TY  - CONF
AU  - Tolić Stojadinović, Ljiljana
AU  - Grujić, Svetlana
AU  - Antić, Nikolina
AU  - Đurkić, Tatjana
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7248
AB  - Municipal wastewater in the Belgrade area is discharged into the Danube and the Sava
Rivers without any treatment. This affects the quality of river water since wastewater is one of the
most important sources of environmental pollutants, including pharmaceuticals. To assess the impact
of this effect, the presence of three commonly used antibiotics in wastewater and receiving river water
was determined. A previously developed liquid chromatography-tandem mass spectrometry method
for the analysis of antibiotics in natural water matrices was validated for wastewater and applied in
analysis of samples from the Belgrade area. All investigated antibiotics were detected in both
wastewater and river water samples. The highest concentration of antibiotics in wastewater was
found for sulfamethoxazole, while trimethoprim was detected at the highest level in surface water.
The most frequently detected antibiotic in surface water was azithromycin. The environmental risk
assessment was performed for surface water biota. Azithromycin was found to pose a high risk to
aquatic organisms, while the risk level of sulfamethoxazole was medium or low. In conclusion, the
obtained results show the detrimental impact of untreated wastewater discharge on the river water
quality in the Belgrade area, emphasizing the need for urban wastewater treatment.
PB  - Belgrade : The Academy of Applied Technical Studies "Belgrade"
C3  - Conference Proceedings / International Scientific and Professional Conference Politehnika 2023, Belgrade, 15th December 2023
T1  - Impact of wastewater antibiotics on river water quality in Belgrade area
EP  - 59
SP  - 54
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7248
ER  - 

@conference{
author = "Tolić Stojadinović, Ljiljana and Grujić, Svetlana and Antić, Nikolina and Đurkić, Tatjana",
year = "2023",
abstract = "Municipal wastewater in the Belgrade area is discharged into the Danube and the Sava
Rivers without any treatment. This affects the quality of river water since wastewater is one of the
most important sources of environmental pollutants, including pharmaceuticals. To assess the impact
of this effect, the presence of three commonly used antibiotics in wastewater and receiving river water
was determined. A previously developed liquid chromatography-tandem mass spectrometry method
for the analysis of antibiotics in natural water matrices was validated for wastewater and applied in
analysis of samples from the Belgrade area. All investigated antibiotics were detected in both
wastewater and river water samples. The highest concentration of antibiotics in wastewater was
found for sulfamethoxazole, while trimethoprim was detected at the highest level in surface water.
The most frequently detected antibiotic in surface water was azithromycin. The environmental risk
assessment was performed for surface water biota. Azithromycin was found to pose a high risk to
aquatic organisms, while the risk level of sulfamethoxazole was medium or low. In conclusion, the
obtained results show the detrimental impact of untreated wastewater discharge on the river water
quality in the Belgrade area, emphasizing the need for urban wastewater treatment.",
publisher = "Belgrade : The Academy of Applied Technical Studies "Belgrade"",
journal = "Conference Proceedings / International Scientific and Professional Conference Politehnika 2023, Belgrade, 15th December 2023",
title = "Impact of wastewater antibiotics on river water quality in Belgrade area",
pages = "59-54",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7248"
}

Tolić Stojadinović, L., Grujić, S., Antić, N.,& Đurkić, T.. (2023). Impact of wastewater antibiotics on river water quality in Belgrade area. in Conference Proceedings / International Scientific and Professional Conference Politehnika 2023, Belgrade, 15th December 2023
Belgrade : The Academy of Applied Technical Studies "Belgrade"., 54-59.
https://hdl.handle.net/21.15107/rcub_technorep_7248

Tolić Stojadinović L, Grujić S, Antić N, Đurkić T. Impact of wastewater antibiotics on river water quality in Belgrade area. in Conference Proceedings / International Scientific and Professional Conference Politehnika 2023, Belgrade, 15th December 2023. 2023;:54-59.
https://hdl.handle.net/21.15107/rcub_technorep_7248 .

Tolić Stojadinović, Ljiljana, Grujić, Svetlana, Antić, Nikolina, Đurkić, Tatjana, "Impact of wastewater antibiotics on river water quality in Belgrade area" in Conference Proceedings / International Scientific and Professional Conference Politehnika 2023, Belgrade, 15th December 2023 (2023):54-59,
https://hdl.handle.net/21.15107/rcub_technorep_7248 .

TY  - CONF
AU  - Tolić Stojadinović, Ljiljana
AU  - Gvozdić, Eleonora
AU  - Grujić, Svetlana
AU  - Antić, Nikolina
AU  - Đurkić, Tatjana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5987
AB  - Glavni put dospevanja lekova u životnu sredinu su komunalne otpadne vode. U regionu
Beograda, otpadne vode se direktno ispuštaju u reke Savu i Dunav, što negativno utiče na kvalitet
rečne vode. Zbog svoje postojanosti i biološke aktivnosti, lekovi mogu imati veoma štetan uticaj na
živi svet u vodenoj sredini. U ovoj studiji je ispitivano prisustvo pet najčešće korišćenih
kardiovaskularnih lekova u rečnoj vodi Beograda, kao i u odgovarajućim otpadnim vodama. Za
ekstrakciju uzoraka vode korišćena je prethodno razvijena metoda za određivanje lekova u
različitim vodenim matricama. Dobijeni ekstrakti su analizirani metodom tečne hromatografije u
sprezi sa tandem masenom spektrometrijom, uz korišćenje elektrosprej jonizacione tehnike.
Rezultati su pokazali da su najčešće detektovani kardiovaskularni lekovi i u površinskim i u
otpadnim vodama bili metoprolol i bisoprolol, koji se na osnovu dosadašnjih ekotoksikoloških
istraživanja smatraju štetnim za vodene organizme.
PB  - Akademija tehničkih strukovnih studija Beograd
C3  - Šesti naučno-stručni skup Politehnika Zbornik radova
T1  - Kardiovaskularni lekovi u rečnoj vodi Beograda
EP  - 58
SP  - 55
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5987
ER  - 

@conference{
author = "Tolić Stojadinović, Ljiljana and Gvozdić, Eleonora and Grujić, Svetlana and Antić, Nikolina and Đurkić, Tatjana",
year = "2021",
abstract = "Glavni put dospevanja lekova u životnu sredinu su komunalne otpadne vode. U regionu
Beograda, otpadne vode se direktno ispuštaju u reke Savu i Dunav, što negativno utiče na kvalitet
rečne vode. Zbog svoje postojanosti i biološke aktivnosti, lekovi mogu imati veoma štetan uticaj na
živi svet u vodenoj sredini. U ovoj studiji je ispitivano prisustvo pet najčešće korišćenih
kardiovaskularnih lekova u rečnoj vodi Beograda, kao i u odgovarajućim otpadnim vodama. Za
ekstrakciju uzoraka vode korišćena je prethodno razvijena metoda za određivanje lekova u
različitim vodenim matricama. Dobijeni ekstrakti su analizirani metodom tečne hromatografije u
sprezi sa tandem masenom spektrometrijom, uz korišćenje elektrosprej jonizacione tehnike.
Rezultati su pokazali da su najčešće detektovani kardiovaskularni lekovi i u površinskim i u
otpadnim vodama bili metoprolol i bisoprolol, koji se na osnovu dosadašnjih ekotoksikoloških
istraživanja smatraju štetnim za vodene organizme.",
publisher = "Akademija tehničkih strukovnih studija Beograd",
journal = "Šesti naučno-stručni skup Politehnika Zbornik radova",
title = "Kardiovaskularni lekovi u rečnoj vodi Beograda",
pages = "58-55",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5987"
}

Tolić Stojadinović, L., Gvozdić, E., Grujić, S., Antić, N.,& Đurkić, T.. (2021). Kardiovaskularni lekovi u rečnoj vodi Beograda. in Šesti naučno-stručni skup Politehnika Zbornik radova
Akademija tehničkih strukovnih studija Beograd., 55-58.
https://hdl.handle.net/21.15107/rcub_technorep_5987

Tolić Stojadinović L, Gvozdić E, Grujić S, Antić N, Đurkić T. Kardiovaskularni lekovi u rečnoj vodi Beograda. in Šesti naučno-stručni skup Politehnika Zbornik radova. 2021;:55-58.
https://hdl.handle.net/21.15107/rcub_technorep_5987 .

Tolić Stojadinović, Ljiljana, Gvozdić, Eleonora, Grujić, Svetlana, Antić, Nikolina, Đurkić, Tatjana, "Kardiovaskularni lekovi u rečnoj vodi Beograda" in Šesti naučno-stručni skup Politehnika Zbornik radova (2021):55-58,
https://hdl.handle.net/21.15107/rcub_technorep_5987 .

TY  - CONF
AU  - Tolić Stojadinović, Ljiljana
AU  - Grujić, Svetlana
AU  - Antić, Nikolina
AU  - Đurkić, Tatjana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5983
AB  - In the city of Belgrade, raw sewage is discharged directly into the Sava and the Danube rivers affecting the quality of river water. To determine the level of this impact, eight frequently used and detected pharmaceuticals were selected for the study. A previously developed method for analysis of pharmaceuticals in different water matrices was used. Sample extracts were analyzed by liquid chromatography-tandem mass spectrometry, using the electrospray ionization technique. The most commonly detected analytes in both municipal wastewater and surface water were carbamazepine, known for its high environmental stability, and diclofenac, known as having high acute ecotoxicity. The dilution effect, noted for most of the detected drugs, was not as pronounced with diclofenac, indicating a higher risk for aquatic organisms.
PB  - Society of Physical Chemists of Serbia
C3  - Physical Chemistry 2021
T1  - Impact of pharmaceutical levels in untreated wastewater on Belgrade river water quality
EP  - 571
SP  - 569
VL  - II
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5983
ER  - 

@conference{
author = "Tolić Stojadinović, Ljiljana and Grujić, Svetlana and Antić, Nikolina and Đurkić, Tatjana",
year = "2021",
abstract = "In the city of Belgrade, raw sewage is discharged directly into the Sava and the Danube rivers affecting the quality of river water. To determine the level of this impact, eight frequently used and detected pharmaceuticals were selected for the study. A previously developed method for analysis of pharmaceuticals in different water matrices was used. Sample extracts were analyzed by liquid chromatography-tandem mass spectrometry, using the electrospray ionization technique. The most commonly detected analytes in both municipal wastewater and surface water were carbamazepine, known for its high environmental stability, and diclofenac, known as having high acute ecotoxicity. The dilution effect, noted for most of the detected drugs, was not as pronounced with diclofenac, indicating a higher risk for aquatic organisms.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical Chemistry 2021",
title = "Impact of pharmaceutical levels in untreated wastewater on Belgrade river water quality",
pages = "571-569",
volume = "II",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5983"
}

Tolić Stojadinović, L., Grujić, S., Antić, N.,& Đurkić, T.. (2021). Impact of pharmaceutical levels in untreated wastewater on Belgrade river water quality. in Physical Chemistry 2021
Society of Physical Chemists of Serbia., II, 569-571.
https://hdl.handle.net/21.15107/rcub_technorep_5983

Tolić Stojadinović L, Grujić S, Antić N, Đurkić T. Impact of pharmaceutical levels in untreated wastewater on Belgrade river water quality. in Physical Chemistry 2021. 2021;II:569-571.
https://hdl.handle.net/21.15107/rcub_technorep_5983 .

Tolić Stojadinović, Ljiljana, Grujić, Svetlana, Antić, Nikolina, Đurkić, Tatjana, "Impact of pharmaceutical levels in untreated wastewater on Belgrade river water quality" in Physical Chemistry 2021, II (2021):569-571,
https://hdl.handle.net/21.15107/rcub_technorep_5983 .

TY  - JOUR
AU  - Antić, Nikolina
AU  - Radišić, Marina
AU  - Radović, Tanja
AU  - Vasiljević, Tatjana
AU  - Grujić, Svetlana
AU  - Petković, Anđelka
AU  - Dimkić, Milan
AU  - Laušević, Mila
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3041
AB  - In this work, a total of 38 pesticides was monitored in the Danube River Basin in Serbia during ten sampling campaigns in 2009, 2010, and 2011. The quantification of analytes was performed using procedures based on solid-phase extraction (SPE) followed by LC-MS/MS or GC-MS. In general, low pesticide levels were found, except for the samples collected during May-June of 2010 and June of 2011. During this period, pesticide application is high and rainfall was described as extremely above normal or above normal, leading to very pronounced runoff and very high detected pesticide levels. At the sampling site Smederevo (the Danube River), high concentrations of terbuthylazine (200ngL(-1)) and metolachlor (150ngL(-1)) were found. In the Danube tributary Morava, high concentrations of carbendazim (269ngL(-1)), atrazine (188ngL(-1)), terbuthylazine (180ngL(-1)), and acetochlor (110ngL(-1)) were detected, while in the tributary Tisa only terbuthylazine was present at high levels (130ngL(-1)). In other sampling campaigns, pesticides were present at low concentrations. The most frequently found pesticide was carbendazim, probably due to slow degradation rate in environment.
PB  - Wiley, Hoboken
T2  - Clean-Soil Air Water
T1  - Pesticide Residues in the Danube River Basin in Serbia - a Survey during 2009-2011
EP  - 204
IS  - 2
SP  - 197
VL  - 43
DO  - 10.1002/clen.201200360
ER  - 

@article{
author = "Antić, Nikolina and Radišić, Marina and Radović, Tanja and Vasiljević, Tatjana and Grujić, Svetlana and Petković, Anđelka and Dimkić, Milan and Laušević, Mila",
year = "2015",
abstract = "In this work, a total of 38 pesticides was monitored in the Danube River Basin in Serbia during ten sampling campaigns in 2009, 2010, and 2011. The quantification of analytes was performed using procedures based on solid-phase extraction (SPE) followed by LC-MS/MS or GC-MS. In general, low pesticide levels were found, except for the samples collected during May-June of 2010 and June of 2011. During this period, pesticide application is high and rainfall was described as extremely above normal or above normal, leading to very pronounced runoff and very high detected pesticide levels. At the sampling site Smederevo (the Danube River), high concentrations of terbuthylazine (200ngL(-1)) and metolachlor (150ngL(-1)) were found. In the Danube tributary Morava, high concentrations of carbendazim (269ngL(-1)), atrazine (188ngL(-1)), terbuthylazine (180ngL(-1)), and acetochlor (110ngL(-1)) were detected, while in the tributary Tisa only terbuthylazine was present at high levels (130ngL(-1)). In other sampling campaigns, pesticides were present at low concentrations. The most frequently found pesticide was carbendazim, probably due to slow degradation rate in environment.",
publisher = "Wiley, Hoboken",
journal = "Clean-Soil Air Water",
title = "Pesticide Residues in the Danube River Basin in Serbia - a Survey during 2009-2011",
pages = "204-197",
number = "2",
volume = "43",
doi = "10.1002/clen.201200360"
}

Antić, N., Radišić, M., Radović, T., Vasiljević, T., Grujić, S., Petković, A., Dimkić, M.,& Laušević, M.. (2015). Pesticide Residues in the Danube River Basin in Serbia - a Survey during 2009-2011. in Clean-Soil Air Water
Wiley, Hoboken., 43(2), 197-204.
https://doi.org/10.1002/clen.201200360

Antić N, Radišić M, Radović T, Vasiljević T, Grujić S, Petković A, Dimkić M, Laušević M. Pesticide Residues in the Danube River Basin in Serbia - a Survey during 2009-2011. in Clean-Soil Air Water. 2015;43(2):197-204.
doi:10.1002/clen.201200360 .

Antić, Nikolina, Radišić, Marina, Radović, Tanja, Vasiljević, Tatjana, Grujić, Svetlana, Petković, Anđelka, Dimkić, Milan, Laušević, Mila, "Pesticide Residues in the Danube River Basin in Serbia - a Survey during 2009-2011" in Clean-Soil Air Water, 43, no. 2 (2015):197-204,
https://doi.org/10.1002/clen.201200360 . .

TY  - CONF
AU  - Tolić, Ljiljana
AU  - Antić, Nikolina
AU  - Grujić, Svetlana
AU  - Bačić, Goran
AU  - Laušević, Mila D.
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7243
AB  - Anizomicin je antibiotik izolovan iz bakterijske vrste Streptomyces griseolus za koji je nekoliko studija pokazalo da je citotoksičan prema ćelijama malignog tu-mora, tj. da može suzbiti njihov rast. Cilj ovog rada bio je razvoj i optimizacija metode  ekstrakcije  ovog  antibiotika  iz  životinjskih  tkiva,  kao  što  su  srce  i  jetra.  Ispitivani  su  različiti  rastvarači  za  ekstrakciju,  kao  i  metode  prečišćavanja  dobijenog ekstrakta. Ekstrakt je analiziran metodom tečne hromatografije sa tandem masenom  spektrometrijom  (LC–MS/MS,  engl.  liquid  chromatography–tandem  mass spectrometry).
PB  - Beograd : Srpsko hemijsko društvo
C3  - Knjiga izvoda / 6. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Vršac, 21-24. maj 2013
T1  - Određivanje anizomicina u životinjskim tkivima
EP  - 209
SP  - 208
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7243
ER  - 

@conference{
author = "Tolić, Ljiljana and Antić, Nikolina and Grujić, Svetlana and Bačić, Goran and Laušević, Mila D.",
year = "2013",
abstract = "Anizomicin je antibiotik izolovan iz bakterijske vrste Streptomyces griseolus za koji je nekoliko studija pokazalo da je citotoksičan prema ćelijama malignog tu-mora, tj. da može suzbiti njihov rast. Cilj ovog rada bio je razvoj i optimizacija metode  ekstrakcije  ovog  antibiotika  iz  životinjskih  tkiva,  kao  što  su  srce  i  jetra.  Ispitivani  su  različiti  rastvarači  za  ekstrakciju,  kao  i  metode  prečišćavanja  dobijenog ekstrakta. Ekstrakt je analiziran metodom tečne hromatografije sa tandem masenom  spektrometrijom  (LC–MS/MS,  engl.  liquid  chromatography–tandem  mass spectrometry).",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "Knjiga izvoda / 6. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Vršac, 21-24. maj 2013",
title = "Određivanje anizomicina u životinjskim tkivima",
pages = "209-208",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7243"
}

Tolić, L., Antić, N., Grujić, S., Bačić, G.,& Laušević, M. D.. (2013). Određivanje anizomicina u životinjskim tkivima. in Knjiga izvoda / 6. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Vršac, 21-24. maj 2013
Beograd : Srpsko hemijsko društvo., 208-209.
https://hdl.handle.net/21.15107/rcub_technorep_7243

Tolić L, Antić N, Grujić S, Bačić G, Laušević MD. Određivanje anizomicina u životinjskim tkivima. in Knjiga izvoda / 6. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Vršac, 21-24. maj 2013. 2013;:208-209.
https://hdl.handle.net/21.15107/rcub_technorep_7243 .

Tolić, Ljiljana, Antić, Nikolina, Grujić, Svetlana, Bačić, Goran, Laušević, Mila D., "Određivanje anizomicina u životinjskim tkivima" in Knjiga izvoda / 6. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Vršac, 21-24. maj 2013 (2013):208-209,
https://hdl.handle.net/21.15107/rcub_technorep_7243 .