TY  - JOUR
AU  - Lazić, Vesna
AU  - Pirković, Andrea
AU  - Sredojević, Dusan
AU  - Marković, Jelena
AU  - Papan, Jelena
AU  - Ahrenkiel, Phillip S.
AU  - Janković-Častvan, Ivona
AU  - Dekanski, Dragana
AU  - Jovanović-Krivokuća, Milica
AU  - Nedeljković, Jovan M.
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4772
AB  - The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3-4 nm in size primary particles organized in 30-60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).
T2  - Chemico-Biological Interactions
T1  - Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells
VL  - 347
DO  - 10.1016/j.cbi.2021.109618
ER  - 

@article{
author = "Lazić, Vesna and Pirković, Andrea and Sredojević, Dusan and Marković, Jelena and Papan, Jelena and Ahrenkiel, Phillip S. and Janković-Častvan, Ivona and Dekanski, Dragana and Jovanović-Krivokuća, Milica and Nedeljković, Jovan M.",
year = "2021",
abstract = "The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3-4 nm in size primary particles organized in 30-60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).",
journal = "Chemico-Biological Interactions",
title = "Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells",
volume = "347",
doi = "10.1016/j.cbi.2021.109618"
}

Lazić, V., Pirković, A., Sredojević, D., Marković, J., Papan, J., Ahrenkiel, P. S., Janković-Častvan, I., Dekanski, D., Jovanović-Krivokuća, M.,& Nedeljković, J. M.. (2021). Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells. in Chemico-Biological Interactions, 347.
https://doi.org/10.1016/j.cbi.2021.109618

Lazić V, Pirković A, Sredojević D, Marković J, Papan J, Ahrenkiel PS, Janković-Častvan I, Dekanski D, Jovanović-Krivokuća M, Nedeljković JM. Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells. in Chemico-Biological Interactions. 2021;347.
doi:10.1016/j.cbi.2021.109618 .

Lazić, Vesna, Pirković, Andrea, Sredojević, Dusan, Marković, Jelena, Papan, Jelena, Ahrenkiel, Phillip S., Janković-Častvan, Ivona, Dekanski, Dragana, Jovanović-Krivokuća, Milica, Nedeljković, Jovan M., "Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells" in Chemico-Biological Interactions, 347 (2021),
https://doi.org/10.1016/j.cbi.2021.109618 . .