TY  - JOUR
AU  - Nastasović, Aleksandra
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
AU  - Marković, Dana D.
AU  - Ekmeščić, Bojana
AU  - Maksin, Danijela
AU  - Onjia, Antonije
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2822
AB  - Inverse gas chromatography at infinite dilution was applied to determine the thermodynamic interactions of poly(l-lactide) (PLLA) and the composite of biphasic calcium phosphate and PLLA (BCP/PLLA). The specific retention volumes, , of 11 organic compounds of different chemical nature and polarity (non-polar, donor or acceptor) were determined in the temperature range of 308-378 K for PLLA and 308-398 K for BCP/PLLA. The weight fraction activity coefficients of test sorbates, , and the Flory-Huggins interaction parameters, , were estimated and discussed in terms of interactions of the sorbates with PLLA and BCP/PLLA. Also, the partial molar free energy, , the partial molar heat of mixing, , the sorption molar free energy, , the sorption enthalpy, , and the sorption entropy, , were analyzed. A different chromatographic behavior of the two investigated samples, PLLA and BCP/PLLA, was observed. The values of indicated n-alkanes, diethyl ether, tetrahydrofurane (THF), cyclohexane, benzene, dioxane (except for 338 K), and ethyl acetate (EtAc) (except for 338 K) as non-solvents, and chloroform (CHCl3) as good solvent (except for 378 K) for PLLA. For BCP/PLLA, CHCl3, EtAc (for 378 K), dioxane (except for 378 K), and THF were indicated as good solvents.
PB  - Springer, New York
T2  - Journal of Materials Science
T1  - Determination of thermodynamic interactions of polylactide and biphasic calcium phosphate/polylactidecomposite by inverse gas chromatography at infinite dilution
EP  - 5086
IS  - 14
SP  - 5076
VL  - 49
DO  - 10.1007/s10853-014-8214-3
ER  - 

@article{
author = "Nastasović, Aleksandra and Ignjatović, Nenad and Uskoković, Dragan and Marković, Dana D. and Ekmeščić, Bojana and Maksin, Danijela and Onjia, Antonije",
year = "2014",
abstract = "Inverse gas chromatography at infinite dilution was applied to determine the thermodynamic interactions of poly(l-lactide) (PLLA) and the composite of biphasic calcium phosphate and PLLA (BCP/PLLA). The specific retention volumes, , of 11 organic compounds of different chemical nature and polarity (non-polar, donor or acceptor) were determined in the temperature range of 308-378 K for PLLA and 308-398 K for BCP/PLLA. The weight fraction activity coefficients of test sorbates, , and the Flory-Huggins interaction parameters, , were estimated and discussed in terms of interactions of the sorbates with PLLA and BCP/PLLA. Also, the partial molar free energy, , the partial molar heat of mixing, , the sorption molar free energy, , the sorption enthalpy, , and the sorption entropy, , were analyzed. A different chromatographic behavior of the two investigated samples, PLLA and BCP/PLLA, was observed. The values of indicated n-alkanes, diethyl ether, tetrahydrofurane (THF), cyclohexane, benzene, dioxane (except for 338 K), and ethyl acetate (EtAc) (except for 338 K) as non-solvents, and chloroform (CHCl3) as good solvent (except for 378 K) for PLLA. For BCP/PLLA, CHCl3, EtAc (for 378 K), dioxane (except for 378 K), and THF were indicated as good solvents.",
publisher = "Springer, New York",
journal = "Journal of Materials Science",
title = "Determination of thermodynamic interactions of polylactide and biphasic calcium phosphate/polylactidecomposite by inverse gas chromatography at infinite dilution",
pages = "5086-5076",
number = "14",
volume = "49",
doi = "10.1007/s10853-014-8214-3"
}

Nastasović, A., Ignjatović, N., Uskoković, D., Marković, D. D., Ekmeščić, B., Maksin, D.,& Onjia, A.. (2014). Determination of thermodynamic interactions of polylactide and biphasic calcium phosphate/polylactidecomposite by inverse gas chromatography at infinite dilution. in Journal of Materials Science
Springer, New York., 49(14), 5076-5086.
https://doi.org/10.1007/s10853-014-8214-3

Nastasović A, Ignjatović N, Uskoković D, Marković DD, Ekmeščić B, Maksin D, Onjia A. Determination of thermodynamic interactions of polylactide and biphasic calcium phosphate/polylactidecomposite by inverse gas chromatography at infinite dilution. in Journal of Materials Science. 2014;49(14):5076-5086.
doi:10.1007/s10853-014-8214-3 .

Nastasović, Aleksandra, Ignjatović, Nenad, Uskoković, Dragan, Marković, Dana D., Ekmeščić, Bojana, Maksin, Danijela, Onjia, Antonije, "Determination of thermodynamic interactions of polylactide and biphasic calcium phosphate/polylactidecomposite by inverse gas chromatography at infinite dilution" in Journal of Materials Science, 49, no. 14 (2014):5076-5086,
https://doi.org/10.1007/s10853-014-8214-3 . .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Jančar, Boštjan
AU  - Maksin, Tatjana
AU  - Ignjatović, Nenad
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5650
AB  - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
EP  - 413
IS  - 2
SP  - 404
VL  - 82
DO  - 10.1016/j.colsurfb.2010.09.011
UR  - https://hdl.handle.net/21.15107/rcub_dais_2749
ER  - 

@article{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana and Ignjatović, Nenad and Uskoković, Vuk and Uskoković, Dragan",
year = "2011",
abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery",
pages = "413-404",
number = "2",
volume = "82",
doi = "10.1016/j.colsurfb.2010.09.011",
url = "https://hdl.handle.net/21.15107/rcub_dais_2749"
}

Vukomanović, M., Škapin, S. D., Jančar, B., Maksin, T., Ignjatović, N., Uskoković, V.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces, 82(2), 404-413.
https://doi.org/10.1016/j.colsurfb.2010.09.011
https://hdl.handle.net/21.15107/rcub_dais_2749

Vukomanović M, Škapin SD, Jančar B, Maksin T, Ignjatović N, Uskoković V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces. 2011;82(2):404-413.
doi:10.1016/j.colsurfb.2010.09.011
https://hdl.handle.net/21.15107/rcub_dais_2749 .

Vukomanović, Marija, Škapin, Srečo Davor, Jančar, Boštjan, Maksin, Tatjana, Ignjatović, Nenad, Uskoković, Vuk, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):404-413,
https://doi.org/10.1016/j.colsurfb.2010.09.011 .,
https://hdl.handle.net/21.15107/rcub_dais_2749 .

TY  - BOOK
AU  - Balać, Igor
AU  - Bugarski, Branko
AU  - Ćosić, Irena
AU  - Dramićanin, Miroslav
AU  - Đorđević, Drago
AU  - Filipović, Nenad D.
AU  - Ignjatović, Nenad
AU  - Janaćković, Đorđe
AU  - Kojić, Miloš
AU  - Manojlović, Verica
AU  - Marković, Zoran
AU  - Obradović, Bojana
AU  - Pajić-Lijaković, Ivana
AU  - Pavlović, Miodrag
AU  - Plavšić, Milenko B.
AU  - Raković, Dejan
AU  - Ranković, Vladimir
AU  - Stojanović, Boban
AU  - Trajković, Vladimir
AU  - Uskoković, Dragan
AU  - Uskoković, Petar
AU  - Veljković, Dejan
AU  - Vlastelica, Ivo
AU  - Vunjak-Novaković, Gordana
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1535
AB  - Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi. Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci. Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti. Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.
PB  - Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala
T1  - Biomaterijali
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7344
ER  - 

@book{
author = "Balać, Igor and Bugarski, Branko and Ćosić, Irena and Dramićanin, Miroslav and Đorđević, Drago and Filipović, Nenad D. and Ignjatović, Nenad and Janaćković, Đorđe and Kojić, Miloš and Manojlović, Verica and Marković, Zoran and Obradović, Bojana and Pajić-Lijaković, Ivana and Pavlović, Miodrag and Plavšić, Milenko B. and Raković, Dejan and Ranković, Vladimir and Stojanović, Boban and Trajković, Vladimir and Uskoković, Dragan and Uskoković, Petar and Veljković, Dejan and Vlastelica, Ivo and Vunjak-Novaković, Gordana",
year = "2010",
abstract = "Početak XXI veka nesumnjivo je obeležen interdisciplinarnim i multidisciplinarnim naporima istraživača u različitim oblastima nauke. Jedna od najizrazitijih tendencija ovog tipa uočava se u biomedicinskim istraživanjima, gde se združuju napori lekara, biologa, genetičara i biohemičara, s jedne strane, i biofizičara i inženjera, s druge strane – sa ciljem dubljeg razumevanja zdravlja i bolesti, i primene ovih saznanja u biomedicinskoj praksi, tako važnoj u svakodnevnom životu ljudi. Kao rezultat ovih svetskih trendova, u Srbiji već više godina na nekoliko fakulteta postoji nastava iz oblasti biomedicinskog inženjerstva, sa ciljem da osposobi inženjere ovih usmerenja za multidisciplinarno povezivanje znanja iz oblasti tehnike sa biomedicinskim znanjima. Jedan od bazičnih predmeta ovih usmerenja jesu Biomaterijali, kojima je i posvećen naš udžbenik, čiji je cilj da predstavi pregled teorije i prakse biomaterijala u biomedicinskoj nauci. Nauka o biomaterijalima je nesumnjivo najmultidisciplinarnija od svih nauka, jer zahteva ovladavanje znanjima iz mnogih oblasti nauke i tehnologije, inženjerstva i medicine, kako bi naučnici iz oblasti biomaterijala mogli da se uhvate u koštac sa ovom profesijom. Zato posle uvodnog dela, udžbenik iz Biomaterijala sadrži četiri celine: (I) Osnovni biomedicinski koncepti i reakcije organizma na biomaterijale, (II) Struktura, fizičko-mehanička karakterizacija i modeliranje biomaterijala i tkiva, (III) Savremeni biomaterijali i tehnologije, (IV) Perspektive biomaterijala i tehnologija, iza kojih slede Zadaci sa rešenjima, Ispitna test pitanja i Ispitna teorijska pitanja, koji pomažu studentima da lakše savladaju veoma obimno i kompleksno gradivo. Na kraju svakog poglavlja data su pitanja za rekapitulaciju, kao i spisak dopunske literature za opcionu detaljniju obradu pojedinih oblasti. Grupa od dvadeset četiri profesionalca sa univerziteta i naučnih instituta, pod okriljem Instituta tehničkih nauka Srpske akademije nauka i umetnosti, Beograd, i Društva za istraživanje materijala Srbije (MRS Srbija) doprinela je pisanju ovog kapitalnog udžbenika o biomaterijalima, prvog do sada na srpskom jeziku. Mada uključivanje veće grupe autora nužno dovodi do stilske neujednačenosti, ipak je oblast biomaterijala toliko multidisciplinarna da je ovakav pristup bio neophodan, kako uostalom pokazuju slična svetska iskustva sa uključivanjem i preko pedeset autora. Ipak urednici su se potrudili da koliko je to moguće stilski i pedagoški ujednače udžbenik, kako bi bio korisna literatura za sve studente diplomskih, master i doktorskih studija iz biomedicinskog inženjerstva u Srbiji i okruženju.",
publisher = "Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala",
title = "Biomaterijali",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7344"
}

Balać, I., Bugarski, B., Ćosić, I., Dramićanin, M., Đorđević, D., Filipović, N. D., Ignjatović, N., Janaćković, Đ., Kojić, M., Manojlović, V., Marković, Z., Obradović, B., Pajić-Lijaković, I., Pavlović, M., Plavšić, M. B., Raković, D., Ranković, V., Stojanović, B., Trajković, V., Uskoković, D., Uskoković, P., Veljković, D., Vlastelica, I.,& Vunjak-Novaković, G.. (2010). Biomaterijali. 
Beograd : Institut tehničkih nauka Srpske akademije nauka i umetnosti; Društvo za istraživanje materijala..
https://hdl.handle.net/21.15107/rcub_vinar_7344

Balać I, Bugarski B, Ćosić I, Dramićanin M, Đorđević D, Filipović ND, Ignjatović N, Janaćković Đ, Kojić M, Manojlović V, Marković Z, Obradović B, Pajić-Lijaković I, Pavlović M, Plavšić MB, Raković D, Ranković V, Stojanović B, Trajković V, Uskoković D, Uskoković P, Veljković D, Vlastelica I, Vunjak-Novaković G. Biomaterijali. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_7344 .

Balać, Igor, Bugarski, Branko, Ćosić, Irena, Dramićanin, Miroslav, Đorđević, Drago, Filipović, Nenad D., Ignjatović, Nenad, Janaćković, Đorđe, Kojić, Miloš, Manojlović, Verica, Marković, Zoran, Obradović, Bojana, Pajić-Lijaković, Ivana, Pavlović, Miodrag, Plavšić, Milenko B., Raković, Dejan, Ranković, Vladimir, Stojanović, Boban, Trajković, Vladimir, Uskoković, Dragan, Uskoković, Petar, Veljković, Dejan, Vlastelica, Ivo, Vunjak-Novaković, Gordana, "Biomaterijali" (2010),
https://hdl.handle.net/21.15107/rcub_vinar_7344 .

TY  - JOUR
AU  - Suljovrujić, Edin H.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
AU  - Mitrić, Miodrag
AU  - Mitrovic, M.
AU  - Tomić, Simonida
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5495
AB  - The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly L-lactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable. (C) 2006 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial
EP  - 728
IS  - 4
SP  - 722
VL  - 76
DO  - 10.1016/j.radphyschem.2006.02.013
UR  - https://hdl.handle.net/21.15107/rcub_dais_2752
ER  - 

@article{
author = "Suljovrujić, Edin H. and Ignjatović, Nenad and Uskoković, Dragan and Mitrić, Miodrag and Mitrovic, M. and Tomić, Simonida",
year = "2007",
abstract = "The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly L-lactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable. (C) 2006 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial",
pages = "728-722",
number = "4",
volume = "76",
doi = "10.1016/j.radphyschem.2006.02.013",
url = "https://hdl.handle.net/21.15107/rcub_dais_2752"
}

Suljovrujić, E. H., Ignjatović, N., Uskoković, D., Mitrić, M., Mitrovic, M.,& Tomić, S.. (2007). Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial. in Radiation Physics and Chemistry, 76(4), 722-728.
https://doi.org/10.1016/j.radphyschem.2006.02.013
https://hdl.handle.net/21.15107/rcub_dais_2752

Suljovrujić EH, Ignjatović N, Uskoković D, Mitrić M, Mitrovic M, Tomić S. Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial. in Radiation Physics and Chemistry. 2007;76(4):722-728.
doi:10.1016/j.radphyschem.2006.02.013
https://hdl.handle.net/21.15107/rcub_dais_2752 .

Suljovrujić, Edin H., Ignjatović, Nenad, Uskoković, Dragan, Mitrić, Miodrag, Mitrovic, M., Tomić, Simonida, "Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial" in Radiation Physics and Chemistry, 76, no. 4 (2007):722-728,
https://doi.org/10.1016/j.radphyschem.2006.02.013 .,
https://hdl.handle.net/21.15107/rcub_dais_2752 .

TY  - JOUR
AU  - Uskoković, Petar
AU  - Tang, C. Y.
AU  - Tsui, C. P.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1119
AB  - Biocomposites with ceramic fillers and polymer matrix are becoming attractive materials for bone tissue replacements. Nanoindentation has been used to locally characterize the surface mechanical properties of the hydroxyapatite/pOly-L-lactide (HAp/PLLA) biocomposite. Additionally, differences in the mechanical properties of HAP phase were successfully characterized as a function of surface morphology by using a highresolution modulus mapping technique. HAP granules consist of agglomerates of grainy clusters. Mechanical properties of ceramic grains and PLLA are in fair agreement with literature data. High-resolution methods were able to measure the properties of boundary phases between grains and the pore regions between particles in the agglomerate. After short-time immersion in distilled water, material surface showed a large decrease in storage modulus.
PB  - Elsevier Sci Ltd, Oxford
T2  - Journal of the European Ceramic Society
T1  - Micromechanical properties of a hydroxyapatite/poly-L-lactide biocomposite using nanoindentation and modulus mapping
EP  - 1564
IS  - 2-3
SP  - 1559
VL  - 27
DO  - 10.1016/j.jeurceramsoc.2006.04.122
ER  - 

@article{
author = "Uskoković, Petar and Tang, C. Y. and Tsui, C. P. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2007",
abstract = "Biocomposites with ceramic fillers and polymer matrix are becoming attractive materials for bone tissue replacements. Nanoindentation has been used to locally characterize the surface mechanical properties of the hydroxyapatite/pOly-L-lactide (HAp/PLLA) biocomposite. Additionally, differences in the mechanical properties of HAP phase were successfully characterized as a function of surface morphology by using a highresolution modulus mapping technique. HAP granules consist of agglomerates of grainy clusters. Mechanical properties of ceramic grains and PLLA are in fair agreement with literature data. High-resolution methods were able to measure the properties of boundary phases between grains and the pore regions between particles in the agglomerate. After short-time immersion in distilled water, material surface showed a large decrease in storage modulus.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Journal of the European Ceramic Society",
title = "Micromechanical properties of a hydroxyapatite/poly-L-lactide biocomposite using nanoindentation and modulus mapping",
pages = "1564-1559",
number = "2-3",
volume = "27",
doi = "10.1016/j.jeurceramsoc.2006.04.122"
}

Uskoković, P., Tang, C. Y., Tsui, C. P., Ignjatović, N.,& Uskoković, D.. (2007). Micromechanical properties of a hydroxyapatite/poly-L-lactide biocomposite using nanoindentation and modulus mapping. in Journal of the European Ceramic Society
Elsevier Sci Ltd, Oxford., 27(2-3), 1559-1564.
https://doi.org/10.1016/j.jeurceramsoc.2006.04.122

Uskoković P, Tang CY, Tsui CP, Ignjatović N, Uskoković D. Micromechanical properties of a hydroxyapatite/poly-L-lactide biocomposite using nanoindentation and modulus mapping. in Journal of the European Ceramic Society. 2007;27(2-3):1559-1564.
doi:10.1016/j.jeurceramsoc.2006.04.122 .

Uskoković, Petar, Tang, C. Y., Tsui, C. P., Ignjatović, Nenad, Uskoković, Dragan, "Micromechanical properties of a hydroxyapatite/poly-L-lactide biocomposite using nanoindentation and modulus mapping" in Journal of the European Ceramic Society, 27, no. 2-3 (2007):1559-1564,
https://doi.org/10.1016/j.jeurceramsoc.2006.04.122 . .

TY  - JOUR
AU  - Balać, Igor
AU  - Tang, C. Y.
AU  - Tsui, C. P.
AU  - Chen, D. Z.
AU  - Uskoković, Petar
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2006
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/986
AB  - In order to obtain more accurate properties after compaction of hydroxyapatite (HAp)/poly-L-lactide (PLLA) composite, high-resolution measurement of mechanical properties method is proposed to determine the properties of each phase separately, leading to information that are valuable for the development of new materials as well as for predictive modeling purposes. The PLLA polymer processing conditions used in hot pressing of the composite strongly influence final mechanical properties of the material in the solid state. Since the aim was to measure PLLA material properties, acceptable findings could only be made using unconstrained, cured in situ nanoindentation tests. A finite element analysis of the in situ indentation experiment was performed to determine required size of plain polymer area, needed for indentation test, which would minimize the particle influence on the matrix elastic behavior.
PB  - Trans Tech Publications Ltd, Durnten-Zurich
T2  - Recent Developments in Advanced Materials and Processes
T1  - Nanoindentation of in situ polymers in hydroxyapatite/poly-L-lactide biocomposites
EP  - 506
SP  - 501
VL  - 518
DO  - 10.4028/www.scientific.net/MSF.518.501
ER  - 

@article{
author = "Balać, Igor and Tang, C. Y. and Tsui, C. P. and Chen, D. Z. and Uskoković, Petar and Ignjatović, Nenad and Uskoković, Dragan",
year = "2006",
abstract = "In order to obtain more accurate properties after compaction of hydroxyapatite (HAp)/poly-L-lactide (PLLA) composite, high-resolution measurement of mechanical properties method is proposed to determine the properties of each phase separately, leading to information that are valuable for the development of new materials as well as for predictive modeling purposes. The PLLA polymer processing conditions used in hot pressing of the composite strongly influence final mechanical properties of the material in the solid state. Since the aim was to measure PLLA material properties, acceptable findings could only be made using unconstrained, cured in situ nanoindentation tests. A finite element analysis of the in situ indentation experiment was performed to determine required size of plain polymer area, needed for indentation test, which would minimize the particle influence on the matrix elastic behavior.",
publisher = "Trans Tech Publications Ltd, Durnten-Zurich",
journal = "Recent Developments in Advanced Materials and Processes",
title = "Nanoindentation of in situ polymers in hydroxyapatite/poly-L-lactide biocomposites",
pages = "506-501",
volume = "518",
doi = "10.4028/www.scientific.net/MSF.518.501"
}

Balać, I., Tang, C. Y., Tsui, C. P., Chen, D. Z., Uskoković, P., Ignjatović, N.,& Uskoković, D.. (2006). Nanoindentation of in situ polymers in hydroxyapatite/poly-L-lactide biocomposites. in Recent Developments in Advanced Materials and Processes
Trans Tech Publications Ltd, Durnten-Zurich., 518, 501-506.
https://doi.org/10.4028/www.scientific.net/MSF.518.501

Balać I, Tang CY, Tsui CP, Chen DZ, Uskoković P, Ignjatović N, Uskoković D. Nanoindentation of in situ polymers in hydroxyapatite/poly-L-lactide biocomposites. in Recent Developments in Advanced Materials and Processes. 2006;518:501-506.
doi:10.4028/www.scientific.net/MSF.518.501 .

Balać, Igor, Tang, C. Y., Tsui, C. P., Chen, D. Z., Uskoković, Petar, Ignjatović, Nenad, Uskoković, Dragan, "Nanoindentation of in situ polymers in hydroxyapatite/poly-L-lactide biocomposites" in Recent Developments in Advanced Materials and Processes, 518 (2006):501-506,
https://doi.org/10.4028/www.scientific.net/MSF.518.501 . .

TY  - JOUR
AU  - Vukašinović-Milić, Tatjana
AU  - Miličević, Dejan S.
AU  - Mićić, Maja M.
AU  - Trifunović, Saša
AU  - Suljovrujić, Edin H.
AU  - Tomić, Simonida
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2006
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/925
AB  - The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly- Llactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable.
AB  - Ispitivan je uticaj γ-zračenja na strukturu i osobine hidroksiapatit/poli-L-laktida (Hap/PLLA). Uticaj zračenja na mikrostrukturu degradaciju polimera i termičku stabilanost kompozita određivani su skenirajućom elektronskom mikroskopijom (SEM), gel-propusnom hromatografijom (GPH) i termogravimetrijskom analizom (TGA), respektivno. Mehaničke osobine su određene na osnovu mehaničke čvrstoće i modula elastičnosti. Dobijeni rezultati pokazuju slabljenje osobina HAp/PLLA sa povećanjem doze zračenja. Za doze zračenja pri kojima se odvija sterilizacija, promene i efekti oštećenja su prihvatljivi.
PB  - Savez inženjera i tehničara Srbije, Beograd
T2  - Tehnika - Novi materijali
T1  - Sterilization of hydroxyapatite/poly-L-lactide composite biomaterial by gamma irradiation
T1  - Sterilizacija hidroksiapatit/poli-L-laktid kompozitnog biomaterijala dejstvom γ-zračenja
EP  - 14
IS  - 4
SP  - 9
VL  - 15
UR  - https://hdl.handle.net/21.15107/rcub_technorep_925
ER  - 

@article{
author = "Vukašinović-Milić, Tatjana and Miličević, Dejan S. and Mićić, Maja M. and Trifunović, Saša and Suljovrujić, Edin H. and Tomić, Simonida and Ignjatović, Nenad and Uskoković, Dragan",
year = "2006",
abstract = "The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly- Llactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable., Ispitivan je uticaj γ-zračenja na strukturu i osobine hidroksiapatit/poli-L-laktida (Hap/PLLA). Uticaj zračenja na mikrostrukturu degradaciju polimera i termičku stabilanost kompozita određivani su skenirajućom elektronskom mikroskopijom (SEM), gel-propusnom hromatografijom (GPH) i termogravimetrijskom analizom (TGA), respektivno. Mehaničke osobine su određene na osnovu mehaničke čvrstoće i modula elastičnosti. Dobijeni rezultati pokazuju slabljenje osobina HAp/PLLA sa povećanjem doze zračenja. Za doze zračenja pri kojima se odvija sterilizacija, promene i efekti oštećenja su prihvatljivi.",
publisher = "Savez inženjera i tehničara Srbije, Beograd",
journal = "Tehnika - Novi materijali",
title = "Sterilization of hydroxyapatite/poly-L-lactide composite biomaterial by gamma irradiation, Sterilizacija hidroksiapatit/poli-L-laktid kompozitnog biomaterijala dejstvom γ-zračenja",
pages = "14-9",
number = "4",
volume = "15",
url = "https://hdl.handle.net/21.15107/rcub_technorep_925"
}

Vukašinović-Milić, T., Miličević, D. S., Mićić, M. M., Trifunović, S., Suljovrujić, E. H., Tomić, S., Ignjatović, N.,& Uskoković, D.. (2006). Sterilization of hydroxyapatite/poly-L-lactide composite biomaterial by gamma irradiation. in Tehnika - Novi materijali
Savez inženjera i tehničara Srbije, Beograd., 15(4), 9-14.
https://hdl.handle.net/21.15107/rcub_technorep_925

Vukašinović-Milić T, Miličević DS, Mićić MM, Trifunović S, Suljovrujić EH, Tomić S, Ignjatović N, Uskoković D. Sterilization of hydroxyapatite/poly-L-lactide composite biomaterial by gamma irradiation. in Tehnika - Novi materijali. 2006;15(4):9-14.
https://hdl.handle.net/21.15107/rcub_technorep_925 .

Vukašinović-Milić, Tatjana, Miličević, Dejan S., Mićić, Maja M., Trifunović, Saša, Suljovrujić, Edin H., Tomić, Simonida, Ignjatović, Nenad, Uskoković, Dragan, "Sterilization of hydroxyapatite/poly-L-lactide composite biomaterial by gamma irradiation" in Tehnika - Novi materijali, 15, no. 4 (2006):9-14,
https://hdl.handle.net/21.15107/rcub_technorep_925 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Nastasović, Aleksandra
AU  - Laninović, Verica
AU  - Onjia, Antonije
AU  - Miljković, Miroslav
AU  - Konstantinović, V
PY  - 2004
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/674
AB  - Bioresorbable barrier membranes have been widely used in dentistry and maxillofacial surgery. When the membranes are placed over bony defects and are closely adapted by the surrounding bone face, an environment that prevents invasion of competing non-osteogenetic cells from the overlying soft tissues can be created. The aim of the present study was to establish whether the production procedure of different polymeric and composite membranes affects their physicochemical properties. The physicochemical properties were examined by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), inverse gas chromatography (lGC) and tensile strength test (TST). The surface microstructure, dependent on the processing parameters, was perforated with smaller or larger pores. The dispersive component of the free surface energy decreased by adding bicalcium phosphate (BCP) to the polymer and, consequently, non-polar interactions with the surroundings became preferential.
PB  - Trans Tech Publications Ltd, Durnten-Zurich
T2  - Progress in Advanced Materials and Processes
T1  - Preparation and properties of polymeric and composite bioresorbable barrier membranes
EP  - 542
SP  - 537
VL  - 453-454
DO  - 10.4028/www.scientific.net/MSF.453-454.537
ER  - 

@article{
author = "Ignjatović, Nenad and Nastasović, Aleksandra and Laninović, Verica and Onjia, Antonije and Miljković, Miroslav and Konstantinović, V",
year = "2004",
abstract = "Bioresorbable barrier membranes have been widely used in dentistry and maxillofacial surgery. When the membranes are placed over bony defects and are closely adapted by the surrounding bone face, an environment that prevents invasion of competing non-osteogenetic cells from the overlying soft tissues can be created. The aim of the present study was to establish whether the production procedure of different polymeric and composite membranes affects their physicochemical properties. The physicochemical properties were examined by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), inverse gas chromatography (lGC) and tensile strength test (TST). The surface microstructure, dependent on the processing parameters, was perforated with smaller or larger pores. The dispersive component of the free surface energy decreased by adding bicalcium phosphate (BCP) to the polymer and, consequently, non-polar interactions with the surroundings became preferential.",
publisher = "Trans Tech Publications Ltd, Durnten-Zurich",
journal = "Progress in Advanced Materials and Processes",
title = "Preparation and properties of polymeric and composite bioresorbable barrier membranes",
pages = "542-537",
volume = "453-454",
doi = "10.4028/www.scientific.net/MSF.453-454.537"
}

Ignjatović, N., Nastasović, A., Laninović, V., Onjia, A., Miljković, M.,& Konstantinović, V.. (2004). Preparation and properties of polymeric and composite bioresorbable barrier membranes. in Progress in Advanced Materials and Processes
Trans Tech Publications Ltd, Durnten-Zurich., 453-454, 537-542.
https://doi.org/10.4028/www.scientific.net/MSF.453-454.537

Ignjatović N, Nastasović A, Laninović V, Onjia A, Miljković M, Konstantinović V. Preparation and properties of polymeric and composite bioresorbable barrier membranes. in Progress in Advanced Materials and Processes. 2004;453-454:537-542.
doi:10.4028/www.scientific.net/MSF.453-454.537 .

Ignjatović, Nenad, Nastasović, Aleksandra, Laninović, Verica, Onjia, Antonije, Miljković, Miroslav, Konstantinović, V, "Preparation and properties of polymeric and composite bioresorbable barrier membranes" in Progress in Advanced Materials and Processes, 453-454 (2004):537-542,
https://doi.org/10.4028/www.scientific.net/MSF.453-454.537 . .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Savić, Vojin
AU  - Najman, Stevo
AU  - Plavšić, Milenko
AU  - Uskoković, Dragan
PY  - 2001
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5350
AB  - Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C=O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found. Copyright © 2001 Elsevier Science Ltd.

Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C double bond O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.
PB  - Elsevier Science Ltd
T2  - Biomaterials
T1  - A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy
EP  - 575
IS  - 6
SP  - 571
VL  - 22
DO  - 10.1016/S0142-9612(00)00215-5
ER  - 

@article{
author = "Ignjatović, Nenad and Savić, Vojin and Najman, Stevo and Plavšić, Milenko and Uskoković, Dragan",
year = "2001",
abstract = "Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C=O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found. Copyright © 2001 Elsevier Science Ltd.

Chemically synthesized hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial was studied in vivo. The biocomposite was implanted into Balb/c Singen mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After 1 week of testing in vivo the implanted sample gave a spectrum in which absorption bands arising from newly formed functional groups of amine and peptide can be seen. After 3 weeks, a spectrum with pronounced absorption bands at 3420 and 1650cm-1 assigned to newly generated collagen, a component of the extracellular connective-tissue matrix, was registered. Also, decrease of the intensity absorption band at 1760cm-1 originating from the C double bond O group of PLLA indicates bioresorption of the PLLA used. Analysis of the microstructure of the sample surface by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial used alone were found.",
publisher = "Elsevier Science Ltd",
journal = "Biomaterials",
title = "A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy",
pages = "575-571",
number = "6",
volume = "22",
doi = "10.1016/S0142-9612(00)00215-5"
}

Ignjatović, N., Savić, V., Najman, S., Plavšić, M.,& Uskoković, D.. (2001). A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. in Biomaterials
Elsevier Science Ltd., 22(6), 571-575.
https://doi.org/10.1016/S0142-9612(00)00215-5

Ignjatović N, Savić V, Najman S, Plavšić M, Uskoković D. A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. in Biomaterials. 2001;22(6):571-575.
doi:10.1016/S0142-9612(00)00215-5 .

Ignjatović, Nenad, Savić, Vojin, Najman, Stevo, Plavšić, Milenko, Uskoković, Dragan, "A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy" in Biomaterials, 22, no. 6 (2001):571-575,
https://doi.org/10.1016/S0142-9612(00)00215-5 . .

TY  - JOUR
AU  - Balać, Igor
AU  - Uskoković, Petar
AU  - Ignjatović, Nenad
AU  - Aleksić, Radoslav
AU  - Uskoković, Dragan
PY  - 2001
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/352
AB  - A three-dimensional (3D) finite element (FE) analysis of the stress concentration factor (SCF) in biocomposite model cell has been performed. The model composite consisted of a hydroxyapatite hard particle (HAp) embedded in poly-L-lactide soft matrix (PLLA). Two cases were considered, namely the shape of the particle was held constant while the volume fraction of HAp was varied and the particle shape was changed whilst the volume fraction was constant. For block shaped embedded particles, it was found that the SCF decreases with an increase of the HAp particle volume fraction. It was also found that the shape of reinforcing particles had little effect on the mechanical behaviour of material.
PB  - Elsevier, Amsterdam
T2  - Computational Materials Science
T1  - Stress analysis in hydroxyapatite/poly-L-lactide composite biomaterials
EP  - 283
IS  - 2
SP  - 275
VL  - 20
DO  - 10.1016/S0927-0256(00)00182-8
ER  - 

@article{
author = "Balać, Igor and Uskoković, Petar and Ignjatović, Nenad and Aleksić, Radoslav and Uskoković, Dragan",
year = "2001",
abstract = "A three-dimensional (3D) finite element (FE) analysis of the stress concentration factor (SCF) in biocomposite model cell has been performed. The model composite consisted of a hydroxyapatite hard particle (HAp) embedded in poly-L-lactide soft matrix (PLLA). Two cases were considered, namely the shape of the particle was held constant while the volume fraction of HAp was varied and the particle shape was changed whilst the volume fraction was constant. For block shaped embedded particles, it was found that the SCF decreases with an increase of the HAp particle volume fraction. It was also found that the shape of reinforcing particles had little effect on the mechanical behaviour of material.",
publisher = "Elsevier, Amsterdam",
journal = "Computational Materials Science",
title = "Stress analysis in hydroxyapatite/poly-L-lactide composite biomaterials",
pages = "283-275",
number = "2",
volume = "20",
doi = "10.1016/S0927-0256(00)00182-8"
}

Balać, I., Uskoković, P., Ignjatović, N., Aleksić, R.,& Uskoković, D.. (2001). Stress analysis in hydroxyapatite/poly-L-lactide composite biomaterials. in Computational Materials Science
Elsevier, Amsterdam., 20(2), 275-283.
https://doi.org/10.1016/S0927-0256(00)00182-8

Balać I, Uskoković P, Ignjatović N, Aleksić R, Uskoković D. Stress analysis in hydroxyapatite/poly-L-lactide composite biomaterials. in Computational Materials Science. 2001;20(2):275-283.
doi:10.1016/S0927-0256(00)00182-8 .

Balać, Igor, Uskoković, Petar, Ignjatović, Nenad, Aleksić, Radoslav, Uskoković, Dragan, "Stress analysis in hydroxyapatite/poly-L-lactide composite biomaterials" in Computational Materials Science, 20, no. 2 (2001):275-283,
https://doi.org/10.1016/S0927-0256(00)00182-8 . .

TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Bugarski, Branko
AU  - Vunjak-Novaković, Gordana
AU  - Uskoković, Dragan
AU  - Goosen, M.F.
AU  - Jovanović, G.N.
AU  - Ignjatović, Nenad
AU  - Tomić, Simonida
AU  - Pajić-Lijaković, Ivana
PY  - 2000
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/316
AB  - The influence of the molecular weight of poly (L-lactide) on the properties important for biomedical application are reviewed. The utilization of polylactides in sutures, drug release systems and bone reconstruction is analyzed, the considering interrelations between their biocompatibility, biodegradability, good mechanical properties and molecular weight, chain stiffness and crystallinity. The results for polylactides having average molecular weight in the range of 20x103-500x103 g/mol are presented, indicating the different optimal values, depending on the usage.
AB  - Dat je pregled rezultata istraživanja uticaja molske mase poli (L-laktida) na svojstva značajna za njegovu primenu u medicini. Analizirano je korišćenje polilaktida pri ušivanju tkiva, kontrolisanom otpuštanju lekova i lečenju preloma kostiju, razmatrajući povezanost njegovih mehaničkih svojstava, biokompatibilnosti i biodegradabilnosti sa molskom masom, krutošću lanca i kristalnošću. Prikazani su rezultati za polilaktid srednje molske kase u opsegu od 20x103-500x103 g/mol i ukazano na javljanje različitih vrednosti kao optimalnih, zavisno od namene materijala.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - The significance of molecular weight for medical purpose application of PLLA
T1  - Značaj molske mase za primenu PLLA u medicini
EP  - 457
IS  - 10
SP  - 447
VL  - 54
UR  - https://hdl.handle.net/21.15107/rcub_technorep_316
ER  - 

@article{
author = "Plavšić, Milenko B. and Bugarski, Branko and Vunjak-Novaković, Gordana and Uskoković, Dragan and Goosen, M.F. and Jovanović, G.N. and Ignjatović, Nenad and Tomić, Simonida and Pajić-Lijaković, Ivana",
year = "2000",
abstract = "The influence of the molecular weight of poly (L-lactide) on the properties important for biomedical application are reviewed. The utilization of polylactides in sutures, drug release systems and bone reconstruction is analyzed, the considering interrelations between their biocompatibility, biodegradability, good mechanical properties and molecular weight, chain stiffness and crystallinity. The results for polylactides having average molecular weight in the range of 20x103-500x103 g/mol are presented, indicating the different optimal values, depending on the usage., Dat je pregled rezultata istraživanja uticaja molske mase poli (L-laktida) na svojstva značajna za njegovu primenu u medicini. Analizirano je korišćenje polilaktida pri ušivanju tkiva, kontrolisanom otpuštanju lekova i lečenju preloma kostiju, razmatrajući povezanost njegovih mehaničkih svojstava, biokompatibilnosti i biodegradabilnosti sa molskom masom, krutošću lanca i kristalnošću. Prikazani su rezultati za polilaktid srednje molske kase u opsegu od 20x103-500x103 g/mol i ukazano na javljanje različitih vrednosti kao optimalnih, zavisno od namene materijala.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "The significance of molecular weight for medical purpose application of PLLA, Značaj molske mase za primenu PLLA u medicini",
pages = "457-447",
number = "10",
volume = "54",
url = "https://hdl.handle.net/21.15107/rcub_technorep_316"
}

Plavšić, M. B., Bugarski, B., Vunjak-Novaković, G., Uskoković, D., Goosen, M.F., Jovanović, G.N., Ignjatović, N., Tomić, S.,& Pajić-Lijaković, I.. (2000). The significance of molecular weight for medical purpose application of PLLA. in Hemijska industrija
Association of Chemical Engineers of Serbia., 54(10), 447-457.
https://hdl.handle.net/21.15107/rcub_technorep_316

Plavšić MB, Bugarski B, Vunjak-Novaković G, Uskoković D, Goosen M, Jovanović G, Ignjatović N, Tomić S, Pajić-Lijaković I. The significance of molecular weight for medical purpose application of PLLA. in Hemijska industrija. 2000;54(10):447-457.
https://hdl.handle.net/21.15107/rcub_technorep_316 .

Plavšić, Milenko B., Bugarski, Branko, Vunjak-Novaković, Gordana, Uskoković, Dragan, Goosen, M.F., Jovanović, G.N., Ignjatović, Nenad, Tomić, Simonida, Pajić-Lijaković, Ivana, "The significance of molecular weight for medical purpose application of PLLA" in Hemijska industrija, 54, no. 10 (2000):447-457,
https://hdl.handle.net/21.15107/rcub_technorep_316 .

TY  - CONF
AU  - Ignjatović, Nenad
AU  - Plavšić, Milenko
AU  - Najman, Stevo
AU  - Savić, Vojin
AU  - Uskoković, Dragan
PY  - 2000
UR  - https://dais.sanu.ac.rs/123456789/3859
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5313
AB  - Hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial with PLLA of 50,000 and 430,000 g/mole molecular weight was studied in vivo. The biocomposite with PLLA of both molecular weights was implanted into mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After one week of testing in vivo, the implanted samples gave spectra in which absorption bands arising from new-formed functional groups of amine and peptide can be seen. Analysis of the spectra revealed faster formation of peptide compounds when the biocomposite with PLLA of lower molecular weight was used. After 3 weeks, the spectra of the biocomposite of both compositions were registered with pronounced absorption bands at about 3420 and 1650 cm-1 assigned to new-generated collagen, a component of the extracellular connective-tissue matrix. Also, in the case of the biocomposite sample with PLLA of lower molecular weight, disappearance of the previously present absorption band at about 1760 cm-1 originating from the C double bond O group of PLLA indicates complete bioresorption of the PLLA used. Analysis of the microstructures of the sample surfaces by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase in the system with PLLA of lower molecular weight and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial alone were found.
PB  - Uetikon-Zuerich : Trans Tech Publ
C3  - Trends in Advanced Materials and Processes
T1  - Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy
EP  - 150
SP  - 143
UR  - https://hdl.handle.net/21.15107/rcub_dais_3859
ER  - 

@conference{
author = "Ignjatović, Nenad and Plavšić, Milenko and Najman, Stevo and Savić, Vojin and Uskoković, Dragan",
year = "2000",
abstract = "Hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial with PLLA of 50,000 and 430,000 g/mole molecular weight was studied in vivo. The biocomposite with PLLA of both molecular weights was implanted into mice and after 1 and 3 weeks removed from their organisms and analyzed by the FT-IR spectroscopy. After one week of testing in vivo, the implanted samples gave spectra in which absorption bands arising from new-formed functional groups of amine and peptide can be seen. Analysis of the spectra revealed faster formation of peptide compounds when the biocomposite with PLLA of lower molecular weight was used. After 3 weeks, the spectra of the biocomposite of both compositions were registered with pronounced absorption bands at about 3420 and 1650 cm-1 assigned to new-generated collagen, a component of the extracellular connective-tissue matrix. Also, in the case of the biocomposite sample with PLLA of lower molecular weight, disappearance of the previously present absorption band at about 1760 cm-1 originating from the C double bond O group of PLLA indicates complete bioresorption of the PLLA used. Analysis of the microstructures of the sample surfaces by scanning electron microscopy before and after implantation revealed bioresorption of the PLLA polymer phase in the system with PLLA of lower molecular weight and generation of collagen fibers at the sites of implanted bioresorptive PLLA. A mixture of autologous bone powder and HAp/PLLA biocomposite was also examined. After implantation, the same final products as in the case of HAp/PLLA composite biomaterial alone were found.",
publisher = "Uetikon-Zuerich : Trans Tech Publ",
journal = "Trends in Advanced Materials and Processes",
title = "Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy",
pages = "150-143",
url = "https://hdl.handle.net/21.15107/rcub_dais_3859"
}

Ignjatović, N., Plavšić, M., Najman, S., Savić, V.,& Uskoković, D.. (2000). Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy. in Trends in Advanced Materials and Processes
Uetikon-Zuerich : Trans Tech Publ., 143-150.
https://hdl.handle.net/21.15107/rcub_dais_3859

Ignjatović N, Plavšić M, Najman S, Savić V, Uskoković D. Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy. in Trends in Advanced Materials and Processes. 2000;:143-150.
https://hdl.handle.net/21.15107/rcub_dais_3859 .

Ignjatović, Nenad, Plavšić, Milenko, Najman, Stevo, Savić, Vojin, Uskoković, Dragan, "Analysis of in vivo substitution of bone tissue by HAp/PLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy" in Trends in Advanced Materials and Processes (2000):143-150,
https://hdl.handle.net/21.15107/rcub_dais_3859 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Tomić, S
AU  - Dakić, M
AU  - Miljković, Miroslav
AU  - Plavšić, Milenko B.
AU  - Uskoković, Dragan
PY  - 1999
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/267
AB  - Calcium hydroxyapatite (HAp) and poly-L-lactide (PLLA) were synthesized chemically. The obtained HAp was of high purity and, after special thermal treatment, of high crystallinity as well. Synthesis of PLLA was performed using L-lactide as a monomer and nontoxic initiator. In this way a polymer of large molar weight (about 400 000) was obtained. The HAp and PLLA obtained were used as constituents of the HAp/PLLA composite biomaterial, a potential material for implants. The composite was obtained by mixing completely dissolved PLLA with granules of HAp. The composite was compacted by cold and hot pressing at pressures of 49.0-490.5 MPa and temperatures of 20-184 degrees C. The material obtained at optimum process parameters had a density of 99.6% and compressive strength of 93.2 MPa.
PB  - Elsevier Sci Ltd, Oxford
T2  - Biomaterials
T1  - Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials
EP  - 816
IS  - 9
SP  - 809
VL  - 20
DO  - 10.1016/S0142-9612(98)00234-8
ER  - 

@article{
author = "Ignjatović, Nenad and Tomić, S and Dakić, M and Miljković, Miroslav and Plavšić, Milenko B. and Uskoković, Dragan",
year = "1999",
abstract = "Calcium hydroxyapatite (HAp) and poly-L-lactide (PLLA) were synthesized chemically. The obtained HAp was of high purity and, after special thermal treatment, of high crystallinity as well. Synthesis of PLLA was performed using L-lactide as a monomer and nontoxic initiator. In this way a polymer of large molar weight (about 400 000) was obtained. The HAp and PLLA obtained were used as constituents of the HAp/PLLA composite biomaterial, a potential material for implants. The composite was obtained by mixing completely dissolved PLLA with granules of HAp. The composite was compacted by cold and hot pressing at pressures of 49.0-490.5 MPa and temperatures of 20-184 degrees C. The material obtained at optimum process parameters had a density of 99.6% and compressive strength of 93.2 MPa.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Biomaterials",
title = "Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials",
pages = "816-809",
number = "9",
volume = "20",
doi = "10.1016/S0142-9612(98)00234-8"
}

Ignjatović, N., Tomić, S., Dakić, M., Miljković, M., Plavšić, M. B.,& Uskoković, D.. (1999). Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials. in Biomaterials
Elsevier Sci Ltd, Oxford., 20(9), 809-816.
https://doi.org/10.1016/S0142-9612(98)00234-8

Ignjatović N, Tomić S, Dakić M, Miljković M, Plavšić MB, Uskoković D. Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials. in Biomaterials. 1999;20(9):809-816.
doi:10.1016/S0142-9612(98)00234-8 .

Ignjatović, Nenad, Tomić, S, Dakić, M, Miljković, Miroslav, Plavšić, Milenko B., Uskoković, Dragan, "Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials" in Biomaterials, 20, no. 9 (1999):809-816,
https://doi.org/10.1016/S0142-9612(98)00234-8 . .

TY  - JOUR
AU  - Ignjatović, NL
AU  - Plavšić, Milenko B.
AU  - Miljković, Miroslav
AU  - Zivković, LM
AU  - Uskoković, Dragan
PY  - 1999
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/233
AB  - Besides its high osteoinductive properties, hydroxyapatite (HAp) exhibits a relatively low mechanical strength. In order to improve the mechanical properties and reliability of HAp based composites, the addition of selected polymers is highly recommended, The main objective of this work is to study the microstructural characteristics of HAp/poly-L-lactide (PLLA) composites obtained by cold or hot processing. The composites were prepared from a mixture of a chloroform solution of poly-L-lactide with granulated HAp. After elimination of chloroform by vacuum evaporation, dense compacts were obtained by cold or hot pressing. The pressing pressure ranged from 98.10 to 294.3 MPa for both cold and hot pressing, The hot pressing was performed in the temperature region 293-457 K for a time period of 15-60 min. Depending on the PLLA amount and the pressing procedure it is possible to obtain highly porous or nearly fully dense composites, The scanning electron microscopy examination of fracture as well as of free surfaces revealed that the final porosity and wetting are affected to a great extent by the synthesis conditions and amount of polymer added. An increase in temperature to 457 K for a longer period of time results in fully dense compacts, The formation of a nearly continuous polymer network that leads to the hardening of HAp has also been observed. However, it should be pointed out that some layers of HAp may be free of polymer film since PLLA penetrates more deeply into the porous HAp.
PB  - Wiley, Hoboken
T2  - Journal of Microscopy
T1  - Microstructural characteristics of calcium hydroxyapatite/poly-L-lactide based composites
EP  - 248
IS  - 2
SP  - 243
VL  - 196
DO  - 10.1046/j.1365-2818.1999.00623.x
ER  - 

@article{
author = "Ignjatović, NL and Plavšić, Milenko B. and Miljković, Miroslav and Zivković, LM and Uskoković, Dragan",
year = "1999",
abstract = "Besides its high osteoinductive properties, hydroxyapatite (HAp) exhibits a relatively low mechanical strength. In order to improve the mechanical properties and reliability of HAp based composites, the addition of selected polymers is highly recommended, The main objective of this work is to study the microstructural characteristics of HAp/poly-L-lactide (PLLA) composites obtained by cold or hot processing. The composites were prepared from a mixture of a chloroform solution of poly-L-lactide with granulated HAp. After elimination of chloroform by vacuum evaporation, dense compacts were obtained by cold or hot pressing. The pressing pressure ranged from 98.10 to 294.3 MPa for both cold and hot pressing, The hot pressing was performed in the temperature region 293-457 K for a time period of 15-60 min. Depending on the PLLA amount and the pressing procedure it is possible to obtain highly porous or nearly fully dense composites, The scanning electron microscopy examination of fracture as well as of free surfaces revealed that the final porosity and wetting are affected to a great extent by the synthesis conditions and amount of polymer added. An increase in temperature to 457 K for a longer period of time results in fully dense compacts, The formation of a nearly continuous polymer network that leads to the hardening of HAp has also been observed. However, it should be pointed out that some layers of HAp may be free of polymer film since PLLA penetrates more deeply into the porous HAp.",
publisher = "Wiley, Hoboken",
journal = "Journal of Microscopy",
title = "Microstructural characteristics of calcium hydroxyapatite/poly-L-lactide based composites",
pages = "248-243",
number = "2",
volume = "196",
doi = "10.1046/j.1365-2818.1999.00623.x"
}

Ignjatović, N., Plavšić, M. B., Miljković, M., Zivković, L.,& Uskoković, D.. (1999). Microstructural characteristics of calcium hydroxyapatite/poly-L-lactide based composites. in Journal of Microscopy
Wiley, Hoboken., 196(2), 243-248.
https://doi.org/10.1046/j.1365-2818.1999.00623.x

Ignjatović N, Plavšić MB, Miljković M, Zivković L, Uskoković D. Microstructural characteristics of calcium hydroxyapatite/poly-L-lactide based composites. in Journal of Microscopy. 1999;196(2):243-248.
doi:10.1046/j.1365-2818.1999.00623.x .

Ignjatović, NL, Plavšić, Milenko B., Miljković, Miroslav, Zivković, LM, Uskoković, Dragan, "Microstructural characteristics of calcium hydroxyapatite/poly-L-lactide based composites" in Journal of Microscopy, 196, no. 2 (1999):243-248,
https://doi.org/10.1046/j.1365-2818.1999.00623.x . .