TY  - CONF
AU  - Marković, Maja D.
AU  - Svetozarević, Milica M.
AU  - Meng, Huan
AU  - Li, Zhen
AU  - Grad, Sibylle
AU  - Panić, Vesna V.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7391
AB  - INTRODUCTION: Inflammation  process  in  human  body  can  lead  to  many serious inflammation-related  diseases. Hence, there are urge to find better solution for the treatment of the inflammation processes. Solution can be found in application  ofpoly(methacrylicacid)  hydrogels  which  have  potential  for  targeted  delivery  and  controlled  release  of drugs. These pH-sensitive hydrogelscan swell at the pH values between 5 and 8,and release drug in the process. So,taking into account that pH value at the inflammation site is around 6, these hydrogels are materials of choice. It  is  very  important thatthe system  for  controlled  releasebe  prepared  through mild  and  non-toxic  conditions  in order to preserve bioactivity of the drug andkeep good impact on environment. Enzymes are good candidates for eco-friendly preparation of hydrogels, because these greensubstancescan initiate polymerisation of various monomers. 
EXPERIMENTAL (or Materials and Methods):In this study, hydrogels based on poly(methacrylic acid) were prepared through  eco-friendly  method  by  using enzyme/hydrogen  peroxide(HP)/ascorbic  acid(AA)as  initiator.  Two  groupsof the samples were prepared: in the first group peroxidase isolated from potato peel waste (with activity of 0.8 IU) was used in the initiation system, whereas in the second group peroxidase isolated from soya bean coats (with activity of 0.8  IU) was  employed  in  the  initiation  system.  The  amounts  of HPand AAin  both  series  were  40  μL  and  10  mg, respectively.Anti-inflammatory drugs,dexamethasone(5 mg/mL)and diclofenac(4.5 mg/mL)were encapsulated in the first and the second group of the PMAA samples, respectively. Anti-inflammatory  effect of the PMAA hydrogels  with encapsulated drugs were tested on the Bovine Chondrocytes cells.
RESULTS  AND  DISCUSSION:Results  showed  that  the  level  of  pro-inflammatory  mediators  NO  and  IL-8  decreased. The PCR analysis showed that the proinflammatory TNα, IL-6 genesexpression level decreased, the matrix catabolism MMP1and MMP3 genesexpression level decreased and the fibrotic COL2 and ACAN genes expression level increased.
CONCLUSIONS:The studyshowed that the PMAA hydrogels have anti-inflammatory effect and have potential for treatment of the inflammation processes.
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - Biocharacterization of hydrogels based on poly(methacrylic acid) prepared by eco-friendly method
IS  - 1S
SP  - 28
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7391
ER  - 

@conference{
author = "Marković, Maja D. and Svetozarević, Milica M. and Meng, Huan and Li, Zhen and Grad, Sibylle and Panić, Vesna V. and Kalagasidis Krušić, Melina T.",
year = "2024",
abstract = "INTRODUCTION: Inflammation  process  in  human  body  can  lead  to  many serious inflammation-related  diseases. Hence, there are urge to find better solution for the treatment of the inflammation processes. Solution can be found in application  ofpoly(methacrylicacid)  hydrogels  which  have  potential  for  targeted  delivery  and  controlled  release  of drugs. These pH-sensitive hydrogelscan swell at the pH values between 5 and 8,and release drug in the process. So,taking into account that pH value at the inflammation site is around 6, these hydrogels are materials of choice. It  is  very  important thatthe system  for  controlled  releasebe  prepared  through mild  and  non-toxic  conditions  in order to preserve bioactivity of the drug andkeep good impact on environment. Enzymes are good candidates for eco-friendly preparation of hydrogels, because these greensubstancescan initiate polymerisation of various monomers. 
EXPERIMENTAL (or Materials and Methods):In this study, hydrogels based on poly(methacrylic acid) were prepared through  eco-friendly  method  by  using enzyme/hydrogen  peroxide(HP)/ascorbic  acid(AA)as  initiator.  Two  groupsof the samples were prepared: in the first group peroxidase isolated from potato peel waste (with activity of 0.8 IU) was used in the initiation system, whereas in the second group peroxidase isolated from soya bean coats (with activity of 0.8  IU) was  employed  in  the  initiation  system.  The  amounts  of HPand AAin  both  series  were  40  μL  and  10  mg, respectively.Anti-inflammatory drugs,dexamethasone(5 mg/mL)and diclofenac(4.5 mg/mL)were encapsulated in the first and the second group of the PMAA samples, respectively. Anti-inflammatory  effect of the PMAA hydrogels  with encapsulated drugs were tested on the Bovine Chondrocytes cells.
RESULTS  AND  DISCUSSION:Results  showed  that  the  level  of  pro-inflammatory  mediators  NO  and  IL-8  decreased. The PCR analysis showed that the proinflammatory TNα, IL-6 genesexpression level decreased, the matrix catabolism MMP1and MMP3 genesexpression level decreased and the fibrotic COL2 and ACAN genes expression level increased.
CONCLUSIONS:The studyshowed that the PMAA hydrogels have anti-inflammatory effect and have potential for treatment of the inflammation processes.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "Biocharacterization of hydrogels based on poly(methacrylic acid) prepared by eco-friendly method",
number = "1S",
pages = "28",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7391"
}

Marković, M. D., Svetozarević, M. M., Meng, H., Li, Z., Grad, S., Panić, V. V.,& Kalagasidis Krušić, M. T.. (2024). Biocharacterization of hydrogels based on poly(methacrylic acid) prepared by eco-friendly method. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 28.
https://hdl.handle.net/21.15107/rcub_technorep_7391

Marković MD, Svetozarević MM, Meng H, Li Z, Grad S, Panić VV, Kalagasidis Krušić MT. Biocharacterization of hydrogels based on poly(methacrylic acid) prepared by eco-friendly method. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):28.
https://hdl.handle.net/21.15107/rcub_technorep_7391 .

Marković, Maja D., Svetozarević, Milica M., Meng, Huan, Li, Zhen, Grad, Sibylle, Panić, Vesna V., Kalagasidis Krušić, Melina T., "Biocharacterization of hydrogels based on poly(methacrylic acid) prepared by eco-friendly method" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):28,
https://hdl.handle.net/21.15107/rcub_technorep_7391 .

TY  - CONF
AU  - Kalagasidis Krušić, Melina
AU  - Lučić Škorić, Marija
AU  - Milovanović, Stoja
AU  - Panić, Vesna
AU  - Marković, Maja
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7392
AB  - The Polymer group of the Faculty of Technology and Metallurgy University of Belgrade deals with environment-sensitive hydrogel as carriersfor biomedical applications, including drug delivery, wound healing, and regenerative medicine. The first hydrogel generation synthesized in our labs was discs made of polyacrylamide and its derivatives. The synthesis was at higher temperatures (50 °C), with traditional crosslinker, N, N’-methylenebisacrylamide, and persulphate/pyrosulphate as initiator. Due to the growing demands for environmental sustainability, the general approach changed to reduce petrochemical raw materials and prepare eco-friendly materials focusing on 1) renewable polymers, initiators, and crosslinkers and 2) the application of simple, cost-effective, and eco-friendly approaches in hydrogel synthesis. To obtain the second hydrogel generation, we use renewable polymers: polysaccharides, proteins, and polyhydroxyalkanoates [1]. Still, the mechanical strength was weak. Hence, the applicationof carboxylic acids, methacrylic and itaconic, and N-isopropyl acrylamide improves mechanical properties and enhances the environmental stimuli of the carriers. Instead of traditional crosslinkers -organic molecules, we gave the advantage to plant extracts like genipin, sodium tripolyphosphate, citric acid, and calcium chloride. We made beads, microgels, aerogels, discs, films, and cylinders sensitive to pH, temperature, magnetic field, or specific molecules such as glucose. Facing an everyday challenge, improving drug delivery routes, especially for poorly water-soluble drugs, and finding an alternative to traditional antibiotics, encapsulation, and controlled release remain a challenge. Therefore, we used a mild condition (e.g., deep coating) to encapsulate/release traditional water-soluble and poorly water-soluble drugs, proteins, phenolic compounds, or supercritical carbon dioxide (scCO2) for thymol, carvacrol, and eugenol, a promising alternative for traditional antibiotics [2]. Furthermore, we reduced the hydrogel production temperature to ambient conditions and made a simple and cost-effective production process that doesn't require special equipment. The promising results we got pushed us further. So, the current research focuses on the encapsulation/controlled release of antioxidant phenolic compounds extracted from orange peel waste by applying ultrasonic-assisted extraction and deep eutectic solvent(DES) based on glycerol: urea: water. We use a new initiator system based on vitamin C and H2O2to polymerizea methacrylic acid[3]that could be useful for other monomers.As a concluding remark, we achieved significant progress in hydrogels encouragingus to continue further.
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - Environmentally friendly hydrogels for medical and pharmaceutical applications
IS  - 1S
SP  - 27
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7392
ER  - 

@conference{
author = "Kalagasidis Krušić, Melina and Lučić Škorić, Marija and Milovanović, Stoja and Panić, Vesna and Marković, Maja",
year = "2024",
abstract = "The Polymer group of the Faculty of Technology and Metallurgy University of Belgrade deals with environment-sensitive hydrogel as carriersfor biomedical applications, including drug delivery, wound healing, and regenerative medicine. The first hydrogel generation synthesized in our labs was discs made of polyacrylamide and its derivatives. The synthesis was at higher temperatures (50 °C), with traditional crosslinker, N, N’-methylenebisacrylamide, and persulphate/pyrosulphate as initiator. Due to the growing demands for environmental sustainability, the general approach changed to reduce petrochemical raw materials and prepare eco-friendly materials focusing on 1) renewable polymers, initiators, and crosslinkers and 2) the application of simple, cost-effective, and eco-friendly approaches in hydrogel synthesis. To obtain the second hydrogel generation, we use renewable polymers: polysaccharides, proteins, and polyhydroxyalkanoates [1]. Still, the mechanical strength was weak. Hence, the applicationof carboxylic acids, methacrylic and itaconic, and N-isopropyl acrylamide improves mechanical properties and enhances the environmental stimuli of the carriers. Instead of traditional crosslinkers -organic molecules, we gave the advantage to plant extracts like genipin, sodium tripolyphosphate, citric acid, and calcium chloride. We made beads, microgels, aerogels, discs, films, and cylinders sensitive to pH, temperature, magnetic field, or specific molecules such as glucose. Facing an everyday challenge, improving drug delivery routes, especially for poorly water-soluble drugs, and finding an alternative to traditional antibiotics, encapsulation, and controlled release remain a challenge. Therefore, we used a mild condition (e.g., deep coating) to encapsulate/release traditional water-soluble and poorly water-soluble drugs, proteins, phenolic compounds, or supercritical carbon dioxide (scCO2) for thymol, carvacrol, and eugenol, a promising alternative for traditional antibiotics [2]. Furthermore, we reduced the hydrogel production temperature to ambient conditions and made a simple and cost-effective production process that doesn't require special equipment. The promising results we got pushed us further. So, the current research focuses on the encapsulation/controlled release of antioxidant phenolic compounds extracted from orange peel waste by applying ultrasonic-assisted extraction and deep eutectic solvent(DES) based on glycerol: urea: water. We use a new initiator system based on vitamin C and H2O2to polymerizea methacrylic acid[3]that could be useful for other monomers.As a concluding remark, we achieved significant progress in hydrogels encouragingus to continue further.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "Environmentally friendly hydrogels for medical and pharmaceutical applications",
number = "1S",
pages = "27",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7392"
}

Kalagasidis Krušić, M., Lučić Škorić, M., Milovanović, S., Panić, V.,& Marković, M.. (2024). Environmentally friendly hydrogels for medical and pharmaceutical applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 27.
https://hdl.handle.net/21.15107/rcub_technorep_7392

Kalagasidis Krušić M, Lučić Škorić M, Milovanović S, Panić V, Marković M. Environmentally friendly hydrogels for medical and pharmaceutical applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):27.
https://hdl.handle.net/21.15107/rcub_technorep_7392 .

Kalagasidis Krušić, Melina, Lučić Škorić, Marija, Milovanović, Stoja, Panić, Vesna, Marković, Maja, "Environmentally friendly hydrogels for medical and pharmaceutical applications" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):27,
https://hdl.handle.net/21.15107/rcub_technorep_7392 .

TY  - CONF
AU  - Ugrinović, Vukašin
AU  - Marković, Maja
AU  - Petrović, Predrag
AU  - Veljović, Đorđe
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7393
AB  - INTRODUCTION: Hydrogels,  characterized  by  their  three-dimensional  hydrophilic  polymer  networks  capable  of retaining substantial amounts of water or biological fluids, hold significant promise for biomedical and pharmaceutical applications.  While  numerous  polymers  have  been  explored  for  hydrogel  development,  those  derived  from  natural sources  possess  inherent  advantages  due  to  their  abundance,  affordability,  biocompatibility,  and  biodegradability. Gelatin, a widely used natural polymer in biomedicine, standsout for its cost-effectiveness, compatibility with biological systems,  and  degradability.  Hydroxypropyl  methylcellulose  (HPMC),  a  cellulose  derivative,  exhibits  hydrophilicity, biodegradability,  and  biocompatibility.  However,  natural  polymer-based  hydrogels  often  exhibit  low  mechanical strength  and  solubility  in  physiological  conditions,  necessitating  innovative  cross-linking  strategies  to  enhance  their functionality. Citric acid (CA) emerges as a promising crosslinking agent owing to its affordability andnon-toxic nature.EXPERIMENTAL:HPMC-G hydrogels were synthesized by dissolving gelatin (0.05 g) and HPMC (0.1 g) with specified amounts of CA and sodium hypophosphitein 1 ml of distilled water in a reaction vessel. The mixture was homogenized, poured into a Teflon mold, and frozen at -20°C for 24 hours. After lyophilization, the hydrogels underwent crosslinking at 160°C for 7 minutes. By varying the CA content from 0%to 40% (w/w) while maintaining constant temperature and time, the optimal CA/HPMC ratio was determined. Subsequently, various heat treatments (140–180°C, 3-12 minutes) were applied to explore the optimal curing conditions.RESULTS AND DISCUSSION:The investigation elucidates how the CA/HPMC ratio and curing conditions impact the physicochemical and mechanical propertiesof HPMC-G hydrogels. Swelling tests and compressive mechanical property evaluations reveal that the incorporation of citric acid, along with increases in curing temperature and time, enhances compressive  modulus  and  degradation  stability  while  reducing  equilibrium  swelling.  Scanning  electron  microscopyanalysis reveals a highly porous microstructure in the resulting hydrogels, while differential scanning calorimetrycurves indicate the formation of strong interactions between gelatin and HPMC.CONCLUSIONS:The utilization of these materials notonly contributes to environmental conservation efforts but also drives the advancement of eco-friendly technology, aligning with the principles of the circular economy. Moreover, it offers promising avenues for innovative solutions in potential biomedicalapplications.
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications
IS  - 1S
SP  - 29
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7393
ER  - 

@conference{
author = "Ugrinović, Vukašin and Marković, Maja and Petrović, Predrag and Veljović, Đorđe",
year = "2024",
abstract = "INTRODUCTION: Hydrogels,  characterized  by  their  three-dimensional  hydrophilic  polymer  networks  capable  of retaining substantial amounts of water or biological fluids, hold significant promise for biomedical and pharmaceutical applications.  While  numerous  polymers  have  been  explored  for  hydrogel  development,  those  derived  from  natural sources  possess  inherent  advantages  due  to  their  abundance,  affordability,  biocompatibility,  and  biodegradability. Gelatin, a widely used natural polymer in biomedicine, standsout for its cost-effectiveness, compatibility with biological systems,  and  degradability.  Hydroxypropyl  methylcellulose  (HPMC),  a  cellulose  derivative,  exhibits  hydrophilicity, biodegradability,  and  biocompatibility.  However,  natural  polymer-based  hydrogels  often  exhibit  low  mechanical strength  and  solubility  in  physiological  conditions,  necessitating  innovative  cross-linking  strategies  to  enhance  their functionality. Citric acid (CA) emerges as a promising crosslinking agent owing to its affordability andnon-toxic nature.EXPERIMENTAL:HPMC-G hydrogels were synthesized by dissolving gelatin (0.05 g) and HPMC (0.1 g) with specified amounts of CA and sodium hypophosphitein 1 ml of distilled water in a reaction vessel. The mixture was homogenized, poured into a Teflon mold, and frozen at -20°C for 24 hours. After lyophilization, the hydrogels underwent crosslinking at 160°C for 7 minutes. By varying the CA content from 0%to 40% (w/w) while maintaining constant temperature and time, the optimal CA/HPMC ratio was determined. Subsequently, various heat treatments (140–180°C, 3-12 minutes) were applied to explore the optimal curing conditions.RESULTS AND DISCUSSION:The investigation elucidates how the CA/HPMC ratio and curing conditions impact the physicochemical and mechanical propertiesof HPMC-G hydrogels. Swelling tests and compressive mechanical property evaluations reveal that the incorporation of citric acid, along with increases in curing temperature and time, enhances compressive  modulus  and  degradation  stability  while  reducing  equilibrium  swelling.  Scanning  electron  microscopyanalysis reveals a highly porous microstructure in the resulting hydrogels, while differential scanning calorimetrycurves indicate the formation of strong interactions between gelatin and HPMC.CONCLUSIONS:The utilization of these materials notonly contributes to environmental conservation efforts but also drives the advancement of eco-friendly technology, aligning with the principles of the circular economy. Moreover, it offers promising avenues for innovative solutions in potential biomedicalapplications.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications",
number = "1S",
pages = "29",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7393"
}

Ugrinović, V., Marković, M., Petrović, P.,& Veljović, Đ.. (2024). Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 29.
https://hdl.handle.net/21.15107/rcub_technorep_7393

Ugrinović V, Marković M, Petrović P, Veljović Đ. Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):29.
https://hdl.handle.net/21.15107/rcub_technorep_7393 .

Ugrinović, Vukašin, Marković, Maja, Petrović, Predrag, Veljović, Đorđe, "Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):29,
https://hdl.handle.net/21.15107/rcub_technorep_7393 .

TY  - JOUR
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Spasojević, Jelena P.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Radulović, Aleksandra M.
AU  - Adnađević, Borivoj K.
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7349
AB  - High concentrations of LTA zeolite (27-52mass%) were embedded in poly(methacrylic acid) (PMAA) matrix to obtain composite hydrogels with porosity and active sites originating from both components. Substandard mechanics of PMAA and aggregation of zeolite particles, were thereby overcome. The composites had remarkably higher density than PMAA xerogel (1700 to1400 kg m−3), higher crosslinking density (54.8 to1.29 mol m−3) and lower swelling degree (41 to 420 kg kg−1). Zeolite particles were uniformly dispersed in PMAA matrix and there was no agglomeration or leaching of zeolite despite very high concentrations. XRD patterns revealed that the inclusion of zeolite particles affected the short-range order in the PMAA matrix. Being an active filler LTA zeolite notably improved thermal stability and mechanics of PMAA hydrogel, multiplying the storage modulus 5.2 times in dry and 21.8 times in swollen state. Structure–property correlations were provided making the base for further development of tailor-made zeolite-PMAA composite hydrogels.
PB  - Elsevier
T2  - Chemical Engineering Science
T1  - Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite
SP  - 119981
VL  - 292
DO  - 10.1016/j.ces.2024.119981
ER  - 

@article{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Spasojević, Jelena P. and Savić, Sanja I. and Marković, Maja D. and Radulović, Aleksandra M. and Adnađević, Borivoj K.",
year = "2024",
abstract = "High concentrations of LTA zeolite (27-52mass%) were embedded in poly(methacrylic acid) (PMAA) matrix to obtain composite hydrogels with porosity and active sites originating from both components. Substandard mechanics of PMAA and aggregation of zeolite particles, were thereby overcome. The composites had remarkably higher density than PMAA xerogel (1700 to1400 kg m−3), higher crosslinking density (54.8 to1.29 mol m−3) and lower swelling degree (41 to 420 kg kg−1). Zeolite particles were uniformly dispersed in PMAA matrix and there was no agglomeration or leaching of zeolite despite very high concentrations. XRD patterns revealed that the inclusion of zeolite particles affected the short-range order in the PMAA matrix. Being an active filler LTA zeolite notably improved thermal stability and mechanics of PMAA hydrogel, multiplying the storage modulus 5.2 times in dry and 21.8 times in swollen state. Structure–property correlations were provided making the base for further development of tailor-made zeolite-PMAA composite hydrogels.",
publisher = "Elsevier",
journal = "Chemical Engineering Science",
title = "Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite",
pages = "119981",
volume = "292",
doi = "10.1016/j.ces.2024.119981"
}

Panić, V. V., Jovanović, J. D., Spasojević, J. P., Savić, S. I., Marković, M. D., Radulović, A. M.,& Adnađević, B. K.. (2024). Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite. in Chemical Engineering Science
Elsevier., 292, 119981.
https://doi.org/10.1016/j.ces.2024.119981

Panić VV, Jovanović JD, Spasojević JP, Savić SI, Marković MD, Radulović AM, Adnađević BK. Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite. in Chemical Engineering Science. 2024;292:119981.
doi:10.1016/j.ces.2024.119981 .

Panić, Vesna V., Jovanović, Jelena D., Spasojević, Jelena P., Savić, Sanja I., Marković, Maja D., Radulović, Aleksandra M., Adnađević, Borivoj K., "Structure–property correlations for composite hydrogels based on poly(methacrylic acid) and high concentrations of LTA zeolite" in Chemical Engineering Science, 292 (2024):119981,
https://doi.org/10.1016/j.ces.2024.119981 . .

TY  - JOUR
AU  - Ugrinović, Vukašin
AU  - Marković, Maja
AU  - Božić, Bojan
AU  - Panić, Vesna
AU  - Veljović, Đorđe
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6852
AB  - Hydrogels are attractive materials for drug delivery applications due to biocompatible, porous structure with the possibility to load and deliver drugs in a controllable manner. In this paper, poly(methacrylic acid) (PMAA) hydrogels are described, which are synthesized by free-radical polymerization, using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. Influence of the PEGDA content on hydrogel properties was investigated and compared to commonly used crosslinker - N,N’-methylenebisacrylamide (MBA). The increasing concentration of crosslinkers led to a higher degree of crosslinking, which was demonstrated by a higher degree of conversion, lower swelling capacity, and improved thermal stability and mechanical properties. Also, the PEGDA-crosslinked hydrogels demonstrated a higher degree of crosslinking than the corresponding MBA-crosslinked hydrogels. Potential application of the synthesized hydrogels for controlled drug delivery was investigated by using two model drugs - oxaprozin and ciprofloxacin. In vitro drug release tests indicated that the interactions between drug, polymer and medium have a key influence on the drug release behavior, rather than the swelling rate. Drug release tests in simulated gastrointestinal conditions indicated that PEGDA-crosslinked PMAA hydrogels are suitable for colon-targeted delivery of oxaprozin.
AB  - Zbog svoje biokompatibilne, visoko-porozne strukture i mogućnosti da nose i kontrolisano
otpuštaju lekove, hidrogelovi su našli široku primenu u biomedicini. U ovom radu,
hidrogelovi na bazi poli(metakrilne kiseline) (PMK), umreženi pomoću poli(etilen-glikol)
diakrilata (PEGDA), sintetisani su metodom toplotno-indukovane slobodno-radikalske
polimerizacije. Ispitan je uticaj sadržaja PEGDA na svojstva hidrogelova i upoređen sa
uticajem najčešće korišćenog umreživača – N,N' – metilenbisakrilamida (MBA). Povećanje
količine oba umreživača dovelo je do većeg stepena umreženja, što je bilo manifestovano
povećanjem stepena konverzije monomera, smanjenjem ravnotežnog stepena bubrenja i
poboljšanim toplotnim i mehaničkim svojstvima. Takođe, hidrogelovi umreženi pomoću
PEGDA pokazali su veći stepen umreženja u odnosu na odgovarajuće hidrogelove umrežene
pomoću MBA. Mogućnost primene dobijenih hidrogelova za kontrolisano otpuštanje lekova,
ispitivano je korišćenjem dva leka – oksaprozina i ciprofloksacina. In vitro testovi
otpuštanja pokazali su da presudan uticaj na kinetiku otpuštanja imaju međusobne interakcije
između leka, hidrogela i medijuma, a ne stepen i brzina bubrenja hidrogela. Prema tome,
otpuštanje ciprofloksacina je bilo intenzivnije u kiseloj sredini, a oksaprozina u baznoj.
Otpuštanje u simuliranim gastrointestinalnim uslovima pokazalo je da su PEGDA-umreženi
hidrogelovi pogodni za kontrolisano otpuštanje oksaprozina u debelo crevo.
PB  - Savez hemijskih inženjera Srbije
T2  - Hemijska industrija
T1  - Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications
T1  - Hidrogelovi na bazi poli(metakrilne kiseline) umreženi korišćenjem poli(etilen-glikol) diakrilata, kao pH-osetljivi nosači za kontrolisano otpuštanje lekova
EP  - 249
IS  - 4
SP  - 235
VL  - 77
DO  - 10.2298/HEMIND221228018U
ER  - 

@article{
author = "Ugrinović, Vukašin and Marković, Maja and Božić, Bojan and Panić, Vesna and Veljović, Đorđe",
year = "2023",
abstract = "Hydrogels are attractive materials for drug delivery applications due to biocompatible, porous structure with the possibility to load and deliver drugs in a controllable manner. In this paper, poly(methacrylic acid) (PMAA) hydrogels are described, which are synthesized by free-radical polymerization, using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. Influence of the PEGDA content on hydrogel properties was investigated and compared to commonly used crosslinker - N,N’-methylenebisacrylamide (MBA). The increasing concentration of crosslinkers led to a higher degree of crosslinking, which was demonstrated by a higher degree of conversion, lower swelling capacity, and improved thermal stability and mechanical properties. Also, the PEGDA-crosslinked hydrogels demonstrated a higher degree of crosslinking than the corresponding MBA-crosslinked hydrogels. Potential application of the synthesized hydrogels for controlled drug delivery was investigated by using two model drugs - oxaprozin and ciprofloxacin. In vitro drug release tests indicated that the interactions between drug, polymer and medium have a key influence on the drug release behavior, rather than the swelling rate. Drug release tests in simulated gastrointestinal conditions indicated that PEGDA-crosslinked PMAA hydrogels are suitable for colon-targeted delivery of oxaprozin., Zbog svoje biokompatibilne, visoko-porozne strukture i mogućnosti da nose i kontrolisano
otpuštaju lekove, hidrogelovi su našli široku primenu u biomedicini. U ovom radu,
hidrogelovi na bazi poli(metakrilne kiseline) (PMK), umreženi pomoću poli(etilen-glikol)
diakrilata (PEGDA), sintetisani su metodom toplotno-indukovane slobodno-radikalske
polimerizacije. Ispitan je uticaj sadržaja PEGDA na svojstva hidrogelova i upoređen sa
uticajem najčešće korišćenog umreživača – N,N' – metilenbisakrilamida (MBA). Povećanje
količine oba umreživača dovelo je do većeg stepena umreženja, što je bilo manifestovano
povećanjem stepena konverzije monomera, smanjenjem ravnotežnog stepena bubrenja i
poboljšanim toplotnim i mehaničkim svojstvima. Takođe, hidrogelovi umreženi pomoću
PEGDA pokazali su veći stepen umreženja u odnosu na odgovarajuće hidrogelove umrežene
pomoću MBA. Mogućnost primene dobijenih hidrogelova za kontrolisano otpuštanje lekova,
ispitivano je korišćenjem dva leka – oksaprozina i ciprofloksacina. In vitro testovi
otpuštanja pokazali su da presudan uticaj na kinetiku otpuštanja imaju međusobne interakcije
između leka, hidrogela i medijuma, a ne stepen i brzina bubrenja hidrogela. Prema tome,
otpuštanje ciprofloksacina je bilo intenzivnije u kiseloj sredini, a oksaprozina u baznoj.
Otpuštanje u simuliranim gastrointestinalnim uslovima pokazalo je da su PEGDA-umreženi
hidrogelovi pogodni za kontrolisano otpuštanje oksaprozina u debelo crevo.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija",
title = "Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications, Hidrogelovi na bazi poli(metakrilne kiseline) umreženi korišćenjem poli(etilen-glikol) diakrilata, kao pH-osetljivi nosači za kontrolisano otpuštanje lekova",
pages = "249-235",
number = "4",
volume = "77",
doi = "10.2298/HEMIND221228018U"
}

Ugrinović, V., Marković, M., Božić, B., Panić, V.,& Veljović, Đ.. (2023). Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications. in Hemijska industrija
Savez hemijskih inženjera Srbije., 77(4), 235-249.
https://doi.org/10.2298/HEMIND221228018U

Ugrinović V, Marković M, Božić B, Panić V, Veljović Đ. Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications. in Hemijska industrija. 2023;77(4):235-249.
doi:10.2298/HEMIND221228018U .

Ugrinović, Vukašin, Marković, Maja, Božić, Bojan, Panić, Vesna, Veljović, Đorđe, "Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications" in Hemijska industrija, 77, no. 4 (2023):235-249,
https://doi.org/10.2298/HEMIND221228018U . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Svetozarević, Milica M.
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Mašulović, Aleksandra D.
AU  - Spasojević, Pavle M.
AU  - Pjanović, Rada V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5860
AB  - This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.
PB  - Elsevier B.V.
T2  - Chemical Engineering Journal
T1  - Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds
SP  - 141580
VL  - 459
DO  - 10.1016/j.cej.2023.141580
ER  - 

@article{
author = "Marković, Maja D. and Svetozarević, Milica M. and Panić, Vesna V. and Savić, Sanja I. and Mašulović, Aleksandra D. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.",
publisher = "Elsevier B.V.",
journal = "Chemical Engineering Journal",
title = "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds",
pages = "141580",
volume = "459",
doi = "10.1016/j.cej.2023.141580"
}

Marković, M. D., Svetozarević, M. M., Panić, V. V., Savić, S. I., Mašulović, A. D., Spasojević, P. M.,& Pjanović, R. V.. (2023). Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal
Elsevier B.V.., 459, 141580.
https://doi.org/10.1016/j.cej.2023.141580

Marković MD, Svetozarević MM, Panić VV, Savić SI, Mašulović AD, Spasojević PM, Pjanović RV. Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal. 2023;459:141580.
doi:10.1016/j.cej.2023.141580 .

Marković, Maja D., Svetozarević, Milica M., Panić, Vesna V., Savić, Sanja I., Mašulović, Aleksandra D., Spasojević, Pavle M., Pjanović, Rada V., "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds" in Chemical Engineering Journal, 459 (2023):141580,
https://doi.org/10.1016/j.cej.2023.141580 . .

TY  - PAT
AU  - Marković, Maja
AU  - Tadić, Julijana
AU  - Šešlija, Sanja
AU  - Mijin, Dušan
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
AU  - Ugrinović, Vukašin
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5950
AB  - Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.
PB  - Zavod za intelektualnu svojinu, Beograd, Srbija
T2  - http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
T1  - SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5950
ER  - 

@misc{
author = "Marković, Maja and Tadić, Julijana and Šešlija, Sanja and Mijin, Dušan and Panić, Vesna and Spasojević, Pavle and Pjanović, Rada and Ugrinović, Vukašin",
year = "2023",
abstract = "Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.",
publisher = "Zavod za intelektualnu svojinu, Beograd, Srbija",
journal = "http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf",
title = "SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5950"
}

Marković, M., Tadić, J., Šešlija, S., Mijin, D., Panić, V., Spasojević, P., Pjanović, R.,& Ugrinović, V.. (2023). SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA. in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
Zavod za intelektualnu svojinu, Beograd, Srbija..
https://hdl.handle.net/21.15107/rcub_technorep_5950

Marković M, Tadić J, Šešlija S, Mijin D, Panić V, Spasojević P, Pjanović R, Ugrinović V. SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA. in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_5950 .

Marković, Maja, Tadić, Julijana, Šešlija, Sanja, Mijin, Dušan, Panić, Vesna, Spasojević, Pavle, Pjanović, Rada, Ugrinović, Vukašin, "SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA" in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf (2023),
https://hdl.handle.net/21.15107/rcub_technorep_5950 .

TY  - JOUR
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Popović, Ivanka G.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Adnađević, Borivoj K.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5966
AB  - High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.
PB  - Elsevier
T2  - Polymer
T1  - The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite
SP  - 125750
VL  - 269
DO  - 10.1016/j.polymer.2023.125750
ER  - 

@article{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Popović, Ivanka G. and Savić, Sanja I. and Marković, Maja D. and Spasojević, Pavle M. and Adnađević, Borivoj K.",
year = "2023",
abstract = "High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.",
publisher = "Elsevier",
journal = "Polymer",
title = "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite",
pages = "125750",
volume = "269",
doi = "10.1016/j.polymer.2023.125750"
}

Panić, V. V., Jovanović, J. D., Popović, I. G., Savić, S. I., Marković, M. D., Spasojević, P. M.,& Adnađević, B. K.. (2023). The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer
Elsevier., 269, 125750.
https://doi.org/10.1016/j.polymer.2023.125750

Panić VV, Jovanović JD, Popović IG, Savić SI, Marković MD, Spasojević PM, Adnađević BK. The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer. 2023;269:125750.
doi:10.1016/j.polymer.2023.125750 .

Panić, Vesna V., Jovanović, Jelena D., Popović, Ivanka G., Savić, Sanja I., Marković, Maja D., Spasojević, Pavle M., Adnađević, Borivoj K., "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite" in Polymer, 269 (2023):125750,
https://doi.org/10.1016/j.polymer.2023.125750 . .

TY  - CONF
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6466
AB  - Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze.
AB  - Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.
PB  - Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija
C3  - 59th Meeting of the Serbian Chemical Society
T1  - Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora
T1  - Composite materials prepared from waste eggshells and biobased unsaturated polyester resin
EP  - 148
SP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6466
ER  - 

@conference{
author = "Pantić, Olga J. and Panić, Vesna V. and Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Kalagasidis Krušić, Melina T.",
year = "2023",
abstract = "Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze., Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.",
publisher = "Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija",
journal = "59th Meeting of the Serbian Chemical Society",
title = "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora, Composite materials prepared from waste eggshells and biobased unsaturated polyester resin",
pages = "148-148",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6466"
}

Pantić, O. J., Panić, V. V., Marković, M. D., Spasojević, P. M., Savić, S. I.,& Kalagasidis Krušić, M. T.. (2023). Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society
Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija., 148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466

Pantić OJ, Panić VV, Marković MD, Spasojević PM, Savić SI, Kalagasidis Krušić MT. Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society. 2023;:148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

Pantić, Olga J., Panić, Vesna V., Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Kalagasidis Krušić, Melina T., "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora" in 59th Meeting of the Serbian Chemical Society (2023):148-148,
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Svetozarević, Milica M.
AU  - Ugrinović, Vukašin Đ.
AU  - Pjanović, Rada V.
AU  - Obradović, Bojana M.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6620
AB  - Everyday struggle of humanity with novel diseases and present once, urge researchers to find novel and improve existing therapies to enhance their efficiency and safety. One of the promising approaches to overcome these challenges is controlled release of drugs. Biomaterials based on poly(methacrylic acid) (PMAA) are excellent drug delivery systems because they can control release rate and released amount of drug. Also, due to their pH sensitivity the PMAA hydrogels can release drug at the site of action. Namely, these nontoxic and biocompatible hydrogels swell in the environment with pH value higher than pKa of PMAA (4.6) and release encapsulated drug during the process. In present study, PMAA hydrogels are synthetized under ambient conditions by simple, cost effective and eco-friendly synthesis. Novel initiation system based on hydrogen peroxide, potato peel peroxidase and vitamin C (VC) is used for the first time for free radical polymerization of PMAA hydrogel. In accordance with the principles of circular economy, peroxidase was isolated from potato peel waste by water extraction for 12 h at 4 ℃. Four PMAA hydrogels were prepared by using potato peel peroxidase with various enzyme activity (0.4; 0.8; 1.2 and 1.8 IU), whereas the amounts of H2O2 (30 mL) and VC (10 mg) have been kept constant. The composition of the PMAA hydrogels was confirmed by FTIR analysis, whereas their porous structure was revealed by SEM. The swelling of the PMAA hydrogels was monitored in two media: 0.1M HCl (as simulation of human stomach) and phosphate buffer with pH 7.4 (as simulation of human intestines). In order to encapsulate anti-inflammatory drug – dexamethasone into the PMAA hydrogels, the hydrogels were immersed into the dexamethasone aqueous solution (5 mg/ml) and left to swell to the equilibrium, after which they were dried at room temperature. Dexamethasone release from the PMAA hydrogels was monitored in the same environments as was the PMAA swelling. The results showed that around seven times higher amount of dexamethasone was released in the medium with pH 7.4 than in the medium with pH 1. Present study has showed that the PMAA hydrogels, prepared through green and eco-friendly method, have huge potential for encapsulation and controlled release of anti-inflammatory drugs and therefore, for the treatment of rheumatoid arthritis.
PB  - AO Foundation
C3  - ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical
T1  - Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs
SP  - 572
VL  - 3
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6620
ER  - 

@conference{
author = "Marković, Maja D. and Svetozarević, Milica M. and Ugrinović, Vukašin Đ. and Pjanović, Rada V. and Obradović, Bojana M. and Kalagasidis Krušić, Melina T.",
year = "2023",
abstract = "Everyday struggle of humanity with novel diseases and present once, urge researchers to find novel and improve existing therapies to enhance their efficiency and safety. One of the promising approaches to overcome these challenges is controlled release of drugs. Biomaterials based on poly(methacrylic acid) (PMAA) are excellent drug delivery systems because they can control release rate and released amount of drug. Also, due to their pH sensitivity the PMAA hydrogels can release drug at the site of action. Namely, these nontoxic and biocompatible hydrogels swell in the environment with pH value higher than pKa of PMAA (4.6) and release encapsulated drug during the process. In present study, PMAA hydrogels are synthetized under ambient conditions by simple, cost effective and eco-friendly synthesis. Novel initiation system based on hydrogen peroxide, potato peel peroxidase and vitamin C (VC) is used for the first time for free radical polymerization of PMAA hydrogel. In accordance with the principles of circular economy, peroxidase was isolated from potato peel waste by water extraction for 12 h at 4 ℃. Four PMAA hydrogels were prepared by using potato peel peroxidase with various enzyme activity (0.4; 0.8; 1.2 and 1.8 IU), whereas the amounts of H2O2 (30 mL) and VC (10 mg) have been kept constant. The composition of the PMAA hydrogels was confirmed by FTIR analysis, whereas their porous structure was revealed by SEM. The swelling of the PMAA hydrogels was monitored in two media: 0.1M HCl (as simulation of human stomach) and phosphate buffer with pH 7.4 (as simulation of human intestines). In order to encapsulate anti-inflammatory drug – dexamethasone into the PMAA hydrogels, the hydrogels were immersed into the dexamethasone aqueous solution (5 mg/ml) and left to swell to the equilibrium, after which they were dried at room temperature. Dexamethasone release from the PMAA hydrogels was monitored in the same environments as was the PMAA swelling. The results showed that around seven times higher amount of dexamethasone was released in the medium with pH 7.4 than in the medium with pH 1. Present study has showed that the PMAA hydrogels, prepared through green and eco-friendly method, have huge potential for encapsulation and controlled release of anti-inflammatory drugs and therefore, for the treatment of rheumatoid arthritis.",
publisher = "AO Foundation",
journal = "ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical",
title = "Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs",
pages = "572",
volume = "3",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6620"
}

Marković, M. D., Svetozarević, M. M., Ugrinović, V. Đ., Pjanović, R. V., Obradović, B. M.,& Kalagasidis Krušić, M. T.. (2023). Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs. in ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical
AO Foundation., 3, 572.
https://hdl.handle.net/21.15107/rcub_technorep_6620

Marković MD, Svetozarević MM, Ugrinović VĐ, Pjanović RV, Obradović BM, Kalagasidis Krušić MT. Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs. in ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical. 2023;3:572.
https://hdl.handle.net/21.15107/rcub_technorep_6620 .

Marković, Maja D., Svetozarević, Milica M., Ugrinović, Vukašin Đ., Pjanović, Rada V., Obradović, Bojana M., Kalagasidis Krušić, Melina T., "Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs" in ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical, 3 (2023):572,
https://hdl.handle.net/21.15107/rcub_technorep_6620 .

TY  - CONF
AU  - Svetozarević, Milica
AU  - Šekuljica, Nataša
AU  - Marković, Maja
AU  - Dajić, Ana
AU  - Mihajlović, Marina
AU  - Mijin, Dušan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6668
AB  - Agro-industrial waste has gained special attention as an abundatly available natural carbon source, which can be used for value-added products such as generating power, biofuel, biogas and biofertilizers production. Further application of agro-industrial waste may be as a substrate for solid state fermentation for production of antibiotics, enzymes, and phytochemicals. Isolation of enzymes from waste material as crude extracts contributes to the concept of sustainability and lowers their cost significantly. The enzyme of interest in this study was peroxidase isolated from soybean hull. Furthermore, the crude peroxidase from soybean hull was crosslinked by oxidized pectin onto the inner walls of PTFE microtubular reactor. The influence of the crosslinker concentration on the enzyme activity and crosslinking efficiency was evaluated, together with the effect of the reagents flow rate on the enzyme activity and crosslinking efficiency. Two different microtubular diameters were examined for the crude peroxidase crosslinking: 0.5 and 0.8 mm. After the immobilization, the possibility of anthraquinone dye removal by crosslinked peroxidase in the microtubular reactor was examined. The reusability of the immobilized enzyme was also evaluated in this study.
AB  - Poljoprivredni otpad predstavlja lako dostupan prirodni izvor ugljenika, koji se može koristiti za dobijanje proizvoda sa dodatom vrednošću. Poljoprivredni otpad se može koristiti kao sirovina za proizvodnju električne energije, biogorivo, biogas i proizvodnju biođubriva. Dalja primena poljoprivrednog otpada može biti kao supstrat za fermentaciju u čvrstom stanju (eng. solid state fermentation), za proizvodnju antibiotika, enzima i fitohemikalija. Izolovanje enzima iz otpadnog materijala kao sirovi ekstrakt doprinosi konceptu održivosti i značajno smanjuje cenu enzima. Enzim od interesa u ovom radu je peroksidaza izolovana iz sojinih ljuspica. Sirova peroksidaza iz sojinih ljuspica umrežena je oksidovanim pektinom na unutrašnje zidove PTFE cevnog mikroreaktor, i ispitivan je uticaj koncentracije umreživača na aktivnost enzima i efikasnost umrežavanja, kao i uticaj protoka reagensa na aktivnost enzima i efikasnost umrežavanja. Nakon toga, vršeno je ispitivanje uticaja prečnika cevnog mikroreaktora na efikasnost umrežavanja i aktivnost peroksidaze: 0,5 i 0,8 mm. Nakon imobilizacije ispitana je mogućnost uklanjanja antrahinonske boje umreženom peroksidazom u cevnom mikroreaktoru. U ovom radu je takođe je ispitivana mogućnost ponovne upotrebe imobilisanog enzima.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
T1  - Flow in the tube: crosslinking of peroxidase from agricultural waste for dye removal in microtubular reactor
T1  - Kontinualni sistem za obezbojavanje otpadnih voda. Primena umrežene peroksidaze iz poljoprivrednog otpada u uklanjanju boje
EP  - 112
SP  - 107
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6668
ER  - 

@conference{
author = "Svetozarević, Milica and Šekuljica, Nataša and Marković, Maja and Dajić, Ana and Mihajlović, Marina and Mijin, Dušan",
year = "2023",
abstract = "Agro-industrial waste has gained special attention as an abundatly available natural carbon source, which can be used for value-added products such as generating power, biofuel, biogas and biofertilizers production. Further application of agro-industrial waste may be as a substrate for solid state fermentation for production of antibiotics, enzymes, and phytochemicals. Isolation of enzymes from waste material as crude extracts contributes to the concept of sustainability and lowers their cost significantly. The enzyme of interest in this study was peroxidase isolated from soybean hull. Furthermore, the crude peroxidase from soybean hull was crosslinked by oxidized pectin onto the inner walls of PTFE microtubular reactor. The influence of the crosslinker concentration on the enzyme activity and crosslinking efficiency was evaluated, together with the effect of the reagents flow rate on the enzyme activity and crosslinking efficiency. Two different microtubular diameters were examined for the crude peroxidase crosslinking: 0.5 and 0.8 mm. After the immobilization, the possibility of anthraquinone dye removal by crosslinked peroxidase in the microtubular reactor was examined. The reusability of the immobilized enzyme was also evaluated in this study., Poljoprivredni otpad predstavlja lako dostupan prirodni izvor ugljenika, koji se može koristiti za dobijanje proizvoda sa dodatom vrednošću. Poljoprivredni otpad se može koristiti kao sirovina za proizvodnju električne energije, biogorivo, biogas i proizvodnju biođubriva. Dalja primena poljoprivrednog otpada može biti kao supstrat za fermentaciju u čvrstom stanju (eng. solid state fermentation), za proizvodnju antibiotika, enzima i fitohemikalija. Izolovanje enzima iz otpadnog materijala kao sirovi ekstrakt doprinosi konceptu održivosti i značajno smanjuje cenu enzima. Enzim od interesa u ovom radu je peroksidaza izolovana iz sojinih ljuspica. Sirova peroksidaza iz sojinih ljuspica umrežena je oksidovanim pektinom na unutrašnje zidove PTFE cevnog mikroreaktor, i ispitivan je uticaj koncentracije umreživača na aktivnost enzima i efikasnost umrežavanja, kao i uticaj protoka reagensa na aktivnost enzima i efikasnost umrežavanja. Nakon toga, vršeno je ispitivanje uticaja prečnika cevnog mikroreaktora na efikasnost umrežavanja i aktivnost peroksidaze: 0,5 i 0,8 mm. Nakon imobilizacije ispitana je mogućnost uklanjanja antrahinonske boje umreženom peroksidazom u cevnom mikroreaktoru. U ovom radu je takođe je ispitivana mogućnost ponovne upotrebe imobilisanog enzima.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac",
title = "Flow in the tube: crosslinking of peroxidase from agricultural waste for dye removal in microtubular reactor, Kontinualni sistem za obezbojavanje otpadnih voda. Primena umrežene peroksidaze iz poljoprivrednog otpada u uklanjanju boje",
pages = "112-107",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6668"
}

Svetozarević, M., Šekuljica, N., Marković, M., Dajić, A., Mihajlović, M.,& Mijin, D.. (2023). Flow in the tube: crosslinking of peroxidase from agricultural waste for dye removal in microtubular reactor. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 107-112.
https://hdl.handle.net/21.15107/rcub_technorep_6668

Svetozarević M, Šekuljica N, Marković M, Dajić A, Mihajlović M, Mijin D. Flow in the tube: crosslinking of peroxidase from agricultural waste for dye removal in microtubular reactor. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac. 2023;:107-112.
https://hdl.handle.net/21.15107/rcub_technorep_6668 .

Svetozarević, Milica, Šekuljica, Nataša, Marković, Maja, Dajić, Ana, Mihajlović, Marina, Mijin, Dušan, "Flow in the tube: crosslinking of peroxidase from agricultural waste for dye removal in microtubular reactor" in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac (2023):107-112,
https://hdl.handle.net/21.15107/rcub_technorep_6668 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6737
AB  - Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced.
AB  - Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
T1  - Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine
T1  - Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina
EP  - 187
SP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6737
ER  - 

@conference{
author = "Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Pantić, Olga J. and Panić, Vesna V.",
year = "2023",
abstract = "Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced., Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac",
title = "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine, Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina",
pages = "187-181",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6737"
}

Marković, M. D., Spasojević, P. M., Savić, S. I., Pantić, O. J.,& Panić, V. V.. (2023). Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 181-187.
https://hdl.handle.net/21.15107/rcub_technorep_6737

Marković MD, Spasojević PM, Savić SI, Pantić OJ, Panić VV. Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac. 2023;:181-187.
https://hdl.handle.net/21.15107/rcub_technorep_6737 .

Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Pantić, Olga J., Panić, Vesna V., "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine" in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac (2023):181-187,
https://hdl.handle.net/21.15107/rcub_technorep_6737 .

TY  - CONF
AU  - Svetozarević Arsović, Milica
AU  - Šekuljica, Nataša
AU  - Dajić, Ana
AU  - Mihajlović, Marina
AU  - Marković, Maja
AU  - Knežević-Jugović, Zorica
AU  - Mijin, Dušan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6741
AB  - Wastewater from textile industry contains considerable amount of dissolved dye that can trigger environmental issues if is not treated properly. Numerous methods have been developed to degrade recalcitrant pollutants safely and utterly. Among them, enzymatic treatment of wastewater is gaining attention due to the enzyme’s specificity, easier manipulation, and generation of less toxic by-products. Still, the cost of enzymatic systems is the main limitation keeping the biocatalysts at lab-scale. Alternative solution for reducing the cost of enzymatic reaction systems is the use of microfluidic systems, which contribute to better mixing, process intensification and cleaner production. In this study, implementation of horseradish peroxidase for removal of the textile dye Acid Violet 109 is performed in a microfluidic reactor. The microreactor consists of three plunger pump units, two mixers and PTFE tube. The process parameters: residence time, dye, hydrogen peroxide, enzyme activity, the reactors’ diameter and length were optimized. Under the optimal process conditions: 30 mg/L dye concentration, 0.8 U/mL horseradish peroxidase activity, 0.1 mM hydrogen peroxide, 0.25 mm reactor's diameter, 97,3 % removal was achieved at residence time of 6 min. The results from this study show that enzymatic microfluidic reactors are a convenient technology for dye removal.
PB  - EDP Sciences
C3  - E3S Web of Conferences
T1  - Microfluidic technology for macro systems: Removal of textile dyes from wastewater in a microreactor
SP  - 10003
VL  - 436
DO  - 10.1051/e3sconf/202343610003
ER  - 

@conference{
author = "Svetozarević Arsović, Milica and Šekuljica, Nataša and Dajić, Ana and Mihajlović, Marina and Marković, Maja and Knežević-Jugović, Zorica and Mijin, Dušan",
year = "2023",
abstract = "Wastewater from textile industry contains considerable amount of dissolved dye that can trigger environmental issues if is not treated properly. Numerous methods have been developed to degrade recalcitrant pollutants safely and utterly. Among them, enzymatic treatment of wastewater is gaining attention due to the enzyme’s specificity, easier manipulation, and generation of less toxic by-products. Still, the cost of enzymatic systems is the main limitation keeping the biocatalysts at lab-scale. Alternative solution for reducing the cost of enzymatic reaction systems is the use of microfluidic systems, which contribute to better mixing, process intensification and cleaner production. In this study, implementation of horseradish peroxidase for removal of the textile dye Acid Violet 109 is performed in a microfluidic reactor. The microreactor consists of three plunger pump units, two mixers and PTFE tube. The process parameters: residence time, dye, hydrogen peroxide, enzyme activity, the reactors’ diameter and length were optimized. Under the optimal process conditions: 30 mg/L dye concentration, 0.8 U/mL horseradish peroxidase activity, 0.1 mM hydrogen peroxide, 0.25 mm reactor's diameter, 97,3 % removal was achieved at residence time of 6 min. The results from this study show that enzymatic microfluidic reactors are a convenient technology for dye removal.",
publisher = "EDP Sciences",
journal = "E3S Web of Conferences",
title = "Microfluidic technology for macro systems: Removal of textile dyes from wastewater in a microreactor",
pages = "10003",
volume = "436",
doi = "10.1051/e3sconf/202343610003"
}

Svetozarević Arsović, M., Šekuljica, N., Dajić, A., Mihajlović, M., Marković, M., Knežević-Jugović, Z.,& Mijin, D.. (2023). Microfluidic technology for macro systems: Removal of textile dyes from wastewater in a microreactor. in E3S Web of Conferences
EDP Sciences., 436, 10003.
https://doi.org/10.1051/e3sconf/202343610003

Svetozarević Arsović M, Šekuljica N, Dajić A, Mihajlović M, Marković M, Knežević-Jugović Z, Mijin D. Microfluidic technology for macro systems: Removal of textile dyes from wastewater in a microreactor. in E3S Web of Conferences. 2023;436:10003.
doi:10.1051/e3sconf/202343610003 .

Svetozarević Arsović, Milica, Šekuljica, Nataša, Dajić, Ana, Mihajlović, Marina, Marković, Maja, Knežević-Jugović, Zorica, Mijin, Dušan, "Microfluidic technology for macro systems: Removal of textile dyes from wastewater in a microreactor" in E3S Web of Conferences, 436 (2023):10003,
https://doi.org/10.1051/e3sconf/202343610003 . .

TY  - CONF
AU  - Pantić, Olga
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6860
AB  - The importance of producing thermoset polymers from natural resources has grown due to environmental concerns. Implementing the biorefinery concept is vital for replacing petroleum-based raw materials and transferring to cleaner technologies. Unsaturated polyester resins (UPRs) are a significant class of thermosetting polymers, with a wide range of properties gained from a considerable number of materials that are used for their synthesis. They can be used as pure resins or resins reinforced with suitable fillers in composite material production, which is the focus of this research. Generally, UPRs consist of two main components, prepolymer and reactive diluents, commercially both of which are commonly derived from petroleum. So, it is important to find an adequate bio-based alternative not only for styrene as a reactive diluent, but also for monomers that are used for prepolymer synthesis. Many bio-based monomers (propylene glycol, isosorbide, neopentyl glycol) and reactive diluents (vinyl levulinate, butanediol dimethacrylate, dimethyl itaconate) were investigated in formulating a bio-based UPR. Alongside this, many different bio-based fillers (hemp fibres, spent coffee grounds, rosehip seed flour) were also examined, to conclusively obtain a fully bio-based composite material. Sole introduction of bio-based raw materials is insufficient for proper implementation of the biorefinery principle. It is equally important that the final formulation of the obtained composite material demonstrates that it is environmentally and economically feasible. The quality and market price of the bio-based composite material must be at least be comparable to or better than those of a product from a conventional process in order to be competitive.
PB  - Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering
C3  - Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
T1  - Bio-based unsaturated polyester resins – a step towards a biorefinery solution
SP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6860
ER  - 

@conference{
author = "Pantić, Olga and Savić, Sanja and Panić, Vesna and Marković, Maja and Spasojević, Pavle",
year = "2023",
abstract = "The importance of producing thermoset polymers from natural resources has grown due to environmental concerns. Implementing the biorefinery concept is vital for replacing petroleum-based raw materials and transferring to cleaner technologies. Unsaturated polyester resins (UPRs) are a significant class of thermosetting polymers, with a wide range of properties gained from a considerable number of materials that are used for their synthesis. They can be used as pure resins or resins reinforced with suitable fillers in composite material production, which is the focus of this research. Generally, UPRs consist of two main components, prepolymer and reactive diluents, commercially both of which are commonly derived from petroleum. So, it is important to find an adequate bio-based alternative not only for styrene as a reactive diluent, but also for monomers that are used for prepolymer synthesis. Many bio-based monomers (propylene glycol, isosorbide, neopentyl glycol) and reactive diluents (vinyl levulinate, butanediol dimethacrylate, dimethyl itaconate) were investigated in formulating a bio-based UPR. Alongside this, many different bio-based fillers (hemp fibres, spent coffee grounds, rosehip seed flour) were also examined, to conclusively obtain a fully bio-based composite material. Sole introduction of bio-based raw materials is insufficient for proper implementation of the biorefinery principle. It is equally important that the final formulation of the obtained composite material demonstrates that it is environmentally and economically feasible. The quality and market price of the bio-based composite material must be at least be comparable to or better than those of a product from a conventional process in order to be competitive.",
publisher = "Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering",
journal = "Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023",
title = "Bio-based unsaturated polyester resins – a step towards a biorefinery solution",
pages = "14",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6860"
}

Pantić, O., Savić, S., Panić, V., Marković, M.,& Spasojević, P.. (2023). Bio-based unsaturated polyester resins – a step towards a biorefinery solution. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering., 14.
https://hdl.handle.net/21.15107/rcub_technorep_6860

Pantić O, Savić S, Panić V, Marković M, Spasojević P. Bio-based unsaturated polyester resins – a step towards a biorefinery solution. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023. 2023;:14.
https://hdl.handle.net/21.15107/rcub_technorep_6860 .

Pantić, Olga, Savić, Sanja, Panić, Vesna, Marković, Maja, Spasojević, Pavle, "Bio-based unsaturated polyester resins – a step towards a biorefinery solution" in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023 (2023):14,
https://hdl.handle.net/21.15107/rcub_technorep_6860 .

TY  - CONF
AU  - Savić, Sanja
AU  - Pantić, Olga
AU  - Vicente, Filipa A.
AU  - Novak, Uroš
AU  - Likozar, Blaž
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6861
AB  - Fruits are the most utilized commodities among all horticultural crops. They are consumed raw, minimally processed, due to their nutrients and health-promoting compounds. With the growing population and changing diet habits, the production and processing of fruits, have increased very significantly to fulfil the increasing demands. Significant losses and waste in the fresh and processing industries are becoming a serious nutritional, economical, and environmental problem. The fruit waste is composed mainly of seed, skin, rind, and pomace, containing good sources of potentially valuable bioactive compounds. The apple pomace is rich in pectic substances and represents important raw material for pectin production all around the world. For example, the portion of residual apple pomace makes about 13 % of the total waste material and on the basis of dry mass, it contains 10–15% pectin. Currently, it is either used for animal feeding or is disposed of as an industrial waste. The extraction of pectin is usually performed using mineral acids, yielding a reasonable quantity of product while also saving time in the process. Even though pectin has various applications in the food manufacturing industry, consumers have a negative perception upon learning that strong acids are used in pectin extraction. Furthermore, high acidity speeds up corrosion and rust formation of the apparatus, leading to water pollution which contributes to environmental concerns.
The present study reports the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DESs) as extraction medium. DESs turned to be an excellent choice for extraction because they are non-volatile at room temperature and non-toxic, while the majority of DESs are water-miscible depending on their components. The process consisted of the processing of apples, employing milling, enzymatic digestion and pressing. The further analysis included temperature and ultrasound assisted extraction and purification of pectin as well as the detailed physicochemical analysis of the obtained product. The applied procedure has resulted in satisfactory yields under mild extraction conditions, optimal extraction time and industrially preferred properties of the isolated pectin.
PB  - Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering
C3  - Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
T1  - Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies
SP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6861
ER  - 

@conference{
author = "Savić, Sanja and Pantić, Olga and Vicente, Filipa A. and Novak, Uroš and Likozar, Blaž and Panić, Vesna and Marković, Maja and Spasojević, Pavle",
year = "2023",
abstract = "Fruits are the most utilized commodities among all horticultural crops. They are consumed raw, minimally processed, due to their nutrients and health-promoting compounds. With the growing population and changing diet habits, the production and processing of fruits, have increased very significantly to fulfil the increasing demands. Significant losses and waste in the fresh and processing industries are becoming a serious nutritional, economical, and environmental problem. The fruit waste is composed mainly of seed, skin, rind, and pomace, containing good sources of potentially valuable bioactive compounds. The apple pomace is rich in pectic substances and represents important raw material for pectin production all around the world. For example, the portion of residual apple pomace makes about 13 % of the total waste material and on the basis of dry mass, it contains 10–15% pectin. Currently, it is either used for animal feeding or is disposed of as an industrial waste. The extraction of pectin is usually performed using mineral acids, yielding a reasonable quantity of product while also saving time in the process. Even though pectin has various applications in the food manufacturing industry, consumers have a negative perception upon learning that strong acids are used in pectin extraction. Furthermore, high acidity speeds up corrosion and rust formation of the apparatus, leading to water pollution which contributes to environmental concerns.
The present study reports the lab-scale procedure for extraction of pectin from the waste industrial apple pomace using deep eutectic solvents (DESs) as extraction medium. DESs turned to be an excellent choice for extraction because they are non-volatile at room temperature and non-toxic, while the majority of DESs are water-miscible depending on their components. The process consisted of the processing of apples, employing milling, enzymatic digestion and pressing. The further analysis included temperature and ultrasound assisted extraction and purification of pectin as well as the detailed physicochemical analysis of the obtained product. The applied procedure has resulted in satisfactory yields under mild extraction conditions, optimal extraction time and industrially preferred properties of the isolated pectin.",
publisher = "Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering",
journal = "Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023",
title = "Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies",
pages = "25",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6861"
}

Savić, S., Pantić, O., Vicente, F. A., Novak, U., Likozar, B., Panić, V., Marković, M.,& Spasojević, P.. (2023). Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023
Ljubljana : National Institute of Chemistry, Department of Catalysis and Chemical Reaction Engineering., 25.
https://hdl.handle.net/21.15107/rcub_technorep_6861

Savić S, Pantić O, Vicente FA, Novak U, Likozar B, Panić V, Marković M, Spasojević P. Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies. in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023. 2023;:25.
https://hdl.handle.net/21.15107/rcub_technorep_6861 .

Savić, Sanja, Pantić, Olga, Vicente, Filipa A., Novak, Uroš, Likozar, Blaž, Panić, Vesna, Marković, Maja, Spasojević, Pavle, "Deep eutectic solvents mediated extraction of pectin from apple pomace: Optimization and characterization studies" in Book of Abstracts / Next Challenges of Biorefineries, 3rd BioSPRINT Workshop 2nd Bilateral Workshop Portugal, Slovenia, June 14-15, 2023 (2023):25,
https://hdl.handle.net/21.15107/rcub_technorep_6861 .

TY  - CONF
AU  - Pantić, Olga
AU  - Panić, Vesna
AU  - Marković, Maja
AU  - Spasojević Savković, Milica
AU  - Savić, Sanja
AU  - Kalagasidis Krušić, Melina
AU  - Spasojević, Pavle
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6867
AB  - Biocomposites are materials that are composed of a matrix and fillers both of which derived from
renewable resources. They offer an alternative to traditional petroleum-based composites and
have gained interest due to potential environmental benefits and sustaina
idea, itaconic and succinic acids and propylene glycol were used in the synthesis of a biobased
unsaturated polyester, diluted with biobased reactive diluent, dimethyl itaconate, to cure fully
biobased unsaturated polyester resin (UPR). Despite having a low environmental impact, the
mechanical properties of biobased UPRs are not considered commercially viable compared to
their petroleum-based counterparts. To lessen the discrepancy between the two, nanocellulose
(NC) was incorporated into the biobased UPR in two ways. Firstly, NC was added during synthesis,
while secondly it was added after the synthesis of UPR was completed. Both series implied the
use of three different quan s of NC (1, 2, 3 wt.%). FTIR spectroscopy, gel content analysis,
SEM, dynamic mechanical analysis, and uniaxial tensile test were used to characterize obtained
biocomposites. It was demonstrcted that when NC was added during the synthesis, it had no
effect on UPR viscosity. On the other hand, adding NC after the synthesis significantly increased
viscosity. Overall results showed that higher quantities of NC increased tensile strength, storage
modulus at lower frequencies, and decreased glass transition temperature.
PB  - University of North Texas
C3  - Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS
SP  - 52
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6867
ER  - 

@conference{
author = "Pantić, Olga and Panić, Vesna and Marković, Maja and Spasojević Savković, Milica and Savić, Sanja and Kalagasidis Krušić, Melina and Spasojević, Pavle",
year = "2023",
abstract = "Biocomposites are materials that are composed of a matrix and fillers both of which derived from
renewable resources. They offer an alternative to traditional petroleum-based composites and
have gained interest due to potential environmental benefits and sustaina
idea, itaconic and succinic acids and propylene glycol were used in the synthesis of a biobased
unsaturated polyester, diluted with biobased reactive diluent, dimethyl itaconate, to cure fully
biobased unsaturated polyester resin (UPR). Despite having a low environmental impact, the
mechanical properties of biobased UPRs are not considered commercially viable compared to
their petroleum-based counterparts. To lessen the discrepancy between the two, nanocellulose
(NC) was incorporated into the biobased UPR in two ways. Firstly, NC was added during synthesis,
while secondly it was added after the synthesis of UPR was completed. Both series implied the
use of three different quan s of NC (1, 2, 3 wt.%). FTIR spectroscopy, gel content analysis,
SEM, dynamic mechanical analysis, and uniaxial tensile test were used to characterize obtained
biocomposites. It was demonstrcted that when NC was added during the synthesis, it had no
effect on UPR viscosity. On the other hand, adding NC after the synthesis significantly increased
viscosity. Overall results showed that higher quantities of NC increased tensile strength, storage
modulus at lower frequencies, and decreased glass transition temperature.",
publisher = "University of North Texas",
journal = "Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS",
pages = "52",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6867"
}

Pantić, O., Panić, V., Marković, M., Spasojević Savković, M., Savić, S., Kalagasidis Krušić, M.,& Spasojević, P.. (2023). ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
University of North Texas., 52.
https://hdl.handle.net/21.15107/rcub_technorep_6867

Pantić O, Panić V, Marković M, Spasojević Savković M, Savić S, Kalagasidis Krušić M, Spasojević P. ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:52.
https://hdl.handle.net/21.15107/rcub_technorep_6867 .

Pantić, Olga, Panić, Vesna, Marković, Maja, Spasojević Savković, Milica, Savić, Sanja, Kalagasidis Krušić, Melina, Spasojević, Pavle, "ADVANCING BIOCOMPOSITES: INTRODUCTION OF NANOCELLULOSE AS A SUSTAINABLE FILLER OF BIOBASED UNSATURATED POLYESTER RESINS" in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):52,
https://hdl.handle.net/21.15107/rcub_technorep_6867 .

TY  - CONF
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pantić, Olga
AU  - Marković, Maja
AU  - Vicente, Filipa A.
AU  - Novak, Uroš
AU  - Likozar, Blaž
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6868
AB  - The present study reports the development of the lab-scale procedure for extraction of pectin
from the waste industrial apple pomace using deep eutectic solvents (DES) as extraction medium.
Compared with conventional extraction solvents, DES have attracted considerable attention due
to the fact that they not only are eco-friendly, non-toxic, and biodegradable organic compounds

but also have a low cost, being easy to produce in the own laboratory. The research included a’

screening study that covered extraction using different DES based on choline chloride ([Ch]Cl) as
hydrogen bond acceptor (HBA), and organic acids as hydrogen bond donors (HBD). The applied
HBA:HBD molar ratio was 1:2. The pectin was extracted by employing solid-liquid (SLE) and
ultrasound assisted extraction (UAE). The DES based on [Ch]Cl and lactic acid turned to be most
promising in terms of obtained extraction yields, that reached 35% when applying UAE. It has
been shown that structure of HBD plays a major role with its hydrophilicity and hydrophobicity
influencing the number of established bonds. The HBD with lower amount of carbon molecules
and higher number of hydroxyl and carboxylic groups formed DES that are more efficient at
extracting pectin. Hidotopy study showed significant influence of water on pectin yield due to
more prominent hydrogen interaction established in the system. Depending on the type of DES,
the highest yields were obtained at 30-50 wt% of water, while an additional increase in water
content resulted in reduced yield. The structural properties of extracted pectin, including
esterification degree, was determined using FTIR spectroscopy.
PB  - University of North Texas
C3  - Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE
SP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6868
ER  - 

@conference{
author = "Savić, Sanja and Panić, Vesna and Spasojević, Pavle and Pantić, Olga and Marković, Maja and Vicente, Filipa A. and Novak, Uroš and Likozar, Blaž",
year = "2023",
abstract = "The present study reports the development of the lab-scale procedure for extraction of pectin
from the waste industrial apple pomace using deep eutectic solvents (DES) as extraction medium.
Compared with conventional extraction solvents, DES have attracted considerable attention due
to the fact that they not only are eco-friendly, non-toxic, and biodegradable organic compounds

but also have a low cost, being easy to produce in the own laboratory. The research included a’

screening study that covered extraction using different DES based on choline chloride ([Ch]Cl) as
hydrogen bond acceptor (HBA), and organic acids as hydrogen bond donors (HBD). The applied
HBA:HBD molar ratio was 1:2. The pectin was extracted by employing solid-liquid (SLE) and
ultrasound assisted extraction (UAE). The DES based on [Ch]Cl and lactic acid turned to be most
promising in terms of obtained extraction yields, that reached 35% when applying UAE. It has
been shown that structure of HBD plays a major role with its hydrophilicity and hydrophobicity
influencing the number of established bonds. The HBD with lower amount of carbon molecules
and higher number of hydroxyl and carboxylic groups formed DES that are more efficient at
extracting pectin. Hidotopy study showed significant influence of water on pectin yield due to
more prominent hydrogen interaction established in the system. Depending on the type of DES,
the highest yields were obtained at 30-50 wt% of water, while an additional increase in water
content resulted in reduced yield. The structural properties of extracted pectin, including
esterification degree, was determined using FTIR spectroscopy.",
publisher = "University of North Texas",
journal = "Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE",
pages = "54",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6868"
}

Savić, S., Panić, V., Spasojević, P., Pantić, O., Marković, M., Vicente, F. A., Novak, U.,& Likozar, B.. (2023). PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
University of North Texas., 54.
https://hdl.handle.net/21.15107/rcub_technorep_6868

Savić S, Panić V, Spasojević P, Pantić O, Marković M, Vicente FA, Novak U, Likozar B. PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:54.
https://hdl.handle.net/21.15107/rcub_technorep_6868 .

Savić, Sanja, Panić, Vesna, Spasojević, Pavle, Pantić, Olga, Marković, Maja, Vicente, Filipa A., Novak, Uroš, Likozar, Blaž, "PERSPECTIVES OF DEEP EUTECTIC SOLVENTS FOR EXTRACTION OF PECTIN FROM WASTE APPLE POMACE" in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):54,
https://hdl.handle.net/21.15107/rcub_technorep_6868 .

TY  - CONF
AU  - Spasojević, Pavle
AU  - Savić, Sanja
AU  - Panić, Vesna
AU  - Spasojević Savković, Milica
AU  - Marković, Maja
AU  - Pantić, Olga
AU  - Popović, Ivanka
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6869
AB  - Emerging efforts in the field of biocomposites established novel combinations of biobased matrix
materials and reinforcements, as well as the optimization of curing conditions, to enhance their
properties and expand their range of applications. The curing conditions of nanocellulose

reinforced biobased unsaturated polyester resin (UPR) based on itaconic acid and it derivatives’

were examined within this work. Since the curing process of biobased UPR requires the presence
of both an initiator and an activator, the optimization was conducted in two phases. The first
phase investigated the effect of different concentrations of an activator, cobalt octoate, (0.5, 1.0
and 1.5 mass%) with a constant concentration of an initiator, a mixture of dibenzoyl peroxide
(DBP) and methyl ethyl ketone peroxide (MEKP) (DBP to MEKP ratio 1.5:1.0; 2.5 mass% total).
The ratios of DBP and MEKP were varied in the second phase of experiments in the following
manner: 2.5:0,1.75:0.75, 0.75:1.75 and 0:2.5 (keeping the total initiator mass% of 2.5). The effect
of the different curing conditions on the UPR properties was monitored via the gel content
analysis and the uniaxial tensile test. It was shown that the increase in activator concentration
led to the decrease in gel content, tensile strength and elongation at the break. On the other
hand, the increase in dibenzoyl peroxide concentration in the initiator mixture revealed
enhanced overall mechanical properties. The optimal curing conditions were found to be 0.5
mass% of activator, and 1.75:0.75 DBP to MEKP ratio in the initiator mixture. Thereby obtained
UPR biocomposite showed a significant increase in elastic attributes suggesting that these
materials can be used where high elasticity is needed.
C3  - Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France
T1  - OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN
SP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6869
ER  - 

@conference{
author = "Spasojević, Pavle and Savić, Sanja and Panić, Vesna and Spasojević Savković, Milica and Marković, Maja and Pantić, Olga and Popović, Ivanka",
year = "2023",
abstract = "Emerging efforts in the field of biocomposites established novel combinations of biobased matrix
materials and reinforcements, as well as the optimization of curing conditions, to enhance their
properties and expand their range of applications. The curing conditions of nanocellulose

reinforced biobased unsaturated polyester resin (UPR) based on itaconic acid and it derivatives’

were examined within this work. Since the curing process of biobased UPR requires the presence
of both an initiator and an activator, the optimization was conducted in two phases. The first
phase investigated the effect of different concentrations of an activator, cobalt octoate, (0.5, 1.0
and 1.5 mass%) with a constant concentration of an initiator, a mixture of dibenzoyl peroxide
(DBP) and methyl ethyl ketone peroxide (MEKP) (DBP to MEKP ratio 1.5:1.0; 2.5 mass% total).
The ratios of DBP and MEKP were varied in the second phase of experiments in the following
manner: 2.5:0,1.75:0.75, 0.75:1.75 and 0:2.5 (keeping the total initiator mass% of 2.5). The effect
of the different curing conditions on the UPR properties was monitored via the gel content
analysis and the uniaxial tensile test. It was shown that the increase in activator concentration
led to the decrease in gel content, tensile strength and elongation at the break. On the other
hand, the increase in dibenzoyl peroxide concentration in the initiator mixture revealed
enhanced overall mechanical properties. The optimal curing conditions were found to be 0.5
mass% of activator, and 1.75:0.75 DBP to MEKP ratio in the initiator mixture. Thereby obtained
UPR biocomposite showed a significant increase in elastic attributes suggesting that these
materials can be used where high elasticity is needed.",
journal = "Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France",
title = "OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN",
pages = "56",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6869"
}

Spasojević, P., Savić, S., Panić, V., Spasojević Savković, M., Marković, M., Pantić, O.,& Popović, I.. (2023). OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France, 56.
https://hdl.handle.net/21.15107/rcub_technorep_6869

Spasojević P, Savić S, Panić V, Spasojević Savković M, Marković M, Pantić O, Popović I. OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN. in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France. 2023;:56.
https://hdl.handle.net/21.15107/rcub_technorep_6869 .

Spasojević, Pavle, Savić, Sanja, Panić, Vesna, Spasojević Savković, Milica, Marković, Maja, Pantić, Olga, Popović, Ivanka, "OPTIMIZATION OF CURING CONDITIONS FOR NANOCELLULOSE REINFORCED BIOBASED UNSATURATED POLYESTER RESIN" in Book of Abstracts / 29thPolyChar - World Forum on Advanced Materials, 26 - 29 September 2023, Nice, France (2023):56,
https://hdl.handle.net/21.15107/rcub_technorep_6869 .

TY  - CONF
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Radulović, Aleksandra M.
AU  - Pantić, Olga
AU  - Adnađević, Borivoj K.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6887
AB  - The preparation of zeolite rich polymeric materials presents a challenge due to the zeolite settling
during synthesis, poor miscibility, the phase separation and generally insufficient interactions
between polymers and zeolites. Combination of LTA, i.e. MFI, zeolite and poly(methacrylic acid) in the
form of soft hydrogel network provided the stabilization of the zeolite particles and enabled synthesis
of composite hydrogels with very high zeolite concentrations (26-52 mass%).
The investigated morphological, mechanical and primary structural properties, water swelling ability
and thermal stability revealed high dependence on zeolite concentration and type. Zeolite particles
were uniformly dispersed in PMAA matrix as confirmed by SEM and there was no agglomeration or
zeolite leaching despite very high concentrations. FTIR spectra disclosed the existence of functional
groups of PMAA network and both zeolite types that interacted mutually and led to increased
crosslinking density. The established interactions changed the PMAA chain dynamics around the
particles, especially of the LTA type, as showed by XRD. Having much more surface groups capable to
generate interaction with PMAA, LTA zeolite stronger affected all of the investigated properties.
Composites’ mechanics was improved both in dry and swollen state compared to the PMAA hydrogel
(up to 21.8 times for the sample with the highest LTA concentration). Thermal stability of the
composites increased with increasing zeolite concentration.
The composition-property correlations were determined making this work the base for further
development of tailor-made zeolite-PMAA composite hydrogels aimed for specific application.
Composites were tested as low-cost, regenerative, environmentally friendly sorbents and showed
better removal of cationic dye compared to both components (PMAA and zeolite) alone.
PB  - Yuktan Technologies
C3  - Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain
T1  - Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels
SP  - 67
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6887
ER  - 

@conference{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Savić, Sanja I. and Marković, Maja D. and Radulović, Aleksandra M. and Pantić, Olga and Adnađević, Borivoj K.",
year = "2023",
abstract = "The preparation of zeolite rich polymeric materials presents a challenge due to the zeolite settling
during synthesis, poor miscibility, the phase separation and generally insufficient interactions
between polymers and zeolites. Combination of LTA, i.e. MFI, zeolite and poly(methacrylic acid) in the
form of soft hydrogel network provided the stabilization of the zeolite particles and enabled synthesis
of composite hydrogels with very high zeolite concentrations (26-52 mass%).
The investigated morphological, mechanical and primary structural properties, water swelling ability
and thermal stability revealed high dependence on zeolite concentration and type. Zeolite particles
were uniformly dispersed in PMAA matrix as confirmed by SEM and there was no agglomeration or
zeolite leaching despite very high concentrations. FTIR spectra disclosed the existence of functional
groups of PMAA network and both zeolite types that interacted mutually and led to increased
crosslinking density. The established interactions changed the PMAA chain dynamics around the
particles, especially of the LTA type, as showed by XRD. Having much more surface groups capable to
generate interaction with PMAA, LTA zeolite stronger affected all of the investigated properties.
Composites’ mechanics was improved both in dry and swollen state compared to the PMAA hydrogel
(up to 21.8 times for the sample with the highest LTA concentration). Thermal stability of the
composites increased with increasing zeolite concentration.
The composition-property correlations were determined making this work the base for further
development of tailor-made zeolite-PMAA composite hydrogels aimed for specific application.
Composites were tested as low-cost, regenerative, environmentally friendly sorbents and showed
better removal of cationic dye compared to both components (PMAA and zeolite) alone.",
publisher = "Yuktan Technologies",
journal = "Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain",
title = "Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels",
pages = "67",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6887"
}

Panić, V. V., Jovanović, J. D., Savić, S. I., Marković, M. D., Radulović, A. M., Pantić, O.,& Adnađević, B. K.. (2023). Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels. in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain
Yuktan Technologies., 67.
https://hdl.handle.net/21.15107/rcub_technorep_6887

Panić VV, Jovanović JD, Savić SI, Marković MD, Radulović AM, Pantić O, Adnađević BK. Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels. in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain. 2023;:67.
https://hdl.handle.net/21.15107/rcub_technorep_6887 .

Panić, Vesna V., Jovanović, Jelena D., Savić, Sanja I., Marković, Maja D., Radulović, Aleksandra M., Pantić, Olga, Adnađević, Borivoj K., "Insight and Comparison of Property Improvement in LTA and MFI Zeolite Reinforced Poly(methacrylic acid) Highly Concentrated Composite Hydrogels" in Abstract Book / 4th International Conference on Advanced Polymer Science and Engineering, 23-25 October, 2023, Valencia, Spain (2023):67,
https://hdl.handle.net/21.15107/rcub_technorep_6887 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Miladinović, Nina N.
AU  - Savić, Sanja I.
AU  - Panić, Vesna V.
AU  - Pantić, Olga J.
AU  - Spasojević, Pavle M.
AU  - Pjanović, Rada V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7300
AB  - Controlled release of drugs is a promising tool for improvement of therapy for many 
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as 
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for 
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate 
if the encapsulation of poorly water-soluble active substance (caffeine) during the 
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels 
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of 
crosslinker are prepared by free radical polymerisation in aqueous solution and 
ambient conditions by using novel initiation system based on hydrogen peroxide and 
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of 
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human 
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount 
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released 
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.
PB  - Leskovac : Faculty of Technology
C3  - Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023
T1  - POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE
SP  - 97
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7300
ER  - 

@conference{
author = "Marković, Maja D. and Miladinović, Nina N. and Savić, Sanja I. and Panić, Vesna V. and Pantić, Olga J. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "Controlled release of drugs is a promising tool for improvement of therapy for many 
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as 
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for 
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate 
if the encapsulation of poorly water-soluble active substance (caffeine) during the 
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels 
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of 
crosslinker are prepared by free radical polymerisation in aqueous solution and 
ambient conditions by using novel initiation system based on hydrogen peroxide and 
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of 
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human 
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount 
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released 
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.",
publisher = "Leskovac : Faculty of Technology",
journal = "Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023",
title = "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE",
pages = "97",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7300"
}

Marković, M. D., Miladinović, N. N., Savić, S. I., Panić, V. V., Pantić, O. J., Spasojević, P. M.,& Pjanović, R. V.. (2023). POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE. in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023
Leskovac : Faculty of Technology., 97.
https://hdl.handle.net/21.15107/rcub_technorep_7300

Marković MD, Miladinović NN, Savić SI, Panić VV, Pantić OJ, Spasojević PM, Pjanović RV. POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE. in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023. 2023;:97.
https://hdl.handle.net/21.15107/rcub_technorep_7300 .

Marković, Maja D., Miladinović, Nina N., Savić, Sanja I., Panić, Vesna V., Pantić, Olga J., Spasojević, Pavle M., Pjanović, Rada V., "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE" in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023 (2023):97,
https://hdl.handle.net/21.15107/rcub_technorep_7300 .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Ugrinović, Vukašin Đ.
AU  - Pjanović, Rada V.
AU  - Spasojević, Milica M.
AU  - Spasojević, Pavle M.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5092
AB  - Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
PB  - Elsevier
T2  - Microporous and Mesoporous Materials
T1  - Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery
SP  - 111817
VL  - 335
DO  - 10.1016/j.micromeso.2022.111817
ER  - 

@article{
author = "Marković, Maja D. and Panić, Vesna V. and Savić, Sanja I. and Ugrinović, Vukašin Đ. and Pjanović, Rada V. and Spasojević, Milica M. and Spasojević, Pavle M.",
year = "2022",
abstract = "Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.",
publisher = "Elsevier",
journal = "Microporous and Mesoporous Materials",
title = "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery",
pages = "111817",
volume = "335",
doi = "10.1016/j.micromeso.2022.111817"
}

Marković, M. D., Panić, V. V., Savić, S. I., Ugrinović, V. Đ., Pjanović, R. V., Spasojević, M. M.,& Spasojević, P. M.. (2022). Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials
Elsevier., 335, 111817.
https://doi.org/10.1016/j.micromeso.2022.111817

Marković MD, Panić VV, Savić SI, Ugrinović VĐ, Pjanović RV, Spasojević MM, Spasojević PM. Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials. 2022;335:111817.
doi:10.1016/j.micromeso.2022.111817 .

Marković, Maja D., Panić, Vesna V., Savić, Sanja I., Ugrinović, Vukašin Đ., Pjanović, Rada V., Spasojević, Milica M., Spasojević, Pavle M., "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery" in Microporous and Mesoporous Materials, 335 (2022):111817,
https://doi.org/10.1016/j.micromeso.2022.111817 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Tadić, Julijana D.
AU  - Savić, Sanja I.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana P.
AU  - Mijin, Dušan
AU  - Panić, Vesna V.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5136
AB  - Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.
PB  - John Wiley and Sons Inc
T2  - Journal of Biomedical Materials Research - Part A
T1  - Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment
DO  - 10.1002/jbm.a.37396
ER  - 

@article{
author = "Marković, Maja D. and Tadić, Julijana D. and Savić, Sanja I. and Matić, Ivana Z. and Stanojković, Tatjana P. and Mijin, Dušan and Panić, Vesna V.",
year = "2022",
abstract = "Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.",
publisher = "John Wiley and Sons Inc",
journal = "Journal of Biomedical Materials Research - Part A",
title = "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment",
doi = "10.1002/jbm.a.37396"
}

Marković, M. D., Tadić, J. D., Savić, S. I., Matić, I. Z., Stanojković, T. P., Mijin, D.,& Panić, V. V.. (2022). Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A
John Wiley and Sons Inc..
https://doi.org/10.1002/jbm.a.37396

Marković MD, Tadić JD, Savić SI, Matić IZ, Stanojković TP, Mijin D, Panić VV. Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A. 2022;.
doi:10.1002/jbm.a.37396 .

Marković, Maja D., Tadić, Julijana D., Savić, Sanja I., Matić, Ivana Z., Stanojković, Tatjana P., Mijin, Dušan, Panić, Vesna V., "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment" in Journal of Biomedical Materials Research - Part A (2022),
https://doi.org/10.1002/jbm.a.37396 . .

TY  - JOUR
AU  - Pantić, Olga
AU  - Spasojević, Milica
AU  - Džunuzović, Enis
AU  - Nikolić, Marija S.
AU  - Savić, Sanja
AU  - Marković, Maja
AU  - Spasojević, Pavle
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5160
AB  - The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.
PB  - MDPI
T2  - Polymers
T1  - The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters
IS  - 15
SP  - 2970
VL  - 14
DO  - https://doi.org/10.3390/polym14152970
ER  - 

@article{
author = "Pantić, Olga and Spasojević, Milica and Džunuzović, Enis and Nikolić, Marija S. and Savić, Sanja and Marković, Maja and Spasojević, Pavle",
year = "2022",
abstract = "The scope of the present study was to prepare fully bio-based unsaturated polyester resins (UPRs) with comparable properties to the commercial formulations. The focus was set on the determination of the optimal prepolymer formulation using the same set of diacids (itaconic and succinic acid) and different diols (propylene glycol, isosorbide and neopentyl glycol) or its equimolar mixtures, keeping the fixed molar ratio of 1:1:2.1 in all feed compositions. Instead of commonly used styrene, bio-based dimethyl itaconate was used as a reactive diluent (RD). The rheology of the obtained resins was studied in detail. The effect of the used diol on structural (FTIR), thermal (DSC), thermomechanical (DMA), and mechanical (tensile) properties was explained. The properties of UPRs were found to be highly dependent on the diol used in the prepolymer formulation. The UPR with an equimolar ratio of propylene glycol and neopentyl glycol was shown to be the most promising candidate to compete with the commercial petroleum-based resins.",
publisher = "MDPI",
journal = "Polymers",
title = "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters",
number = "15",
pages = "2970",
volume = "14",
doi = "https://doi.org/10.3390/polym14152970"
}

Pantić, O., Spasojević, M., Džunuzović, E., Nikolić, M. S., Savić, S., Marković, M.,& Spasojević, P.. (2022). The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers
MDPI., 14(15), 2970.
https://doi.org/https://doi.org/10.3390/polym14152970

Pantić O, Spasojević M, Džunuzović E, Nikolić MS, Savić S, Marković M, Spasojević P. The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters. in Polymers. 2022;14(15):2970.
doi:https://doi.org/10.3390/polym14152970 .

Pantić, Olga, Spasojević, Milica, Džunuzović, Enis, Nikolić, Marija S., Savić, Sanja, Marković, Maja, Spasojević, Pavle, "The Effect of Glycol Derivatives on the Properties of Bio-Based Unsaturated Polyesters" in Polymers, 14, no. 15 (2022):2970,
https://doi.org/https://doi.org/10.3390/polym14152970 . .

TY  - CONF
AU  - Pantić, Olga J.
AU  - Spasojević, Pavle M.
AU  - Panić, Vesna V.
AU  - Marković, Maja D.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5159
AB  - Pectin and pectin derived oligosaccharides can be obtained from waste apple pomace
(biomass). Traditional method for pectin extraction involves use of diluted mineral acids at
elevated temperatures, with yields of about 10 to 15%. As an alternative to conventional
methods, the use of eutectic solvents is increasing because of their superior properties
when it comes to targeted extraction of certain components from biomass. The aim of this
paper is ultrasound assisted extraction of pectin from waste apple pomace using choline
chloride based eutectic solvents and lactic acid. Properties of extracted products were
examined using FTIR spectroscopy and differential scanning calorimetry.
PB  - Serbian Chemical Society
C3  - 58th Meeting of the Serbian Chemical Society
T1  - Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5159
ER  - 

@conference{
author = "Pantić, Olga J. and Spasojević, Pavle M. and Panić, Vesna V. and Marković, Maja D. and Savić, Sanja I. and Kalagasidis Krušić, Melina T.",
year = "2022",
abstract = "Pectin and pectin derived oligosaccharides can be obtained from waste apple pomace
(biomass). Traditional method for pectin extraction involves use of diluted mineral acids at
elevated temperatures, with yields of about 10 to 15%. As an alternative to conventional
methods, the use of eutectic solvents is increasing because of their superior properties
when it comes to targeted extraction of certain components from biomass. The aim of this
paper is ultrasound assisted extraction of pectin from waste apple pomace using choline
chloride based eutectic solvents and lactic acid. Properties of extracted products were
examined using FTIR spectroscopy and differential scanning calorimetry.",
publisher = "Serbian Chemical Society",
journal = "58th Meeting of the Serbian Chemical Society",
title = "Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5159"
}

Pantić, O. J., Spasojević, P. M., Panić, V. V., Marković, M. D., Savić, S. I.,& Kalagasidis Krušić, M. T.. (2022). Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 58th Meeting of the Serbian Chemical Society
Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_technorep_5159

Pantić OJ, Spasojević PM, Panić VV, Marković MD, Savić SI, Kalagasidis Krušić MT. Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents. in 58th Meeting of the Serbian Chemical Society. 2022;.
https://hdl.handle.net/21.15107/rcub_technorep_5159 .

Pantić, Olga J., Spasojević, Pavle M., Panić, Vesna V., Marković, Maja D., Savić, Sanja I., Kalagasidis Krušić, Melina T., "Ultrasound assisted extraction of pectin from waste apple pomace using choline chloride based eutectic solvents" in 58th Meeting of the Serbian Chemical Society (2022),
https://hdl.handle.net/21.15107/rcub_technorep_5159 .

TY  - CONF
AU  - Miladinović, Nina N.
AU  - Marković, Maja
AU  - Pjanović, Rada
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5228
AB  - Several million tons of orange peel are generated annually as a result of the industrial
processing of this fruit. Orange peels are rich in polyphenols, that show antioxidant
activity. Hence, converting orange peels into antioxidant extract by using green eutectic
solvents (GES) would be a good solution. GES represent a mixture of organic substances
that are not harmful to human health, environmentally friendly and highly selective
towards the targeted active substance. The aim of this work was the extraction of
polyphenols from orange peel waste using a GES based on urea and glycerol, their
encapsulation into hydrogels based on poly(methacrylic acid) (PMAA), and controlled
release from these hydrogels. PMAA are non-toxic, biocompatible and pH sensitive, so
they are widely used for the targeted delivery of active substances. Swelling of PMAA
and the controlled release of polyphenols from PMAA were monitored in two mediums
with different pH values: 0.1 M hydrochloric acid (pH=1) and phosphate buffer
(pH=6.8) at 37 °C. The influence of the crosslinker amount and neutralization degree of
methacrylic acid (ND) on the PMAA swelling and the release of polyphenols was
examined. The kinetics of PMAA swelling and polyphenol release were analyzed using
the Peppas model. It was concluded that the swelling degree of PMAA increased with
an increase in pH value of medium and ND, and decreased with an increase in crosslinker
amount. As a consequence, the cumulative release of polyphenols was around three
times higher in pH=6.8 than in pH=1 for both series of the samples. Peppas model
showed that diffusion was the primary mechanism of polyphenols release for most
samples. Based on the analysis of the results, it is concluded that the sample with optimal
characteristics for the controlled release of polyphenols is the sample with 0%
neutralized methacrylic acid and 0.4 mol% MBA.
PB  - Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia
C3  - 8th Conference of Young Chemists of Serbia Book of Abstract
T1  - Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels
SP  - 88
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5228
ER  - 

@conference{
author = "Miladinović, Nina N. and Marković, Maja and Pjanović, Rada",
year = "2022",
abstract = "Several million tons of orange peel are generated annually as a result of the industrial
processing of this fruit. Orange peels are rich in polyphenols, that show antioxidant
activity. Hence, converting orange peels into antioxidant extract by using green eutectic
solvents (GES) would be a good solution. GES represent a mixture of organic substances
that are not harmful to human health, environmentally friendly and highly selective
towards the targeted active substance. The aim of this work was the extraction of
polyphenols from orange peel waste using a GES based on urea and glycerol, their
encapsulation into hydrogels based on poly(methacrylic acid) (PMAA), and controlled
release from these hydrogels. PMAA are non-toxic, biocompatible and pH sensitive, so
they are widely used for the targeted delivery of active substances. Swelling of PMAA
and the controlled release of polyphenols from PMAA were monitored in two mediums
with different pH values: 0.1 M hydrochloric acid (pH=1) and phosphate buffer
(pH=6.8) at 37 °C. The influence of the crosslinker amount and neutralization degree of
methacrylic acid (ND) on the PMAA swelling and the release of polyphenols was
examined. The kinetics of PMAA swelling and polyphenol release were analyzed using
the Peppas model. It was concluded that the swelling degree of PMAA increased with
an increase in pH value of medium and ND, and decreased with an increase in crosslinker
amount. As a consequence, the cumulative release of polyphenols was around three
times higher in pH=6.8 than in pH=1 for both series of the samples. Peppas model
showed that diffusion was the primary mechanism of polyphenols release for most
samples. Based on the analysis of the results, it is concluded that the sample with optimal
characteristics for the controlled release of polyphenols is the sample with 0%
neutralized methacrylic acid and 0.4 mol% MBA.",
publisher = "Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia",
journal = "8th Conference of Young Chemists of Serbia Book of Abstract",
title = "Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels",
pages = "88",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5228"
}

Miladinović, N. N., Marković, M.,& Pjanović, R.. (2022). Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels. in 8th Conference of Young Chemists of Serbia Book of Abstract
Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia., 88.
https://hdl.handle.net/21.15107/rcub_technorep_5228

Miladinović NN, Marković M, Pjanović R. Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels. in 8th Conference of Young Chemists of Serbia Book of Abstract. 2022;:88.
https://hdl.handle.net/21.15107/rcub_technorep_5228 .

Miladinović, Nina N., Marković, Maja, Pjanović, Rada, "Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels" in 8th Conference of Young Chemists of Serbia Book of Abstract (2022):88,
https://hdl.handle.net/21.15107/rcub_technorep_5228 .