TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša B.
AU  - Nikolić, Vesna
AU  - Stanković, Mihajlo
AU  - Stamenković, Jakov
AU  - Mladenović-Ranisavljević, Ivana
AU  - Petrović, Slobodan
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2069
AB  - The synthesis of the poly(N-isopropylacrylamide-co-2-hydroxypropyl-methacrylate) hydrogel along with the analysis of the residual monomers content and influence of monomer and crosslinker molar ratios on the swelling behaviour was investigated. Synthesis of thermosensitive hydrogel based on N-isopropylacrylamide was carried out with the molar ratios of 5, 10, 15 and 20 mol% of monomer 2-hydroxypropyl-methacrylate, in the presence of ethylene glycol dimethacrylate as a crosslinker (1, 1.5, 2 and 3 mol%) and 2,2'-azobis(2-methylpropionitrile) as an initiator in acetone. The quantities of residual monomers in the synthesized copolymers were determined by HPLC method, ranging from 0.19 to 0.49% for N-isopropylacrylamide and from 0.13 to 0.63% for 2- -hydroxypropyl-methacrylate, counting the amount of xerogel. The hydrogels swelling ratio depending on time at 20 and 40°C was examined. It was found that the hydrogel with 5 mol% 2-hydroxypropyl-methacrylate and 1 mol% ethylene glycol dimethacrylate had the highest degree of swelling (( = 29.59) at 20°C, and that the hydrogel with 20 mol% 2-hydroxypropyl-methacrylate and 3 mol% ethylene glycol dimethacrylate had the lowest swelling degree ((=2.17) at 40°C.
AB  - Predmet ovog rada je sinteza kopolimernog hidrogela poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), analiza sadržaja rezidualnih monomera i ispitivanje uticaja molskog odnosa monomera i umreživača na karakteristike bubrenja. Sinteza termoosetljivog hidrogela na bazi N-izopropilakrilamida izvršena je sa molarnim udelom 5, 10, 15 i 20 mol% monomera 2-hidroksipropilmetakrilata, u prisustvu umreživača etilenglikoldimetakrilata (u koncentraciji: 1, 1,5 , 2 i 3 mol%) i inicijatora 2,2'-azobis(2-metilpropionitrila) u acetonu. Sadržaj zaostalih monomera u sintetizovanim kopolimerima analiziran je pomoću HPLC metode. Vrednosti se nalaze u granicama od 0,19 do 0,49% za N-izopropilakrilamid i od 0,13 do 0,63% za 2-hidroksipropilmetakrilat računajući na količinu kserogela. Ispitan je stepen bubrenja dobijenih hidrogelova u zavisnosti od temperature. Najveći stepen bubrenja (( = 29,59) pri konstantnoj temperaturi od 20°C dostigao je uzorak hidrogela sa 5 mol% 2-hidroksipropilmetakrilata i 1 mol% umreživača EGDM-a, a najmanji (( = 2.17) pri temperaturi od 40°C dostigao je uzorak hidrogela sa 20 mol% 2-hidroksipropilmetakrilata i 3 mol% umreživača EGDM-a. PR Projekat Ministarstva nauke Republike Srbije, br. TR 34012.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels
T1  - Uticaj molarnog odnosa monomera i umreživača na karakteristike bubrenja termoosetljivih hidrogelova
EP  - 9
IS  - 1
SP  - 1
VL  - 18
DO  - 10.2298/CICEQ110711040I
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna and Stanković, Mihajlo and Stamenković, Jakov and Mladenović-Ranisavljević, Ivana and Petrović, Slobodan",
year = "2012",
abstract = "The synthesis of the poly(N-isopropylacrylamide-co-2-hydroxypropyl-methacrylate) hydrogel along with the analysis of the residual monomers content and influence of monomer and crosslinker molar ratios on the swelling behaviour was investigated. Synthesis of thermosensitive hydrogel based on N-isopropylacrylamide was carried out with the molar ratios of 5, 10, 15 and 20 mol% of monomer 2-hydroxypropyl-methacrylate, in the presence of ethylene glycol dimethacrylate as a crosslinker (1, 1.5, 2 and 3 mol%) and 2,2'-azobis(2-methylpropionitrile) as an initiator in acetone. The quantities of residual monomers in the synthesized copolymers were determined by HPLC method, ranging from 0.19 to 0.49% for N-isopropylacrylamide and from 0.13 to 0.63% for 2- -hydroxypropyl-methacrylate, counting the amount of xerogel. The hydrogels swelling ratio depending on time at 20 and 40°C was examined. It was found that the hydrogel with 5 mol% 2-hydroxypropyl-methacrylate and 1 mol% ethylene glycol dimethacrylate had the highest degree of swelling (( = 29.59) at 20°C, and that the hydrogel with 20 mol% 2-hydroxypropyl-methacrylate and 3 mol% ethylene glycol dimethacrylate had the lowest swelling degree ((=2.17) at 40°C., Predmet ovog rada je sinteza kopolimernog hidrogela poli(N-izopropilakrilamid-ko-2-hidroksipropilmetakrilata), analiza sadržaja rezidualnih monomera i ispitivanje uticaja molskog odnosa monomera i umreživača na karakteristike bubrenja. Sinteza termoosetljivog hidrogela na bazi N-izopropilakrilamida izvršena je sa molarnim udelom 5, 10, 15 i 20 mol% monomera 2-hidroksipropilmetakrilata, u prisustvu umreživača etilenglikoldimetakrilata (u koncentraciji: 1, 1,5 , 2 i 3 mol%) i inicijatora 2,2'-azobis(2-metilpropionitrila) u acetonu. Sadržaj zaostalih monomera u sintetizovanim kopolimerima analiziran je pomoću HPLC metode. Vrednosti se nalaze u granicama od 0,19 do 0,49% za N-izopropilakrilamid i od 0,13 do 0,63% za 2-hidroksipropilmetakrilat računajući na količinu kserogela. Ispitan je stepen bubrenja dobijenih hidrogelova u zavisnosti od temperature. Najveći stepen bubrenja (( = 29,59) pri konstantnoj temperaturi od 20°C dostigao je uzorak hidrogela sa 5 mol% 2-hidroksipropilmetakrilata i 1 mol% umreživača EGDM-a, a najmanji (( = 2.17) pri temperaturi od 40°C dostigao je uzorak hidrogela sa 20 mol% 2-hidroksipropilmetakrilata i 3 mol% umreživača EGDM-a. PR Projekat Ministarstva nauke Republike Srbije, br. TR 34012.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels, Uticaj molarnog odnosa monomera i umreživača na karakteristike bubrenja termoosetljivih hidrogelova",
pages = "9-1",
number = "1",
volume = "18",
doi = "10.2298/CICEQ110711040I"
}

Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V., Stanković, M., Stamenković, J., Mladenović-Ranisavljević, I.,& Petrović, S.. (2012). Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 18(1), 1-9.
https://doi.org/10.2298/CICEQ110711040I

Ilić-Stojanović S, Nikolić LB, Nikolić V, Stanković M, Stamenković J, Mladenović-Ranisavljević I, Petrović S. Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels. in Chemical Industry & Chemical Engineering Quarterly. 2012;18(1):1-9.
doi:10.2298/CICEQ110711040I .

Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna, Stanković, Mihajlo, Stamenković, Jakov, Mladenović-Ranisavljević, Ivana, Petrović, Slobodan, "Influence of monomer and crosslinker molar ratio on the swelling behaviour of thermosensitive hydrogels" in Chemical Industry & Chemical Engineering Quarterly, 18, no. 1 (2012):1-9,
https://doi.org/10.2298/CICEQ110711040I . .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša B.
AU  - Nikolić, Vesna
AU  - Petrović, Slobodan
AU  - Stanković, Mihajlo
AU  - Mladenović-Ranisavljević, Ivana
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1837
AB  - Hydrogels are three-dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. They are very sensitive to environmental stimulus, which is manifested by a sharp phase transition. This feature is important for their application in the pharmaceutical field, especially for making formulations with controlled release of active ingredients, with the correction of the solubility, degradation and their toxicity reducing. Because of the compatibility with living tissues, hydrogels can be used in different medical purposes (for making contact lenses, stents, balloon catheters, artificial muscles, substitutes for arteries and veins, trachea, oviduct). This work presents methods (chemical and physical) for obtaining hydrogels, their properties and sensitivity to environmental stimuli (temperature, pH, magnetic field), as well as their potential application in medicine and pharmacy.
AB  - Hidrogelovi su umreženi trodimenzionalni hidrofilni polimeri koji bubre u vodi i vodenim rastvorima, a sami se ne rastvaraju u njima. Jako su osetljivi na spoljne stimulanse, što se manifestuje oštrim faznim prelazom. Ova osobina je važna za njihovu primenu u oblasti farmacije, i to pre svega za izradu formulacija sa kontrolisanim oslobađanjem aktivnih principa, uz korigovanje rastvorljivosti, degradacije i smanjenja njihove toksičnosti. Zahvaljujući kompatibilnosti sa živim tkivima, primena hidrogelova je važna i za rešavanje različitih medicinskih potreba (za izradu kontaktnih sočiva, stentova, balon katetera, veštačkih mišića, zamena za arterije i vene, traheja, jajovoda). U radu su detaljno prikazane metode za njihovo dobijanje (hemijske i fizičke), svojstva i osetljivost na spoljne stimulanse (temperatura, pH, magnetno polje), kao i moguće primene u oblasti medicine i farmacije.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Physics, Chemistry and Technology
T1  - Stimuli-sensitive hydrogels for pharmaceutical and medical applications
T1  - Hidrogelovi osetljivi na spoljne stimulanse za farmaceutsku i medicinsku primenu
EP  - 56
IS  - 1
SP  - 37
VL  - 9
DO  - 10.2298/FUPCT1101037I
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna and Petrović, Slobodan and Stanković, Mihajlo and Mladenović-Ranisavljević, Ivana",
year = "2011",
abstract = "Hydrogels are three-dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. They are very sensitive to environmental stimulus, which is manifested by a sharp phase transition. This feature is important for their application in the pharmaceutical field, especially for making formulations with controlled release of active ingredients, with the correction of the solubility, degradation and their toxicity reducing. Because of the compatibility with living tissues, hydrogels can be used in different medical purposes (for making contact lenses, stents, balloon catheters, artificial muscles, substitutes for arteries and veins, trachea, oviduct). This work presents methods (chemical and physical) for obtaining hydrogels, their properties and sensitivity to environmental stimuli (temperature, pH, magnetic field), as well as their potential application in medicine and pharmacy., Hidrogelovi su umreženi trodimenzionalni hidrofilni polimeri koji bubre u vodi i vodenim rastvorima, a sami se ne rastvaraju u njima. Jako su osetljivi na spoljne stimulanse, što se manifestuje oštrim faznim prelazom. Ova osobina je važna za njihovu primenu u oblasti farmacije, i to pre svega za izradu formulacija sa kontrolisanim oslobađanjem aktivnih principa, uz korigovanje rastvorljivosti, degradacije i smanjenja njihove toksičnosti. Zahvaljujući kompatibilnosti sa živim tkivima, primena hidrogelova je važna i za rešavanje različitih medicinskih potreba (za izradu kontaktnih sočiva, stentova, balon katetera, veštačkih mišića, zamena za arterije i vene, traheja, jajovoda). U radu su detaljno prikazane metode za njihovo dobijanje (hemijske i fizičke), svojstva i osetljivost na spoljne stimulanse (temperatura, pH, magnetno polje), kao i moguće primene u oblasti medicine i farmacije.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Stimuli-sensitive hydrogels for pharmaceutical and medical applications, Hidrogelovi osetljivi na spoljne stimulanse za farmaceutsku i medicinsku primenu",
pages = "56-37",
number = "1",
volume = "9",
doi = "10.2298/FUPCT1101037I"
}

Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V., Petrović, S., Stanković, M.,& Mladenović-Ranisavljević, I.. (2011). Stimuli-sensitive hydrogels for pharmaceutical and medical applications. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 9(1), 37-56.
https://doi.org/10.2298/FUPCT1101037I

Ilić-Stojanović S, Nikolić LB, Nikolić V, Petrović S, Stanković M, Mladenović-Ranisavljević I. Stimuli-sensitive hydrogels for pharmaceutical and medical applications. in Facta universitatis - series: Physics, Chemistry and Technology. 2011;9(1):37-56.
doi:10.2298/FUPCT1101037I .

Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna, Petrović, Slobodan, Stanković, Mihajlo, Mladenović-Ranisavljević, Ivana, "Stimuli-sensitive hydrogels for pharmaceutical and medical applications" in Facta universitatis - series: Physics, Chemistry and Technology, 9, no. 1 (2011):37-56,
https://doi.org/10.2298/FUPCT1101037I . .