybridoma cell growth inside the alginate-poly-L-lysine microcapsule" in Process Biochemistry, 42, no. 2 (2007):167-174,
https://doi.org/10.1016/j.procbio.2006.07.023 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
AU  - Bugarski, Branko
AU  - Nedović, Viktor
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1091
AB  - A mathematical model was formulated to describe yeast cell growth within the Ca-alginate microbead during air-lift bioreactor cultivation. Model development was based on experimentally obtained data for the intra-bead cell concentration profile, after reached the equilibrium state, as well as, total yeast cell concentration per microbed and microbead volume as function of time. Relatively uniform cell concentration in the carrier matrix indicated that no internal nutrient diffusion limitations, but microenvironmental restriction, affected dominantly the dynamics of cell growth. Also interesting phenomenon of very different rates of cell number growth during cultivation is observed. After some critical time, the growth rate of cell colonies decreased drastically, but than suddenly increased again under all other experimental condition been the same. It is interpreted as disintegration of gel network and opening new free space for growth of cell clusters. These complex phenomena are modeled using the thermodynamical, free energy formalism. The particular form of free energy functional is proposed to describe various kinds of interactions, which affected the dynamics of cell growth and cause pseudo-phase transition of hydrogel. The good agreement of experimentally obtained data and model predictions are obtained. In that way the model provides both, the quantitative tools for further technological optimization of the process and deeper insight into dynamics of cell growth mechanism.
PB  - Elsevier, Amsterdam
T2  - Journal of Biotechnology
T1  - Ca-alginate hydrogel mechanical transformations - The influence on yeast cell growth dynamics
EP  - 452
IS  - 3
SP  - 446
VL  - 129
DO  - 10.1016/j.jbiotec.2007.01.017
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Plavšić, Milenko B. and Bugarski, Branko and Nedović, Viktor",
year = "2007",
abstract = "A mathematical model was formulated to describe yeast cell growth within the Ca-alginate microbead during air-lift bioreactor cultivation. Model development was based on experimentally obtained data for the intra-bead cell concentration profile, after reached the equilibrium state, as well as, total yeast cell concentration per microbed and microbead volume as function of time. Relatively uniform cell concentration in the carrier matrix indicated that no internal nutrient diffusion limitations, but microenvironmental restriction, affected dominantly the dynamics of cell growth. Also interesting phenomenon of very different rates of cell number growth during cultivation is observed. After some critical time, the growth rate of cell colonies decreased drastically, but than suddenly increased again under all other experimental condition been the same. It is interpreted as disintegration of gel network and opening new free space for growth of cell clusters. These complex phenomena are modeled using the thermodynamical, free energy formalism. The particular form of free energy functional is proposed to describe various kinds of interactions, which affected the dynamics of cell growth and cause pseudo-phase transition of hydrogel. The good agreement of experimentally obtained data and model predictions are obtained. In that way the model provides both, the quantitative tools for further technological optimization of the process and deeper insight into dynamics of cell growth mechanism.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Biotechnology",
title = "Ca-alginate hydrogel mechanical transformations - The influence on yeast cell growth dynamics",
pages = "452-446",
number = "3",
volume = "129",
doi = "10.1016/j.jbiotec.2007.01.017"
}

Pajić-Lijaković, I., Plavšić, M. B., Bugarski, B.,& Nedović, V.. (2007). Ca-alginate hydrogel mechanical transformations - The influence on yeast cell growth dynamics. in Journal of Biotechnology
Elsevier, Amsterdam., 129(3), 446-452.
https://doi.org/10.1016/j.jbiotec.2007.01.017

Pajić-Lijaković I, Plavšić MB, Bugarski B, Nedović V. Ca-alginate hydrogel mechanical transformations - The influence on yeast cell growth dynamics. in Journal of Biotechnology. 2007;129(3):446-452.
doi:10.1016/j.jbiotec.2007.01.017 .

Pajić-Lijaković, Ivana, Plavšić, Milenko B., Bugarski, Branko, Nedović, Viktor, "Ca-alginate hydrogel mechanical transformations - The influence on yeast cell growth dynamics" in Journal of Biotechnology, 129, no. 3 (2007):446-452,
https://doi.org/10.1016/j.jbiotec.2007.01.017 . .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1013
AB  - Scaling of the real and the imaginary part of dynamic moduli with frequency, for fully cured elastomer materials as gum and active carbon black filled butyl rubbers, is considered experimentally and theoretically. For gum rubber in different ranges of frequency complete agreement with G ''-scaling predicted by the Rouse theory is obtained. Obtained slopes for all G' and G '' of filled rubber are much lower.
PB  - 8th Conference of the Yugoslav Materials Research Society
T2  - Materials Science Forum
T1  - Fracton scaling and dynamical properties of elastomer materials
EP  - 472
SP  - 467
VL  - 555
DO  - 10.4028/0-87849-441-3.467
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana",
year = "2007",
abstract = "Scaling of the real and the imaginary part of dynamic moduli with frequency, for fully cured elastomer materials as gum and active carbon black filled butyl rubbers, is considered experimentally and theoretically. For gum rubber in different ranges of frequency complete agreement with G ''-scaling predicted by the Rouse theory is obtained. Obtained slopes for all G' and G '' of filled rubber are much lower.",
publisher = "8th Conference of the Yugoslav Materials Research Society",
journal = "Materials Science Forum",
title = "Fracton scaling and dynamical properties of elastomer materials",
pages = "472-467",
volume = "555",
doi = "10.4028/0-87849-441-3.467"
}

Plavšić, M. B.,& Pajić-Lijaković, I.. (2007). Fracton scaling and dynamical properties of elastomer materials. in Materials Science Forum
8th Conference of the Yugoslav Materials Research Society., 555, 467-472.
https://doi.org/10.4028/0-87849-441-3.467

Plavšić MB, Pajić-Lijaković I. Fracton scaling and dynamical properties of elastomer materials. in Materials Science Forum. 2007;555:467-472.
doi:10.4028/0-87849-441-3.467 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, "Fracton scaling and dynamical properties of elastomer materials" in Materials Science Forum, 555 (2007):467-472,
https://doi.org/10.4028/0-87849-441-3.467 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1159
AB  - The rheological model is developed to elucidate the mechanism of Ca-alginate microbead deformation in the course of cell growth within. It is a complex process influenced by relaxation of the expanded polymer network inside a bead, and forces generated by cell growth inside the bead and interactions between solvent, network parts and cells as well. The resulting effects are measured experimentally by estimating isotropic volumetric deformations of beads with yeast cells as function of time and cell concentration per bead. The mathematical model of the process is developed based on a modified general Zener model with fractional derivatives. It is particularly suitable for incorporating effects of different nature also during different stages of such complex process development. The results of theoretical analyses using the model developed and comparison with experimental values obtained, indicate a high impact of partial decomposition, i.e. plastic response of polymer network inside a bead due to cell growth, on bead deformation. For comparison, corresponding deformation measurements and modelling were performed on the same network system exposed to swelling in the solvent, but without the cells. In this case elastic forces are dominant, indicating different mechanism of relaxation without the influence of cells, in agreement with previous conclusions.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Microencapsulation
T1  - Investigation of Ca-alginate hydrogel rheological behaviour in conjunction with immobilized yeast cell growth dynamics
EP  - 429
IS  - 5
SP  - 420
VL  - 24
DO  - 10.1080/02652040701362843
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Plavšić, Milenko B. and Nedović, Viktor and Bugarski, Branko",
year = "2007",
abstract = "The rheological model is developed to elucidate the mechanism of Ca-alginate microbead deformation in the course of cell growth within. It is a complex process influenced by relaxation of the expanded polymer network inside a bead, and forces generated by cell growth inside the bead and interactions between solvent, network parts and cells as well. The resulting effects are measured experimentally by estimating isotropic volumetric deformations of beads with yeast cells as function of time and cell concentration per bead. The mathematical model of the process is developed based on a modified general Zener model with fractional derivatives. It is particularly suitable for incorporating effects of different nature also during different stages of such complex process development. The results of theoretical analyses using the model developed and comparison with experimental values obtained, indicate a high impact of partial decomposition, i.e. plastic response of polymer network inside a bead due to cell growth, on bead deformation. For comparison, corresponding deformation measurements and modelling were performed on the same network system exposed to swelling in the solvent, but without the cells. In this case elastic forces are dominant, indicating different mechanism of relaxation without the influence of cells, in agreement with previous conclusions.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Microencapsulation",
title = "Investigation of Ca-alginate hydrogel rheological behaviour in conjunction with immobilized yeast cell growth dynamics",
pages = "429-420",
number = "5",
volume = "24",
doi = "10.1080/02652040701362843"
}

Pajić-Lijaković, I., Plavšić, M. B., Nedović, V.,& Bugarski, B.. (2007). Investigation of Ca-alginate hydrogel rheological behaviour in conjunction with immobilized yeast cell growth dynamics. in Journal of Microencapsulation
Taylor & Francis Ltd, Abingdon., 24(5), 420-429.
https://doi.org/10.1080/02652040701362843

Pajić-Lijaković I, Plavšić MB, Nedović V, Bugarski B. Investigation of Ca-alginate hydrogel rheological behaviour in conjunction with immobilized yeast cell growth dynamics. in Journal of Microencapsulation. 2007;24(5):420-429.
doi:10.1080/02652040701362843 .

Pajić-Lijaković, Ivana, Plavšić, Milenko B., Nedović, Viktor, Bugarski, Branko, "Investigation of Ca-alginate hydrogel rheological behaviour in conjunction with immobilized yeast cell growth dynamics" in Journal of Microencapsulation, 24, no. 5 (2007):420-429,
https://doi.org/10.1080/02652040701362843 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Plavšić, Milenko B.
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1194
AB  - A phase-field model was formulated to describe yeast cell growth within the Ca-alginate microbead during air-lift bioreactor cultivation. Model development was based on experimentally obtained data for intra-bead yeast cell volume fraction profile after reaching the equilibrium state, as well as, total yeast cell volume fraction per microbead and microbead volume as functions of time. Relatively uniform cell concentration in the microbead, experimentally obtained, indicated microenvironmental restriction effects due to deformation and disintegration of previously swollen alginate hydrogel, while internal nutrient diffusion limitation could be neglected in the case of alginate microbeads used in this study. Microbead with growing yeast cells is treated as two phase system. One phase represents the cell agglomerates, while the other is the alginate hydrogel matrices. The interactions between phases are modeled using the Langevin class, non-conservative phase-field model. Such class of models is suitable for considering the growth of small domains of one phase as nucleation. Besides giving useful insights into the dynamics of restrictive cell growth within the Ca-alginate microbead, the model can be used as a tool to design/optimize the performance of microbead and studying the microenvironmental restrictive mechanism action on the cell growth. .
AB  - Fazni model je formulisan da opiše rast ćelija kvasaca unutar Ca-alginatnih nosača za vreme perioda kultivacije u air-lift bioreaktoru. Model je razvijen na osnovu prikupljenih eksperimentalnih podataka za profil yapreminskog udela ćelija unutar nosača nakon postizanja stacionarnog stanja, za yapreminski udeo ćelija po nosaču u funkciji vremena i za promenu zapremine nosača u toku vremena. Relativno uniformna koncentracija ćelija, eksperimentalno primećena, unutar Ca-alginatnih nosača ukazuje na postojanje restriktivnih efekata sredine koji limitiraju rast ćelija, kao što su deformisanje i razgradnja matrice nosača. Otpori difuziji nutrenata kroz nosač se mogu zanemariti. Mironosač sa imobilisanim ćelijama koje rastu se može tretirati kao dvo-fazni sistem. Jednu fazu pretstavljaju aglomerati ćelija, a drugu matrica Ca-alginatnog hidrogela. Interakcije izmedju faza su modelovane koristeći Lanževinovu klasu ne konzervativnih faznih modela. Ova klasa modela je pogodna za razmatranje rasta malih domena jedne faze u toku procesa nukleacije. S obziromda daje koristan uvid u dinamiku restriktivnog rasta ćelija unutar Ca-alginatnih nosača, ovaj model može biti korišćen kao sredstvo za dizajniranje/optimizaciju osobina mikronosača i proučavanje mehanizama restriktivnog dejstva mikrookoline ćelija unutar nosača na dinamiku rasta ćelija. .
PB  - Univerzitet u Nišu - Tehnološki fakultet, Leskovac
T2  - Zbornik radova Tehnološkog fakulteta, Leskovac
T1  - Phase-field modeling of dynamics of immobilized yeast cell growth in Ca-alginate microbead
T1  - Fazno modelovanje dinamike rasta imobilisanih ćelija kvasca u Ca-alginatnim nosačima
EP  - 63
IS  - 16
SP  - 57
UR  - https://hdl.handle.net/21.15107/rcub_technorep_1194
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Plavšić, Milenko B. and Nedović, Viktor and Bugarski, Branko",
year = "2007",
abstract = "A phase-field model was formulated to describe yeast cell growth within the Ca-alginate microbead during air-lift bioreactor cultivation. Model development was based on experimentally obtained data for intra-bead yeast cell volume fraction profile after reaching the equilibrium state, as well as, total yeast cell volume fraction per microbead and microbead volume as functions of time. Relatively uniform cell concentration in the microbead, experimentally obtained, indicated microenvironmental restriction effects due to deformation and disintegration of previously swollen alginate hydrogel, while internal nutrient diffusion limitation could be neglected in the case of alginate microbeads used in this study. Microbead with growing yeast cells is treated as two phase system. One phase represents the cell agglomerates, while the other is the alginate hydrogel matrices. The interactions between phases are modeled using the Langevin class, non-conservative phase-field model. Such class of models is suitable for considering the growth of small domains of one phase as nucleation. Besides giving useful insights into the dynamics of restrictive cell growth within the Ca-alginate microbead, the model can be used as a tool to design/optimize the performance of microbead and studying the microenvironmental restrictive mechanism action on the cell growth. ., Fazni model je formulisan da opiše rast ćelija kvasaca unutar Ca-alginatnih nosača za vreme perioda kultivacije u air-lift bioreaktoru. Model je razvijen na osnovu prikupljenih eksperimentalnih podataka za profil yapreminskog udela ćelija unutar nosača nakon postizanja stacionarnog stanja, za yapreminski udeo ćelija po nosaču u funkciji vremena i za promenu zapremine nosača u toku vremena. Relativno uniformna koncentracija ćelija, eksperimentalno primećena, unutar Ca-alginatnih nosača ukazuje na postojanje restriktivnih efekata sredine koji limitiraju rast ćelija, kao što su deformisanje i razgradnja matrice nosača. Otpori difuziji nutrenata kroz nosač se mogu zanemariti. Mironosač sa imobilisanim ćelijama koje rastu se može tretirati kao dvo-fazni sistem. Jednu fazu pretstavljaju aglomerati ćelija, a drugu matrica Ca-alginatnog hidrogela. Interakcije izmedju faza su modelovane koristeći Lanževinovu klasu ne konzervativnih faznih modela. Ova klasa modela je pogodna za razmatranje rasta malih domena jedne faze u toku procesa nukleacije. S obziromda daje koristan uvid u dinamiku restriktivnog rasta ćelija unutar Ca-alginatnih nosača, ovaj model može biti korišćen kao sredstvo za dizajniranje/optimizaciju osobina mikronosača i proučavanje mehanizama restriktivnog dejstva mikrookoline ćelija unutar nosača na dinamiku rasta ćelija. .",
publisher = "Univerzitet u Nišu - Tehnološki fakultet, Leskovac",
journal = "Zbornik radova Tehnološkog fakulteta, Leskovac",
title = "Phase-field modeling of dynamics of immobilized yeast cell growth in Ca-alginate microbead, Fazno modelovanje dinamike rasta imobilisanih ćelija kvasca u Ca-alginatnim nosačima",
pages = "63-57",
number = "16",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1194"
}

Pajić-Lijaković, I., Plavšić, M. B., Nedović, V.,& Bugarski, B.. (2007). Phase-field modeling of dynamics of immobilized yeast cell growth in Ca-alginate microbead. in Zbornik radova Tehnološkog fakulteta, Leskovac
Univerzitet u Nišu - Tehnološki fakultet, Leskovac.(16), 57-63.
https://hdl.handle.net/21.15107/rcub_technorep_1194

Pajić-Lijaković I, Plavšić MB, Nedović V, Bugarski B. Phase-field modeling of dynamics of immobilized yeast cell growth in Ca-alginate microbead. in Zbornik radova Tehnološkog fakulteta, Leskovac. 2007;(16):57-63.
https://hdl.handle.net/21.15107/rcub_technorep_1194 .

Pajić-Lijaković, Ivana, Plavšić, Milenko B., Nedović, Viktor, Bugarski, Branko, "Phase-field modeling of dynamics of immobilized yeast cell growth in Ca-alginate microbead" in Zbornik radova Tehnološkog fakulteta, Leskovac, no. 16 (2007):57-63,
https://hdl.handle.net/21.15107/rcub_technorep_1194 .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Bugarski, Branko
AU  - Plavšić, Milenko B.
PY  - 2005
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/842
AB  - The development of lipid-based fine particles as potential drug carriers requires a detailed investigation of the possible effects of these carriers on the rheological properties of blood. In this study, we investigated the influence of dynamic conditions on aggregate formation and stability in dispersions of lipid-based fine particles in whole blood under in vitro conditions. The rheological parameters of two concentrations of liposome dispersion and two concentrations of lipid emulsion in blood were examined. A micro-rheological model of aggregating dispersions is proposed in which the apparent viscosity is estimated as the sum of the hydrodynamic and structural parts which are correlated with system structural ordering in the flow. The dynamics of structural ordering of the aggregating system an considered by examining the evolution of the state of the system in phase space depending on the shear rate. The addition of lipid-based particles induced aggregate formation in the blood, which was more pronounced at higher concentrations of lipid-based fine particles. Furthermore, larger and more stable aggregates are formed in liposome dispersions as compared to lipid emulsions in blood.
AB  - Razvoj lipidnih čestica za primenu kao nosači lekova zahteva dodatno ispitivanje efekata koje ovi nosači imaju na reološke osobine krvi. U ovoj studiji je ispitivan uticaj dinamičkih uslova na formiranje agregata l njihovu stabilnost u disperzijama lipidnih čestica u krvi, u uslovima in vitro. Određivani su reološki parametri za dve koncentracije lipozoma i lipidne emulzije u krvi. U radu je predložen mikro-reološki model za agregirajuće disperzije kod koga se prividna viskoznost izražava kao suma hidrodinamičkog i strukturnog dela koji se povezuju sa strukturnim uređivanjem u toku. Razmatrana je dinamika strukturnog uređivanja agregišućeg sistema ispitivanjem evolucije sistema u faznom prostoru u zavisnosti od brzine smicanja. Dodavanje lipidnih čestica krvi izazivaju formiranje agregata, što je više izraženo pri većim koncentracijama lipidnih čestica. Veći i znatno stabilniji agregati se formiraju u disperzijama lipozoma nego u disperzijama lipidnih emulzija.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Rheological examination of erythrocyte aggregation in the presence of lipid-based fine particles
T1  - Reološko ispitivanje agregacije eritrocita u prisustvu lipidnih čestica
EP  - 54
IS  - 2
SP  - 49
VL  - 11
DO  - 10.2298/CICEQ0502049P
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Bugarski, Branko and Plavšić, Milenko B.",
year = "2005",
abstract = "The development of lipid-based fine particles as potential drug carriers requires a detailed investigation of the possible effects of these carriers on the rheological properties of blood. In this study, we investigated the influence of dynamic conditions on aggregate formation and stability in dispersions of lipid-based fine particles in whole blood under in vitro conditions. The rheological parameters of two concentrations of liposome dispersion and two concentrations of lipid emulsion in blood were examined. A micro-rheological model of aggregating dispersions is proposed in which the apparent viscosity is estimated as the sum of the hydrodynamic and structural parts which are correlated with system structural ordering in the flow. The dynamics of structural ordering of the aggregating system an considered by examining the evolution of the state of the system in phase space depending on the shear rate. The addition of lipid-based particles induced aggregate formation in the blood, which was more pronounced at higher concentrations of lipid-based fine particles. Furthermore, larger and more stable aggregates are formed in liposome dispersions as compared to lipid emulsions in blood., Razvoj lipidnih čestica za primenu kao nosači lekova zahteva dodatno ispitivanje efekata koje ovi nosači imaju na reološke osobine krvi. U ovoj studiji je ispitivan uticaj dinamičkih uslova na formiranje agregata l njihovu stabilnost u disperzijama lipidnih čestica u krvi, u uslovima in vitro. Određivani su reološki parametri za dve koncentracije lipozoma i lipidne emulzije u krvi. U radu je predložen mikro-reološki model za agregirajuće disperzije kod koga se prividna viskoznost izražava kao suma hidrodinamičkog i strukturnog dela koji se povezuju sa strukturnim uređivanjem u toku. Razmatrana je dinamika strukturnog uređivanja agregišućeg sistema ispitivanjem evolucije sistema u faznom prostoru u zavisnosti od brzine smicanja. Dodavanje lipidnih čestica krvi izazivaju formiranje agregata, što je više izraženo pri većim koncentracijama lipidnih čestica. Veći i znatno stabilniji agregati se formiraju u disperzijama lipozoma nego u disperzijama lipidnih emulzija.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Rheological examination of erythrocyte aggregation in the presence of lipid-based fine particles, Reološko ispitivanje agregacije eritrocita u prisustvu lipidnih čestica",
pages = "54-49",
number = "2",
volume = "11",
doi = "10.2298/CICEQ0502049P"
}

Pajić-Lijaković, I., Bugarski, B.,& Plavšić, M. B.. (2005). Rheological examination of erythrocyte aggregation in the presence of lipid-based fine particles. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 11(2), 49-54.
https://doi.org/10.2298/CICEQ0502049P

Pajić-Lijaković I, Bugarski B, Plavšić MB. Rheological examination of erythrocyte aggregation in the presence of lipid-based fine particles. in Chemical Industry & Chemical Engineering Quarterly. 2005;11(2):49-54.
doi:10.2298/CICEQ0502049P .

Pajić-Lijaković, Ivana, Bugarski, Branko, Plavšić, Milenko B., "Rheological examination of erythrocyte aggregation in the presence of lipid-based fine particles" in Chemical Industry & Chemical Engineering Quarterly, 11, no. 2 (2005):49-54,
https://doi.org/10.2298/CICEQ0502049P . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Bugarski, Branko
AU  - Nedović, Viktor
AU  - Plavšić, Milenko B.
PY  - 2005
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/724
AB  - Aim. The aggregation of phospholipid vesicles (liposomes) in water is analyzed experimentally and theoretically and compared with the well-examined alumina dispersions. The steady-state aggregation followed rheologically for various volume fractions of particles and shear rates. Methods. A micro-rheological model of aggregating dispersions is proposed in which the apparent viscosity is estimated as the sum of hydrodynamic and structural parts, which are correlated with system structural ordering. Langevin equation is used to describe the dynamics of evolution of steady-states of liposome systems in phase space, for various shear rates. Results. These results established a link between the local dynamics of liposome dispersions and their flow behavior. Conclusion. Aggregates become more compact and embedded higher volume of fluid when shear rate increases. Hydrodynamic part of viscosity increases, while structural part of viscosity decreases with shear rate. Calculated value of bond energy between liposomes corresponds to hydrogen bond energy.
T2  - Minerva Biotecnologica
T1  - Rheological quantification of liposomes aggregation
EP  - 249
IS  - 4
SP  - 245
VL  - 17
UR  - https://hdl.handle.net/21.15107/rcub_technorep_724
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Bugarski, Branko and Nedović, Viktor and Plavšić, Milenko B.",
year = "2005",
abstract = "Aim. The aggregation of phospholipid vesicles (liposomes) in water is analyzed experimentally and theoretically and compared with the well-examined alumina dispersions. The steady-state aggregation followed rheologically for various volume fractions of particles and shear rates. Methods. A micro-rheological model of aggregating dispersions is proposed in which the apparent viscosity is estimated as the sum of hydrodynamic and structural parts, which are correlated with system structural ordering. Langevin equation is used to describe the dynamics of evolution of steady-states of liposome systems in phase space, for various shear rates. Results. These results established a link between the local dynamics of liposome dispersions and their flow behavior. Conclusion. Aggregates become more compact and embedded higher volume of fluid when shear rate increases. Hydrodynamic part of viscosity increases, while structural part of viscosity decreases with shear rate. Calculated value of bond energy between liposomes corresponds to hydrogen bond energy.",
journal = "Minerva Biotecnologica",
title = "Rheological quantification of liposomes aggregation",
pages = "249-245",
number = "4",
volume = "17",
url = "https://hdl.handle.net/21.15107/rcub_technorep_724"
}

Pajić-Lijaković, I., Bugarski, B., Nedović, V.,& Plavšić, M. B.. (2005). Rheological quantification of liposomes aggregation. in Minerva Biotecnologica, 17(4), 245-249.
https://hdl.handle.net/21.15107/rcub_technorep_724

Pajić-Lijaković I, Bugarski B, Nedović V, Plavšić MB. Rheological quantification of liposomes aggregation. in Minerva Biotecnologica. 2005;17(4):245-249.
https://hdl.handle.net/21.15107/rcub_technorep_724 .

Pajić-Lijaković, Ivana, Bugarski, Branko, Nedović, Viktor, Plavšić, Milenko B., "Rheological quantification of liposomes aggregation" in Minerva Biotecnologica, 17, no. 4 (2005):245-249,
https://hdl.handle.net/21.15107/rcub_technorep_724 .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Putanov, P
PY  - 2005
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/833
AB  - Design of mechanical properties, especially the relation between tensile and dynamic moduli in terms of chain conformational statistics is considered. Data on new elastomer blends with gradient properties, able for mixing on molecular level and partial networking with separation of phases, are analyzed in parallel to classical commodity materials. Especial attention is paid to synergetic effects of the increase of blend modulus, relative to moduli obtained by linear "rule of mixtures" for component polymer moduli, described by Kleiner-Karasz-MacKnight equation, and new models based on self-similar scaling of elastomer network dynamics. New data on model blends exposing synergetic effects with the change of conformational statistics are presented as well.
PB  - Amer Chemical Soc, Washington
T2  - New Polymeric Materials
T1  - Chain conformational statistics and mechanical properties of elastomer blends
EP  - 266
SP  - 252
VL  - 916
UR  - https://hdl.handle.net/21.15107/rcub_technorep_833
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Putanov, P",
year = "2005",
abstract = "Design of mechanical properties, especially the relation between tensile and dynamic moduli in terms of chain conformational statistics is considered. Data on new elastomer blends with gradient properties, able for mixing on molecular level and partial networking with separation of phases, are analyzed in parallel to classical commodity materials. Especial attention is paid to synergetic effects of the increase of blend modulus, relative to moduli obtained by linear "rule of mixtures" for component polymer moduli, described by Kleiner-Karasz-MacKnight equation, and new models based on self-similar scaling of elastomer network dynamics. New data on model blends exposing synergetic effects with the change of conformational statistics are presented as well.",
publisher = "Amer Chemical Soc, Washington",
journal = "New Polymeric Materials",
title = "Chain conformational statistics and mechanical properties of elastomer blends",
pages = "266-252",
volume = "916",
url = "https://hdl.handle.net/21.15107/rcub_technorep_833"
}

Plavšić, M. B., Pajić-Lijaković, I.,& Putanov, P.. (2005). Chain conformational statistics and mechanical properties of elastomer blends. in New Polymeric Materials
Amer Chemical Soc, Washington., 916, 252-266.
https://hdl.handle.net/21.15107/rcub_technorep_833

Plavšić MB, Pajić-Lijaković I, Putanov P. Chain conformational statistics and mechanical properties of elastomer blends. in New Polymeric Materials. 2005;916:252-266.
https://hdl.handle.net/21.15107/rcub_technorep_833 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Putanov, P, "Chain conformational statistics and mechanical properties of elastomer blends" in New Polymeric Materials, 916 (2005):252-266,
https://hdl.handle.net/21.15107/rcub_technorep_833 .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Lazić, N
PY  - 2005
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/714
AB  - The change in elastomer tensile moduli, as formulated in the Gaussian statistical theory of rubber elasticity, with deformation, is considered both experimentally and theoretically. Gum elastomers of different structures and corresponding materials filled with carbon black, as reinforcing filler, are investigated experimentally. For all materials considered, the same scaling pattern with negative and low slope for small deformations, and positive and higher slope for large deformations is obtained, indicating two distinct mechanisms of elastic response. Most pronounced is the similarity of small deformation responses for filled materials. Considering the modulus as an elastic energy density gradient dependent on structure changes with deformation, and interpreting the changes for small deformations in terms of conformational energy change, the fractal dimension of a new type is formulated. It describes the decrease in elastomer network connectivity with deformations, which is discussed in terms of conformon dynamics. Possibilities of application of Faynman's path integral method and statistical method of random walk to the lattice are considered for the conformon, as well.
PB  - 6th Conference of the Yugoslav Materials Research Society, YUCOMAT VI: Current Research in Advanced Materials and Processes
T2  - Materials Science Forum
T1  - Scaling of network segment dimensions in hyperelastic composites
EP  - 468
SP  - 463
VL  - 494
DO  - 10.4028/0-87849-971-7.463
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Lazić, N",
year = "2005",
abstract = "The change in elastomer tensile moduli, as formulated in the Gaussian statistical theory of rubber elasticity, with deformation, is considered both experimentally and theoretically. Gum elastomers of different structures and corresponding materials filled with carbon black, as reinforcing filler, are investigated experimentally. For all materials considered, the same scaling pattern with negative and low slope for small deformations, and positive and higher slope for large deformations is obtained, indicating two distinct mechanisms of elastic response. Most pronounced is the similarity of small deformation responses for filled materials. Considering the modulus as an elastic energy density gradient dependent on structure changes with deformation, and interpreting the changes for small deformations in terms of conformational energy change, the fractal dimension of a new type is formulated. It describes the decrease in elastomer network connectivity with deformations, which is discussed in terms of conformon dynamics. Possibilities of application of Faynman's path integral method and statistical method of random walk to the lattice are considered for the conformon, as well.",
publisher = "6th Conference of the Yugoslav Materials Research Society, YUCOMAT VI: Current Research in Advanced Materials and Processes",
journal = "Materials Science Forum",
title = "Scaling of network segment dimensions in hyperelastic composites",
pages = "468-463",
volume = "494",
doi = "10.4028/0-87849-971-7.463"
}

Plavšić, M. B., Pajić-Lijaković, I.,& Lazić, N.. (2005). Scaling of network segment dimensions in hyperelastic composites. in Materials Science Forum
6th Conference of the Yugoslav Materials Research Society, YUCOMAT VI: Current Research in Advanced Materials and Processes., 494, 463-468.
https://doi.org/10.4028/0-87849-971-7.463

Plavšić MB, Pajić-Lijaković I, Lazić N. Scaling of network segment dimensions in hyperelastic composites. in Materials Science Forum. 2005;494:463-468.
doi:10.4028/0-87849-971-7.463 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Lazić, N, "Scaling of network segment dimensions in hyperelastic composites" in Materials Science Forum, 494 (2005):463-468,
https://doi.org/10.4028/0-87849-971-7.463 . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Bugarski, Branko
AU  - Plavšić, Milenko B.
PY  - 2004
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/604
AB  - The evolution of oscillatory-induced structure of Na-alginate solutions was studied for various frequencies and concentrations. The specific rate of elastic modulus increase, as well as the specific rate of loss modulus increase were used as a measure of chains flexibility in the flow field. The results were compared with the theory of Rouse proposed for flexible chains. All values of the specific rate of elastic modulus increase and the specific rate of loss modulus increase were higher then value from Rouse theory, indicating specific scaling and high rigidity of Na-alginate chains.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Viscoelastic properties of Na-alginate solution
EP  - 45
IS  - 6a
SP  - 44
VL  - 58
UR  - https://hdl.handle.net/21.15107/rcub_technorep_604
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Bugarski, Branko and Plavšić, Milenko B.",
year = "2004",
abstract = "The evolution of oscillatory-induced structure of Na-alginate solutions was studied for various frequencies and concentrations. The specific rate of elastic modulus increase, as well as the specific rate of loss modulus increase were used as a measure of chains flexibility in the flow field. The results were compared with the theory of Rouse proposed for flexible chains. All values of the specific rate of elastic modulus increase and the specific rate of loss modulus increase were higher then value from Rouse theory, indicating specific scaling and high rigidity of Na-alginate chains.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Viscoelastic properties of Na-alginate solution",
pages = "45-44",
number = "6a",
volume = "58",
url = "https://hdl.handle.net/21.15107/rcub_technorep_604"
}

Pajić-Lijaković, I., Bugarski, B.,& Plavšić, M. B.. (2004). Viscoelastic properties of Na-alginate solution. in Hemijska industrija
Association of Chemical Engineers of Serbia., 58(6a), 44-45.
https://hdl.handle.net/21.15107/rcub_technorep_604

Pajić-Lijaković I, Bugarski B, Plavšić MB. Viscoelastic properties of Na-alginate solution. in Hemijska industrija. 2004;58(6a):44-45.
https://hdl.handle.net/21.15107/rcub_technorep_604 .

Pajić-Lijaković, Ivana, Bugarski, Branko, Plavšić, Milenko B., "Viscoelastic properties of Na-alginate solution" in Hemijska industrija, 58, no. 6a (2004):44-45,
https://hdl.handle.net/21.15107/rcub_technorep_604 .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Cubrić, B
AU  - Popović, RS
AU  - Bugarski, Branko
AU  - Cvetković, M
AU  - Lazić, N
PY  - 2004
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/602
AB  - A new equation of state for elastomer network under constrains due to fillers has been proposed and verified for two most common and industry important rubbers, natural rubber and styrene-butadiene rubber. A series of elastomer materials without and with reinforcing carbon black Was prepared. Analyses of the obtained data confirm that the most important parameter is extensibility parameter q, describing the effective network density for a given space distribution of chains. Conformational statistics changes with addition of fillers have been discussed.
PB  - Progress in Advanced Materials and Processes: Proceedings of the Fifth Jugoslav Materials Research Society, YUCOMAT V
T2  - Materials Science Forum
T1  - Chain conformational statistics and mechanical properties of elastomer composites
EP  - 490
SP  - 485
VL  - 453-454
UR  - https://hdl.handle.net/21.15107/rcub_technorep_602
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Cubrić, B and Popović, RS and Bugarski, Branko and Cvetković, M and Lazić, N",
year = "2004",
abstract = "A new equation of state for elastomer network under constrains due to fillers has been proposed and verified for two most common and industry important rubbers, natural rubber and styrene-butadiene rubber. A series of elastomer materials without and with reinforcing carbon black Was prepared. Analyses of the obtained data confirm that the most important parameter is extensibility parameter q, describing the effective network density for a given space distribution of chains. Conformational statistics changes with addition of fillers have been discussed.",
publisher = "Progress in Advanced Materials and Processes: Proceedings of the Fifth Jugoslav Materials Research Society, YUCOMAT V",
journal = "Materials Science Forum",
title = "Chain conformational statistics and mechanical properties of elastomer composites",
pages = "490-485",
volume = "453-454",
url = "https://hdl.handle.net/21.15107/rcub_technorep_602"
}

Plavšić, M. B., Pajić-Lijaković, I., Cubrić, B., Popović, R., Bugarski, B., Cvetković, M.,& Lazić, N.. (2004). Chain conformational statistics and mechanical properties of elastomer composites. in Materials Science Forum
Progress in Advanced Materials and Processes: Proceedings of the Fifth Jugoslav Materials Research Society, YUCOMAT V., 453-454, 485-490.
https://hdl.handle.net/21.15107/rcub_technorep_602

Plavšić MB, Pajić-Lijaković I, Cubrić B, Popović R, Bugarski B, Cvetković M, Lazić N. Chain conformational statistics and mechanical properties of elastomer composites. in Materials Science Forum. 2004;453-454:485-490.
https://hdl.handle.net/21.15107/rcub_technorep_602 .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Cubrić, B, Popović, RS, Bugarski, Branko, Cvetković, M, Lazić, N, "Chain conformational statistics and mechanical properties of elastomer composites" in Materials Science Forum, 453-454 (2004):485-490,
https://hdl.handle.net/21.15107/rcub_technorep_602 .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Pajić-Lijaković, Ivana
AU  - Čubrić, Branislav
AU  - Popović, Radivoj S.
AU  - Bugarski, Branko
AU  - Popović, Ružica G.
AU  - Lazić, Nada L.
PY  - 2003
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/564
AB  - The relations between the structure and mechanical properties of a polymer blend of natural (NR) and polybutadiene (BR) rubber (i.e. a NR/BR blend with the weight ratio of the components 70/30) filled with active carbon black were analysed. The properties of the individual phases in the blend were resolved by modeling the stress-strain relationship according to the Bauer procedure for high extensions. The obtained results indicated that BR is the dispersed phase, having a higher modulus, which was also confirmed by the much better fit of the experimental data to the series type of phase coupling according to the Takanayagy theory.
AB  - U radu se analizira zavisnost strukture i mehaničkih svojstava elastomernih materijala na bazi prirodnog (NR) i polibutadienskog (BR) kaučuka punjenih aktivnim čađima i blende ovih smesa NR/BR u masenom odnosu 70/30. Svojstva individualnih faza u 70/30 NR/BR blendi mogu se na zadovoljavajući način definisati modelom koji uzima u obzir zavisnost napon-deformacija pri velikim istezanjima. U sistemu NR/BR dispergovana faza BR ima viši modul u odnosu na kontinualnu NR fazu, te se interakcija izmedu faza blendi može modelovati na redni način.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Phase topology of a NR/BR elastomer blend with active filler
T1  - Fazna topologija elastomernih blendi NR/BR sa aktivnim punilom
EP  - 572
IS  - 11
SP  - 568
VL  - 57
DO  - 10.2298/HEMIND0311568P
ER  - 

@article{
author = "Plavšić, Milenko B. and Pajić-Lijaković, Ivana and Čubrić, Branislav and Popović, Radivoj S. and Bugarski, Branko and Popović, Ružica G. and Lazić, Nada L.",
year = "2003",
abstract = "The relations between the structure and mechanical properties of a polymer blend of natural (NR) and polybutadiene (BR) rubber (i.e. a NR/BR blend with the weight ratio of the components 70/30) filled with active carbon black were analysed. The properties of the individual phases in the blend were resolved by modeling the stress-strain relationship according to the Bauer procedure for high extensions. The obtained results indicated that BR is the dispersed phase, having a higher modulus, which was also confirmed by the much better fit of the experimental data to the series type of phase coupling according to the Takanayagy theory., U radu se analizira zavisnost strukture i mehaničkih svojstava elastomernih materijala na bazi prirodnog (NR) i polibutadienskog (BR) kaučuka punjenih aktivnim čađima i blende ovih smesa NR/BR u masenom odnosu 70/30. Svojstva individualnih faza u 70/30 NR/BR blendi mogu se na zadovoljavajući način definisati modelom koji uzima u obzir zavisnost napon-deformacija pri velikim istezanjima. U sistemu NR/BR dispergovana faza BR ima viši modul u odnosu na kontinualnu NR fazu, te se interakcija izmedu faza blendi može modelovati na redni način.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Phase topology of a NR/BR elastomer blend with active filler, Fazna topologija elastomernih blendi NR/BR sa aktivnim punilom",
pages = "572-568",
number = "11",
volume = "57",
doi = "10.2298/HEMIND0311568P"
}

Plavšić, M. B., Pajić-Lijaković, I., Čubrić, B., Popović, R. S., Bugarski, B., Popović, R. G.,& Lazić, N. L.. (2003). Phase topology of a NR/BR elastomer blend with active filler. in Hemijska industrija
Association of Chemical Engineers of Serbia., 57(11), 568-572.
https://doi.org/10.2298/HEMIND0311568P

Plavšić MB, Pajić-Lijaković I, Čubrić B, Popović RS, Bugarski B, Popović RG, Lazić NL. Phase topology of a NR/BR elastomer blend with active filler. in Hemijska industrija. 2003;57(11):568-572.
doi:10.2298/HEMIND0311568P .

Plavšić, Milenko B., Pajić-Lijaković, Ivana, Čubrić, Branislav, Popović, Radivoj S., Bugarski, Branko, Popović, Ružica G., Lazić, Nada L., "Phase topology of a NR/BR elastomer blend with active filler" in Hemijska industrija, 57, no. 11 (2003):568-572,
https://doi.org/10.2298/HEMIND0311568P . .

TY  - JOUR
AU  - Pajić-Lijaković, Ivana
AU  - Bugarski, Branko
AU  - Obradović, Bojana
AU  - Plavšić, Milenko B.
AU  - Bugarski, Diana
PY  - 2003
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/560
AB  - Development of lipid-based fine particles as potential drug carriers requires detailed investigation of possible effects of these carriers on rheological properties of blood. In this study, we have investigated the influence of dynamic conditions on aggregate formation and stability in dispersions of lipid-based fine particles in whole blood under in vitro conditions. Rheological parameters of two concentrations of liposome dispersion and two concentrations of lipid emulsion in blood were studied by assessing shear stress/shear rate relationships. The magnitude of attractive interactions between aggregates and/or particles, A, and the effective-to-real volume fraction of particles, phi(f)/phi(p) , were estimated for rheological quantification of lipid-based fine particles-blood interactions and aggregate stability. Addition of lipid-based particles induced aggregate formation in blood, which was more pronounced at higher concentrations of lipid-based fine particles. Furthermore, larger and more stable aggregates were formed in liposome dispersions as compared to lipid emulsions in blood.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Chemical Engineering Communications
T1  - Examination of rheological properties of fine particles as carriers for controlled drug release
EP  - 93
IS  - 1
SP  - 83
VL  - 190
DO  - 10.1080/00986440302091
ER  - 

@article{
author = "Pajić-Lijaković, Ivana and Bugarski, Branko and Obradović, Bojana and Plavšić, Milenko B. and Bugarski, Diana",
year = "2003",
abstract = "Development of lipid-based fine particles as potential drug carriers requires detailed investigation of possible effects of these carriers on rheological properties of blood. In this study, we have investigated the influence of dynamic conditions on aggregate formation and stability in dispersions of lipid-based fine particles in whole blood under in vitro conditions. Rheological parameters of two concentrations of liposome dispersion and two concentrations of lipid emulsion in blood were studied by assessing shear stress/shear rate relationships. The magnitude of attractive interactions between aggregates and/or particles, A, and the effective-to-real volume fraction of particles, phi(f)/phi(p) , were estimated for rheological quantification of lipid-based fine particles-blood interactions and aggregate stability. Addition of lipid-based particles induced aggregate formation in blood, which was more pronounced at higher concentrations of lipid-based fine particles. Furthermore, larger and more stable aggregates were formed in liposome dispersions as compared to lipid emulsions in blood.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Chemical Engineering Communications",
title = "Examination of rheological properties of fine particles as carriers for controlled drug release",
pages = "93-83",
number = "1",
volume = "190",
doi = "10.1080/00986440302091"
}

Pajić-Lijaković, I., Bugarski, B., Obradović, B., Plavšić, M. B.,& Bugarski, D.. (2003). Examination of rheological properties of fine particles as carriers for controlled drug release. in Chemical Engineering Communications
Taylor & Francis Inc, Philadelphia., 190(1), 83-93.
https://doi.org/10.1080/00986440302091

Pajić-Lijaković I, Bugarski B, Obradović B, Plavšić MB, Bugarski D. Examination of rheological properties of fine particles as carriers for controlled drug release. in Chemical Engineering Communications. 2003;190(1):83-93.
doi:10.1080/00986440302091 .

Pajić-Lijaković, Ivana, Bugarski, Branko, Obradović, Bojana, Plavšić, Milenko B., Bugarski, Diana, "Examination of rheological properties of fine particles as carriers for controlled drug release" in Chemical Engineering Communications, 190, no. 1 (2003):83-93,
https://doi.org/10.1080/00986440302091 . .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Paunović, Mihailo
AU  - Ušćumlić, Gordana
AU  - Koruga, D
PY  - 2002
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/410
AB  - A new procedure for introduction of aromatic diamines into polymer, in particular into poly(vinyl chloride) (PVC) molecule, was developed. Produced materials have attractive properties such as combination of good film-forming, coating and adhesive features (especially adhesion to hard-to-adhere substrates, as glass) and functionalization possibilities. Free pendent amine groups enable nucleophilic additions with fullerene molecule C-60, for creating especial properties of such a film.
PB  - Proceedings of the fourth Yugoslav Materials Research Society Conference (YUCOMAT IV)
T2  - Materials Science Forum
T1  - New functional polymers obtained by amination of PVC
EP  - 242
SP  - 237
VL  - 413
DO  - 10.4028/www.scientific.net/msf.413.237
ER  - 

@article{
author = "Plavšić, Milenko B. and Paunović, Mihailo and Ušćumlić, Gordana and Koruga, D",
year = "2002",
abstract = "A new procedure for introduction of aromatic diamines into polymer, in particular into poly(vinyl chloride) (PVC) molecule, was developed. Produced materials have attractive properties such as combination of good film-forming, coating and adhesive features (especially adhesion to hard-to-adhere substrates, as glass) and functionalization possibilities. Free pendent amine groups enable nucleophilic additions with fullerene molecule C-60, for creating especial properties of such a film.",
publisher = "Proceedings of the fourth Yugoslav Materials Research Society Conference (YUCOMAT IV)",
journal = "Materials Science Forum",
title = "New functional polymers obtained by amination of PVC",
pages = "242-237",
volume = "413",
doi = "10.4028/www.scientific.net/msf.413.237"
}

Plavšić, M. B., Paunović, M., Ušćumlić, G.,& Koruga, D.. (2002). New functional polymers obtained by amination of PVC. in Materials Science Forum
Proceedings of the fourth Yugoslav Materials Research Society Conference (YUCOMAT IV)., 413, 237-242.
https://doi.org/10.4028/www.scientific.net/msf.413.237

Plavšić MB, Paunović M, Ušćumlić G, Koruga D. New functional polymers obtained by amination of PVC. in Materials Science Forum. 2002;413:237-242.
doi:10.4028/www.scientific.net/msf.413.237 .

Plavšić, Milenko B., Paunović, Mihailo, Ušćumlić, Gordana, Koruga, D, "New functional polymers obtained by amination of PVC" in Materials Science Forum, 413 (2002):237-242,
https://doi.org/10.4028/www.scientific.net/msf.413.237 . .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Savić, Vojin
AU  - Najman, Stevo
AU  - Plavšić, Milenko
AU  - Uskoković, Dragan
PY  - 2001
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5350
AB  - Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C=O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found. Copyright © 2001 Elsevier Science Ltd.

Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C double bond O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.
PB  - Elsevier Science Ltd
T2  - Biomaterials
T1  - A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy
EP  - 575
IS  - 6
SP  - 571
VL  - 22
DO  - 10.1016/S0142-9612(00)00215-5
ER  - 

@article{
author = "Ignjatović, Nenad and Savić, Vojin and Najman, Stevo and Plavšić, Milenko and Uskoković, Dragan",
year = "2001",
abstract = "Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C=O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found. Copyright © 2001 Elsevier Science Ltd.

Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C double bond O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.",
publisher = "Elsevier Science Ltd",
journal = "Biomaterials",
title = "A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy",
pages = "575-571",
number = "6",
volume = "22",
doi = "10.1016/S0142-9612(00)00215-5"
}

Ignjatović, N., Savić, V., Najman, S., Plavšić, M.,& Uskoković, D.. (2001). A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. in Biomaterials
Elsevier Science Ltd., 22(6), 571-575.
https://doi.org/10.1016/S0142-9612(00)00215-5

Ignjatović N, Savić V, Najman S, Plavšić M, Uskoković D. A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. in Biomaterials. 2001;22(6):571-575.
doi:10.1016/S0142-9612(00)00215-5 .

Ignjatović, Nenad, Savić, Vojin, Najman, Stevo, Plavšić, Milenko, Uskoković, Dragan, "A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy" in Biomaterials, 22, no. 6 (2001):571-575,
https://doi.org/10.1016/S0142-9612(00)00215-5 . .