TY  - JOUR
AU  - Vuković, Jovana S.
AU  - Babić Radić, Marija M.
AU  - Trifunović, Saša B.
AU  - Koch, Thomas
AU  - Perić-Grujić, Aleksandra A.
AU  - Vojnović, Sandra
AU  - Tomić, Simonida Lj.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6759
AB  - Antibacterial hydrogels, as an advanced approach, can create optimal conditions for wound healing, even in the fight against stubborn and difficult-to-treat wound infections. Interestingly, pH is an often neglected clinical parameter, although it has a significant impact on the wound healing process. At different stages of wound healing, the pH in the wound bed changes from slightly alkaline to neutral to acidic. To develop novel pH-sensitive antibacterial hydrogel dressings, Zn2+-loaded poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels are synthesized. The hydrogels exhibit pH-sensitive swelling in the physiologically relevant pH range, with a pronounced swelling ability at neutral pH. The controlled release of Zn2+ occurs in a buffer of pH 7.40 at 37 °C. The liquid transport mechanism and release kinetics are evaluated using the specific kinetic models of Ritger-Peppas and Peppas-Sahlin. The effect of Zn2+ on structural, thermal, swelling, cytocompatibility, and antibacterial properties is evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, swelling studies, MTT, and antibacterial tests. The hydrogels show excellent antibacterial activity against Escherichia coli. The research opens new perspectives for efficient wound healing management, and the extension of the study will be orchestrated by optimising the hydrogel composition to achieve improved performance.
PB  - John Wiley and Sons Inc.
T2  - Macromolecular Chemistry and Physics
T1  - Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings
SP  - 2300310
DO  - 10.1002/macp.202300310
ER  - 

@article{
author = "Vuković, Jovana S. and Babić Radić, Marija M. and Trifunović, Saša B. and Koch, Thomas and Perić-Grujić, Aleksandra A. and Vojnović, Sandra and Tomić, Simonida Lj.",
year = "2023",
abstract = "Antibacterial hydrogels, as an advanced approach, can create optimal conditions for wound healing, even in the fight against stubborn and difficult-to-treat wound infections. Interestingly, pH is an often neglected clinical parameter, although it has a significant impact on the wound healing process. At different stages of wound healing, the pH in the wound bed changes from slightly alkaline to neutral to acidic. To develop novel pH-sensitive antibacterial hydrogel dressings, Zn2+-loaded poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels are synthesized. The hydrogels exhibit pH-sensitive swelling in the physiologically relevant pH range, with a pronounced swelling ability at neutral pH. The controlled release of Zn2+ occurs in a buffer of pH 7.40 at 37 °C. The liquid transport mechanism and release kinetics are evaluated using the specific kinetic models of Ritger-Peppas and Peppas-Sahlin. The effect of Zn2+ on structural, thermal, swelling, cytocompatibility, and antibacterial properties is evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, swelling studies, MTT, and antibacterial tests. The hydrogels show excellent antibacterial activity against Escherichia coli. The research opens new perspectives for efficient wound healing management, and the extension of the study will be orchestrated by optimising the hydrogel composition to achieve improved performance.",
publisher = "John Wiley and Sons Inc.",
journal = "Macromolecular Chemistry and Physics",
title = "Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings",
pages = "2300310",
doi = "10.1002/macp.202300310"
}

Vuković, J. S., Babić Radić, M. M., Trifunović, S. B., Koch, T., Perić-Grujić, A. A., Vojnović, S.,& Tomić, S. Lj.. (2023). Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings. in Macromolecular Chemistry and Physics
John Wiley and Sons Inc.., 2300310.
https://doi.org/10.1002/macp.202300310

Vuković JS, Babić Radić MM, Trifunović SB, Koch T, Perić-Grujić AA, Vojnović S, Tomić SL. Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings. in Macromolecular Chemistry and Physics. 2023;:2300310.
doi:10.1002/macp.202300310 .

Vuković, Jovana S., Babić Radić, Marija M., Trifunović, Saša B., Koch, Thomas, Perić-Grujić, Aleksandra A., Vojnović, Sandra, Tomić, Simonida Lj., "Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings" in Macromolecular Chemistry and Physics (2023):2300310,
https://doi.org/10.1002/macp.202300310 . .