TY  - CONF
AU  - Veljović, Đorđe
AU  - Janaćković, Đorđe
AU  - Petrović, Rada
AU  - Radovanović, Željko
AU  - Ugrinović, Vukašin
AU  - Matić, Tamara
AU  - Milivojević, Marija
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7439
AB  - Bioactive  materials  for  the repairand  regeneration  of human bone  tissue,  as  well  as  for  the restoration  of  teeth,  are  the focus of  numerous  studies  in  the  field  of  biomaterials.Orthopaedic  surgeons  anticipate that  bioactive materialshave  the  potential  to  facilitate  the  formation  of  new  apatite-like  crystals  upon  contact  with body fluids, promoting the development of new bone tissue under in vivoconditions. On the other hand, dentists expect that bioactive  materials  have  the  potential  for  remineralization  of  partially  demineralized  enamel  and  dentin. In  the preceding years, the Bioceramic Materials Group, founded within the Department of Inorganic Chemical Technology at the  Faculty  of  Technology  and  Metallurgy,  University  of  Belgrade (FTM-UB),  conducted  extensive  research  on  the advancement of bioactive and biocompatible materials with adequate mechanical properties, designed for applicationin dentistry, orthopaedics, maxillofacial surgery, and also bone tissue engineering(BTE).
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - The current trend in innovative bioactive materials for dental and orthopedic applications
IS  - 1S
SP  - 37
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7439
ER  - 

@conference{
author = "Veljović, Đorđe and Janaćković, Đorđe and Petrović, Rada and Radovanović, Željko and Ugrinović, Vukašin and Matić, Tamara and Milivojević, Marija",
year = "2024",
abstract = "Bioactive  materials  for  the repairand  regeneration  of human bone  tissue,  as  well  as  for  the restoration  of  teeth,  are  the focus of  numerous  studies  in  the  field  of  biomaterials.Orthopaedic  surgeons  anticipate that  bioactive materialshave  the  potential  to  facilitate  the  formation  of  new  apatite-like  crystals  upon  contact  with body fluids, promoting the development of new bone tissue under in vivoconditions. On the other hand, dentists expect that bioactive  materials  have  the  potential  for  remineralization  of  partially  demineralized  enamel  and  dentin. In  the preceding years, the Bioceramic Materials Group, founded within the Department of Inorganic Chemical Technology at the  Faculty  of  Technology  and  Metallurgy,  University  of  Belgrade (FTM-UB),  conducted  extensive  research  on  the advancement of bioactive and biocompatible materials with adequate mechanical properties, designed for applicationin dentistry, orthopaedics, maxillofacial surgery, and also bone tissue engineering(BTE).",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "The current trend in innovative bioactive materials for dental and orthopedic applications",
number = "1S",
pages = "37",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7439"
}

Veljović, Đ., Janaćković, Đ., Petrović, R., Radovanović, Ž., Ugrinović, V., Matić, T.,& Milivojević, M.. (2024). The current trend in innovative bioactive materials for dental and orthopedic applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 37.
https://hdl.handle.net/21.15107/rcub_technorep_7439

Veljović Đ, Janaćković Đ, Petrović R, Radovanović Ž, Ugrinović V, Matić T, Milivojević M. The current trend in innovative bioactive materials for dental and orthopedic applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):37.
https://hdl.handle.net/21.15107/rcub_technorep_7439 .

Veljović, Đorđe, Janaćković, Đorđe, Petrović, Rada, Radovanović, Željko, Ugrinović, Vukašin, Matić, Tamara, Milivojević, Marija, "The current trend in innovative bioactive materials for dental and orthopedic applications" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):37,
https://hdl.handle.net/21.15107/rcub_technorep_7439 .

TY  - CONF
AU  - Ugrinović, Vukašin
AU  - Marković, Maja
AU  - Petrović, Predrag
AU  - Veljović, Đorđe
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7393
AB  - INTRODUCTION: Hydrogels,  characterized  by  their  three-dimensional  hydrophilic  polymer  networks  capable  of retaining substantial amounts of water or biological fluids, hold significant promise for biomedical and pharmaceutical applications.  While  numerous  polymers  have  been  explored  for  hydrogel  development,  those  derived  from  natural sources  possess  inherent  advantages  due  to  their  abundance,  affordability,  biocompatibility,  and  biodegradability. Gelatin, a widely used natural polymer in biomedicine, standsout for its cost-effectiveness, compatibility with biological systems,  and  degradability.  Hydroxypropyl  methylcellulose  (HPMC),  a  cellulose  derivative,  exhibits  hydrophilicity, biodegradability,  and  biocompatibility.  However,  natural  polymer-based  hydrogels  often  exhibit  low  mechanical strength  and  solubility  in  physiological  conditions,  necessitating  innovative  cross-linking  strategies  to  enhance  their functionality. Citric acid (CA) emerges as a promising crosslinking agent owing to its affordability andnon-toxic nature.EXPERIMENTAL:HPMC-G hydrogels were synthesized by dissolving gelatin (0.05 g) and HPMC (0.1 g) with specified amounts of CA and sodium hypophosphitein 1 ml of distilled water in a reaction vessel. The mixture was homogenized, poured into a Teflon mold, and frozen at -20°C for 24 hours. After lyophilization, the hydrogels underwent crosslinking at 160°C for 7 minutes. By varying the CA content from 0%to 40% (w/w) while maintaining constant temperature and time, the optimal CA/HPMC ratio was determined. Subsequently, various heat treatments (140–180°C, 3-12 minutes) were applied to explore the optimal curing conditions.RESULTS AND DISCUSSION:The investigation elucidates how the CA/HPMC ratio and curing conditions impact the physicochemical and mechanical propertiesof HPMC-G hydrogels. Swelling tests and compressive mechanical property evaluations reveal that the incorporation of citric acid, along with increases in curing temperature and time, enhances compressive  modulus  and  degradation  stability  while  reducing  equilibrium  swelling.  Scanning  electron  microscopyanalysis reveals a highly porous microstructure in the resulting hydrogels, while differential scanning calorimetrycurves indicate the formation of strong interactions between gelatin and HPMC.CONCLUSIONS:The utilization of these materials notonly contributes to environmental conservation efforts but also drives the advancement of eco-friendly technology, aligning with the principles of the circular economy. Moreover, it offers promising avenues for innovative solutions in potential biomedicalapplications.
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications
IS  - 1S
SP  - 29
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7393
ER  - 

@conference{
author = "Ugrinović, Vukašin and Marković, Maja and Petrović, Predrag and Veljović, Đorđe",
year = "2024",
abstract = "INTRODUCTION: Hydrogels,  characterized  by  their  three-dimensional  hydrophilic  polymer  networks  capable  of retaining substantial amounts of water or biological fluids, hold significant promise for biomedical and pharmaceutical applications.  While  numerous  polymers  have  been  explored  for  hydrogel  development,  those  derived  from  natural sources  possess  inherent  advantages  due  to  their  abundance,  affordability,  biocompatibility,  and  biodegradability. Gelatin, a widely used natural polymer in biomedicine, standsout for its cost-effectiveness, compatibility with biological systems,  and  degradability.  Hydroxypropyl  methylcellulose  (HPMC),  a  cellulose  derivative,  exhibits  hydrophilicity, biodegradability,  and  biocompatibility.  However,  natural  polymer-based  hydrogels  often  exhibit  low  mechanical strength  and  solubility  in  physiological  conditions,  necessitating  innovative  cross-linking  strategies  to  enhance  their functionality. Citric acid (CA) emerges as a promising crosslinking agent owing to its affordability andnon-toxic nature.EXPERIMENTAL:HPMC-G hydrogels were synthesized by dissolving gelatin (0.05 g) and HPMC (0.1 g) with specified amounts of CA and sodium hypophosphitein 1 ml of distilled water in a reaction vessel. The mixture was homogenized, poured into a Teflon mold, and frozen at -20°C for 24 hours. After lyophilization, the hydrogels underwent crosslinking at 160°C for 7 minutes. By varying the CA content from 0%to 40% (w/w) while maintaining constant temperature and time, the optimal CA/HPMC ratio was determined. Subsequently, various heat treatments (140–180°C, 3-12 minutes) were applied to explore the optimal curing conditions.RESULTS AND DISCUSSION:The investigation elucidates how the CA/HPMC ratio and curing conditions impact the physicochemical and mechanical propertiesof HPMC-G hydrogels. Swelling tests and compressive mechanical property evaluations reveal that the incorporation of citric acid, along with increases in curing temperature and time, enhances compressive  modulus  and  degradation  stability  while  reducing  equilibrium  swelling.  Scanning  electron  microscopyanalysis reveals a highly porous microstructure in the resulting hydrogels, while differential scanning calorimetrycurves indicate the formation of strong interactions between gelatin and HPMC.CONCLUSIONS:The utilization of these materials notonly contributes to environmental conservation efforts but also drives the advancement of eco-friendly technology, aligning with the principles of the circular economy. Moreover, it offers promising avenues for innovative solutions in potential biomedicalapplications.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications",
number = "1S",
pages = "29",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7393"
}

Ugrinović, V., Marković, M., Petrović, P.,& Veljović, Đ.. (2024). Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 29.
https://hdl.handle.net/21.15107/rcub_technorep_7393

Ugrinović V, Marković M, Petrović P, Veljović Đ. Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):29.
https://hdl.handle.net/21.15107/rcub_technorep_7393 .

Ugrinović, Vukašin, Marković, Maja, Petrović, Predrag, Veljović, Đorđe, "Citric acid-crosslinked gelatin/hydroxypropyl methylcellulose hydrogels for biomedical applications" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):29,
https://hdl.handle.net/21.15107/rcub_technorep_7393 .

TY  - JOUR
AU  - Ugrinović, Vukašin
AU  - Marković, Maja
AU  - Božić, Bojan
AU  - Panić, Vesna
AU  - Veljović, Đorđe
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6852
AB  - Hydrogels are attractive materials for drug delivery applications due to biocompatible, porous structure with the possibility to load and deliver drugs in a controllable manner. In this paper, poly(methacrylic acid) (PMAA) hydrogels are described, which are synthesized by free-radical polymerization, using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. Influence of the PEGDA content on hydrogel properties was investigated and compared to commonly used crosslinker - N,N’-methylenebisacrylamide (MBA). The increasing concentration of crosslinkers led to a higher degree of crosslinking, which was demonstrated by a higher degree of conversion, lower swelling capacity, and improved thermal stability and mechanical properties. Also, the PEGDA-crosslinked hydrogels demonstrated a higher degree of crosslinking than the corresponding MBA-crosslinked hydrogels. Potential application of the synthesized hydrogels for controlled drug delivery was investigated by using two model drugs - oxaprozin and ciprofloxacin. In vitro drug release tests indicated that the interactions between drug, polymer and medium have a key influence on the drug release behavior, rather than the swelling rate. Drug release tests in simulated gastrointestinal conditions indicated that PEGDA-crosslinked PMAA hydrogels are suitable for colon-targeted delivery of oxaprozin.
AB  - Zbog svoje biokompatibilne, visoko-porozne strukture i mogućnosti da nose i kontrolisano
otpuštaju lekove, hidrogelovi su našli široku primenu u biomedicini. U ovom radu,
hidrogelovi na bazi poli(metakrilne kiseline) (PMK), umreženi pomoću poli(etilen-glikol)
diakrilata (PEGDA), sintetisani su metodom toplotno-indukovane slobodno-radikalske
polimerizacije. Ispitan je uticaj sadržaja PEGDA na svojstva hidrogelova i upoređen sa
uticajem najčešće korišćenog umreživača – N,N' – metilenbisakrilamida (MBA). Povećanje
količine oba umreživača dovelo je do većeg stepena umreženja, što je bilo manifestovano
povećanjem stepena konverzije monomera, smanjenjem ravnotežnog stepena bubrenja i
poboljšanim toplotnim i mehaničkim svojstvima. Takođe, hidrogelovi umreženi pomoću
PEGDA pokazali su veći stepen umreženja u odnosu na odgovarajuće hidrogelove umrežene
pomoću MBA. Mogućnost primene dobijenih hidrogelova za kontrolisano otpuštanje lekova,
ispitivano je korišćenjem dva leka – oksaprozina i ciprofloksacina. In vitro testovi
otpuštanja pokazali su da presudan uticaj na kinetiku otpuštanja imaju međusobne interakcije
između leka, hidrogela i medijuma, a ne stepen i brzina bubrenja hidrogela. Prema tome,
otpuštanje ciprofloksacina je bilo intenzivnije u kiseloj sredini, a oksaprozina u baznoj.
Otpuštanje u simuliranim gastrointestinalnim uslovima pokazalo je da su PEGDA-umreženi
hidrogelovi pogodni za kontrolisano otpuštanje oksaprozina u debelo crevo.
PB  - Savez hemijskih inženjera Srbije
T2  - Hemijska industrija
T1  - Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications
T1  - Hidrogelovi na bazi poli(metakrilne kiseline) umreženi korišćenjem poli(etilen-glikol) diakrilata, kao pH-osetljivi nosači za kontrolisano otpuštanje lekova
EP  - 249
IS  - 4
SP  - 235
VL  - 77
DO  - 10.2298/HEMIND221228018U
ER  - 

@article{
author = "Ugrinović, Vukašin and Marković, Maja and Božić, Bojan and Panić, Vesna and Veljović, Đorđe",
year = "2023",
abstract = "Hydrogels are attractive materials for drug delivery applications due to biocompatible, porous structure with the possibility to load and deliver drugs in a controllable manner. In this paper, poly(methacrylic acid) (PMAA) hydrogels are described, which are synthesized by free-radical polymerization, using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. Influence of the PEGDA content on hydrogel properties was investigated and compared to commonly used crosslinker - N,N’-methylenebisacrylamide (MBA). The increasing concentration of crosslinkers led to a higher degree of crosslinking, which was demonstrated by a higher degree of conversion, lower swelling capacity, and improved thermal stability and mechanical properties. Also, the PEGDA-crosslinked hydrogels demonstrated a higher degree of crosslinking than the corresponding MBA-crosslinked hydrogels. Potential application of the synthesized hydrogels for controlled drug delivery was investigated by using two model drugs - oxaprozin and ciprofloxacin. In vitro drug release tests indicated that the interactions between drug, polymer and medium have a key influence on the drug release behavior, rather than the swelling rate. Drug release tests in simulated gastrointestinal conditions indicated that PEGDA-crosslinked PMAA hydrogels are suitable for colon-targeted delivery of oxaprozin., Zbog svoje biokompatibilne, visoko-porozne strukture i mogućnosti da nose i kontrolisano
otpuštaju lekove, hidrogelovi su našli široku primenu u biomedicini. U ovom radu,
hidrogelovi na bazi poli(metakrilne kiseline) (PMK), umreženi pomoću poli(etilen-glikol)
diakrilata (PEGDA), sintetisani su metodom toplotno-indukovane slobodno-radikalske
polimerizacije. Ispitan je uticaj sadržaja PEGDA na svojstva hidrogelova i upoređen sa
uticajem najčešće korišćenog umreživača – N,N' – metilenbisakrilamida (MBA). Povećanje
količine oba umreživača dovelo je do većeg stepena umreženja, što je bilo manifestovano
povećanjem stepena konverzije monomera, smanjenjem ravnotežnog stepena bubrenja i
poboljšanim toplotnim i mehaničkim svojstvima. Takođe, hidrogelovi umreženi pomoću
PEGDA pokazali su veći stepen umreženja u odnosu na odgovarajuće hidrogelove umrežene
pomoću MBA. Mogućnost primene dobijenih hidrogelova za kontrolisano otpuštanje lekova,
ispitivano je korišćenjem dva leka – oksaprozina i ciprofloksacina. In vitro testovi
otpuštanja pokazali su da presudan uticaj na kinetiku otpuštanja imaju međusobne interakcije
između leka, hidrogela i medijuma, a ne stepen i brzina bubrenja hidrogela. Prema tome,
otpuštanje ciprofloksacina je bilo intenzivnije u kiseloj sredini, a oksaprozina u baznoj.
Otpuštanje u simuliranim gastrointestinalnim uslovima pokazalo je da su PEGDA-umreženi
hidrogelovi pogodni za kontrolisano otpuštanje oksaprozina u debelo crevo.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija",
title = "Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications, Hidrogelovi na bazi poli(metakrilne kiseline) umreženi korišćenjem poli(etilen-glikol) diakrilata, kao pH-osetljivi nosači za kontrolisano otpuštanje lekova",
pages = "249-235",
number = "4",
volume = "77",
doi = "10.2298/HEMIND221228018U"
}

Ugrinović, V., Marković, M., Božić, B., Panić, V.,& Veljović, Đ.. (2023). Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications. in Hemijska industrija
Savez hemijskih inženjera Srbije., 77(4), 235-249.
https://doi.org/10.2298/HEMIND221228018U

Ugrinović V, Marković M, Božić B, Panić V, Veljović Đ. Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications. in Hemijska industrija. 2023;77(4):235-249.
doi:10.2298/HEMIND221228018U .

Ugrinović, Vukašin, Marković, Maja, Božić, Bojan, Panić, Vesna, Veljović, Đorđe, "Poly(methacrylic acid) hydrogels crosslinked by poly(ethylene glycol) diacrylate as pH-responsive systems for drug delivery applications" in Hemijska industrija, 77, no. 4 (2023):235-249,
https://doi.org/10.2298/HEMIND221228018U . .

TY  - PAT
AU  - Marković, Maja
AU  - Tadić, Julijana
AU  - Šešlija, Sanja
AU  - Mijin, Dušan
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Pjanović, Rada
AU  - Ugrinović, Vukašin
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5950
AB  - Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.
PB  - Zavod za intelektualnu svojinu, Beograd, Srbija
T2  - http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
T1  - SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5950
ER  - 

@misc{
author = "Marković, Maja and Tadić, Julijana and Šešlija, Sanja and Mijin, Dušan and Panić, Vesna and Spasojević, Pavle and Pjanović, Rada and Ugrinović, Vukašin",
year = "2023",
abstract = "Predmetnim pronalaskom postignuta je inkapsulacija slabo vodorastvorne aktivne supstance heterocikličnog azo jedinjenja sa antikancerogenim svojstvima u hidrofilni hidrogel na bazi poli(metakrilne kiseline) modifikovanog amfifilnim kazeinom, ciljana dostava inkapsuliranog azo derivata i njegovo kontrolisano i produženo otpuštanje (i do 72h) bez naglog inicijalnog oslobadanja iz hidrofilnog hidrogela. Takođe, predmetnim pronalaskom su dobijeni nosači koji bi imali potencijalnu primenu u tretmanu hronične mijeloidne leukemije (HML), čijom bi se primenom smanjio broj potrebnih terapeutskih doza i redukovali neželjeni efekti (kao što je povraćanje i iritacija gastrointestinalnog trakta) koji se najčešće javljaju kod primene lekova za terapiju HML.",
publisher = "Zavod za intelektualnu svojinu, Beograd, Srbija",
journal = "http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf",
title = "SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5950"
}

Marković, M., Tadić, J., Šešlija, S., Mijin, D., Panić, V., Spasojević, P., Pjanović, R.,& Ugrinović, V.. (2023). SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA. in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf
Zavod za intelektualnu svojinu, Beograd, Srbija..
https://hdl.handle.net/21.15107/rcub_technorep_5950

Marković M, Tadić J, Šešlija S, Mijin D, Panić V, Spasojević P, Pjanović R, Ugrinović V. SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA. in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_5950 .

Marković, Maja, Tadić, Julijana, Šešlija, Sanja, Mijin, Dušan, Panić, Vesna, Spasojević, Pavle, Pjanović, Rada, Ugrinović, Vukašin, "SISTEM NA BAZI POLI (METAKRILNE KISELINE) I KAZEINA ZA KONTROLISANO OTPUŠTANJE HETEROCIKLIČNOG AZO JEDINJENJA SA POTENCIJALNOM PRIMENOM U TRETMANU MALIGNOG OBOLJENJA BELIH KRVNIH ĆELIJA" in http://pub.zis.gov.rs/rs-pubserver/document?iDocId=103007&iepatch=.pdf (2023),
https://hdl.handle.net/21.15107/rcub_technorep_5950 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Svetozarević, Milica M.
AU  - Ugrinović, Vukašin Đ.
AU  - Pjanović, Rada V.
AU  - Obradović, Bojana M.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6620
AB  - Everyday struggle of humanity with novel diseases and present once, urge researchers to find novel and improve existing therapies to enhance their efficiency and safety. One of the promising approaches to overcome these challenges is controlled release of drugs. Biomaterials based on poly(methacrylic acid) (PMAA) are excellent drug delivery systems because they can control release rate and released amount of drug. Also, due to their pH sensitivity the PMAA hydrogels can release drug at the site of action. Namely, these nontoxic and biocompatible hydrogels swell in the environment with pH value higher than pKa of PMAA (4.6) and release encapsulated drug during the process. In present study, PMAA hydrogels are synthetized under ambient conditions by simple, cost effective and eco-friendly synthesis. Novel initiation system based on hydrogen peroxide, potato peel peroxidase and vitamin C (VC) is used for the first time for free radical polymerization of PMAA hydrogel. In accordance with the principles of circular economy, peroxidase was isolated from potato peel waste by water extraction for 12 h at 4 ℃. Four PMAA hydrogels were prepared by using potato peel peroxidase with various enzyme activity (0.4; 0.8; 1.2 and 1.8 IU), whereas the amounts of H2O2 (30 mL) and VC (10 mg) have been kept constant. The composition of the PMAA hydrogels was confirmed by FTIR analysis, whereas their porous structure was revealed by SEM. The swelling of the PMAA hydrogels was monitored in two media: 0.1M HCl (as simulation of human stomach) and phosphate buffer with pH 7.4 (as simulation of human intestines). In order to encapsulate anti-inflammatory drug – dexamethasone into the PMAA hydrogels, the hydrogels were immersed into the dexamethasone aqueous solution (5 mg/ml) and left to swell to the equilibrium, after which they were dried at room temperature. Dexamethasone release from the PMAA hydrogels was monitored in the same environments as was the PMAA swelling. The results showed that around seven times higher amount of dexamethasone was released in the medium with pH 7.4 than in the medium with pH 1. Present study has showed that the PMAA hydrogels, prepared through green and eco-friendly method, have huge potential for encapsulation and controlled release of anti-inflammatory drugs and therefore, for the treatment of rheumatoid arthritis.
PB  - AO Foundation
C3  - ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical
T1  - Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs
SP  - 572
VL  - 3
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6620
ER  - 

@conference{
author = "Marković, Maja D. and Svetozarević, Milica M. and Ugrinović, Vukašin Đ. and Pjanović, Rada V. and Obradović, Bojana M. and Kalagasidis Krušić, Melina T.",
year = "2023",
abstract = "Everyday struggle of humanity with novel diseases and present once, urge researchers to find novel and improve existing therapies to enhance their efficiency and safety. One of the promising approaches to overcome these challenges is controlled release of drugs. Biomaterials based on poly(methacrylic acid) (PMAA) are excellent drug delivery systems because they can control release rate and released amount of drug. Also, due to their pH sensitivity the PMAA hydrogels can release drug at the site of action. Namely, these nontoxic and biocompatible hydrogels swell in the environment with pH value higher than pKa of PMAA (4.6) and release encapsulated drug during the process. In present study, PMAA hydrogels are synthetized under ambient conditions by simple, cost effective and eco-friendly synthesis. Novel initiation system based on hydrogen peroxide, potato peel peroxidase and vitamin C (VC) is used for the first time for free radical polymerization of PMAA hydrogel. In accordance with the principles of circular economy, peroxidase was isolated from potato peel waste by water extraction for 12 h at 4 ℃. Four PMAA hydrogels were prepared by using potato peel peroxidase with various enzyme activity (0.4; 0.8; 1.2 and 1.8 IU), whereas the amounts of H2O2 (30 mL) and VC (10 mg) have been kept constant. The composition of the PMAA hydrogels was confirmed by FTIR analysis, whereas their porous structure was revealed by SEM. The swelling of the PMAA hydrogels was monitored in two media: 0.1M HCl (as simulation of human stomach) and phosphate buffer with pH 7.4 (as simulation of human intestines). In order to encapsulate anti-inflammatory drug – dexamethasone into the PMAA hydrogels, the hydrogels were immersed into the dexamethasone aqueous solution (5 mg/ml) and left to swell to the equilibrium, after which they were dried at room temperature. Dexamethasone release from the PMAA hydrogels was monitored in the same environments as was the PMAA swelling. The results showed that around seven times higher amount of dexamethasone was released in the medium with pH 7.4 than in the medium with pH 1. Present study has showed that the PMAA hydrogels, prepared through green and eco-friendly method, have huge potential for encapsulation and controlled release of anti-inflammatory drugs and therefore, for the treatment of rheumatoid arthritis.",
publisher = "AO Foundation",
journal = "ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical",
title = "Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs",
pages = "572",
volume = "3",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6620"
}

Marković, M. D., Svetozarević, M. M., Ugrinović, V. Đ., Pjanović, R. V., Obradović, B. M.,& Kalagasidis Krušić, M. T.. (2023). Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs. in ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical
AO Foundation., 3, 572.
https://hdl.handle.net/21.15107/rcub_technorep_6620

Marković MD, Svetozarević MM, Ugrinović VĐ, Pjanović RV, Obradović BM, Kalagasidis Krušić MT. Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs. in ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical. 2023;3:572.
https://hdl.handle.net/21.15107/rcub_technorep_6620 .

Marković, Maja D., Svetozarević, Milica M., Ugrinović, Vukašin Đ., Pjanović, Rada V., Obradović, Bojana M., Kalagasidis Krušić, Melina T., "Hydrogels based on poly(methacrylic acid) for controlled release of anti-inflammatory drugs" in ESB2023: 33rd Annual Conference of the European Society for Biomaterials, ARI Abstracts Periodical, 3 (2023):572,
https://hdl.handle.net/21.15107/rcub_technorep_6620 .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Ugrinović, Vukašin Đ.
AU  - Pjanović, Rada V.
AU  - Spasojević, Milica M.
AU  - Spasojević, Pavle M.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5092
AB  - Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
PB  - Elsevier
T2  - Microporous and Mesoporous Materials
T1  - Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery
SP  - 111817
VL  - 335
DO  - 10.1016/j.micromeso.2022.111817
ER  - 

@article{
author = "Marković, Maja D. and Panić, Vesna V. and Savić, Sanja I. and Ugrinović, Vukašin Đ. and Pjanović, Rada V. and Spasojević, Milica M. and Spasojević, Pavle M.",
year = "2022",
abstract = "Materials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.",
publisher = "Elsevier",
journal = "Microporous and Mesoporous Materials",
title = "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery",
pages = "111817",
volume = "335",
doi = "10.1016/j.micromeso.2022.111817"
}

Marković, M. D., Panić, V. V., Savić, S. I., Ugrinović, V. Đ., Pjanović, R. V., Spasojević, M. M.,& Spasojević, P. M.. (2022). Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials
Elsevier., 335, 111817.
https://doi.org/10.1016/j.micromeso.2022.111817

Marković MD, Panić VV, Savić SI, Ugrinović VĐ, Pjanović RV, Spasojević MM, Spasojević PM. Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery. in Microporous and Mesoporous Materials. 2022;335:111817.
doi:10.1016/j.micromeso.2022.111817 .

Marković, Maja D., Panić, Vesna V., Savić, Sanja I., Ugrinović, Vukašin Đ., Pjanović, Rada V., Spasojević, Milica M., Spasojević, Pavle M., "Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery" in Microporous and Mesoporous Materials, 335 (2022):111817,
https://doi.org/10.1016/j.micromeso.2022.111817 . .

TY  - CONF
AU  - Ugrinović, Vukašin
AU  - Hristara, Veroniki
AU  - Marković, Maja
AU  - Petrović, Predrag
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5240
AB  - Hydrogels are three-dimensional hydrophilic networks of polymers capable of retaining large
amounts of water or biological fluids, which makes them attractive for biomedical and
pharmaceutical applications. Although various types of polymers have been investigated as
hydrogels for biomedical purposes, those obtained from natural polymers have intrinsic
advantages as they are abundant, cheap, biocompatible and biodegradable. Gelatin is a natural
polymer that has been applied in biomedicine due to its low price, biocompatibility, and
biodegradability. HPMC, a derivative of cellulose, is a hydrophilic, biodegradable, and
biocompatible polymer. However, natural polymer-based hydrogels have low mechanical
properties and are relatively soluble in physiological conditions, which requires creative crosslinking strategies to improve the functionality of the hydrogels. The citric acid (CA) is an
inexpensive and non-toxic compound that has been proven to be an effective crosslinker for
natural polymers. In addition, the incorporation of bioactive calcium phosphate particles could
further improve mechanical properties and add new functionalities to the hydrogels.
In this work, we present novel composite hydrogels for biomedical applications, based on CAcrosslinked gelatin/HPMC (HPMC-G) matrix and Mg-doped biphasic calcium phosphate filler
(BCP). Firstly, the HPMC-G hydrogels crosslinking conditions were optimized. Different CA
concentrations, curing temperatures (140-180°C) and times (3-9 min) were applied. During the
second step, the optimaly crosslinked HPMC-G hydrogel was incorporated with different amounts
of BCP. BCP was obtained by calcination of Mg-doped hydroxyapatite (HA) powder synthesized
by the hydrothermal method. XRD analysis confirmed that powder was constituted only of HA
and beta-tricalcium phosphate. The obtained composite hydrogels were characterized by
mechanical testing, FTIR, SEM, swelling behavior and drug deliverability.
PB  - Materials Research Society of Serbia, Belgrade, Serbia
C3  - TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro
T1  - Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5240
ER  - 

@conference{
author = "Ugrinović, Vukašin and Hristara, Veroniki and Marković, Maja and Petrović, Predrag and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2022",
abstract = "Hydrogels are three-dimensional hydrophilic networks of polymers capable of retaining large
amounts of water or biological fluids, which makes them attractive for biomedical and
pharmaceutical applications. Although various types of polymers have been investigated as
hydrogels for biomedical purposes, those obtained from natural polymers have intrinsic
advantages as they are abundant, cheap, biocompatible and biodegradable. Gelatin is a natural
polymer that has been applied in biomedicine due to its low price, biocompatibility, and
biodegradability. HPMC, a derivative of cellulose, is a hydrophilic, biodegradable, and
biocompatible polymer. However, natural polymer-based hydrogels have low mechanical
properties and are relatively soluble in physiological conditions, which requires creative crosslinking strategies to improve the functionality of the hydrogels. The citric acid (CA) is an
inexpensive and non-toxic compound that has been proven to be an effective crosslinker for
natural polymers. In addition, the incorporation of bioactive calcium phosphate particles could
further improve mechanical properties and add new functionalities to the hydrogels.
In this work, we present novel composite hydrogels for biomedical applications, based on CAcrosslinked gelatin/HPMC (HPMC-G) matrix and Mg-doped biphasic calcium phosphate filler
(BCP). Firstly, the HPMC-G hydrogels crosslinking conditions were optimized. Different CA
concentrations, curing temperatures (140-180°C) and times (3-9 min) were applied. During the
second step, the optimaly crosslinked HPMC-G hydrogel was incorporated with different amounts
of BCP. BCP was obtained by calcination of Mg-doped hydroxyapatite (HA) powder synthesized
by the hydrothermal method. XRD analysis confirmed that powder was constituted only of HA
and beta-tricalcium phosphate. The obtained composite hydrogels were characterized by
mechanical testing, FTIR, SEM, swelling behavior and drug deliverability.",
publisher = "Materials Research Society of Serbia, Belgrade, Serbia",
journal = "TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro",
title = "Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5240"
}

Ugrinović, V., Hristara, V., Marković, M., Petrović, P., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2022). Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications. in TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro
Materials Research Society of Serbia, Belgrade, Serbia..
https://hdl.handle.net/21.15107/rcub_technorep_5240

Ugrinović V, Hristara V, Marković M, Petrović P, Petrović R, Janaćković Đ, Veljović Đ. Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications. in TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro. 2022;.
https://hdl.handle.net/21.15107/rcub_technorep_5240 .

Ugrinović, Vukašin, Hristara, Veroniki, Marković, Maja, Petrović, Predrag, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "Composite hydrogels based on gelatin, hydroxypropyl methylcellulose and Mg-doped biphasic calcium phosphate for biomedical applications" in TWENTY THIRD ANNUAL CONFERENCE - YUCOMAT 2022, Herceg Novi, Montenegro (2022),
https://hdl.handle.net/21.15107/rcub_technorep_5240 .

TY  - JOUR
AU  - Ugrinović, Vukašin
AU  - Panić, Vesna
AU  - Spasojević, Pavle
AU  - Seslija, Sanja
AU  - Bozic, Bojan
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4984
AB  - Hydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.
T2  - Polymer Engineering and Science
T1  - Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)
DO  - 10.1002/pen.25870
ER  - 

@article{
author = "Ugrinović, Vukašin and Panić, Vesna and Spasojević, Pavle and Seslija, Sanja and Bozic, Bojan and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2022",
abstract = "Hydrogels are promising materials for biomedical applications due to highly hydrated, porous, permeable structure with possibility to accommodate living cells, drugs, or bioactive factors. In this paper, we reported poly(methacrylic acid) (PMAA)/gelatin IPN hydrogels, synthesized by free-radical polymerization, with adjustable mechanical, structural, physicochemical, and biological characteristics. The influence of methacrylic acid (MAA), gelatin, and cross-linker in the precursor solution on hydrogels properties was investigated. The increasing concentration of MAA, gelatin, and cross-linker led to better mechanical properties, lower porosity, and water content. The compressive mechanical properties of hydrogels were significantly better in comparison to a single-network PMAA hydrogel, while the obtained compressive strength values up to 16 MPa were comparable with tough hydrogels. The increasing concentration of MAA and cross-linker reduced fatigue resistance and degradability, while the increase in gelatin content acted in the opposite way. Swelling tests in different pH conditions demonstrated strong pH-sensibility of the hydrogels, which was more pronounced as MAA concentration was higher, and gelatin and cross-linker concentrations were lower. In addition, the hydrogels strongly promoted the proliferation of human periodontal ligament stem cells and MRC-5 cells as assayed by MTT assay.",
journal = "Polymer Engineering and Science",
title = "Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)",
doi = "10.1002/pen.25870"
}

Ugrinović, V., Panić, V., Spasojević, P., Seslija, S., Bozic, B., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2022). Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid). in Polymer Engineering and Science.
https://doi.org/10.1002/pen.25870

Ugrinović V, Panić V, Spasojević P, Seslija S, Bozic B, Petrović R, Janaćković Đ, Veljović Đ. Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid). in Polymer Engineering and Science. 2022;.
doi:10.1002/pen.25870 .

Ugrinović, Vukašin, Panić, Vesna, Spasojević, Pavle, Seslija, Sanja, Bozic, Bojan, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "Strong and tough, pH sensible, interpenetrating network hydrogels based on gelatin and poly(methacrylic acid)" in Polymer Engineering and Science (2022),
https://doi.org/10.1002/pen.25870 . .

TY  - JOUR
AU  - Jelić, Aleksandra
AU  - Sekulić, Milica
AU  - Travica, Milan
AU  - Gržetić, Jelena
AU  - Ugrinović, Vukašin
AU  - Marinković, Aleksandar D.
AU  - Božić, Aleksandra
AU  - Stamenović, Marina
AU  - Putić, Slaviša
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5110
AB  - In this study, silicate nanofillers; dicalcium silicate, magnesium silicate, tricalcium silicate, and wollastonite; were synthesized using four different methods and incorporated into the epoxy resin to improve its mechanical properties. Characterization of the newly synthesized nanofillers was performed using Fourier-transformation infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The purpose of this study was to analyze newly developed composite materials reinforced with silicate nanoparticles utilizing tensile testing and a full-field non-contact 3D Digital Image Correlation (DIC) method. Analysis of deformation and displacement fields gives precise material behavior during testing. Testing results allowed a more reliable assessment of the structural integrity of epoxy composite materials reinforced using different silicate nanofillers. It was concluded that the addition of 3% of dicalcium silicate, magnesium silicate, tricalcium silicate, and wollastonite lead to the increasement of tensile strength up to 31.5%, 29.0%, 27.5%, and 23.5% in comparison with neat epoxy, respectively. In order to offer more trustworthy information about the viscoelastic behavior of neat epoxy and composites, a dynamic mechanical analysis (DMA) was also performed and rheological measurements of uncured epoxy matrix and epoxy suspensions were obtained.
PB  - MDPI
T2  - Polymers
T1  - Determination of Mechanical Properties of Epoxy Composite Materials Reinforced with Silicate Nanofillers Using Digital Image Correlation (DIC)
IS  - 6
SP  - 1255
VL  - 14
DO  - 10.3390/polym14061255
ER  - 

@article{
author = "Jelić, Aleksandra and Sekulić, Milica and Travica, Milan and Gržetić, Jelena and Ugrinović, Vukašin and Marinković, Aleksandar D. and Božić, Aleksandra and Stamenović, Marina and Putić, Slaviša",
year = "2022",
abstract = "In this study, silicate nanofillers; dicalcium silicate, magnesium silicate, tricalcium silicate, and wollastonite; were synthesized using four different methods and incorporated into the epoxy resin to improve its mechanical properties. Characterization of the newly synthesized nanofillers was performed using Fourier-transformation infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The purpose of this study was to analyze newly developed composite materials reinforced with silicate nanoparticles utilizing tensile testing and a full-field non-contact 3D Digital Image Correlation (DIC) method. Analysis of deformation and displacement fields gives precise material behavior during testing. Testing results allowed a more reliable assessment of the structural integrity of epoxy composite materials reinforced using different silicate nanofillers. It was concluded that the addition of 3% of dicalcium silicate, magnesium silicate, tricalcium silicate, and wollastonite lead to the increasement of tensile strength up to 31.5%, 29.0%, 27.5%, and 23.5% in comparison with neat epoxy, respectively. In order to offer more trustworthy information about the viscoelastic behavior of neat epoxy and composites, a dynamic mechanical analysis (DMA) was also performed and rheological measurements of uncured epoxy matrix and epoxy suspensions were obtained.",
publisher = "MDPI",
journal = "Polymers",
title = "Determination of Mechanical Properties of Epoxy Composite Materials Reinforced with Silicate Nanofillers Using Digital Image Correlation (DIC)",
number = "6",
pages = "1255",
volume = "14",
doi = "10.3390/polym14061255"
}

Jelić, A., Sekulić, M., Travica, M., Gržetić, J., Ugrinović, V., Marinković, A. D., Božić, A., Stamenović, M.,& Putić, S.. (2022). Determination of Mechanical Properties of Epoxy Composite Materials Reinforced with Silicate Nanofillers Using Digital Image Correlation (DIC). in Polymers
MDPI., 14(6), 1255.
https://doi.org/10.3390/polym14061255

Jelić A, Sekulić M, Travica M, Gržetić J, Ugrinović V, Marinković AD, Božić A, Stamenović M, Putić S. Determination of Mechanical Properties of Epoxy Composite Materials Reinforced with Silicate Nanofillers Using Digital Image Correlation (DIC). in Polymers. 2022;14(6):1255.
doi:10.3390/polym14061255 .

Jelić, Aleksandra, Sekulić, Milica, Travica, Milan, Gržetić, Jelena, Ugrinović, Vukašin, Marinković, Aleksandar D., Božić, Aleksandra, Stamenović, Marina, Putić, Slaviša, "Determination of Mechanical Properties of Epoxy Composite Materials Reinforced with Silicate Nanofillers Using Digital Image Correlation (DIC)" in Polymers, 14, no. 6 (2022):1255,
https://doi.org/10.3390/polym14061255 . .

TY  - CONF
AU  - Veljović, Đorđe
AU  - Ugrinović, Vukašin
AU  - Matić, Tamara
AU  - Tadić, Julijana
AU  - Dragutinović, Olivera
AU  - Jakovljević, Teodora
AU  - Stanisavljević, Jelena
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6678
PB  - Belgrade : Materials Research Society of Serbia
C3  - Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2
T1  - Biodegradable coatings improved mechanical properties and bioactivity of sintered calcium phosphate scaffolds
SP  - 166
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6678
ER  - 

@conference{
author = "Veljović, Đorđe and Ugrinović, Vukašin and Matić, Tamara and Tadić, Julijana and Dragutinović, Olivera and Jakovljević, Teodora and Stanisavljević, Jelena",
year = "2022",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2",
title = "Biodegradable coatings improved mechanical properties and bioactivity of sintered calcium phosphate scaffolds",
pages = "166",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6678"
}

Veljović, Đ., Ugrinović, V., Matić, T., Tadić, J., Dragutinović, O., Jakovljević, T.,& Stanisavljević, J.. (2022). Biodegradable coatings improved mechanical properties and bioactivity of sintered calcium phosphate scaffolds. in Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2
Belgrade : Materials Research Society of Serbia., 166.
https://hdl.handle.net/21.15107/rcub_technorep_6678

Veljović Đ, Ugrinović V, Matić T, Tadić J, Dragutinović O, Jakovljević T, Stanisavljević J. Biodegradable coatings improved mechanical properties and bioactivity of sintered calcium phosphate scaffolds. in Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2. 2022;:166.
https://hdl.handle.net/21.15107/rcub_technorep_6678 .

Veljović, Đorđe, Ugrinović, Vukašin, Matić, Tamara, Tadić, Julijana, Dragutinović, Olivera, Jakovljević, Teodora, Stanisavljević, Jelena, "Biodegradable coatings improved mechanical properties and bioactivity of sintered calcium phosphate scaffolds" in Programme and The Book of Abstracts / Twenty-third Annual Conference YUCOMAT 2022 & Twelfth World Round Table Conference on Sintering XII WRTCS 2022, Herceg Novi, Montenegro, August 29 - September 2 (2022):166,
https://hdl.handle.net/21.15107/rcub_technorep_6678 .

TY  - JOUR
AU  - Marković, Maja
AU  - Seslija, Sanja, I
AU  - Ugrinović, Vukašin
AU  - Kunaver, Matjaz
AU  - Panić, Vesna
AU  - Pjanović, Rada
AU  - Spasojević, Pavle
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4802
AB  - pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer-Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.
T2  - Cellulose
T1  - Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen
EP  - 11132
IS  - 17
SP  - 11109
VL  - 28
DO  - 10.1007/s10570-021-04222-w
ER  - 

@article{
author = "Marković, Maja and Seslija, Sanja, I and Ugrinović, Vukašin and Kunaver, Matjaz and Panić, Vesna and Pjanović, Rada and Spasojević, Pavle",
year = "2021",
abstract = "pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer-Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.",
journal = "Cellulose",
title = "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen",
pages = "11132-11109",
number = "17",
volume = "28",
doi = "10.1007/s10570-021-04222-w"
}

Marković, M., Seslija, S. I., Ugrinović, V., Kunaver, M., Panić, V., Pjanović, R.,& Spasojević, P.. (2021). Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose, 28(17), 11109-11132.
https://doi.org/10.1007/s10570-021-04222-w

Marković M, Seslija SI, Ugrinović V, Kunaver M, Panić V, Pjanović R, Spasojević P. Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose. 2021;28(17):11109-11132.
doi:10.1007/s10570-021-04222-w .

Marković, Maja, Seslija, Sanja, I, Ugrinović, Vukašin, Kunaver, Matjaz, Panić, Vesna, Pjanović, Rada, Spasojević, Pavle, "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen" in Cellulose, 28, no. 17 (2021):11109-11132,
https://doi.org/10.1007/s10570-021-04222-w . .

TY  - JOUR
AU  - Jelić, Aleksandra
AU  - Marinković, Aleksandar
AU  - Sekulic, Milica
AU  - Dikić, Stefan
AU  - Ugrinović, Vukašin
AU  - Pavlović, Vladimir
AU  - Putić, Slaviša
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4961
AB  - In this study, halloysite nanotubes (HNT) were modified by: 3-glycidyloxypropyltrimethoxysilane (GLYMO), 3-aminopropyltrimethoxysilane (APTES), and 2,2-Bis[4-(glycidyloxy) phenyl] propane (DGEBA), and incorporated in the epoxy resin matrix to enhance its mechanical properties. The HNT/epoxy nanocomposite materials were prepared by mixing different ratios of untreated/treated HNT with neat epoxy resin. Characterization of untreated/treated HNT was performed by Fourier-transformation infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The quantity of grafted molecules and thermal stability of newly synthesized materials were determined by thermogravimetric (TG) and derivative thermogravimetric (DTG) analysis. Tensile properties of newly synthesized materials were compared, and scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis of the fracture surfaces were performed. Incorporation of APTES modified HNT (HNTAPT) and two-step modification APTES followed by DGEBA (HNTAPTDG) has increased the tensile strength of the nanocomposite materials up to 72% and 61%, and strain at break up to 1082% and 1216%, respectively, compared to neat epoxy. It was concluded that the modification of HNT contributed to the enhancement of the dispersion and the cross-linking in the epoxy resin matrix.
T2  - Polymer Composites
T1  - Design of halloysite modification for improvement of mechanical properties of the epoxy based nanocomposites
EP  - 2192
IS  - 5
SP  - 2180
VL  - 42
DO  - 10.1002/pc.25967
ER  - 

@article{
author = "Jelić, Aleksandra and Marinković, Aleksandar and Sekulic, Milica and Dikić, Stefan and Ugrinović, Vukašin and Pavlović, Vladimir and Putić, Slaviša",
year = "2021",
abstract = "In this study, halloysite nanotubes (HNT) were modified by: 3-glycidyloxypropyltrimethoxysilane (GLYMO), 3-aminopropyltrimethoxysilane (APTES), and 2,2-Bis[4-(glycidyloxy) phenyl] propane (DGEBA), and incorporated in the epoxy resin matrix to enhance its mechanical properties. The HNT/epoxy nanocomposite materials were prepared by mixing different ratios of untreated/treated HNT with neat epoxy resin. Characterization of untreated/treated HNT was performed by Fourier-transformation infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The quantity of grafted molecules and thermal stability of newly synthesized materials were determined by thermogravimetric (TG) and derivative thermogravimetric (DTG) analysis. Tensile properties of newly synthesized materials were compared, and scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis of the fracture surfaces were performed. Incorporation of APTES modified HNT (HNTAPT) and two-step modification APTES followed by DGEBA (HNTAPTDG) has increased the tensile strength of the nanocomposite materials up to 72% and 61%, and strain at break up to 1082% and 1216%, respectively, compared to neat epoxy. It was concluded that the modification of HNT contributed to the enhancement of the dispersion and the cross-linking in the epoxy resin matrix.",
journal = "Polymer Composites",
title = "Design of halloysite modification for improvement of mechanical properties of the epoxy based nanocomposites",
pages = "2192-2180",
number = "5",
volume = "42",
doi = "10.1002/pc.25967"
}

Jelić, A., Marinković, A., Sekulic, M., Dikić, S., Ugrinović, V., Pavlović, V.,& Putić, S.. (2021). Design of halloysite modification for improvement of mechanical properties of the epoxy based nanocomposites. in Polymer Composites, 42(5), 2180-2192.
https://doi.org/10.1002/pc.25967

Jelić A, Marinković A, Sekulic M, Dikić S, Ugrinović V, Pavlović V, Putić S. Design of halloysite modification for improvement of mechanical properties of the epoxy based nanocomposites. in Polymer Composites. 2021;42(5):2180-2192.
doi:10.1002/pc.25967 .

Jelić, Aleksandra, Marinković, Aleksandar, Sekulic, Milica, Dikić, Stefan, Ugrinović, Vukašin, Pavlović, Vladimir, Putić, Slaviša, "Design of halloysite modification for improvement of mechanical properties of the epoxy based nanocomposites" in Polymer Composites, 42, no. 5 (2021):2180-2192,
https://doi.org/10.1002/pc.25967 . .

TY  - JOUR
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Spasojević, Pavle
AU  - Ugrinović, Vukašin
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4382
AB  - pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly water-soluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.
PB  - Wiley, Hoboken
T2  - Polymer Engineering and Science
T1  - Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance
EP  - 2510
IS  - 10
SP  - 2496
VL  - 60
DO  - 10.1002/pen.25487
ER  - 

@article{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Spasojević, Pavle and Ugrinović, Vukašin and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2020",
abstract = "pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly water-soluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.",
publisher = "Wiley, Hoboken",
journal = "Polymer Engineering and Science",
title = "Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance",
pages = "2510-2496",
number = "10",
volume = "60",
doi = "10.1002/pen.25487"
}

Marković, M., Panić, V., Šešlija, S., Spasojević, P., Ugrinović, V., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance. in Polymer Engineering and Science
Wiley, Hoboken., 60(10), 2496-2510.
https://doi.org/10.1002/pen.25487

Marković M, Panić V, Šešlija S, Spasojević P, Ugrinović V, Bošković-Vragolović N, Pjanović R. Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance. in Polymer Engineering and Science. 2020;60(10):2496-2510.
doi:10.1002/pen.25487 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Spasojević, Pavle, Ugrinović, Vukašin, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance" in Polymer Engineering and Science, 60, no. 10 (2020):2496-2510,
https://doi.org/10.1002/pen.25487 . .

TY  - JOUR
AU  - Jelić, Aleksandra
AU  - Sekulić, Milica
AU  - Stamenović, Marina
AU  - Ugrinović, Vukašin
AU  - Putić, Slaviša
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4399
AB  - The paper presents static and dynamic tests of carbon/epoxy composite materials with fiber orientation at 0 degrees/90 degrees and +/- 45 degrees. The main tensile properties were determined as a basis for subsequent dynamic tests, in which permanent dynamic strength, crack growth, and crack growth rate in the material due to the action of fatigue load were assessed. Comparisons were made regarding the structure of the tested specimens. Samples were obtained from prepregs with a specific density of 1600 kg/m(3). The tests were performed at room temperature. Scanning electron microscopy (SEM) was used to analyze the damage in the material during these tests, the mechanisms of their further damage progression and, the impact on the growth and growth rate of the initial crack in the material. The analysis of numerical results and micromechanical analysis confirmed the dominant role of the reinforcing structural element in the material in all performed tests. The obtained results are of great importance in the application of composite materials of such structures under different operating conditions and load regimes.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Micromechanical analysis of fatigue and crack growth in carbon-fiber epoxy composites based on mechanical testing
EP  - 264
IS  - 4
SP  - 257
VL  - 74
DO  - 10.2298/HEMIND200615022J
ER  - 

@article{
author = "Jelić, Aleksandra and Sekulić, Milica and Stamenović, Marina and Ugrinović, Vukašin and Putić, Slaviša",
year = "2020",
abstract = "The paper presents static and dynamic tests of carbon/epoxy composite materials with fiber orientation at 0 degrees/90 degrees and +/- 45 degrees. The main tensile properties were determined as a basis for subsequent dynamic tests, in which permanent dynamic strength, crack growth, and crack growth rate in the material due to the action of fatigue load were assessed. Comparisons were made regarding the structure of the tested specimens. Samples were obtained from prepregs with a specific density of 1600 kg/m(3). The tests were performed at room temperature. Scanning electron microscopy (SEM) was used to analyze the damage in the material during these tests, the mechanisms of their further damage progression and, the impact on the growth and growth rate of the initial crack in the material. The analysis of numerical results and micromechanical analysis confirmed the dominant role of the reinforcing structural element in the material in all performed tests. The obtained results are of great importance in the application of composite materials of such structures under different operating conditions and load regimes.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Micromechanical analysis of fatigue and crack growth in carbon-fiber epoxy composites based on mechanical testing",
pages = "264-257",
number = "4",
volume = "74",
doi = "10.2298/HEMIND200615022J"
}

Jelić, A., Sekulić, M., Stamenović, M., Ugrinović, V.,& Putić, S.. (2020). Micromechanical analysis of fatigue and crack growth in carbon-fiber epoxy composites based on mechanical testing. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 74(4), 257-264.
https://doi.org/10.2298/HEMIND200615022J

Jelić A, Sekulić M, Stamenović M, Ugrinović V, Putić S. Micromechanical analysis of fatigue and crack growth in carbon-fiber epoxy composites based on mechanical testing. in Hemijska industrija. 2020;74(4):257-264.
doi:10.2298/HEMIND200615022J .

Jelić, Aleksandra, Sekulić, Milica, Stamenović, Marina, Ugrinović, Vukašin, Putić, Slaviša, "Micromechanical analysis of fatigue and crack growth in carbon-fiber epoxy composites based on mechanical testing" in Hemijska industrija, 74, no. 4 (2020):257-264,
https://doi.org/10.2298/HEMIND200615022J . .

TY  - JOUR
AU  - Perendija, Jovana
AU  - Veličković, Zlate
AU  - Cvijetić, Ilija
AU  - Rusmirović, Jelena
AU  - Ugrinović, Vukašin
AU  - Marinković, Aleksandar
AU  - Onjia, Antonije
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4348
AB  - An optimized method is presented to make magnetite (MG) modified cellulose membrane (Cell-MG) from 3-aminopropyltriethoxysilane and diethylenetriaminepentaacetic acid dianhydride functionalized waste cell fibers; (Cell-NH(2)and Cell-DTPA), and amino-modified diatomite. Functionalized Cell-NH2, Cell-DTPA fibers, and diatomite were structurally and morphologically characterized using FT-IR, Raman, and FE-SEM analysis. Amino and carboxyl group content was determined via standard volumetric methods. Response surface method was applied to rationalize the number of experiments related to Cell-MG synthesis and heavy metal ions column adsorption experiments. The effects of pH, contact time, temperature, and initial concentration of pollutants on adsorption and kinetics were studied in a batch, while initial concentration and flow rate were studied in a flow system. The calculated capacities of 88.2, 100.7, 95.8 and 78.2 mg g(-1)for Ni2+, Pb2+, Cr(VI) and As(V) ions, respectively, were obtained from Langmuir model fitting. Intra-particle diffusion as a rate-limiting step was evaluated from pseudo-second-order and Weber-Morris model fitting. Thermodynamic parameters indicated spontaneous and low endothermic processes. The results from reusability study, wastewater purification and fixed-bed column study proved the high applicability of Cell-MG. Additionally, high removal capacity of four dyes together with density functional theory and molecular interaction fields, help in the establishment of relation between the adsorption performances and contribution of non-specific and specific interactions at adsorbate/adsorbent interface.
PB  - Springer, Dordrecht
T2  - Cellulose
T1  - Batch and column adsorption of cations, oxyanions and dyes on a magnetite modified cellulose-based membrane
EP  - 8235
IS  - 14
SP  - 8215
VL  - 27
DO  - 10.1007/s10570-020-03352-x
ER  - 

@article{
author = "Perendija, Jovana and Veličković, Zlate and Cvijetić, Ilija and Rusmirović, Jelena and Ugrinović, Vukašin and Marinković, Aleksandar and Onjia, Antonije",
year = "2020",
abstract = "An optimized method is presented to make magnetite (MG) modified cellulose membrane (Cell-MG) from 3-aminopropyltriethoxysilane and diethylenetriaminepentaacetic acid dianhydride functionalized waste cell fibers; (Cell-NH(2)and Cell-DTPA), and amino-modified diatomite. Functionalized Cell-NH2, Cell-DTPA fibers, and diatomite were structurally and morphologically characterized using FT-IR, Raman, and FE-SEM analysis. Amino and carboxyl group content was determined via standard volumetric methods. Response surface method was applied to rationalize the number of experiments related to Cell-MG synthesis and heavy metal ions column adsorption experiments. The effects of pH, contact time, temperature, and initial concentration of pollutants on adsorption and kinetics were studied in a batch, while initial concentration and flow rate were studied in a flow system. The calculated capacities of 88.2, 100.7, 95.8 and 78.2 mg g(-1)for Ni2+, Pb2+, Cr(VI) and As(V) ions, respectively, were obtained from Langmuir model fitting. Intra-particle diffusion as a rate-limiting step was evaluated from pseudo-second-order and Weber-Morris model fitting. Thermodynamic parameters indicated spontaneous and low endothermic processes. The results from reusability study, wastewater purification and fixed-bed column study proved the high applicability of Cell-MG. Additionally, high removal capacity of four dyes together with density functional theory and molecular interaction fields, help in the establishment of relation between the adsorption performances and contribution of non-specific and specific interactions at adsorbate/adsorbent interface.",
publisher = "Springer, Dordrecht",
journal = "Cellulose",
title = "Batch and column adsorption of cations, oxyanions and dyes on a magnetite modified cellulose-based membrane",
pages = "8235-8215",
number = "14",
volume = "27",
doi = "10.1007/s10570-020-03352-x"
}

Perendija, J., Veličković, Z., Cvijetić, I., Rusmirović, J., Ugrinović, V., Marinković, A.,& Onjia, A.. (2020). Batch and column adsorption of cations, oxyanions and dyes on a magnetite modified cellulose-based membrane. in Cellulose
Springer, Dordrecht., 27(14), 8215-8235.
https://doi.org/10.1007/s10570-020-03352-x

Perendija J, Veličković Z, Cvijetić I, Rusmirović J, Ugrinović V, Marinković A, Onjia A. Batch and column adsorption of cations, oxyanions and dyes on a magnetite modified cellulose-based membrane. in Cellulose. 2020;27(14):8215-8235.
doi:10.1007/s10570-020-03352-x .

Perendija, Jovana, Veličković, Zlate, Cvijetić, Ilija, Rusmirović, Jelena, Ugrinović, Vukašin, Marinković, Aleksandar, Onjia, Antonije, "Batch and column adsorption of cations, oxyanions and dyes on a magnetite modified cellulose-based membrane" in Cellulose, 27, no. 14 (2020):8215-8235,
https://doi.org/10.1007/s10570-020-03352-x . .

TY  - CONF
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Spasojević, Pavle
AU  - Ugrinović, Vukašin
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5075
AB  - Soft polymeric networks based on poly(methacrylic
acid) (PMAA) are attractive candidates for targeted and
controlled drug release due to their non-toxicity,
biocompatibility and pH-sensitivity. The highly hydrophilic
nature of PMAA networks enables transport of hydrophilic
drugs only. This limitation has been overcome in present work
by a PMAA modification with casein and liposomes. Casein is a
natural amphiphilic protein which enabled the encapsulation
and targeted and controlled release of the model drug- caffeine.
The FTIR spectra showed that the hydrophobic interactions and
hydrogen bonds were established between the casein and
caffeine. The caffeine in vitro release was monitored in two media
at 37C: phosphate buffer pH=6.8, which simulated the pH
environment in the human intestines and 0.1M HCl pH=1.2,
which simulated the pH environment in the human stomach. The
presence of liposomes with the encapsulated caffeine in the
carriers caused the decrease in the speed of caffeine release.
Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused
an increase in swelling rate of the carriers and an increase in
speed of caffeine release. All obtained results showed that the
targeted and controlled release of a poorly water-soluble
substance was achieved.
PB  - ETRAN Society, Belgrade, Academic Mind, Belgrade
C3  - 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019
T1  - Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance
EP  - 670
SP  - 665
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5075
ER  - 

@conference{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Spasojević, Pavle and Ugrinović, Vukašin and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2019",
abstract = "Soft polymeric networks based on poly(methacrylic
acid) (PMAA) are attractive candidates for targeted and
controlled drug release due to their non-toxicity,
biocompatibility and pH-sensitivity. The highly hydrophilic
nature of PMAA networks enables transport of hydrophilic
drugs only. This limitation has been overcome in present work
by a PMAA modification with casein and liposomes. Casein is a
natural amphiphilic protein which enabled the encapsulation
and targeted and controlled release of the model drug- caffeine.
The FTIR spectra showed that the hydrophobic interactions and
hydrogen bonds were established between the casein and
caffeine. The caffeine in vitro release was monitored in two media
at 37C: phosphate buffer pH=6.8, which simulated the pH
environment in the human intestines and 0.1M HCl pH=1.2,
which simulated the pH environment in the human stomach. The
presence of liposomes with the encapsulated caffeine in the
carriers caused the decrease in the speed of caffeine release.
Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused
an increase in swelling rate of the carriers and an increase in
speed of caffeine release. All obtained results showed that the
targeted and controlled release of a poorly water-soluble
substance was achieved.",
publisher = "ETRAN Society, Belgrade, Academic Mind, Belgrade",
journal = "6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019",
title = "Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance",
pages = "670-665",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5075"
}

Marković, M., Panić, V., Šešlija, S., Spasojević, P., Ugrinović, V., Bošković-Vragolović, N.,& Pjanović, R.. (2019). Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance. in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019
ETRAN Society, Belgrade, Academic Mind, Belgrade., 665-670.
https://hdl.handle.net/21.15107/rcub_technorep_5075

Marković M, Panić V, Šešlija S, Spasojević P, Ugrinović V, Bošković-Vragolović N, Pjanović R. Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance. in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019. 2019;:665-670.
https://hdl.handle.net/21.15107/rcub_technorep_5075 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Spasojević, Pavle, Ugrinović, Vukašin, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance" in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019 (2019):665-670,
https://hdl.handle.net/21.15107/rcub_technorep_5075 .

TY  - JOUR
AU  - Ugrinović, Vukašin
AU  - Panić, Vesna
AU  - Veljović, Đorđe
AU  - Spasojević, Pavle
AU  - Šešlija, Sanja I.
AU  - Janaćković, Đorđe
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3804
AB  - Goals. The goal of this study was a development of biocompatible composite hydrogels, structurally similar to native bone tissue, by incorporation of ~60 wt % of calcium hydroxyapatite (HA) into a matrix of hydrogels. Also, a possibility to control swelling kinetic and equilibrium swelling degree (SDeq) of hydrogels, by altering the degree of neutralization of the precursor (DN) was examined. Methods. Composite hydrogels, based on HA and poly(methacrylic acid) (PMAA), were synthesized by free-radical polymerization with different DN. Theoretical content of HA in synthesized composites was 60 wt %. Composites were synthesized by methods of dynamic mechanical analysis and scanning electron microscopy. SDeq and swelling kinetic were examined in distilled water and simulated body fluid. Results. Morphological observations revealed uniform distribution and strong bond of spherical HA particles within the polymer matrix. Swelling analyses demonstrated that SDeq is directly proportional to DN, while rheological examinations indicated inverse proportion between DN and storage modulus, but due to the HA particles inclusion, mechanical properties of composites were significantly better compared to monophasic PMAA hydrogels. Significance. Simple method of synthesis of composite hydrogels with high content of filler nanoparticles is presented. Incorporation of HA nanoparticles significantly improved mechanical properties of hydrogels, while at the same time was demonstrated a possibility to control swelling kinetic by influencing the DN.
AB  - Ciljevi - Cilj ove studije bio je razvoj biokompatibilnih kompozitnih hidrogelova, koji su slične strukture kao prirodno koštano tkivo, inkorporacijom ∼60 mas % kalcijum-hidroksiapatita (HA) u matricu hidro-gela. Takođe, ispitan je uticaj neutralizacije prekursora polimerne mreže na kinetiku bubrenja i ravnotežni stepen bubrenja (SDeq).Metode - Kompozitni hidrogelovi, sastavljeni od HA i poli(metakrilne kiseline) (PMAA), sintetisani su slobodno-radikalskom polimerizacijom, pri različitim stepenima neutralizacije prekursora (SN). Svi sintetisani kompoziti sadrže visok maseni udeo HA (~60 mas %). Kompoziti su okarakterisani metodama skenirajuće elektronske mikroskopije (SEM) i dinamičko-mehaničke analize (DMA). SDeq i kinetika bubrenja ispitivani su u destilovanoj vodi i simuliranoj telesnoj tečnosti (SBF). Rezultati - Morfološka ispitivanja pokazala su uniformnu raspodelu i dobru povezanost sferičnih čestica apatita sa polimernom matricom. Analiza procesa bubrenja pokazala je proporcionalnu zavisnost SN i SDeq kompozita. Reološka ispitivanja ukazala su na obrnuto proporcionalnu zavisnost između SN i vrednosti modula sačuvane energije, koji su iznosili 55130 Pa u slučaju potpune neutralizacije i 77480 Pa u slučaju 0% neutralizacije. Značaj - Predstavljena je jednostavna metoda za sintezu kompozitnih hidrogelova sa visokim masenim udelom nanočestica punioca. Inkorporacijom nanočestica HA postignuto je značajno poboljšanje mehaničkih svojstava hidrogelova, dok je istovremeno pokazano da je promenom SN moguće kontrolisati kinetiku bubrenja hidrogelova. .
PB  - Savez inženjera i tehničara Srbije, Beograd
T2  - Tehnika
T1  - Synthesis and properties of nano-hydroxyapatite/poly (methacrylic acid) composite hydrogels
T1  - Uticaj neutralizacije na svojstva poroznih hidrogelova na bazi hidroksiapatita i poli(metakrilne kiseline) sintetisanih slobodno-radikalskom polimerizacijom
EP  - 620
IS  - 5
SP  - 613
VL  - 73
DO  - 10.5937/tehnika1805613U
ER  - 

@article{
author = "Ugrinović, Vukašin and Panić, Vesna and Veljović, Đorđe and Spasojević, Pavle and Šešlija, Sanja I. and Janaćković, Đorđe",
year = "2018",
abstract = "Goals. The goal of this study was a development of biocompatible composite hydrogels, structurally similar to native bone tissue, by incorporation of ~60 wt % of calcium hydroxyapatite (HA) into a matrix of hydrogels. Also, a possibility to control swelling kinetic and equilibrium swelling degree (SDeq) of hydrogels, by altering the degree of neutralization of the precursor (DN) was examined. Methods. Composite hydrogels, based on HA and poly(methacrylic acid) (PMAA), were synthesized by free-radical polymerization with different DN. Theoretical content of HA in synthesized composites was 60 wt %. Composites were synthesized by methods of dynamic mechanical analysis and scanning electron microscopy. SDeq and swelling kinetic were examined in distilled water and simulated body fluid. Results. Morphological observations revealed uniform distribution and strong bond of spherical HA particles within the polymer matrix. Swelling analyses demonstrated that SDeq is directly proportional to DN, while rheological examinations indicated inverse proportion between DN and storage modulus, but due to the HA particles inclusion, mechanical properties of composites were significantly better compared to monophasic PMAA hydrogels. Significance. Simple method of synthesis of composite hydrogels with high content of filler nanoparticles is presented. Incorporation of HA nanoparticles significantly improved mechanical properties of hydrogels, while at the same time was demonstrated a possibility to control swelling kinetic by influencing the DN., Ciljevi - Cilj ove studije bio je razvoj biokompatibilnih kompozitnih hidrogelova, koji su slične strukture kao prirodno koštano tkivo, inkorporacijom ∼60 mas % kalcijum-hidroksiapatita (HA) u matricu hidro-gela. Takođe, ispitan je uticaj neutralizacije prekursora polimerne mreže na kinetiku bubrenja i ravnotežni stepen bubrenja (SDeq).Metode - Kompozitni hidrogelovi, sastavljeni od HA i poli(metakrilne kiseline) (PMAA), sintetisani su slobodno-radikalskom polimerizacijom, pri različitim stepenima neutralizacije prekursora (SN). Svi sintetisani kompoziti sadrže visok maseni udeo HA (~60 mas %). Kompoziti su okarakterisani metodama skenirajuće elektronske mikroskopije (SEM) i dinamičko-mehaničke analize (DMA). SDeq i kinetika bubrenja ispitivani su u destilovanoj vodi i simuliranoj telesnoj tečnosti (SBF). Rezultati - Morfološka ispitivanja pokazala su uniformnu raspodelu i dobru povezanost sferičnih čestica apatita sa polimernom matricom. Analiza procesa bubrenja pokazala je proporcionalnu zavisnost SN i SDeq kompozita. Reološka ispitivanja ukazala su na obrnuto proporcionalnu zavisnost između SN i vrednosti modula sačuvane energije, koji su iznosili 55130 Pa u slučaju potpune neutralizacije i 77480 Pa u slučaju 0% neutralizacije. Značaj - Predstavljena je jednostavna metoda za sintezu kompozitnih hidrogelova sa visokim masenim udelom nanočestica punioca. Inkorporacijom nanočestica HA postignuto je značajno poboljšanje mehaničkih svojstava hidrogelova, dok je istovremeno pokazano da je promenom SN moguće kontrolisati kinetiku bubrenja hidrogelova. .",
publisher = "Savez inženjera i tehničara Srbije, Beograd",
journal = "Tehnika",
title = "Synthesis and properties of nano-hydroxyapatite/poly (methacrylic acid) composite hydrogels, Uticaj neutralizacije na svojstva poroznih hidrogelova na bazi hidroksiapatita i poli(metakrilne kiseline) sintetisanih slobodno-radikalskom polimerizacijom",
pages = "620-613",
number = "5",
volume = "73",
doi = "10.5937/tehnika1805613U"
}

Ugrinović, V., Panić, V., Veljović, Đ., Spasojević, P., Šešlija, S. I.,& Janaćković, Đ.. (2018). Synthesis and properties of nano-hydroxyapatite/poly (methacrylic acid) composite hydrogels. in Tehnika
Savez inženjera i tehničara Srbije, Beograd., 73(5), 613-620.
https://doi.org/10.5937/tehnika1805613U

Ugrinović V, Panić V, Veljović Đ, Spasojević P, Šešlija SI, Janaćković Đ. Synthesis and properties of nano-hydroxyapatite/poly (methacrylic acid) composite hydrogels. in Tehnika. 2018;73(5):613-620.
doi:10.5937/tehnika1805613U .

Ugrinović, Vukašin, Panić, Vesna, Veljović, Đorđe, Spasojević, Pavle, Šešlija, Sanja I., Janaćković, Đorđe, "Synthesis and properties of nano-hydroxyapatite/poly (methacrylic acid) composite hydrogels" in Tehnika, 73, no. 5 (2018):613-620,
https://doi.org/10.5937/tehnika1805613U . .