TY  - PAT
AU  - Tadić, Vanja
AU  - Žugić, Ana
AU  - Nešić, Ivana
AU  - Krgović, Nemanja
AU  - Mudrić, Jelena
AU  - Martinović, Milica
AU  - Stojanović, Sanja
AU  - Maksimović, Svetolik
AU  - Lukić, Ivana
AU  - Petrović, Slobodan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6924
T2  - Zavod za intelektualnu svojinu republike Srbije
T1  - Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6924
ER  - 

@misc{
author = "Tadić, Vanja and Žugić, Ana and Nešić, Ivana and Krgović, Nemanja and Mudrić, Jelena and Martinović, Milica and Stojanović, Sanja and Maksimović, Svetolik and Lukić, Ivana and Petrović, Slobodan",
year = "2023",
journal = "Zavod za intelektualnu svojinu republike Srbije",
title = "Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6924"
}

Tadić, V., Žugić, A., Nešić, I., Krgović, N., Mudrić, J., Martinović, M., Stojanović, S., Maksimović, S., Lukić, I.,& Petrović, S.. (2023). Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja. in Zavod za intelektualnu svojinu republike Srbije.
https://hdl.handle.net/21.15107/rcub_technorep_6924

Tadić V, Žugić A, Nešić I, Krgović N, Mudrić J, Martinović M, Stojanović S, Maksimović S, Lukić I, Petrović S. Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja. in Zavod za intelektualnu svojinu republike Srbije. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_6924 .

Tadić, Vanja, Žugić, Ana, Nešić, Ivana, Krgović, Nemanja, Mudrić, Jelena, Martinović, Milica, Stojanović, Sanja, Maksimović, Svetolik, Lukić, Ivana, Petrović, Slobodan, "Gastroretentivni fitopreparat sa sistemskim delovanjem za sniženje nivoa šećera u krvi i postupak dobijanja" in Zavod za intelektualnu svojinu republike Srbije (2023),
https://hdl.handle.net/21.15107/rcub_technorep_6924 .

TY  - PAT
AU  - Tadić, Vanja
AU  - Nešić, Ivana
AU  - Milenković, Marina
AU  - Martinović, Milica
AU  - Žugić, Ana
AU  - Maksimović, Svetolik
AU  - Stojanović, Sanja
AU  - Milovanović, Stoja
AU  - Krgović, Nemanja
AU  - Petrović, Slobodan
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6900
T2  - Zavod za intelektualnu svojinu republike Srbije
T1  - Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6900
ER  - 

@misc{
author = "Tadić, Vanja and Nešić, Ivana and Milenković, Marina and Martinović, Milica and Žugić, Ana and Maksimović, Svetolik and Stojanović, Sanja and Milovanović, Stoja and Krgović, Nemanja and Petrović, Slobodan",
year = "2023",
journal = "Zavod za intelektualnu svojinu republike Srbije",
title = "Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6900"
}

Tadić, V., Nešić, I., Milenković, M., Martinović, M., Žugić, A., Maksimović, S., Stojanović, S., Milovanović, S., Krgović, N.,& Petrović, S.. (2023). Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom. in Zavod za intelektualnu svojinu republike Srbije.
https://hdl.handle.net/21.15107/rcub_technorep_6900

Tadić V, Nešić I, Milenković M, Martinović M, Žugić A, Maksimović S, Stojanović S, Milovanović S, Krgović N, Petrović S. Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom. in Zavod za intelektualnu svojinu republike Srbije. 2023;.
https://hdl.handle.net/21.15107/rcub_technorep_6900 .

Tadić, Vanja, Nešić, Ivana, Milenković, Marina, Martinović, Milica, Žugić, Ana, Maksimović, Svetolik, Stojanović, Sanja, Milovanović, Stoja, Krgović, Nemanja, Petrović, Slobodan, "Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom" in Zavod za intelektualnu svojinu republike Srbije (2023),
https://hdl.handle.net/21.15107/rcub_technorep_6900 .

TY  - JOUR
AU  - Krezović, Bojana D.
AU  - Miljković, Miona
AU  - Stojanović, Sanja T.
AU  - Najman, Stevo
AU  - Filipović, Jovanka
AU  - Tomić, Simonida
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3709
AB  - The aim of this work was to synthesize a series of semi-interpenetrating polymer networks (semi-IPNs) of 2-hydroxyethyl acrylate and itaconic acid, in the presence of poly(N-vinylpyrrolidone). Samples were synthesized by free radical copolymerization with constant PVP and variable IA content and characterized for structural, morphological, thermal, swelling, drug release, antibacterial and cytotoxic properties. The chemical structure of samples was confirmed by Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) was used to examine morphology of samples and glass transition temperatures were determined by differential scanning calorimetry (DCS). The pH and temperature sensitivity was confirmed by measuring the dependence of the degree of swelling on pH and temperature. All samples show volume phase transition temperature (VPTT) around 47 degrees C. Drug release profiles were investigated using vitamin B-3 as a model drug. The vitamin B-3 transport mechanism was studied by fitting experimental data to five different model equations and calculating the corresponding parameters. It was also observed that IA content has a marked influence on the release profiles of vitamin B-3, so the rate of drug release can be designed by changing the HEA/IA ratio. Cell viability, performed using MTT test, was high for all samples and all concentration of extract used. The antibacterial activity of hydrogels was determined against Pseudomonas aeruginosa. It turns out that IA content and time of exposure have an influence on the antibacterial potential. All samples showed satisfied cell viability. Due to these characteristics, P(HEA/IA)/PVP semi-IPNs represent interesting biomaterials for biomedical applications.
PB  - Inst Chemical Engineers, Rugby
T2  - Chemical Engineering Research & Design
T1  - Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEMA)/PVP semi-IPN hydrogels
EP  - 380
SP  - 368
VL  - 121
DO  - 10.1016/j.cherd.2017.03.030
ER  - 

@article{
author = "Krezović, Bojana D. and Miljković, Miona and Stojanović, Sanja T. and Najman, Stevo and Filipović, Jovanka and Tomić, Simonida",
year = "2017",
abstract = "The aim of this work was to synthesize a series of semi-interpenetrating polymer networks (semi-IPNs) of 2-hydroxyethyl acrylate and itaconic acid, in the presence of poly(N-vinylpyrrolidone). Samples were synthesized by free radical copolymerization with constant PVP and variable IA content and characterized for structural, morphological, thermal, swelling, drug release, antibacterial and cytotoxic properties. The chemical structure of samples was confirmed by Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) was used to examine morphology of samples and glass transition temperatures were determined by differential scanning calorimetry (DCS). The pH and temperature sensitivity was confirmed by measuring the dependence of the degree of swelling on pH and temperature. All samples show volume phase transition temperature (VPTT) around 47 degrees C. Drug release profiles were investigated using vitamin B-3 as a model drug. The vitamin B-3 transport mechanism was studied by fitting experimental data to five different model equations and calculating the corresponding parameters. It was also observed that IA content has a marked influence on the release profiles of vitamin B-3, so the rate of drug release can be designed by changing the HEA/IA ratio. Cell viability, performed using MTT test, was high for all samples and all concentration of extract used. The antibacterial activity of hydrogels was determined against Pseudomonas aeruginosa. It turns out that IA content and time of exposure have an influence on the antibacterial potential. All samples showed satisfied cell viability. Due to these characteristics, P(HEA/IA)/PVP semi-IPNs represent interesting biomaterials for biomedical applications.",
publisher = "Inst Chemical Engineers, Rugby",
journal = "Chemical Engineering Research & Design",
title = "Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEMA)/PVP semi-IPN hydrogels",
pages = "380-368",
volume = "121",
doi = "10.1016/j.cherd.2017.03.030"
}

Krezović, B. D., Miljković, M., Stojanović, S. T., Najman, S., Filipović, J.,& Tomić, S.. (2017). Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEMA)/PVP semi-IPN hydrogels. in Chemical Engineering Research & Design
Inst Chemical Engineers, Rugby., 121, 368-380.
https://doi.org/10.1016/j.cherd.2017.03.030

Krezović BD, Miljković M, Stojanović ST, Najman S, Filipović J, Tomić S. Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEMA)/PVP semi-IPN hydrogels. in Chemical Engineering Research & Design. 2017;121:368-380.
doi:10.1016/j.cherd.2017.03.030 .

Krezović, Bojana D., Miljković, Miona, Stojanović, Sanja T., Najman, Stevo, Filipović, Jovanka, Tomić, Simonida, "Structural, thermal, mechanical, swelling, drug release, antibacterial and cytotoxic properties of P(HEMA)/PVP semi-IPN hydrogels" in Chemical Engineering Research & Design, 121 (2017):368-380,
https://doi.org/10.1016/j.cherd.2017.03.030 . .

TY  - JOUR
AU  - Vuković, Jovana
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Filipović, Jovanka M.
AU  - Stojanović, Sanja T.
AU  - Najman, Stevo
AU  - Tomić, Simonida
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3352
AB  - In order to evaluate biological response and potential toxicity prior to clinical use as wound dressing materials, three series of hydrogels, based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), unloaded, with incorporated copper(II) ions and reduced copper, were subjected to cytotoxicity testing on L929 cell line (mouse fibroblasts). MTT test revealed proper fibroblast growth in the presence of tested hydrogels, with an absence of any acute toxic effects. Mechanical properties of all three hydrogel series were studied by dynamic mechanical analysis (DMA) and obtained results indicated dominant elastic over viscous behaviour, which supports their application in wound management. The temperature sensitive behaviour of the hydrogels was detected in swelling study conducted in wide range of temperature values 25-50 degrees C, in buffer pH 7.40. The hydrogels exhibited excellent microbial barrier characteristics against Pseudomonas aeruginosa, reducing the risk of bacterial infection in wound bed.
PB  - Elsevier Science Sa, Lausanne
T2  - Materials Chemistry and Physics
T1  - In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management
EP  - 163
SP  - 158
VL  - 175
DO  - 10.1016/j.matchemphys.2016.03.009
ER  - 

@article{
author = "Vuković, Jovana and Babić, Marija and Antić, Katarina and Filipović, Jovanka M. and Stojanović, Sanja T. and Najman, Stevo and Tomić, Simonida",
year = "2016",
abstract = "In order to evaluate biological response and potential toxicity prior to clinical use as wound dressing materials, three series of hydrogels, based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), unloaded, with incorporated copper(II) ions and reduced copper, were subjected to cytotoxicity testing on L929 cell line (mouse fibroblasts). MTT test revealed proper fibroblast growth in the presence of tested hydrogels, with an absence of any acute toxic effects. Mechanical properties of all three hydrogel series were studied by dynamic mechanical analysis (DMA) and obtained results indicated dominant elastic over viscous behaviour, which supports their application in wound management. The temperature sensitive behaviour of the hydrogels was detected in swelling study conducted in wide range of temperature values 25-50 degrees C, in buffer pH 7.40. The hydrogels exhibited excellent microbial barrier characteristics against Pseudomonas aeruginosa, reducing the risk of bacterial infection in wound bed.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Materials Chemistry and Physics",
title = "In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management",
pages = "163-158",
volume = "175",
doi = "10.1016/j.matchemphys.2016.03.009"
}

Vuković, J., Babić, M., Antić, K., Filipović, J. M., Stojanović, S. T., Najman, S.,& Tomić, S.. (2016). In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management. in Materials Chemistry and Physics
Elsevier Science Sa, Lausanne., 175, 158-163.
https://doi.org/10.1016/j.matchemphys.2016.03.009

Vuković J, Babić M, Antić K, Filipović JM, Stojanović ST, Najman S, Tomić S. In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management. in Materials Chemistry and Physics. 2016;175:158-163.
doi:10.1016/j.matchemphys.2016.03.009 .

Vuković, Jovana, Babić, Marija, Antić, Katarina, Filipović, Jovanka M., Stojanović, Sanja T., Najman, Stevo, Tomić, Simonida, "In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management" in Materials Chemistry and Physics, 175 (2016):158-163,
https://doi.org/10.1016/j.matchemphys.2016.03.009 . .

TY  - JOUR
AU  - Takić-Miladinov, Dijana
AU  - Tomić, Simonida
AU  - Stojanović, Sanja T.
AU  - Najdanović, Jelena
AU  - Filipović, Jovanka
AU  - Trajanović, Miroslav
AU  - Najman, Stevo
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3307
AB  - In this study we prepared hydrogels based on 2-hydroxyethyl methacrylate (HEMA): PHEMA homopolymer and two terpolymers of HEMA, itaconic acid (IA) and two poly(alkylene glycol) (meth) acrylates (PAGM): poly(ethylene glycol)(6) acrylate (P(HEMA/IA/PAGM1)) and poly(propylene glycol)(5) methacrylate (P(HEMA/IA/PAGM2)). Hydrogels were synthesized by gamma-irradiated radical polymerization and subjected to swelling measurements and genotoxicity evaluation. Swelling studies confirmed that these hydrogels deserve consideration as biomaterials due to their ability to swell in phosphate buffer but maintaining physical integrity for a prolonged contact time after equilibrium state has been reached. Comet assay showed certain genotoxic effect following cell exposure to extracts of hydrogels, which was dependent on the concentration of extracts, chemical composition of hydrogels and the degree of crosslinking. The influence of concentration on genotoxicity was the most pronounced. The synthesis of these novel HEMA-based hydrogels should be optimized so as to reduce their toxicity and enable the use in clinical practice.
PB  - University of Fed Sao Carlos, Dept Engenharia Materials, Sao Carlos
T2  - Materials Research-Ibero-American Journal of Materials
T1  - Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid
EP  - 1079
IS  - 5
SP  - 1070
VL  - 19
DO  - 10.1590/1980-5373-MR-2016-0222
ER  - 

@article{
author = "Takić-Miladinov, Dijana and Tomić, Simonida and Stojanović, Sanja T. and Najdanović, Jelena and Filipović, Jovanka and Trajanović, Miroslav and Najman, Stevo",
year = "2016",
abstract = "In this study we prepared hydrogels based on 2-hydroxyethyl methacrylate (HEMA): PHEMA homopolymer and two terpolymers of HEMA, itaconic acid (IA) and two poly(alkylene glycol) (meth) acrylates (PAGM): poly(ethylene glycol)(6) acrylate (P(HEMA/IA/PAGM1)) and poly(propylene glycol)(5) methacrylate (P(HEMA/IA/PAGM2)). Hydrogels were synthesized by gamma-irradiated radical polymerization and subjected to swelling measurements and genotoxicity evaluation. Swelling studies confirmed that these hydrogels deserve consideration as biomaterials due to their ability to swell in phosphate buffer but maintaining physical integrity for a prolonged contact time after equilibrium state has been reached. Comet assay showed certain genotoxic effect following cell exposure to extracts of hydrogels, which was dependent on the concentration of extracts, chemical composition of hydrogels and the degree of crosslinking. The influence of concentration on genotoxicity was the most pronounced. The synthesis of these novel HEMA-based hydrogels should be optimized so as to reduce their toxicity and enable the use in clinical practice.",
publisher = "University of Fed Sao Carlos, Dept Engenharia Materials, Sao Carlos",
journal = "Materials Research-Ibero-American Journal of Materials",
title = "Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid",
pages = "1079-1070",
number = "5",
volume = "19",
doi = "10.1590/1980-5373-MR-2016-0222"
}

Takić-Miladinov, D., Tomić, S., Stojanović, S. T., Najdanović, J., Filipović, J., Trajanović, M.,& Najman, S.. (2016). Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid. in Materials Research-Ibero-American Journal of Materials
University of Fed Sao Carlos, Dept Engenharia Materials, Sao Carlos., 19(5), 1070-1079.
https://doi.org/10.1590/1980-5373-MR-2016-0222

Takić-Miladinov D, Tomić S, Stojanović ST, Najdanović J, Filipović J, Trajanović M, Najman S. Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid. in Materials Research-Ibero-American Journal of Materials. 2016;19(5):1070-1079.
doi:10.1590/1980-5373-MR-2016-0222 .

Takić-Miladinov, Dijana, Tomić, Simonida, Stojanović, Sanja T., Najdanović, Jelena, Filipović, Jovanka, Trajanović, Miroslav, Najman, Stevo, "Synthesis, Swelling Properties and Evaluation of Genotoxicity of Hydrogels Based on (Meth)acrylates and Itaconic Acid" in Materials Research-Ibero-American Journal of Materials, 19, no. 5 (2016):1070-1079,
https://doi.org/10.1590/1980-5373-MR-2016-0222 . .