@conference{
author = "Trifković, Kata and Isailović, Bojana and Milašinović, Nikola and Jovanović, Aleksandra and Knežević-Jugović, Zorica and Đorđević, Verica and Bugarski, Branko",
year = "2015",
abstract = "In this work mechanical behavior of four different formulations of alginate-based beads was
tested. The alginate beads were prepared by means of extrusion technique. As a model
encapsulated bioactive substance resveratrol-loaded liposomes were used. The beads were
composed as follows: 1.5% alginate beads; 1.5% alginate beads encapsulating liposomes; 1.5%
alginate/30% sucrose beads encapsulating liposomes and 1.5% alginate/0.5% chitosan beads
encapsulating liposomes. The mechanical properties (e.g. maximal forces required for reaching
the default deformation, maximal stresses and the Young’s modulus) of aforementioned beads
were determined by testing the single bead submerged in water using the AG-X plus Universal
Testing Machine (Shimadzu, Japan). Results showed the decrease in maximal forces (stresses)
and increase in elasticity of the examined beads upon encapsulation of resveratrol-loaded
liposomes. After addition of sucrose and coating with chitosan, maximal forces respectively
remained constant and decreased, while elastic modulus also remained constant and increased,
respectively. Tested compression method can be used in the determination of mechanical
properties of different alginate-based beads., U ovom radu su ispitane mehaničke karakteristike četiri različite formulacije čestica na bazi
alginata. Čestice su pripremljenje koristeći metodu ekstruzije. Kao model supstanca za
inkapsulaciju korišćni su lipozomi sa inkapsuliranim resveratrolom. Formulacije čestica su
sledeće: 1,5% alginatne čestice; 1,5% alginatne čestice sa inkapsuliranim lipozomima; 1,5%
alginatne čestice sa inkapsuliranim lipozomima sa dodatkom 30% saharoze i 1,5% alginatne
čestice sa inkapsuliranim lipozomima sa dodatnim slojem 0,5% hitozana. Mehaničke
karakteristike (tj. maksimalne sile potrebne za dostizanje unapred definisane deformacije,
maksimalni naponi i Jungovi moduli elastičnosti) gore pomenutih čestica su određene
testiranjem pojedinačnih čestica uronjenih u vodu, koristeći AG-X plus Universal Testing
Machine (Shimadzu, Japan). Rezultati su pokazali da nakon inkapsulacije lipozoma sa
resveratrolom u alginatne čestice dolazi do smanjenja maksimalne sile potrebne za postizanje
zadate deformacije, kao i do povećanja elastičnosti ispitivanh čestica. Nakon dodatka saharoze i
oblaganja alginatnih čestica slojem hitozana, maksimalna sila ostaje nepromenjana, odnosno
dolazi do njenog smanjenja; slicno, vrednosti modula elastičnosti takođe ostaju konstantne,
odnosno povećavaju se. Ispitivana metoda kompresije može se koristiti za određivanje
mehaničkih karakteristika različitih čestica na bazi alginata.",
publisher = "Faculty of Technology, Zvornik",
journal = "IV International Congress of “Engineering, Environment and Materials in Processing Industry“",
title = "Mechanical properties of alginate-liposomes-based beads with encapsulated resveratrol, Mehaničke karakteristike čestica alginat-lipozomi sa inkapsuliranim resveratrolom",
pages = "325-318",
doi = "10.7251/EEMEN1501318T"
}