TY  - JOUR
AU  - Kasalović, Marijana P.
AU  - Jelača, Sanja
AU  - Milanović, Žiko
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Lađarević, Jelena
AU  - Božić, Bojan
AU  - Marković, Zoran
AU  - Dunđerović, Duško
AU  - Rüffer, Tobias
AU  - Kretschmer, Robert
AU  - Kaluđerović, Goran N.
AU  - Pantelić, Nebojša Đ.
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7458
AB  - Three newly synthesized triphenyltin(iv) compounds, Ph3SnL1 (L1− = 3-(4-methyl-2-oxoquinolin-1(2H)-yl)propanoato), Ph3SnL2 (L2− = 2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato), and Ph3SnL3 (L3− = 2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethanoato), were characterized by elemental microanalysis, FT-IR spectroscopy and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. A single X-ray diffraction study indicates that compounds Ph3SnL1 and Ph3SnL2 exhibit a 1D zig-zag chain polymeric structure, which in the case of Ph3SnL2 is additionally stabilized by π-interactions. In addition, the synthesized compounds were further examined using density functional theory and natural bond orbital analysis. The compounds have been evaluated for their in vitro anticancer activity against three human cell lines: MCF-7 (breast adenocarcinoma), A375 (melanoma), HCT116 (colorectal carcinoma), and three murine cell lines: 4T1 (breast carcinoma), B16 (melanoma), CT26 (colon carcinoma) using MTT and CV assays. The IC50 values fall in the nanomolar range, indicating that these compounds possess better anticancer activity than cisplatin. The study of the effect of the newly developed drug Ph3SnL1 showed its plasticity in achieving an antitumor effect in vitro, which depends on the specificity of the phenotype and the redox status of the malignant cell line and ranges from the initiation of apoptotic cell death to the induction of differentiation to a more mature cell form. In the syngeneic model of murine melanoma, Ph3SnL1 showed the potential to reduce the tumor volume similar to cisplatin, but in a well-tolerated form and with low systemic toxicity, representing a significant advantage over the conventional drug.
PB  - Royal Society of Chemistry
T2  - Dalton Transactions
T1  - Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation
DO  - 10.1039/D4DT00182F
ER  - 

@article{
author = "Kasalović, Marijana P. and Jelača, Sanja and Milanović, Žiko and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Lađarević, Jelena and Božić, Bojan and Marković, Zoran and Dunđerović, Duško and Rüffer, Tobias and Kretschmer, Robert and Kaluđerović, Goran N. and Pantelić, Nebojša Đ.",
year = "2024",
abstract = "Three newly synthesized triphenyltin(iv) compounds, Ph3SnL1 (L1− = 3-(4-methyl-2-oxoquinolin-1(2H)-yl)propanoato), Ph3SnL2 (L2− = 2-(4-methyl-2-oxoquinolin-1(2H)-yl)ethanoato), and Ph3SnL3 (L3− = 2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)ethanoato), were characterized by elemental microanalysis, FT-IR spectroscopy and multinuclear (1H, 13C and 119Sn) NMR spectroscopy. A single X-ray diffraction study indicates that compounds Ph3SnL1 and Ph3SnL2 exhibit a 1D zig-zag chain polymeric structure, which in the case of Ph3SnL2 is additionally stabilized by π-interactions. In addition, the synthesized compounds were further examined using density functional theory and natural bond orbital analysis. The compounds have been evaluated for their in vitro anticancer activity against three human cell lines: MCF-7 (breast adenocarcinoma), A375 (melanoma), HCT116 (colorectal carcinoma), and three murine cell lines: 4T1 (breast carcinoma), B16 (melanoma), CT26 (colon carcinoma) using MTT and CV assays. The IC50 values fall in the nanomolar range, indicating that these compounds possess better anticancer activity than cisplatin. The study of the effect of the newly developed drug Ph3SnL1 showed its plasticity in achieving an antitumor effect in vitro, which depends on the specificity of the phenotype and the redox status of the malignant cell line and ranges from the initiation of apoptotic cell death to the induction of differentiation to a more mature cell form. In the syngeneic model of murine melanoma, Ph3SnL1 showed the potential to reduce the tumor volume similar to cisplatin, but in a well-tolerated form and with low systemic toxicity, representing a significant advantage over the conventional drug.",
publisher = "Royal Society of Chemistry",
journal = "Dalton Transactions",
title = "Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation",
doi = "10.1039/D4DT00182F"
}

Kasalović, M. P., Jelača, S., Milanović, Ž., Maksimović-Ivanić, D., Mijatović, S., Lađarević, J., Božić, B., Marković, Z., Dunđerović, D., Rüffer, T., Kretschmer, R., Kaluđerović, G. N.,& Pantelić, N. Đ.. (2024). Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation. in Dalton Transactions
Royal Society of Chemistry..
https://doi.org/10.1039/D4DT00182F

Kasalović MP, Jelača S, Milanović Ž, Maksimović-Ivanić D, Mijatović S, Lađarević J, Božić B, Marković Z, Dunđerović D, Rüffer T, Kretschmer R, Kaluđerović GN, Pantelić NĐ. Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation. in Dalton Transactions. 2024;.
doi:10.1039/D4DT00182F .

Kasalović, Marijana P., Jelača, Sanja, Milanović, Žiko, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Lađarević, Jelena, Božić, Bojan, Marković, Zoran, Dunđerović, Duško, Rüffer, Tobias, Kretschmer, Robert, Kaluđerović, Goran N., Pantelić, Nebojša Đ., "Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation" in Dalton Transactions (2024),
https://doi.org/10.1039/D4DT00182F . .

TY  - CONF
AU  - Mandić, Marija
AU  - Lunić, Tanja
AU  - Lađarević, Jelena
AU  - Veruševski, Vanja
AU  - Mijin, Dušan
AU  - Božić, Bojan
AU  - Božić Nedeljković, Biljana
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6779
AB  - Različito supstituisani derivati 2-piridona čine posebnu klasu heterocikličnih jedinjenja za koje je prethodno pokazano da poseduju različita biološka svojstva: anti-mikrobna, anti-inflamatorna, anti-oksidativna, kao i anti-tumorska. U predstavljenoj studiji, serija od dvadeset četiri derivata 2-piridona ispitina je upotrebom ABTS testa kako bi se odabrali derivati sa najvećom anti-oksidativnom aktivnošću za dalju in vitro i in silico analizu. Anti-oksidativna aktivnost sedam odabranih piridona ispitina je dalje metodom izbeljivanja β-karotena, gde su selektovana jedinjenja pokazala veći anti-oksidativni potencijal u poređenju sa standardom – vitaminom Ce. Takođe, selektovani 2-piridoni pokazali su anti-neuroinflamatornu aktivnost smanjenjem produkcije proinflamatornih medijatora (ROS, NO, IL-6 i TNF-α) od strane LPS-om stimulisanih BV2 ćelija. Pored toga, pokazano da tretman 2-piridonima LPS-om stimulisanih BV2 ćelija eliminiše i neurotoksičnost tih ćelija (model sistem prenosa supernatanta BV2 ćelija na SH-SY5Y neurone). In silico analizom ispitani su anti-neuroinflamatorni mehanizmi odabranih 2-piridona primenom molekulskog dokinga na proteine TLR4 signalnog puta, kao i inducibilnu azot oksid sintazu. Dobijeni rezulati ukazuju na značajan anti-neuroinflamatorni potencijal odabranih 2-piridona, što ih čini odličnim kandidatima za dalja istraživanja u cilju pronalaska novih potencijalnih terapeutika za lečenje neurodegenerativnih bolesti.
PB  - Beograd : Srpska akademija nauka i umetnosti (SANU)
C3  - Naučni skup Svetski dan imunologije 2022, 28. april 2022. godine, Beograd
T1  - Anti-oksidativna i neuroprotektivna aktivnost odabranih 2-piridona: in vitro i in silico studija
SP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6779
ER  - 

@conference{
author = "Mandić, Marija and Lunić, Tanja and Lađarević, Jelena and Veruševski, Vanja and Mijin, Dušan and Božić, Bojan and Božić Nedeljković, Biljana",
year = "2022",
abstract = "Različito supstituisani derivati 2-piridona čine posebnu klasu heterocikličnih jedinjenja za koje je prethodno pokazano da poseduju različita biološka svojstva: anti-mikrobna, anti-inflamatorna, anti-oksidativna, kao i anti-tumorska. U predstavljenoj studiji, serija od dvadeset četiri derivata 2-piridona ispitina je upotrebom ABTS testa kako bi se odabrali derivati sa najvećom anti-oksidativnom aktivnošću za dalju in vitro i in silico analizu. Anti-oksidativna aktivnost sedam odabranih piridona ispitina je dalje metodom izbeljivanja β-karotena, gde su selektovana jedinjenja pokazala veći anti-oksidativni potencijal u poređenju sa standardom – vitaminom Ce. Takođe, selektovani 2-piridoni pokazali su anti-neuroinflamatornu aktivnost smanjenjem produkcije proinflamatornih medijatora (ROS, NO, IL-6 i TNF-α) od strane LPS-om stimulisanih BV2 ćelija. Pored toga, pokazano da tretman 2-piridonima LPS-om stimulisanih BV2 ćelija eliminiše i neurotoksičnost tih ćelija (model sistem prenosa supernatanta BV2 ćelija na SH-SY5Y neurone). In silico analizom ispitani su anti-neuroinflamatorni mehanizmi odabranih 2-piridona primenom molekulskog dokinga na proteine TLR4 signalnog puta, kao i inducibilnu azot oksid sintazu. Dobijeni rezulati ukazuju na značajan anti-neuroinflamatorni potencijal odabranih 2-piridona, što ih čini odličnim kandidatima za dalja istraživanja u cilju pronalaska novih potencijalnih terapeutika za lečenje neurodegenerativnih bolesti.",
publisher = "Beograd : Srpska akademija nauka i umetnosti (SANU)",
journal = "Naučni skup Svetski dan imunologije 2022, 28. april 2022. godine, Beograd",
title = "Anti-oksidativna i neuroprotektivna aktivnost odabranih 2-piridona: in vitro i in silico studija",
pages = "19",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6779"
}

Mandić, M., Lunić, T., Lađarević, J., Veruševski, V., Mijin, D., Božić, B.,& Božić Nedeljković, B.. (2022). Anti-oksidativna i neuroprotektivna aktivnost odabranih 2-piridona: in vitro i in silico studija. in Naučni skup Svetski dan imunologije 2022, 28. april 2022. godine, Beograd
Beograd : Srpska akademija nauka i umetnosti (SANU)., 19.
https://hdl.handle.net/21.15107/rcub_technorep_6779

Mandić M, Lunić T, Lađarević J, Veruševski V, Mijin D, Božić B, Božić Nedeljković B. Anti-oksidativna i neuroprotektivna aktivnost odabranih 2-piridona: in vitro i in silico studija. in Naučni skup Svetski dan imunologije 2022, 28. april 2022. godine, Beograd. 2022;:19.
https://hdl.handle.net/21.15107/rcub_technorep_6779 .

Mandić, Marija, Lunić, Tanja, Lađarević, Jelena, Veruševski, Vanja, Mijin, Dušan, Božić, Bojan, Božić Nedeljković, Biljana, "Anti-oksidativna i neuroprotektivna aktivnost odabranih 2-piridona: in vitro i in silico studija" in Naučni skup Svetski dan imunologije 2022, 28. april 2022. godine, Beograd (2022):19,
https://hdl.handle.net/21.15107/rcub_technorep_6779 .

TY  - CONF
AU  - Kasalović, Marijana P.
AU  - Lađarević, Jelena
AU  - Božić, Bojan
AU  - Jevtić, Verica V.
AU  - Kaluđerović, Goran N.
AU  - Pantelić, Nebojša Đ.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6778
AB  - U datom radu opisana je sinteza 2-(4-hidroksi-2-oksohinolinil)etanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen hidrolizom metil-estra sintetisanog u reakciji između4-hidroksi-2-hinolona i metil-2-bromoetanoata. U reakciji deprotonovanog liganda i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka ispitivanju antitumorske aktivnosti prema raznim ćelijskim linijama karcinoma.
AB  - Synthesis of 2-(4-methyl-2-oxoquinolinyl)ethanoic acid and its triphenyltin(IV) complex has been performed. The ligand has been obtained by the hydrolysis of methyl ester synthesized in the reaction between 4-hydroxy-2-quinolone and methyl 2-bromoethanoate. In the reaction of deprotonated ligand with equimolar amount of Ph3SnCl, the desired complex was precipitated as a white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on examining their antitumor activity against various cancer cell lines.
PB  - Beograd : Srpsko hemijsko društvo
C3  - Kratki izvodi radova ; Knjiga radova / 58. savetovanje Srpskog hemijskog društva, Beograd, 9. i 10. jun 2022. godine
T1  - Sinteza i karakterizacija kompleksa trifenilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)etanskom kiselinom
T1  - Synthesis and characterization of novel triphenyltin(IV) complex with 2-(4-hydroxy-2-oxoquinolinyl)ethanoic acid
SP  - 114
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6778
ER  - 

@conference{
author = "Kasalović, Marijana P. and Lađarević, Jelena and Božić, Bojan and Jevtić, Verica V. and Kaluđerović, Goran N. and Pantelić, Nebojša Đ.",
year = "2022",
abstract = "U datom radu opisana je sinteza 2-(4-hidroksi-2-oksohinolinil)etanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen hidrolizom metil-estra sintetisanog u reakciji između4-hidroksi-2-hinolona i metil-2-bromoetanoata. U reakciji deprotonovanog liganda i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka ispitivanju antitumorske aktivnosti prema raznim ćelijskim linijama karcinoma., Synthesis of 2-(4-methyl-2-oxoquinolinyl)ethanoic acid and its triphenyltin(IV) complex has been performed. The ligand has been obtained by the hydrolysis of methyl ester synthesized in the reaction between 4-hydroxy-2-quinolone and methyl 2-bromoethanoate. In the reaction of deprotonated ligand with equimolar amount of Ph3SnCl, the desired complex was precipitated as a white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on examining their antitumor activity against various cancer cell lines.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "Kratki izvodi radova ; Knjiga radova / 58. savetovanje Srpskog hemijskog društva, Beograd, 9. i 10. jun 2022. godine",
title = "Sinteza i karakterizacija kompleksa trifenilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)etanskom kiselinom, Synthesis and characterization of novel triphenyltin(IV) complex with 2-(4-hydroxy-2-oxoquinolinyl)ethanoic acid",
pages = "114",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6778"
}

Kasalović, M. P., Lađarević, J., Božić, B., Jevtić, V. V., Kaluđerović, G. N.,& Pantelić, N. Đ.. (2022). Sinteza i karakterizacija kompleksa trifenilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)etanskom kiselinom. in Kratki izvodi radova ; Knjiga radova / 58. savetovanje Srpskog hemijskog društva, Beograd, 9. i 10. jun 2022. godine
Beograd : Srpsko hemijsko društvo., 114.
https://hdl.handle.net/21.15107/rcub_technorep_6778

Kasalović MP, Lađarević J, Božić B, Jevtić VV, Kaluđerović GN, Pantelić NĐ. Sinteza i karakterizacija kompleksa trifenilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)etanskom kiselinom. in Kratki izvodi radova ; Knjiga radova / 58. savetovanje Srpskog hemijskog društva, Beograd, 9. i 10. jun 2022. godine. 2022;:114.
https://hdl.handle.net/21.15107/rcub_technorep_6778 .

Kasalović, Marijana P., Lađarević, Jelena, Božić, Bojan, Jevtić, Verica V., Kaluđerović, Goran N., Pantelić, Nebojša Đ., "Sinteza i karakterizacija kompleksa trifenilkalaja(IV) sa 2-(4- hidroksi-2-oksohinolinil)etanskom kiselinom" in Kratki izvodi radova ; Knjiga radova / 58. savetovanje Srpskog hemijskog društva, Beograd, 9. i 10. jun 2022. godine (2022):114,
https://hdl.handle.net/21.15107/rcub_technorep_6778 .

TY  - CONF
AU  - Kasalović, Marijana P.
AU  - Lađarević, Jelena
AU  - Božić, Bojan
AU  - Jevtić, Verica V.
AU  - Pantelić, Nebojša Đ.
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6781
AB  - U poslednjoj deceniji jedinjenja organokalaja(IV) privukla su veliku pažnju istraživača zbog svoje izvanredne citotoksične aktivnosti protiv raznih oblika tumora. Ovde je prikazana sinteza 3-(4-metil-2-oksohinolinil)propanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen u dva koraka. U prvom koraku, u reakciji između 4-metil-hinolin-2-ona i metil-3-bromopropionata sintetisan je odgovarajući metil-estar, čijom hidrolizom, u drugom koraku, je dobijen ligand. U reakciji liganda, koji je deprotonovan LiOH, i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka in vitro ispitivanju citotoksične aktivnosti prema raznim ćelijskim linijama karcinoma, kao i na ispitivanje mehanizma njihovog delovanja.
AB  - Organotin(IV) compounds have greatly attracted researchers' attention in the last decade for their outstanding cytotoxic activity against different tumor cells. Herein, the synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic acid and its triphenyltin(IV) complex has been performed. The ligand precursor has been synthesized in two steps. In the first step, reaction between 4-methylquinoline-2-on and methyl 3-bromopropionate afforded corresponding methyl ester, whose hydrolysis, in the second step, produced targeted ligand. In the reaction of ligand precursor, which was deprotonated with LiOH, with equimolar amount of Ph3SnCl, the expected complex was obtained as white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on in vitro cytotoxic activity against various cancer cell lines, as well as investigation of mechanism of their action.
PB  - Beograd : Srpsko hemijsko društvo
C3  - Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021
T1  - Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom
T1  - Synthesis and characterization of novel triphenyltin(IV) compound with 3-(4-methyl-2-oxoquinolinyl)propanoic acid
SP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6781
ER  - 

@conference{
author = "Kasalović, Marijana P. and Lađarević, Jelena and Božić, Bojan and Jevtić, Verica V. and Pantelić, Nebojša Đ.",
year = "2021",
abstract = "U poslednjoj deceniji jedinjenja organokalaja(IV) privukla su veliku pažnju istraživača zbog svoje izvanredne citotoksične aktivnosti protiv raznih oblika tumora. Ovde je prikazana sinteza 3-(4-metil-2-oksohinolinil)propanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen u dva koraka. U prvom koraku, u reakciji između 4-metil-hinolin-2-ona i metil-3-bromopropionata sintetisan je odgovarajući metil-estar, čijom hidrolizom, u drugom koraku, je dobijen ligand. U reakciji liganda, koji je deprotonovan LiOH, i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka in vitro ispitivanju citotoksične aktivnosti prema raznim ćelijskim linijama karcinoma, kao i na ispitivanje mehanizma njihovog delovanja., Organotin(IV) compounds have greatly attracted researchers' attention in the last decade for their outstanding cytotoxic activity against different tumor cells. Herein, the synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic acid and its triphenyltin(IV) complex has been performed. The ligand precursor has been synthesized in two steps. In the first step, reaction between 4-methylquinoline-2-on and methyl 3-bromopropionate afforded corresponding methyl ester, whose hydrolysis, in the second step, produced targeted ligand. In the reaction of ligand precursor, which was deprotonated with LiOH, with equimolar amount of Ph3SnCl, the expected complex was obtained as white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on in vitro cytotoxic activity against various cancer cell lines, as well as investigation of mechanism of their action.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021",
title = "Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom, Synthesis and characterization of novel triphenyltin(IV) compound with 3-(4-methyl-2-oxoquinolinyl)propanoic acid",
pages = "62",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6781"
}

Kasalović, M. P., Lađarević, J., Božić, B., Jevtić, V. V.,& Pantelić, N. Đ.. (2021). Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom. in Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021
Beograd : Srpsko hemijsko društvo., 62.
https://hdl.handle.net/21.15107/rcub_technorep_6781

Kasalović MP, Lađarević J, Božić B, Jevtić VV, Pantelić NĐ. Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom. in Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021. 2021;:62.
https://hdl.handle.net/21.15107/rcub_technorep_6781 .

Kasalović, Marijana P., Lađarević, Jelena, Božić, Bojan, Jevtić, Verica V., Pantelić, Nebojša Đ., "Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom" in Kratki izvodi radova ; Knjiga radova / 57. savetovanje Srpskog hemijskog društva, Kragujevac 18. i 19. juni 2021 (2021):62,
https://hdl.handle.net/21.15107/rcub_technorep_6781 .

TY  - CONF
AU  - Lazić, Anita M.
AU  - Božić, Bojan Đ.
AU  - Vitnik, Vesna D.
AU  - Vitnik, Željko J.
AU  - Valentić, Nataša V.
AU  - Ušćumlić, Gordana S.
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7467
AB  - U radu je sintetizovana serija 3-(4-supstituisanih benzil)-1,3-diazaspiro4.4nonan-2,4-diona čija je struktura određena temperaturama topljenja, FT-IR, 1H i 13C NMR i UV/Vis spektroskopijom. Uticaj supstituenata na apsorpcione spektre spirohidantoina, u različitim rastvaračima, proučavan je Hametovom jednačinom. Eksperimentalni rezultati su pokazali zadovoljavajuću saglasnost sa rezultatima kvantnohemijskih proračuna dobijenih primenom DFT metode. Pokazano je da supstituenti značajno utiču na intramolekulski transfer naelektrisanja (ICT) kao i na reaktivnost proučavanih hidantoina razmatranu na osnovu molekulskog elektrostatičkog potencijala (MEP).
AB  - In this work, a series of 3(4-substituted benzyl)-1,3-diazaspiro4.4nonane-2,4-dione was
synthesized and fully characterized by melting points, FT-IR, 1H, and 13C NMR and UV/Vis
spectroscopy. The Hammett equation was used to quantitatively evaluate the effects of
substituents on the absorption frequencies in different solvents. The experimental results
showed very good agreement with quantum chemical calculations obtained using DFT
method. It was shown that substituents change the extent of conjugation, and affect
intramolecular charge transfer (ICT) character. To estimate chemical reactivity of the
molecules, the molecular electrostatic potential (MEP) surface maps were calculated for the
optimized geometries of the investigated molecules.
PB  - Beograd : Srpsko hemijsko društvo = Serbian Chemical Society
C3  - Program i kratki izvodi radova = Program & Book of abstracts / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29 i 30. maj 2015 = 52nd Meeting of the Serbian Chemical Society, Novi Sad, Serbia, May 29 and 30, 2015
T1  - Eksperimentalna i kvantnohemijska proučavanja strukture 3-(4-supstituisanih benzil)-1,3-diazaspiro(4.4)nonan-2,4-diona)
T1  - Experimental and quantum chemical studies on the structure of 3-(4-substituted benzyl)-1,3-diazaspiro(4.4)nonane-2,4-dione
SP  - 131
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7467
ER  - 

@conference{
author = "Lazić, Anita M. and Božić, Bojan Đ. and Vitnik, Vesna D. and Vitnik, Željko J. and Valentić, Nataša V. and Ušćumlić, Gordana S.",
year = "2015",
abstract = "U radu je sintetizovana serija 3-(4-supstituisanih benzil)-1,3-diazaspiro4.4nonan-2,4-diona čija je struktura određena temperaturama topljenja, FT-IR, 1H i 13C NMR i UV/Vis spektroskopijom. Uticaj supstituenata na apsorpcione spektre spirohidantoina, u različitim rastvaračima, proučavan je Hametovom jednačinom. Eksperimentalni rezultati su pokazali zadovoljavajuću saglasnost sa rezultatima kvantnohemijskih proračuna dobijenih primenom DFT metode. Pokazano je da supstituenti značajno utiču na intramolekulski transfer naelektrisanja (ICT) kao i na reaktivnost proučavanih hidantoina razmatranu na osnovu molekulskog elektrostatičkog potencijala (MEP)., In this work, a series of 3(4-substituted benzyl)-1,3-diazaspiro4.4nonane-2,4-dione was
synthesized and fully characterized by melting points, FT-IR, 1H, and 13C NMR and UV/Vis
spectroscopy. The Hammett equation was used to quantitatively evaluate the effects of
substituents on the absorption frequencies in different solvents. The experimental results
showed very good agreement with quantum chemical calculations obtained using DFT
method. It was shown that substituents change the extent of conjugation, and affect
intramolecular charge transfer (ICT) character. To estimate chemical reactivity of the
molecules, the molecular electrostatic potential (MEP) surface maps were calculated for the
optimized geometries of the investigated molecules.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Program i kratki izvodi radova = Program & Book of abstracts / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29 i 30. maj 2015 = 52nd Meeting of the Serbian Chemical Society, Novi Sad, Serbia, May 29 and 30, 2015",
title = "Eksperimentalna i kvantnohemijska proučavanja strukture 3-(4-supstituisanih benzil)-1,3-diazaspiro(4.4)nonan-2,4-diona), Experimental and quantum chemical studies on the structure of 3-(4-substituted benzyl)-1,3-diazaspiro(4.4)nonane-2,4-dione",
pages = "131",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7467"
}

Lazić, A. M., Božić, B. Đ., Vitnik, V. D., Vitnik, Ž. J., Valentić, N. V.,& Ušćumlić, G. S.. (2015). Eksperimentalna i kvantnohemijska proučavanja strukture 3-(4-supstituisanih benzil)-1,3-diazaspiro(4.4)nonan-2,4-diona). in Program i kratki izvodi radova = Program & Book of abstracts / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29 i 30. maj 2015 = 52nd Meeting of the Serbian Chemical Society, Novi Sad, Serbia, May 29 and 30, 2015
Beograd : Srpsko hemijsko društvo = Serbian Chemical Society., 131.
https://hdl.handle.net/21.15107/rcub_technorep_7467

Lazić AM, Božić BĐ, Vitnik VD, Vitnik ŽJ, Valentić NV, Ušćumlić GS. Eksperimentalna i kvantnohemijska proučavanja strukture 3-(4-supstituisanih benzil)-1,3-diazaspiro(4.4)nonan-2,4-diona). in Program i kratki izvodi radova = Program & Book of abstracts / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29 i 30. maj 2015 = 52nd Meeting of the Serbian Chemical Society, Novi Sad, Serbia, May 29 and 30, 2015. 2015;:131.
https://hdl.handle.net/21.15107/rcub_technorep_7467 .

Lazić, Anita M., Božić, Bojan Đ., Vitnik, Vesna D., Vitnik, Željko J., Valentić, Nataša V., Ušćumlić, Gordana S., "Eksperimentalna i kvantnohemijska proučavanja strukture 3-(4-supstituisanih benzil)-1,3-diazaspiro(4.4)nonan-2,4-diona)" in Program i kratki izvodi radova = Program & Book of abstracts / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29 i 30. maj 2015 = 52nd Meeting of the Serbian Chemical Society, Novi Sad, Serbia, May 29 and 30, 2015 (2015):131,
https://hdl.handle.net/21.15107/rcub_technorep_7467 .