TY  - JOUR
AU  - Vuković, Jovana S.
AU  - Babić Radić, Marija M.
AU  - Trifunović, Saša B.
AU  - Koch, Thomas
AU  - Perić-Grujić, Aleksandra A.
AU  - Vojnović, Sandra
AU  - Tomić, Simonida Lj.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6759
AB  - Antibacterial hydrogels, as an advanced approach, can create optimal conditions for wound healing, even in the fight against stubborn and difficult-to-treat wound infections. Interestingly, pH is an often neglected clinical parameter, although it has a significant impact on the wound healing process. At different stages of wound healing, the pH in the wound bed changes from slightly alkaline to neutral to acidic. To develop novel pH-sensitive antibacterial hydrogel dressings, Zn2+-loaded poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels are synthesized. The hydrogels exhibit pH-sensitive swelling in the physiologically relevant pH range, with a pronounced swelling ability at neutral pH. The controlled release of Zn2+ occurs in a buffer of pH 7.40 at 37 °C. The liquid transport mechanism and release kinetics are evaluated using the specific kinetic models of Ritger-Peppas and Peppas-Sahlin. The effect of Zn2+ on structural, thermal, swelling, cytocompatibility, and antibacterial properties is evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, swelling studies, MTT, and antibacterial tests. The hydrogels show excellent antibacterial activity against Escherichia coli. The research opens new perspectives for efficient wound healing management, and the extension of the study will be orchestrated by optimising the hydrogel composition to achieve improved performance.
PB  - John Wiley and Sons Inc.
T2  - Macromolecular Chemistry and Physics
T1  - Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings
SP  - 2300310
DO  - 10.1002/macp.202300310
ER  - 

@article{
author = "Vuković, Jovana S. and Babić Radić, Marija M. and Trifunović, Saša B. and Koch, Thomas and Perić-Grujić, Aleksandra A. and Vojnović, Sandra and Tomić, Simonida Lj.",
year = "2023",
abstract = "Antibacterial hydrogels, as an advanced approach, can create optimal conditions for wound healing, even in the fight against stubborn and difficult-to-treat wound infections. Interestingly, pH is an often neglected clinical parameter, although it has a significant impact on the wound healing process. At different stages of wound healing, the pH in the wound bed changes from slightly alkaline to neutral to acidic. To develop novel pH-sensitive antibacterial hydrogel dressings, Zn2+-loaded poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels are synthesized. The hydrogels exhibit pH-sensitive swelling in the physiologically relevant pH range, with a pronounced swelling ability at neutral pH. The controlled release of Zn2+ occurs in a buffer of pH 7.40 at 37 °C. The liquid transport mechanism and release kinetics are evaluated using the specific kinetic models of Ritger-Peppas and Peppas-Sahlin. The effect of Zn2+ on structural, thermal, swelling, cytocompatibility, and antibacterial properties is evaluated by Fourier transform infrared spectroscopy, differential scanning calorimetry, swelling studies, MTT, and antibacterial tests. The hydrogels show excellent antibacterial activity against Escherichia coli. The research opens new perspectives for efficient wound healing management, and the extension of the study will be orchestrated by optimising the hydrogel composition to achieve improved performance.",
publisher = "John Wiley and Sons Inc.",
journal = "Macromolecular Chemistry and Physics",
title = "Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings",
pages = "2300310",
doi = "10.1002/macp.202300310"
}

Vuković, J. S., Babić Radić, M. M., Trifunović, S. B., Koch, T., Perić-Grujić, A. A., Vojnović, S.,& Tomić, S. Lj.. (2023). Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings. in Macromolecular Chemistry and Physics
John Wiley and Sons Inc.., 2300310.
https://doi.org/10.1002/macp.202300310

Vuković JS, Babić Radić MM, Trifunović SB, Koch T, Perić-Grujić AA, Vojnović S, Tomić SL. Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings. in Macromolecular Chemistry and Physics. 2023;:2300310.
doi:10.1002/macp.202300310 .

Vuković, Jovana S., Babić Radić, Marija M., Trifunović, Saša B., Koch, Thomas, Perić-Grujić, Aleksandra A., Vojnović, Sandra, Tomić, Simonida Lj., "Zn2+/Poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hydrogels as Potential Antibacterial Wound Dressings" in Macromolecular Chemistry and Physics (2023):2300310,
https://doi.org/10.1002/macp.202300310 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Vuković, Jovana S.
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk V.
AU  - Živanović, Dubravka P.
AU  - Nikolić, Miloš M.
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5869
AB  - Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a novel combination of the bioactive agent Manuka honey (MHo) with 2-hydroxyethyl methacrylate/gelatin (HG) hydrogel scaffolds was created as an efficient bioactive platform for biomedical applications. The effects of Manuka honey content on structural characteristics, porosity, swelling performance, in vitro degradation, and in vitro biocompatibility (fibroblast and keratinocyte cell lines) of hybrid hydrogel scaffolds were studied using Fourier transform infrared spectroscopy, the gravimetric method, and in vitro MTT biocompatibility assays. The engineered hybrid hydrogel scaffolds show advantageous properties, including porosity in the range of 71.25% to 90.09%, specific pH- and temperature-dependent swelling performance, and convenient absorption capacity. In vitro degradation studies showed scaffold degradability ranging from 6.27% to 27.18% for four weeks. In vitro biocompatibility assays on healthy human fibroblast (MRC5 cells) and keratinocyte (HaCaT cells) cell lines by MTT tests showed that cell viability depends on the Manuka honey content loaded in the HG hydrogel scaffolds. A sample containing the highest Manuka honey content (30%) exhibited the best biocompatible properties. The obtained results reveal that the synergy of the bioactive agent, Manuka honey, with 2-hydroxyethyl methacrylate/gelatin as hybrid hydrogel scaffolds has potential for biomedical purposes. By tuning the Manuka honey content in HG hydrogel scaffolds advantageous properties of hybrid scaffolds can be achieved for biomedical applications.
PB  - MDPI
T2  - Polymers
T1  - Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration
IS  - 3
SP  - 589
VL  - 15
DO  - 10.3390/polym15030589
ER  - 

@article{
author = "Tomić, Simonida Lj. and Vuković, Jovana S. and Babić Radić, Marija M. and Filipović, Vuk V. and Živanović, Dubravka P. and Nikolić, Miloš M. and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a novel combination of the bioactive agent Manuka honey (MHo) with 2-hydroxyethyl methacrylate/gelatin (HG) hydrogel scaffolds was created as an efficient bioactive platform for biomedical applications. The effects of Manuka honey content on structural characteristics, porosity, swelling performance, in vitro degradation, and in vitro biocompatibility (fibroblast and keratinocyte cell lines) of hybrid hydrogel scaffolds were studied using Fourier transform infrared spectroscopy, the gravimetric method, and in vitro MTT biocompatibility assays. The engineered hybrid hydrogel scaffolds show advantageous properties, including porosity in the range of 71.25% to 90.09%, specific pH- and temperature-dependent swelling performance, and convenient absorption capacity. In vitro degradation studies showed scaffold degradability ranging from 6.27% to 27.18% for four weeks. In vitro biocompatibility assays on healthy human fibroblast (MRC5 cells) and keratinocyte (HaCaT cells) cell lines by MTT tests showed that cell viability depends on the Manuka honey content loaded in the HG hydrogel scaffolds. A sample containing the highest Manuka honey content (30%) exhibited the best biocompatible properties. The obtained results reveal that the synergy of the bioactive agent, Manuka honey, with 2-hydroxyethyl methacrylate/gelatin as hybrid hydrogel scaffolds has potential for biomedical purposes. By tuning the Manuka honey content in HG hydrogel scaffolds advantageous properties of hybrid scaffolds can be achieved for biomedical applications.",
publisher = "MDPI",
journal = "Polymers",
title = "Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration",
number = "3",
pages = "589",
volume = "15",
doi = "10.3390/polym15030589"
}

Tomić, S. Lj., Vuković, J. S., Babić Radić, M. M., Filipović, V. V., Živanović, D. P., Nikolić, M. M.,& Nikodinović-Runić, J.. (2023). Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration. in Polymers
MDPI., 15(3), 589.
https://doi.org/10.3390/polym15030589

Tomić SL, Vuković JS, Babić Radić MM, Filipović VV, Živanović DP, Nikolić MM, Nikodinović-Runić J. Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration. in Polymers. 2023;15(3):589.
doi:10.3390/polym15030589 .

Tomić, Simonida Lj., Vuković, Jovana S., Babić Radić, Marija M., Filipović, Vuk V., Živanović, Dubravka P., Nikolić, Miloš M., Nikodinović-Runić, Jasmina, "Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration" in Polymers, 15, no. 3 (2023):589,
https://doi.org/10.3390/polym15030589 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk V.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida Lj.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6360
AB  - The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.
PB  - MDPI
T2  - Polymers
T1  - 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform
IS  - 7
SP  - 1643
VL  - 15
DO  - 10.3390/polym15071643
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipović, Vuk V. and Vuković, Jovana S. and Vukomanović, Marija and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida Lj.",
year = "2023",
abstract = "The idea of this study was to create a new scaffolding system based on 2-hydroxyethyl methacrylate, gelatin, and alginate that contains titanium(IV) oxide nanoparticles as a platform for the controlled release of the bioactive agent curcumin. The innovative strategy to develop hybrid scaffolds was the modified porogenation method. The effect of the scaffold composition on the chemical, morphology, porosity, mechanical, hydrophilicity, swelling, degradation, biocompatibility, loading, and release features of hybrid scaffolds was evaluated. A porous structure with interconnected pores in the range of 52.33–65.76%, favorable swelling capacity, fully hydrophilic surfaces, degradability to 45% for 6 months, curcumin loading efficiency above 96%, and favorable controlled release profiles were obtained. By applying four kinetic models of release, valuable parameters were obtained for the curcumin/PHEMA/gelatin/alginate/TiO2 release platform. Cytotoxicity test results depend on the composition of the scaffolds and showed satisfactory cell growth with visible cell accumulation on the hybrid surfaces. The constructed hybrid scaffolds have suitable high-performance properties, suggesting potential for further in vivo and clinical studies.",
publisher = "MDPI",
journal = "Polymers",
title = "2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform",
number = "7",
pages = "1643",
volume = "15",
doi = "10.3390/polym15071643"
}

Babić Radić, M. M., Filipović, V. V., Vuković, J. S., Vukomanović, M., Ilić-Tomić, T., Nikodinović-Runić, J.,& Tomić, S. Lj.. (2023). 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform. in Polymers
MDPI., 15(7), 1643.
https://doi.org/10.3390/polym15071643

Babić Radić MM, Filipović VV, Vuković JS, Vukomanović M, Ilić-Tomić T, Nikodinović-Runić J, Tomić SL. 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform. in Polymers. 2023;15(7):1643.
doi:10.3390/polym15071643 .

Babić Radić, Marija M., Filipović, Vuk V., Vuković, Jovana S., Vukomanović, Marija, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida Lj., "2-Hydroxyethyl Methacrylate/Gelatin/Alginate Scaffolds Reinforced with Nano TiO2 as a Promising Curcumin Release Platform" in Polymers, 15, no. 7 (2023):1643,
https://doi.org/10.3390/polym15071643 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Babić Radić, Marija M.
AU  - Vuković, Jovana S.
AU  - Filipović, Vuk V.
AU  - Nikodinović-Runić, Jasmina
AU  - Vukomanović, Marija
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6356
AB  - Alginate is a natural polymer of marine origin and, due to its exceptional properties, has great importance as an essential component for the preparation of hydrogels and scaffolds for biomedical applications. The design of biologically interactive hydrogels and scaffolds with advanced, expected and required properties are one of the key issues for successful outcomes in the healing of injured tissues. This review paper presents the multifunctional biomedical applications of alginate-based hydrogels and scaffolds in selected areas, highlighting the key effect of alginate and its influence on the essential properties of the selected biomedical applications. The first part covers scientific achievements for alginate in dermal tissue regeneration, drug delivery systems, cancer treatment, and antimicrobials. The second part is dedicated to our scientific results obtained for the research opus of hydrogel materials for scaffolds based on alginate in synergy with different materials (polymers and bioactive agents). Alginate has proved to be an exceptional polymer for combining with other naturally occurring and synthetic polymers, as well as loading bioactive therapeutic agents to achieve dermal, controlled drug delivery, cancer treatment, and antimicrobial purposes. Our research was based on combinations of alginate with gelatin, 2-hydroxyethyl methacrylate, apatite, graphene oxide and iron(III) oxide, as well as curcumin and resveratrol as bioactive agents. Important features of the prepared scaffolds, such as morphology, porosity, absorption capacity, hydrophilicity, mechanical properties, in vitro degradation, and in vitro and in vivo biocompatibility, have shown favorable properties for the aforementioned applications, and alginate has been an important link in achieving these properties. Alginate, as a component of these systems, proved to be an indispensable factor and played an excellent “role” in the optimal adjustment of the tested properties. This study provides valuable data and information for researchers and demonstrates the importance of the role of alginate as a biomaterial in the design of hydrogels and scaffolds that are powerful medical “tools” for biomedical applications.
PB  - MDPI
T2  - Marine Drugs
T1  - Alginate-Based Hydrogels and Scaffolds for Biomedical Applications
IS  - 3
SP  - 177
VL  - 21
DO  - 10.3390/md21030177
ER  - 

@article{
author = "Tomić, Simonida Lj. and Babić Radić, Marija M. and Vuković, Jovana S. and Filipović, Vuk V. and Nikodinović-Runić, Jasmina and Vukomanović, Marija",
year = "2023",
abstract = "Alginate is a natural polymer of marine origin and, due to its exceptional properties, has great importance as an essential component for the preparation of hydrogels and scaffolds for biomedical applications. The design of biologically interactive hydrogels and scaffolds with advanced, expected and required properties are one of the key issues for successful outcomes in the healing of injured tissues. This review paper presents the multifunctional biomedical applications of alginate-based hydrogels and scaffolds in selected areas, highlighting the key effect of alginate and its influence on the essential properties of the selected biomedical applications. The first part covers scientific achievements for alginate in dermal tissue regeneration, drug delivery systems, cancer treatment, and antimicrobials. The second part is dedicated to our scientific results obtained for the research opus of hydrogel materials for scaffolds based on alginate in synergy with different materials (polymers and bioactive agents). Alginate has proved to be an exceptional polymer for combining with other naturally occurring and synthetic polymers, as well as loading bioactive therapeutic agents to achieve dermal, controlled drug delivery, cancer treatment, and antimicrobial purposes. Our research was based on combinations of alginate with gelatin, 2-hydroxyethyl methacrylate, apatite, graphene oxide and iron(III) oxide, as well as curcumin and resveratrol as bioactive agents. Important features of the prepared scaffolds, such as morphology, porosity, absorption capacity, hydrophilicity, mechanical properties, in vitro degradation, and in vitro and in vivo biocompatibility, have shown favorable properties for the aforementioned applications, and alginate has been an important link in achieving these properties. Alginate, as a component of these systems, proved to be an indispensable factor and played an excellent “role” in the optimal adjustment of the tested properties. This study provides valuable data and information for researchers and demonstrates the importance of the role of alginate as a biomaterial in the design of hydrogels and scaffolds that are powerful medical “tools” for biomedical applications.",
publisher = "MDPI",
journal = "Marine Drugs",
title = "Alginate-Based Hydrogels and Scaffolds for Biomedical Applications",
number = "3",
pages = "177",
volume = "21",
doi = "10.3390/md21030177"
}

Tomić, S. Lj., Babić Radić, M. M., Vuković, J. S., Filipović, V. V., Nikodinović-Runić, J.,& Vukomanović, M.. (2023). Alginate-Based Hydrogels and Scaffolds for Biomedical Applications. in Marine Drugs
MDPI., 21(3), 177.
https://doi.org/10.3390/md21030177

Tomić SL, Babić Radić MM, Vuković JS, Filipović VV, Nikodinović-Runić J, Vukomanović M. Alginate-Based Hydrogels and Scaffolds for Biomedical Applications. in Marine Drugs. 2023;21(3):177.
doi:10.3390/md21030177 .

Tomić, Simonida Lj., Babić Radić, Marija M., Vuković, Jovana S., Filipović, Vuk V., Nikodinović-Runić, Jasmina, Vukomanović, Marija, "Alginate-Based Hydrogels and Scaffolds for Biomedical Applications" in Marine Drugs, 21, no. 3 (2023):177,
https://doi.org/10.3390/md21030177 . .

TY  - JOUR
AU  - Filipović, Vuk V.
AU  - Babić Radić, Marija M.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Rubert, Marina
AU  - Hofmann, Sandra
AU  - Müller, Ralph
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5018
AB  - New composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2-hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component, nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer, to be able to tune the structure and the physicochemical and mechanical properties, and a natural polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied. The goal was to make a new material with superior properties for applications in the biomedical field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegradable PHEMA hydrogel was obtained by crosslinking HEMA by poly(beta-amino esters) (PBAE). The scaffold's physicochemical and mechanical properties, in vitro degradation, and biological activity were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin) hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity, swelling, porosity, and percent of mass loss during degradation than the samples obtained by porogenation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss, and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate, which was 15-20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of culture was higher in the composites, although not statistically different. After 28 days, cell metabolic activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which influenced the mechanical behavior, structure, physicochemical properties, and interactions with biological species.
T2  - Polymers
T1  - Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite
IS  - 1
SP  - 18
VL  - 14
DO  - 10.3390/polym14010018
ER  - 

@article{
author = "Filipović, Vuk V. and Babić Radić, Marija M. and Vuković, Jovana S. and Vukomanović, Marija and Rubert, Marina and Hofmann, Sandra and Müller, Ralph and Tomić, Simonida Lj.",
year = "2022",
abstract = "New composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2-hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component, nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer, to be able to tune the structure and the physicochemical and mechanical properties, and a natural polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied. The goal was to make a new material with superior properties for applications in the biomedical field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegradable PHEMA hydrogel was obtained by crosslinking HEMA by poly(beta-amino esters) (PBAE). The scaffold's physicochemical and mechanical properties, in vitro degradation, and biological activity were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin) hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity, swelling, porosity, and percent of mass loss during degradation than the samples obtained by porogenation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss, and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate, which was 15-20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of culture was higher in the composites, although not statistically different. After 28 days, cell metabolic activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which influenced the mechanical behavior, structure, physicochemical properties, and interactions with biological species.",
journal = "Polymers",
title = "Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite",
number = "1",
pages = "18",
volume = "14",
doi = "10.3390/polym14010018"
}

Filipović, V. V., Babić Radić, M. M., Vuković, J. S., Vukomanović, M., Rubert, M., Hofmann, S., Müller, R.,& Tomić, S. Lj.. (2022). Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite. in Polymers, 14(1), 18.
https://doi.org/10.3390/polym14010018

Filipović VV, Babić Radić MM, Vuković JS, Vukomanović M, Rubert M, Hofmann S, Müller R, Tomić SL. Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite. in Polymers. 2022;14(1):18.
doi:10.3390/polym14010018 .

Filipović, Vuk V., Babić Radić, Marija M., Vuković, Jovana S., Vukomanović, Marija, Rubert, Marina, Hofmann, Sandra, Müller, Ralph, Tomić, Simonida Lj., "Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite" in Polymers, 14, no. 1 (2022):18,
https://doi.org/10.3390/polym14010018 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Vuković, Jovana S.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5065
AB  - The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve
human health. The use of metals in various forms as antimicrobial therapeutics has been known since
ancient times. In this sense, polymeric hydrogel matrices as multifunctional materials and in combination with various metal forms can be a great alternative to conventional treatments for infections.
Hydrogels possess high hydrophilicity, specific three-dimensional networks, fine biocompatibility,
and cell adhesion and are therefore suitable as materials for the loading of active antimicrobial agents
and acting in antimicrobial areas. The biocompatible nature of hydrogels’ matrices makes them a
convenient starting platform to develop biocompatible, selective, active controlled-release antimicrobial materials. Hydrogels based on acrylate and itaconic acid were synthesized and loaded with
silver (Ag+
), copper (Cu2+), and zinc (Zn2+) ions as a controlled release and antimicrobial system to
test release properties and antimicrobial activity in contact with microbes. The metal ions/hydrogel
systems exhibited favorable biocompatibility, release profiles, and antimicrobial activity against
methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA),
Staphylococcus aureus, Escherichia coli, and Candida albicans microbes, and have shown that they have
the capacity to “fight” with the life-threatening infections. Antimicrobial activity depends on types
of metal ions, the composition of polymeric matrices, as well as the types of microbes. Designed
metal ions/poly(acrylate/itaconic acid) antimicrobial systems have shown to have good potential as
antimicrobial therapeutics and suitable biomaterials for medical applications.
PB  - MDPI
T2  - Inorganics
T1  - Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices
IS  - 3
SP  - 38
VL  - 10
DO  - 10.3390/inorganics10030038
ER  - 

@article{
author = "Tomić, Simonida Lj. and Vuković, Jovana S.",
year = "2022",
abstract = "The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve
human health. The use of metals in various forms as antimicrobial therapeutics has been known since
ancient times. In this sense, polymeric hydrogel matrices as multifunctional materials and in combination with various metal forms can be a great alternative to conventional treatments for infections.
Hydrogels possess high hydrophilicity, specific three-dimensional networks, fine biocompatibility,
and cell adhesion and are therefore suitable as materials for the loading of active antimicrobial agents
and acting in antimicrobial areas. The biocompatible nature of hydrogels’ matrices makes them a
convenient starting platform to develop biocompatible, selective, active controlled-release antimicrobial materials. Hydrogels based on acrylate and itaconic acid were synthesized and loaded with
silver (Ag+
), copper (Cu2+), and zinc (Zn2+) ions as a controlled release and antimicrobial system to
test release properties and antimicrobial activity in contact with microbes. The metal ions/hydrogel
systems exhibited favorable biocompatibility, release profiles, and antimicrobial activity against
methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA),
Staphylococcus aureus, Escherichia coli, and Candida albicans microbes, and have shown that they have
the capacity to “fight” with the life-threatening infections. Antimicrobial activity depends on types
of metal ions, the composition of polymeric matrices, as well as the types of microbes. Designed
metal ions/poly(acrylate/itaconic acid) antimicrobial systems have shown to have good potential as
antimicrobial therapeutics and suitable biomaterials for medical applications.",
publisher = "MDPI",
journal = "Inorganics",
title = "Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices",
number = "3",
pages = "38",
volume = "10",
doi = "10.3390/inorganics10030038"
}

Tomić, S. Lj.,& Vuković, J. S.. (2022). Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices. in Inorganics
MDPI., 10(3), 38.
https://doi.org/10.3390/inorganics10030038

Tomić SL, Vuković JS. Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices. in Inorganics. 2022;10(3):38.
doi:10.3390/inorganics10030038 .

Tomić, Simonida Lj., Vuković, Jovana S., "Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices" in Inorganics, 10, no. 3 (2022):38,
https://doi.org/10.3390/inorganics10030038 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk V.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Rubert, Marina
AU  - Hofmann, Sandra
AU  - Müller, Ralph
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5201
AB  - Our goal was to create bioimitated scaffolding materials for biomedical purposes. The guiding idea was that we used an interpenetrating structural hierarchy of natural extracellular matrix as a “pattern” to design hydrogel scaffolds that show favorable properties for tissue regeneration. Polymeric hydrogel scaffolds are made in a simple, environmentally friendly way without additional functionalization. Gelatin and 2-hydroxyethyl methacrylate were selected to prepare interpenetrating polymeric networks and linear alginate chains were added as an interpenetrant to study their influence on the scaffold’s functionalities. Cryogelation and porogenation methods were used to obtain the designed scaffolding biomaterials. The scaffold’s structural, morphological, and mechanical properties, in vitro degradation, and cell viability properties were assessed to study the effects of the preparation method and alginate loading. Apatite as an inorganic agent was incorporated into cryogelated scaffolds to perform an extensive biological assay. Cryogelated scaffolds possess superior functionalities essential for tissue regeneration: fully hydrophilicity, degradability and mechanical features (2.08–9.75 MPa), and an optimal LDH activity. Furthermore, cryogelated scaffolds loaded with apatite showed good cell adhesion capacity, biocompatibility, and non-toxic behavior. All scaffolds performed equally in terms of metabolic activity and osteoconductivity. Cryogelated scaffolds with/without HAp could represent a new advance to promote osteoconductivity and enhance hard tissue repair. The obtained series of scaffolding biomaterials described here can provide a wide range of potential applications in the area of biomedical engineering.
PB  - MDPI
T2  - Polymers
T1  - Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials
IS  - 15
SP  - 3112
VL  - 14
DO  - 10.3390/polym14153112
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipović, Vuk V. and Vuković, Jovana S. and Vukomanović, Marija and Rubert, Marina and Hofmann, Sandra and Müller, Ralph and Tomić, Simonida Lj.",
year = "2022",
abstract = "Our goal was to create bioimitated scaffolding materials for biomedical purposes. The guiding idea was that we used an interpenetrating structural hierarchy of natural extracellular matrix as a “pattern” to design hydrogel scaffolds that show favorable properties for tissue regeneration. Polymeric hydrogel scaffolds are made in a simple, environmentally friendly way without additional functionalization. Gelatin and 2-hydroxyethyl methacrylate were selected to prepare interpenetrating polymeric networks and linear alginate chains were added as an interpenetrant to study their influence on the scaffold’s functionalities. Cryogelation and porogenation methods were used to obtain the designed scaffolding biomaterials. The scaffold’s structural, morphological, and mechanical properties, in vitro degradation, and cell viability properties were assessed to study the effects of the preparation method and alginate loading. Apatite as an inorganic agent was incorporated into cryogelated scaffolds to perform an extensive biological assay. Cryogelated scaffolds possess superior functionalities essential for tissue regeneration: fully hydrophilicity, degradability and mechanical features (2.08–9.75 MPa), and an optimal LDH activity. Furthermore, cryogelated scaffolds loaded with apatite showed good cell adhesion capacity, biocompatibility, and non-toxic behavior. All scaffolds performed equally in terms of metabolic activity and osteoconductivity. Cryogelated scaffolds with/without HAp could represent a new advance to promote osteoconductivity and enhance hard tissue repair. The obtained series of scaffolding biomaterials described here can provide a wide range of potential applications in the area of biomedical engineering.",
publisher = "MDPI",
journal = "Polymers",
title = "Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials",
number = "15",
pages = "3112",
volume = "14",
doi = "10.3390/polym14153112"
}

Babić Radić, M. M., Filipović, V. V., Vuković, J. S., Vukomanović, M., Rubert, M., Hofmann, S., Müller, R.,& Tomić, S. Lj.. (2022). Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. in Polymers
MDPI., 14(15), 3112.
https://doi.org/10.3390/polym14153112

Babić Radić MM, Filipović VV, Vuković JS, Vukomanović M, Rubert M, Hofmann S, Müller R, Tomić SL. Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. in Polymers. 2022;14(15):3112.
doi:10.3390/polym14153112 .

Babić Radić, Marija M., Filipović, Vuk V., Vuković, Jovana S., Vukomanović, Marija, Rubert, Marina, Hofmann, Sandra, Müller, Ralph, Tomić, Simonida Lj., "Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials" in Polymers, 14, no. 15 (2022):3112,
https://doi.org/10.3390/polym14153112 . .

TY  - JOUR
AU  - Vuković, Jovana S.
AU  - Filipović, Vuk V.
AU  - Babić Radić, Marija M.
AU  - Vukomanović, Marija
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5242
AB  - Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.
PB  - MDPI
T2  - Polymers
T1  - In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds
IS  - 20
SP  - 4459
VL  - 14
DO  - 10.3390/polym14204459
ER  - 

@article{
author = "Vuković, Jovana S. and Filipović, Vuk V. and Babić Radić, Marija M. and Vukomanović, Marija and Milivojević, Dušan and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida Lj.",
year = "2022",
abstract = "Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.",
publisher = "MDPI",
journal = "Polymers",
title = "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds",
number = "20",
pages = "4459",
volume = "14",
doi = "10.3390/polym14204459"
}

Vuković, J. S., Filipović, V. V., Babić Radić, M. M., Vukomanović, M., Milivojević, D., Ilić-Tomić, T., Nikodinović-Runić, J.,& Tomić, S. Lj.. (2022). In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers
MDPI., 14(20), 4459.
https://doi.org/10.3390/polym14204459

Vuković JS, Filipović VV, Babić Radić MM, Vukomanović M, Milivojević D, Ilić-Tomić T, Nikodinović-Runić J, Tomić SL. In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers. 2022;14(20):4459.
doi:10.3390/polym14204459 .

Vuković, Jovana S., Filipović, Vuk V., Babić Radić, Marija M., Vukomanović, Marija, Milivojević, Dušan, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida Lj., "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds" in Polymers, 14, no. 20 (2022):4459,
https://doi.org/10.3390/polym14204459 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Nikodinović-Runić, Jasmina
AU  - Vukomanovic, Marija
AU  - Babić, Marija M.
AU  - Vuković, Jovana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4926
AB  - Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.
T2  - Polymers
T1  - Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite
IS  - 6
SP  - 932
VL  - 13
DO  - 10.3390/polym13060932
ER  - 

@article{
author = "Tomić, Simonida and Nikodinović-Runić, Jasmina and Vukomanovic, Marija and Babić, Marija M. and Vuković, Jovana",
year = "2021",
abstract = "Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.",
journal = "Polymers",
title = "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite",
number = "6",
pages = "932",
volume = "13",
doi = "10.3390/polym13060932"
}

Tomić, S., Nikodinović-Runić, J., Vukomanovic, M., Babić, M. M.,& Vuković, J.. (2021). Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers, 13(6), 932.
https://doi.org/10.3390/polym13060932

Tomić S, Nikodinović-Runić J, Vukomanovic M, Babić MM, Vuković J. Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers. 2021;13(6):932.
doi:10.3390/polym13060932 .

Tomić, Simonida, Nikodinović-Runić, Jasmina, Vukomanovic, Marija, Babić, Marija M., Vuković, Jovana, "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite" in Polymers, 13, no. 6 (2021):932,
https://doi.org/10.3390/polym13060932 . .

TY  - JOUR
AU  - Vuković, Jovana
AU  - Perić-Grujić, Aleksandra
AU  - Mitić-Culafić, Dragana S.
AU  - Božić-Nedeljković, Biljana
AU  - Tomić, Simonida
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4345
AB  - Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.
PB  - Polymer Soc Korea, Seoul
T2  - Macromolecular Research
T1  - Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels
EP  - 389
IS  - 4
SP  - 382
VL  - 28
DO  - 10.1007/s13233-020-8050-z
ER  - 

@article{
author = "Vuković, Jovana and Perić-Grujić, Aleksandra and Mitić-Culafić, Dragana S. and Božić-Nedeljković, Biljana and Tomić, Simonida",
year = "2020",
abstract = "Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.",
publisher = "Polymer Soc Korea, Seoul",
journal = "Macromolecular Research",
title = "Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels",
pages = "389-382",
number = "4",
volume = "28",
doi = "10.1007/s13233-020-8050-z"
}

Vuković, J., Perić-Grujić, A., Mitić-Culafić, D. S., Božić-Nedeljković, B.,& Tomić, S.. (2020). Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels. in Macromolecular Research
Polymer Soc Korea, Seoul., 28(4), 382-389.
https://doi.org/10.1007/s13233-020-8050-z

Vuković J, Perić-Grujić A, Mitić-Culafić DS, Božić-Nedeljković B, Tomić S. Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels. in Macromolecular Research. 2020;28(4):382-389.
doi:10.1007/s13233-020-8050-z .

Vuković, Jovana, Perić-Grujić, Aleksandra, Mitić-Culafić, Dragana S., Božić-Nedeljković, Biljana, Tomić, Simonida, "Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels" in Macromolecular Research, 28, no. 4 (2020):382-389,
https://doi.org/10.1007/s13233-020-8050-z . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Vuković, Jovana
AU  - Đokić, Lidija
AU  - Pavić, Aleksandar
AU  - Nikodinović-Runić, Jasmina
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4379
AB  - We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.
PB  - Springer, Dordrecht
T2  - Journal of Polymer Research
T1  - Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties
IS  - 10
SP  - 305
VL  - 27
DO  - 10.1007/s10965-020-02219-w
ER  - 

@article{
author = "Tomić, Simonida and Babić, Marija and Vuković, Jovana and Đokić, Lidija and Pavić, Aleksandar and Nikodinović-Runić, Jasmina",
year = "2020",
abstract = "We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.",
publisher = "Springer, Dordrecht",
journal = "Journal of Polymer Research",
title = "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties",
number = "10",
pages = "305",
volume = "27",
doi = "10.1007/s10965-020-02219-w"
}

Tomić, S., Babić, M., Vuković, J., Đokić, L., Pavić, A.,& Nikodinović-Runić, J.. (2020). Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research
Springer, Dordrecht., 27(10), 305.
https://doi.org/10.1007/s10965-020-02219-w

Tomić S, Babić M, Vuković J, Đokić L, Pavić A, Nikodinović-Runić J. Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research. 2020;27(10):305.
doi:10.1007/s10965-020-02219-w .

Tomić, Simonida, Babić, Marija, Vuković, Jovana, Đokić, Lidija, Pavić, Aleksandar, Nikodinović-Runić, Jasmina, "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties" in Journal of Polymer Research, 27, no. 10 (2020):305,
https://doi.org/10.1007/s10965-020-02219-w . .

TY  - CHAP
AU  - Tomić, Simonida
AU  - Vuković, Jovana
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4580
AB  - The rapid emergence of antibiotic-resistant pathogens is becoming an imminent global public health problem. The development of novel antimicrobial materials aiming to prevent or control infections caused by these pathogens is a very important issue. Polymeric hydrogels are versatile materials, which can be a great alternative to conventional treatments of infections. Because of its high hydrophilicity, unique threedimensional network, fine biocompatibility, and cell adhesion, the hydrogels are suitable biomaterials for drug delivery in antimicrobial areas. The biocompatible nature of hydrogels makes them a convenient starting platform to develop selectively active antimicrobial materials. Hydrogels with antimicrobial properties can be designed by loading of known antimicrobial agents, or the material itself can be designed to possess inherent antimicrobial activity. The combination of polymeric hydrogels based on (meth)acrylate with metal ions (Ag, Cu, and Zn) is a simple and effective approach for obtaining multicomponent systems with diversefunctionalities. Silver (Ag+), copper (Cu2+), and zinc (Zn2+) ions have been loaded into hydrogels for antimicrobial applications. The incorporation of metal ions into hydrogels not only enhances the antimicrobial activity of hydrogels but also influences their swelling and release characteristics. Herein, we summarize recent findings in (meth)acrylate hydrogels containing metal ions with antimicrobial properties.
T2  - An Introduction to Antibacterial Properties
T1  - Antimicrobial properties of (meth)acrylate based hydrogels
EP  - 84
SP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_technorep_4580
ER  - 

@inbook{
author = "Tomić, Simonida and Vuković, Jovana",
year = "2020",
abstract = "The rapid emergence of antibiotic-resistant pathogens is becoming an imminent global public health problem. The development of novel antimicrobial materials aiming to prevent or control infections caused by these pathogens is a very important issue. Polymeric hydrogels are versatile materials, which can be a great alternative to conventional treatments of infections. Because of its high hydrophilicity, unique threedimensional network, fine biocompatibility, and cell adhesion, the hydrogels are suitable biomaterials for drug delivery in antimicrobial areas. The biocompatible nature of hydrogels makes them a convenient starting platform to develop selectively active antimicrobial materials. Hydrogels with antimicrobial properties can be designed by loading of known antimicrobial agents, or the material itself can be designed to possess inherent antimicrobial activity. The combination of polymeric hydrogels based on (meth)acrylate with metal ions (Ag, Cu, and Zn) is a simple and effective approach for obtaining multicomponent systems with diversefunctionalities. Silver (Ag+), copper (Cu2+), and zinc (Zn2+) ions have been loaded into hydrogels for antimicrobial applications. The incorporation of metal ions into hydrogels not only enhances the antimicrobial activity of hydrogels but also influences their swelling and release characteristics. Herein, we summarize recent findings in (meth)acrylate hydrogels containing metal ions with antimicrobial properties.",
journal = "An Introduction to Antibacterial Properties",
booktitle = "Antimicrobial properties of (meth)acrylate based hydrogels",
pages = "84-41",
url = "https://hdl.handle.net/21.15107/rcub_technorep_4580"
}

Tomić, S.,& Vuković, J.. (2020). Antimicrobial properties of (meth)acrylate based hydrogels. in An Introduction to Antibacterial Properties, 41-84.
https://hdl.handle.net/21.15107/rcub_technorep_4580

Tomić S, Vuković J. Antimicrobial properties of (meth)acrylate based hydrogels. in An Introduction to Antibacterial Properties. 2020;:41-84.
https://hdl.handle.net/21.15107/rcub_technorep_4580 .

Tomić, Simonida, Vuković, Jovana, "Antimicrobial properties of (meth)acrylate based hydrogels" in An Introduction to Antibacterial Properties (2020):41-84,
https://hdl.handle.net/21.15107/rcub_technorep_4580 .

TY  - THES
AU  - Vuković, Jovana
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3983
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13373/bdef:Content/download
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:13522/bdef:Izvestaj/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48269071
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4639
AB  - In this doctoral dissertation, the novel polymeric materials were synthesized as carriers for the incorporation and controlled release of therapeutically active metal ions, for the application in wound treatment and soft tissue regeneration. Ability to control the process of local release of incorporated active agent and managеment/prevention of infections, along with the appropriate biological activity, provides successful wound healing, which is the goal of this work. pH and temperature sensitive hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized by free radical polymerization, whereby the itaconic acid content was varied which resulted in H hydrogel series. CI hydrogel series was obtained by incorporation of copper(II) ions in synthesized hydrogels. In order to evaluate the influence of the incorporated metal form on the characteristics and behavior of the hydrogels, the chemical reduction of copper(II) ions was conducted and CR hydrogel series was obtained. The prepared hydrogel series were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC) and monitoring of swelling kinetics, as well as pH and temperature swelling behaviour...
AB  - U ovoj doktorskoj disertaciji sintetisani su novi polimerni materijali kao nosači za ugradnju i kontrolisano otpuštanje terapeutski aktivnih jona metala, za primenu u tretmanu rana i regeneraciji mekog tkiva. Sposobnost kontrole procesa lokalnog otpuštanja ugrađenog aktivnog agensa, kao i kontrole postojećih i sprečavanje nastanka novih infekcija, uz odgovarajuću biološku aktivnost, obezbeđuje uspešno zarastanje rana, što predstavlja cilj ovog rada. Polimerizacijom preko slobodnih radikala sintetisani su rN i temperaturno osetljivi hidrogelovi na bazi 2-hidroksietil akrilata i itakonske kiseline, pri čemu je variran sadržaj itakonske kiseline i na taj način dobijena N serija hidrogelova. Ugradnjom bakar(II) jona u sintetisane hidrogelove dobijeni su hidrogelovi CI serije. U cilju ispitivanja uticaja oblika ugrađenog metala na svojstva i ponašanje hidrogelova, izvršena je hemijska redukcija bakar(II) jona i tako dobijena CR serija hidrogelova sa redukovanim bakrom. Karakterizacija sve tri serije hidrogelova izvršena je primenom infracrvene spektroskopije Furijeovom (Fourier-ovom) transformacijom (FTIR), skenirajuće elektronske mikroskopije (SEM), dinamičko-mehaničke analize (DMA), diferencijalno skenirajuće kalorimetrije (DSK) i praćenjem kinetike bubrenja, kao i rN i temperaturno osetljivog ponašanja pri bubrenju...
PB  - Univerzitet u Beogradu, Tehnološko-metalurški fakultet
T1  - Synthesis and characterization of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid for controlled release of therapeutically active metal ions аpplication.
T1  - Sinteza i karakterizacija hidrogelova na bazi 2-hidroksietil akrilata i itakonske kiseline za primenu u kontrolisanom otpuštanju terapeutski aktivnih jona metala
UR  - https://hdl.handle.net/21.15107/rcub_technorep_4639
ER  - 

@phdthesis{
author = "Vuković, Jovana",
year = "2016",
abstract = "In this doctoral dissertation, the novel polymeric materials were synthesized as carriers for the incorporation and controlled release of therapeutically active metal ions, for the application in wound treatment and soft tissue regeneration. Ability to control the process of local release of incorporated active agent and managеment/prevention of infections, along with the appropriate biological activity, provides successful wound healing, which is the goal of this work. pH and temperature sensitive hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized by free radical polymerization, whereby the itaconic acid content was varied which resulted in H hydrogel series. CI hydrogel series was obtained by incorporation of copper(II) ions in synthesized hydrogels. In order to evaluate the influence of the incorporated metal form on the characteristics and behavior of the hydrogels, the chemical reduction of copper(II) ions was conducted and CR hydrogel series was obtained. The prepared hydrogel series were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), differential scanning calorimetry (DSC) and monitoring of swelling kinetics, as well as pH and temperature swelling behaviour..., U ovoj doktorskoj disertaciji sintetisani su novi polimerni materijali kao nosači za ugradnju i kontrolisano otpuštanje terapeutski aktivnih jona metala, za primenu u tretmanu rana i regeneraciji mekog tkiva. Sposobnost kontrole procesa lokalnog otpuštanja ugrađenog aktivnog agensa, kao i kontrole postojećih i sprečavanje nastanka novih infekcija, uz odgovarajuću biološku aktivnost, obezbeđuje uspešno zarastanje rana, što predstavlja cilj ovog rada. Polimerizacijom preko slobodnih radikala sintetisani su rN i temperaturno osetljivi hidrogelovi na bazi 2-hidroksietil akrilata i itakonske kiseline, pri čemu je variran sadržaj itakonske kiseline i na taj način dobijena N serija hidrogelova. Ugradnjom bakar(II) jona u sintetisane hidrogelove dobijeni su hidrogelovi CI serije. U cilju ispitivanja uticaja oblika ugrađenog metala na svojstva i ponašanje hidrogelova, izvršena je hemijska redukcija bakar(II) jona i tako dobijena CR serija hidrogelova sa redukovanim bakrom. Karakterizacija sve tri serije hidrogelova izvršena je primenom infracrvene spektroskopije Furijeovom (Fourier-ovom) transformacijom (FTIR), skenirajuće elektronske mikroskopije (SEM), dinamičko-mehaničke analize (DMA), diferencijalno skenirajuće kalorimetrije (DSK) i praćenjem kinetike bubrenja, kao i rN i temperaturno osetljivog ponašanja pri bubrenju...",
publisher = "Univerzitet u Beogradu, Tehnološko-metalurški fakultet",
title = "Synthesis and characterization of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid for controlled release of therapeutically active metal ions аpplication., Sinteza i karakterizacija hidrogelova na bazi 2-hidroksietil akrilata i itakonske kiseline za primenu u kontrolisanom otpuštanju terapeutski aktivnih jona metala",
url = "https://hdl.handle.net/21.15107/rcub_technorep_4639"
}

Vuković, J.. (2016). Synthesis and characterization of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid for controlled release of therapeutically active metal ions аpplication.. 
Univerzitet u Beogradu, Tehnološko-metalurški fakultet..
https://hdl.handle.net/21.15107/rcub_technorep_4639

Vuković J. Synthesis and characterization of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid for controlled release of therapeutically active metal ions аpplication.. 2016;.
https://hdl.handle.net/21.15107/rcub_technorep_4639 .

Vuković, Jovana, "Synthesis and characterization of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid for controlled release of therapeutically active metal ions аpplication." (2016),
https://hdl.handle.net/21.15107/rcub_technorep_4639 .

TY  - CONF
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Vuković, Jovana
AU  - Perišić, Marija D.
AU  - Filipović, Vuk
AU  - Davidović, Slađana
AU  - Filipović, Jovanka M.
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3296
AB  - In this study, superporous hydrogels were synthesized by free radical polymerization of 2-hydroxyethyl methacrylate without and in the presence of gelatin. Highly porous hydrogel structures were obtained by two different techniques: using a gas blowing agent, sodium bicarbonate, and a cryogenic treatment followed by freeze-drying. After the gel synthesis, gelatin molecules were covalently immobilised onto PHEMA via glytaraldehyde activation. All samples were characterized for morphological, mechanical, swelling and antibacterial properties. The results obtained show that samples with gelatin show better properties in comparison with PHEMA samples, which make these materials highly attractive for developing hydrogel scaffolds for tissue regeneration.
PB  - Amer Inst Physics, Melville
C3  - VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology
T1  - 2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration
SP  - 4949668
VL  - 1736
DO  - 10.1063/1.4949668
ER  - 

@conference{
author = "Tomić, Simonida and Babić, Marija and Vuković, Jovana and Perišić, Marija D. and Filipović, Vuk and Davidović, Slađana and Filipović, Jovanka M.",
year = "2016",
abstract = "In this study, superporous hydrogels were synthesized by free radical polymerization of 2-hydroxyethyl methacrylate without and in the presence of gelatin. Highly porous hydrogel structures were obtained by two different techniques: using a gas blowing agent, sodium bicarbonate, and a cryogenic treatment followed by freeze-drying. After the gel synthesis, gelatin molecules were covalently immobilised onto PHEMA via glytaraldehyde activation. All samples were characterized for morphological, mechanical, swelling and antibacterial properties. The results obtained show that samples with gelatin show better properties in comparison with PHEMA samples, which make these materials highly attractive for developing hydrogel scaffolds for tissue regeneration.",
publisher = "Amer Inst Physics, Melville",
journal = "VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology",
title = "2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration",
pages = "4949668",
volume = "1736",
doi = "10.1063/1.4949668"
}

Tomić, S., Babić, M., Vuković, J., Perišić, M. D., Filipović, V., Davidović, S.,& Filipović, J. M.. (2016). 2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration. in VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology
Amer Inst Physics, Melville., 1736, 4949668.
https://doi.org/10.1063/1.4949668

Tomić S, Babić M, Vuković J, Perišić MD, Filipović V, Davidović S, Filipović JM. 2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration. in VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology. 2016;1736:4949668.
doi:10.1063/1.4949668 .

Tomić, Simonida, Babić, Marija, Vuković, Jovana, Perišić, Marija D., Filipović, Vuk, Davidović, Slađana, Filipović, Jovanka M., "2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration" in VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology, 1736 (2016):4949668,
https://doi.org/10.1063/1.4949668 . .

TY  - JOUR
AU  - Antić, Katarina
AU  - Babić, Marija
AU  - Vuković, Jovana
AU  - Onjia, Antonije
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3231
AB  - A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb2+ from environment containing Cu2+, Zn2+, Cd2+, Ni2+ and Co2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels
EP  - 705
IS  - 6
SP  - 695
VL  - 70
DO  - 10.2298/HEMIND151225006A
ER  - 

@article{
author = "Antić, Katarina and Babić, Marija and Vuković, Jovana and Onjia, Antonije and Filipović, Jovanka M. and Tomić, Simonida",
year = "2016",
abstract = "A series of poly(2-hydroxyethyl acrylate-co-itaconic acid), P(HEA/IA), hydrogels with different HEA/IA ratio, were synthesized using free radical crosslinking/copolymerization and investigated as sorbents for Pb2+ from aqueous solutions. Hydrogels were characterized using DMA, FTIR, DSC, SEM and AFM. The adsorption was found to be highly dependent on hydrogel composition, solution pH, sorbent weight, ionic strength and contact time. Five isotherm models, Langmuir, Freundlich, Redlich-Peterson, Temkin and Dubinin-Radushkevich, were applied to the sorption data. The best fit was obtained with Redlich-Peterson isotherm. The separation factor, RL, value indicated favorable sorption for Pb2+. The maximum sorption capacities were 392.2 and 409.8 mg/g for P(HEA/2IA) and P(HEA/10IA), respectively. Kinetic data showed best fit with pseudo-second-order model. Thermodynamic studies revealed that the reaction was exothermic and proceeds with a decrease in entropy. Moreover, P(HEA/IA) hydrogel showed the most pronounced sorption toward Pb2+ from environment containing Cu2+, Zn2+, Cd2+, Ni2+ and Co2+. Sorption/desorption experiments, showed that the P(HEA/IA) hydrogels could be reused without significant loss of the initial properties even after three adsorption-desorption cycles.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels",
pages = "705-695",
number = "6",
volume = "70",
doi = "10.2298/HEMIND151225006A"
}

Antić, K., Babić, M., Vuković, J., Onjia, A., Filipović, J. M.,& Tomić, S.. (2016). Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 70(6), 695-705.
https://doi.org/10.2298/HEMIND151225006A

Antić K, Babić M, Vuković J, Onjia A, Filipović JM, Tomić S. Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels. in Hemijska industrija. 2016;70(6):695-705.
doi:10.2298/HEMIND151225006A .

Antić, Katarina, Babić, Marija, Vuković, Jovana, Onjia, Antonije, Filipović, Jovanka M., Tomić, Simonida, "Removal of Pb2+ from aqueous solution by P(HEA/IA) hydrogels" in Hemijska industrija, 70, no. 6 (2016):695-705,
https://doi.org/10.2298/HEMIND151225006A . .

TY  - JOUR
AU  - Vuković, Jovana
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Filipović, Jovanka M.
AU  - Stojanović, Sanja T.
AU  - Najman, Stevo
AU  - Tomić, Simonida
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3352
AB  - In order to evaluate biological response and potential toxicity prior to clinical use as wound dressing materials, three series of hydrogels, based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), unloaded, with incorporated copper(II) ions and reduced copper, were subjected to cytotoxicity testing on L929 cell line (mouse fibroblasts). MTT test revealed proper fibroblast growth in the presence of tested hydrogels, with an absence of any acute toxic effects. Mechanical properties of all three hydrogel series were studied by dynamic mechanical analysis (DMA) and obtained results indicated dominant elastic over viscous behaviour, which supports their application in wound management. The temperature sensitive behaviour of the hydrogels was detected in swelling study conducted in wide range of temperature values 25-50 degrees C, in buffer pH 7.40. The hydrogels exhibited excellent microbial barrier characteristics against Pseudomonas aeruginosa, reducing the risk of bacterial infection in wound bed.
PB  - Elsevier Science Sa, Lausanne
T2  - Materials Chemistry and Physics
T1  - In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management
EP  - 163
SP  - 158
VL  - 175
DO  - 10.1016/j.matchemphys.2016.03.009
ER  - 

@article{
author = "Vuković, Jovana and Babić, Marija and Antić, Katarina and Filipović, Jovanka M. and Stojanović, Sanja T. and Najman, Stevo and Tomić, Simonida",
year = "2016",
abstract = "In order to evaluate biological response and potential toxicity prior to clinical use as wound dressing materials, three series of hydrogels, based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), unloaded, with incorporated copper(II) ions and reduced copper, were subjected to cytotoxicity testing on L929 cell line (mouse fibroblasts). MTT test revealed proper fibroblast growth in the presence of tested hydrogels, with an absence of any acute toxic effects. Mechanical properties of all three hydrogel series were studied by dynamic mechanical analysis (DMA) and obtained results indicated dominant elastic over viscous behaviour, which supports their application in wound management. The temperature sensitive behaviour of the hydrogels was detected in swelling study conducted in wide range of temperature values 25-50 degrees C, in buffer pH 7.40. The hydrogels exhibited excellent microbial barrier characteristics against Pseudomonas aeruginosa, reducing the risk of bacterial infection in wound bed.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Materials Chemistry and Physics",
title = "In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management",
pages = "163-158",
volume = "175",
doi = "10.1016/j.matchemphys.2016.03.009"
}

Vuković, J., Babić, M., Antić, K., Filipović, J. M., Stojanović, S. T., Najman, S.,& Tomić, S.. (2016). In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management. in Materials Chemistry and Physics
Elsevier Science Sa, Lausanne., 175, 158-163.
https://doi.org/10.1016/j.matchemphys.2016.03.009

Vuković J, Babić M, Antić K, Filipović JM, Stojanović ST, Najman S, Tomić S. In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management. in Materials Chemistry and Physics. 2016;175:158-163.
doi:10.1016/j.matchemphys.2016.03.009 .

Vuković, Jovana, Babić, Marija, Antić, Katarina, Filipović, Jovanka M., Stojanović, Sanja T., Najman, Stevo, Tomić, Simonida, "In vitro cytotoxicity assessment of intelligent acrylate based hydrogels with incorporated copper in wound management" in Materials Chemistry and Physics, 175 (2016):158-163,
https://doi.org/10.1016/j.matchemphys.2016.03.009 . .

TY  - JOUR
AU  - Babić, Marija
AU  - Božić, Bojan
AU  - Antić, Katarina
AU  - Jovašević-Vuković, Jovana J.
AU  - Perišić, Marija D.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2970
AB  - Series of novel dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels were designed as multifunctional drug delivery system which can provide several advantages including drug protection, self-regulated oscillatory release and targeted delivery to a single entity. The hydrogels were synthesized by the free-radical crosslinking copolymerization and evaluated as carriers for hydrophobic drug, Oxaprozin, with specific controlled release properties. Structural, morphological, thermal, surface charge, swelling and antimicrobial properties of the hydrogels were investigated for unloaded and Oxaprozin-loaded samples. Swelling studies demonstrated pH- and temperature-sensitivity of drug-free and drug-loaded P(HPA/IA) hydrogels. The results of swelling and oscillatory swelling, and swelling behavior of drug-free, and drug-loaded hydrogels in simulated gastrointestinal conditions, and in vitro Oxaprozin release studies confirmed these hydrogels as a highly effective colon-specific drug delivery system with excellent performance of long-term controlled release. These unique properties make the P(HPA/IA) hydrogels highly attractive materials for developing multifunctional drug delivery systems.
PB  - Elsevier Science Bv, Amsterdam
T2  - Materials Letters
T1  - Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels
EP  - 68
SP  - 64
VL  - 147
DO  - 10.1016/j.matlet.2015.02.035
ER  - 

@article{
author = "Babić, Marija and Božić, Bojan and Antić, Katarina and Jovašević-Vuković, Jovana J. and Perišić, Marija D. and Filipović, Jovanka M. and Tomić, Simonida",
year = "2015",
abstract = "Series of novel dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels were designed as multifunctional drug delivery system which can provide several advantages including drug protection, self-regulated oscillatory release and targeted delivery to a single entity. The hydrogels were synthesized by the free-radical crosslinking copolymerization and evaluated as carriers for hydrophobic drug, Oxaprozin, with specific controlled release properties. Structural, morphological, thermal, surface charge, swelling and antimicrobial properties of the hydrogels were investigated for unloaded and Oxaprozin-loaded samples. Swelling studies demonstrated pH- and temperature-sensitivity of drug-free and drug-loaded P(HPA/IA) hydrogels. The results of swelling and oscillatory swelling, and swelling behavior of drug-free, and drug-loaded hydrogels in simulated gastrointestinal conditions, and in vitro Oxaprozin release studies confirmed these hydrogels as a highly effective colon-specific drug delivery system with excellent performance of long-term controlled release. These unique properties make the P(HPA/IA) hydrogels highly attractive materials for developing multifunctional drug delivery systems.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Materials Letters",
title = "Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels",
pages = "68-64",
volume = "147",
doi = "10.1016/j.matlet.2015.02.035"
}

Babić, M., Božić, B., Antić, K., Jovašević-Vuković, J. J., Perišić, M. D., Filipović, J. M.,& Tomić, S.. (2015). Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels. in Materials Letters
Elsevier Science Bv, Amsterdam., 147, 64-68.
https://doi.org/10.1016/j.matlet.2015.02.035

Babić M, Božić B, Antić K, Jovašević-Vuković JJ, Perišić MD, Filipović JM, Tomić S. Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels. in Materials Letters. 2015;147:64-68.
doi:10.1016/j.matlet.2015.02.035 .

Babić, Marija, Božić, Bojan, Antić, Katarina, Jovašević-Vuković, Jovana J., Perišić, Marija D., Filipović, Jovanka M., Tomić, Simonida, "Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels" in Materials Letters, 147 (2015):64-68,
https://doi.org/10.1016/j.matlet.2015.02.035 . .

TY  - JOUR
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Jovašević-Vuković, Jovana J.
AU  - Božić, Bojan
AU  - Davidović, Slađana
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3023
AB  - In this study, a series of novel stimuli-sensitive hydrogels based on 2-hydroxyethyl acrylate and itaconic acid monomers were designed for the controlled release of hydrophobic drug, Oxaprozin. All samples were synthesized by the free-radical crosslinking copolymerization and characterized for structural, morphological, thermal, surface charge, swelling and antibacterial properties. In order to investigate the influence of the drug on hydrogel properties the same characterization was conducted for all Oxaprozin-loaded samples. The chemical composition of hydrogels was studied using Fourier transform infrared spectroscopy, while their morphology and thermal properties were examined by scanning electron microscopy and differential scanning calorimetry. Swelling studies, conducted in the physiological pH range from 2.20 to 8.00 and in the temperature range from 25 to 50 degrees C, showed that the loaded drug does not modify the pH and temperature sensitivity of the hydrogels, but reduces their swelling capacity. The in vitro drug release study conducted at pH 2.20 and 7.40 showed that all hydrogels can be tailored as colon specific drug delivery systems, and the drug release rate can be effectively controlled by IA content. In addition, the antibacterial activity of the hydrogels was determined against Escherichia coli and Staphylococcus aureus, by the zone of inhibition test. Results of our study indicate that these "smart" hydrogels, with specific morphology, surface charge, swelling capacity, drug loading efficiency and release behavior, could be designed to obtain an enhanced and site-specific controlled drug release system by simply adjusting their composition.
PB  - Springer, New York
T2  - Journal of Materials Science
T1  - Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties
EP  - 922
IS  - 2
SP  - 906
VL  - 50
DO  - 10.1007/s10853-014-8651-z
ER  - 

@article{
author = "Babić, Marija and Antić, Katarina and Jovašević-Vuković, Jovana J. and Božić, Bojan and Davidović, Slađana and Filipović, Jovanka M. and Tomić, Simonida",
year = "2015",
abstract = "In this study, a series of novel stimuli-sensitive hydrogels based on 2-hydroxyethyl acrylate and itaconic acid monomers were designed for the controlled release of hydrophobic drug, Oxaprozin. All samples were synthesized by the free-radical crosslinking copolymerization and characterized for structural, morphological, thermal, surface charge, swelling and antibacterial properties. In order to investigate the influence of the drug on hydrogel properties the same characterization was conducted for all Oxaprozin-loaded samples. The chemical composition of hydrogels was studied using Fourier transform infrared spectroscopy, while their morphology and thermal properties were examined by scanning electron microscopy and differential scanning calorimetry. Swelling studies, conducted in the physiological pH range from 2.20 to 8.00 and in the temperature range from 25 to 50 degrees C, showed that the loaded drug does not modify the pH and temperature sensitivity of the hydrogels, but reduces their swelling capacity. The in vitro drug release study conducted at pH 2.20 and 7.40 showed that all hydrogels can be tailored as colon specific drug delivery systems, and the drug release rate can be effectively controlled by IA content. In addition, the antibacterial activity of the hydrogels was determined against Escherichia coli and Staphylococcus aureus, by the zone of inhibition test. Results of our study indicate that these "smart" hydrogels, with specific morphology, surface charge, swelling capacity, drug loading efficiency and release behavior, could be designed to obtain an enhanced and site-specific controlled drug release system by simply adjusting their composition.",
publisher = "Springer, New York",
journal = "Journal of Materials Science",
title = "Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties",
pages = "922-906",
number = "2",
volume = "50",
doi = "10.1007/s10853-014-8651-z"
}

Babić, M., Antić, K., Jovašević-Vuković, J. J., Božić, B., Davidović, S., Filipović, J. M.,& Tomić, S.. (2015). Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties. in Journal of Materials Science
Springer, New York., 50(2), 906-922.
https://doi.org/10.1007/s10853-014-8651-z

Babić M, Antić K, Jovašević-Vuković JJ, Božić B, Davidović S, Filipović JM, Tomić S. Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties. in Journal of Materials Science. 2015;50(2):906-922.
doi:10.1007/s10853-014-8651-z .

Babić, Marija, Antić, Katarina, Jovašević-Vuković, Jovana J., Božić, Bojan, Davidović, Slađana, Filipović, Jovanka M., Tomić, Simonida, "Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties" in Journal of Materials Science, 50, no. 2 (2015):906-922,
https://doi.org/10.1007/s10853-014-8651-z . .

TY  - JOUR
AU  - Antić, Katarina
AU  - Babić, Marija
AU  - Jovašević-Vuković, Jovana J.
AU  - Vasiljević-Radović, Dana
AU  - Onjia, Antonije
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3027
AB  - Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal.
PB  - Elsevier Science Bv, Amsterdam
T2  - Applied Surface Science
T1  - Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution
EP  - 189
SP  - 178
VL  - 338
DO  - 10.1016/j.apsusc.2015.02.133
ER  - 

@article{
author = "Antić, Katarina and Babić, Marija and Jovašević-Vuković, Jovana J. and Vasiljević-Radović, Dana and Onjia, Antonije and Filipović, Jovanka M. and Tomić, Simonida",
year = "2015",
abstract = "Series of novel hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA), P(HEA/IA) copolymers, were prepared by free radical cross-linking copolymerization and investigated as potential adsorbents for Cd2+ removal from aqueous solution. The hydrogels before and after Cd2+ adsorption were characterized using FTIR, temperature sensitive. In order to evaluate adsorption behavior of samples various factors affecting the Cd2+ uptake behavior, such as: contact time, temperature, pH, ionic strength, adsorbent weight, competitive ions and initial concentration of the metal ions were investigated. Five adsorption isotherms and two kinetic models were studied. The adsorption behavior can be very well described by the pseudo-second order kinetic model and Langmuir isotherm. Multicomponent adsorption studies revealed that adsorption of cadmium depends on the type of metal ions present in the system. Desorption studies showed that hydrogel can be reused three times with only 15% loss of adsorption capacity. All results indicate that the sample with the highest IA content is the most promising adsorbent for Cd2+ removal.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Applied Surface Science",
title = "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution",
pages = "189-178",
volume = "338",
doi = "10.1016/j.apsusc.2015.02.133"
}

Antić, K., Babić, M., Jovašević-Vuković, J. J., Vasiljević-Radović, D., Onjia, A., Filipović, J. M.,& Tomić, S.. (2015). Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science
Elsevier Science Bv, Amsterdam., 338, 178-189.
https://doi.org/10.1016/j.apsusc.2015.02.133

Antić K, Babić M, Jovašević-Vuković JJ, Vasiljević-Radović D, Onjia A, Filipović JM, Tomić S. Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution. in Applied Surface Science. 2015;338:178-189.
doi:10.1016/j.apsusc.2015.02.133 .

Antić, Katarina, Babić, Marija, Jovašević-Vuković, Jovana J., Vasiljević-Radović, Dana, Onjia, Antonije, Filipović, Jovanka M., Tomić, Simonida, "Preparation and characterization of novel P(HEA/IA) hydrogels for Cd2+ ion removal from aqueous solution" in Applied Surface Science, 338 (2015):178-189,
https://doi.org/10.1016/j.apsusc.2015.02.133 . .

TY  - JOUR
AU  - Vuković, Jovana
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Miljković, Miona
AU  - Perić-Grujić, Aleksandra
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3139
AB  - In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.
PB  - Elsevier Science Sa, Lausanne
T2  - Materials Chemistry and Physics
T1  - A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application
EP  - 62
SP  - 51
VL  - 164
DO  - 10.1016/j.matchemphys.2015.08.022
ER  - 

@article{
author = "Vuković, Jovana and Babić, Marija and Antić, Katarina and Miljković, Miona and Perić-Grujić, Aleksandra and Filipović, Jovanka M. and Tomić, Simonida",
year = "2015",
abstract = "In this study, three series of hydrogels based on 2-hydroxyethyl acrylate and itaconic acid, unloaded, with incorporated copper(II) ions and reduced copper, were successfully prepared, characterized and evaluated as novel wound healing materials. Fourier transform infrared spectroscopy (FTIR) confirmed the expected structure of obtained hydrogels. Scanning electron microscopy (SEM) revealed porous morphology of unloaded hydrogels, and the morphological modifications in case of loaded hydrogels. Thermal characteristics were examined by differential scanning calorimetry (DSC) and the glass transition temperatures were observed in range of 12-50 degrees C. Swelling study was conducted in wide range of pHs at 37 degrees C, confirming pH sensitive behaviour for all three series of hydrogels. The in vitro copper release was investigated and the experimental data were analysed using several models in order to elucidate the transport mechanism. The antimicrobial assay revealed excellent antimicrobial activity, over 99% against Escherichia coli, Staphylococcus aureus and Candida albicans, as well as good correlation with the copper release experiments. In accordance with potential application, water vapour transmission rate, oxygen penetration, dispersion characteristics, fluid retention were observed and the suitability of the hydrogels for wound healing application was discussed.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Materials Chemistry and Physics",
title = "A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application",
pages = "62-51",
volume = "164",
doi = "10.1016/j.matchemphys.2015.08.022"
}

Vuković, J., Babić, M., Antić, K., Miljković, M., Perić-Grujić, A., Filipović, J. M.,& Tomić, S.. (2015). A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application. in Materials Chemistry and Physics
Elsevier Science Sa, Lausanne., 164, 51-62.
https://doi.org/10.1016/j.matchemphys.2015.08.022

Vuković J, Babić M, Antić K, Miljković M, Perić-Grujić A, Filipović JM, Tomić S. A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application. in Materials Chemistry and Physics. 2015;164:51-62.
doi:10.1016/j.matchemphys.2015.08.022 .

Vuković, Jovana, Babić, Marija, Antić, Katarina, Miljković, Miona, Perić-Grujić, Aleksandra, Filipović, Jovanka M., Tomić, Simonida, "A high efficacy antimicrobial acrylate based hydrogels with incorporated copper for wound healing application" in Materials Chemistry and Physics, 164 (2015):51-62,
https://doi.org/10.1016/j.matchemphys.2015.08.022 . .

TY  - JOUR
AU  - Malešić, Neda B.
AU  - Rusmirović, Jelena
AU  - Jovašević, Jovana S.
AU  - Perišić, Marija D.
AU  - Dimitrijević, Suzana
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2595
AB  - The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time.
AB  - Cilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.
PB  - Savez inženjera i tehničara Srbije, Beograd
T2  - Tehnika
T1  - Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion
T1  - Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon
EP  - 568
IS  - 4
SP  - 563
VL  - 69
DO  - 10.5937/tehnika1404563M
ER  - 

@article{
author = "Malešić, Neda B. and Rusmirović, Jelena and Jovašević, Jovana S. and Perišić, Marija D. and Dimitrijević, Suzana and Filipović, Jovanka M. and Tomić, Simonida",
year = "2014",
abstract = "The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time., Cilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.",
publisher = "Savez inženjera i tehničara Srbije, Beograd",
journal = "Tehnika",
title = "Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion, Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon",
pages = "568-563",
number = "4",
volume = "69",
doi = "10.5937/tehnika1404563M"
}

Malešić, N. B., Rusmirović, J., Jovašević, J. S., Perišić, M. D., Dimitrijević, S., Filipović, J. M.,& Tomić, S.. (2014). Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion. in Tehnika
Savez inženjera i tehničara Srbije, Beograd., 69(4), 563-568.
https://doi.org/10.5937/tehnika1404563M

Malešić NB, Rusmirović J, Jovašević JS, Perišić MD, Dimitrijević S, Filipović JM, Tomić S. Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion. in Tehnika. 2014;69(4):563-568.
doi:10.5937/tehnika1404563M .

Malešić, Neda B., Rusmirović, Jelena, Jovašević, Jovana S., Perišić, Marija D., Dimitrijević, Suzana, Filipović, Jovanka M., Tomić, Simonida, "Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion" in Tehnika, 69, no. 4 (2014):563-568,
https://doi.org/10.5937/tehnika1404563M . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Jovašević-Vuković, Jovana J.
AU  - Malešić, Neda B.
AU  - Filipović, Jovanka M.
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2719
AB  - Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.
PB  - Polymer Soc Korea, Seoul
T2  - Macromolecular Research
T1  - pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid
EP  - 1213
IS  - 11
SP  - 1203
VL  - 22
DO  - 10.1007/s13233-014-2172-0
ER  - 

@article{
author = "Tomić, Simonida and Babić, Marija and Antić, Katarina and Jovašević-Vuković, Jovana J. and Malešić, Neda B. and Filipović, Jovanka M.",
year = "2014",
abstract = "Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.",
publisher = "Polymer Soc Korea, Seoul",
journal = "Macromolecular Research",
title = "pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid",
pages = "1213-1203",
number = "11",
volume = "22",
doi = "10.1007/s13233-014-2172-0"
}

Tomić, S., Babić, M., Antić, K., Jovašević-Vuković, J. J., Malešić, N. B.,& Filipović, J. M.. (2014). pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid. in Macromolecular Research
Polymer Soc Korea, Seoul., 22(11), 1203-1213.
https://doi.org/10.1007/s13233-014-2172-0

Tomić S, Babić M, Antić K, Jovašević-Vuković JJ, Malešić NB, Filipović JM. pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid. in Macromolecular Research. 2014;22(11):1203-1213.
doi:10.1007/s13233-014-2172-0 .

Tomić, Simonida, Babić, Marija, Antić, Katarina, Jovašević-Vuković, Jovana J., Malešić, Neda B., Filipović, Jovanka M., "pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid" in Macromolecular Research, 22, no. 11 (2014):1203-1213,
https://doi.org/10.1007/s13233-014-2172-0 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Jovašević, Jovana S.
AU  - Filipović, Jovanka M.
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2399
AB  - Two series of novel hydrogels, based on 2-hydroxyethyl acrylate (HEA), itaconic acid (IA), and two poly(ethylene glycol) dimethacrylates (PEGDMA), of different ethylene glycol chain lengths, were prepared by free radical crosslinking copolymerization. The influence of different ethylene glycol chain lengths and concentration in P(HEA/IA/PEGDMA) hydrogels on biocompatibility, swelling and thermal properties was investigated. All samples in contact with blood showed a mean hemolysis value  lt  1.0 % in the direct contact assay, and even  lt  0.5 % in the indirect contact assay, for in vitro testing conditions. Swelling studies, conducted in a physiological pH and temperature range, showed pH sensitivity and relatively small changes of equilibrium swelling with temperature, which varied with PEGDMA molecular weight. The glass transition temperatures (T (g)) of P(HEA/IA/PEGDMA) networks were in the range 28.1-36.9 A degrees C, respectively, and also dependent on copolymer composition. Due to good biocompatibility, favorable swelling, and thermal properties these hydrogels show good potential for biomedical uses.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate
EP  - 2909
IS  - 10
SP  - 2895
VL  - 70
DO  - 10.1007/s00289-013-0995-z
ER  - 

@article{
author = "Tomić, Simonida and Jovašević, Jovana S. and Filipović, Jovanka M.",
year = "2013",
abstract = "Two series of novel hydrogels, based on 2-hydroxyethyl acrylate (HEA), itaconic acid (IA), and two poly(ethylene glycol) dimethacrylates (PEGDMA), of different ethylene glycol chain lengths, were prepared by free radical crosslinking copolymerization. The influence of different ethylene glycol chain lengths and concentration in P(HEA/IA/PEGDMA) hydrogels on biocompatibility, swelling and thermal properties was investigated. All samples in contact with blood showed a mean hemolysis value  lt  1.0 % in the direct contact assay, and even  lt  0.5 % in the indirect contact assay, for in vitro testing conditions. Swelling studies, conducted in a physiological pH and temperature range, showed pH sensitivity and relatively small changes of equilibrium swelling with temperature, which varied with PEGDMA molecular weight. The glass transition temperatures (T (g)) of P(HEA/IA/PEGDMA) networks were in the range 28.1-36.9 A degrees C, respectively, and also dependent on copolymer composition. Due to good biocompatibility, favorable swelling, and thermal properties these hydrogels show good potential for biomedical uses.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate",
pages = "2909-2895",
number = "10",
volume = "70",
doi = "10.1007/s00289-013-0995-z"
}

Tomić, S., Jovašević, J. S.,& Filipović, J. M.. (2013). Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate. in Polymer Bulletin
Springer, New York., 70(10), 2895-2909.
https://doi.org/10.1007/s00289-013-0995-z

Tomić S, Jovašević JS, Filipović JM. Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate. in Polymer Bulletin. 2013;70(10):2895-2909.
doi:10.1007/s00289-013-0995-z .

Tomić, Simonida, Jovašević, Jovana S., Filipović, Jovanka M., "Hemocompatibility, swelling and thermal properties of hydrogels based on 2-hydroxyethyl acrylate, itaconic acid and poly(ethylene glycol) dimethacrylate" in Polymer Bulletin, 70, no. 10 (2013):2895-2909,
https://doi.org/10.1007/s00289-013-0995-z . .

TY  - JOUR
AU  - Babić, Marija
AU  - Jovašević, Jovana S.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2093
AB  - The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly- (2-hydroxyethylmethacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethylacrylate/ita- conic acid) (P(HEA/IA)), and poly(2-hydroxyethylmethacrylate/poly(alkyleneglycol) (meth)- acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkyleneglycol) (meth)acrylates), ultimately defined the pore size available for drug diffusion. The hydrogels synthesized ranged from nonporous to microporous, based on the classification in accordance to the pore size, and could be classified as hydrogels that contain ionic groups and hydrogels without ionic groups. The drugs selected for this study are bronchodilators-theophylline (TPH), fenethylline hydrochloride (FE), and antibiotic cephalexin (CEX). Results of in vitro drug release tests defined the release systems based on the drug type, as well as the type of hydrogel used. The diffusion coefficient of drugs and the restriction coefficient, λ, defined as the ratio of solute to 'pore' radius (rs/rζ) that describes the ease of drug release from the gels, were used as factors that govern the release process.
AB  - Cilj ove studije je da se predlože difuzione jednačine za ispitivane sisteme lek/hidrogel. Korišćeni su hidrogelovi poli(2-hidroksietilmetakrilat/itakonska kiselina) (P(HEMA/IK)), poli(2-hidroksietilakrilat/itakonska kiselina) (P(HEA/IK)) i poli-(2-hidroksietilmetakrilat/poli(alkilenglikol)-(met)akrilati) (P(HEMA/BIS)). Komponenta koja se menja u sastavu hidrogela HEMA, HEA, kao i udeo komponente sa promenljivim sadržajem (udeo jonizujućeg komonomera (IK) i tip BIS komponente) definiše veličinu pora koja je dostupna za difuziju leka. U ovoj studiji su korišćeni lekovi bronhodilatori teofilin (TPH) i fenetilin-hidrohlorid (FE), i antibiotik cefaleksin (CEX). Ovi gelovi su klasifikovani u režimu poroznosti kao neporozni i mikroporozni, sa veličinom pora u opsegu 0,18-24,9 nm. Kontrolisano otpuštanje lekova je izvedeno u in vitro uslovima u puferu pH 7,40 i na 37 °C, da bi se odredili difuzioni koeficijenti leka u hidrogelovima. Na osnovu toga su predložene jednačine difuzije leka kroz hidrogel za svaki sistem lek/hidrogel. Rezultati dobijeni fitovanjem eksperimentalnih podataka su pokazali da difuzija leka zavisi od hemijske strukture i morfologije hidrogela i parametra λ, koji predstavlja odnos prečnika leka i veličine pora. Eksponencijalna zavisnost koeficijenta restrikcije od normalizovanog koeficijenta difuzije je dobijena za sisteme TPH/P(HEMA/IA), FE/P(HEMA/ /IA), CEX/P(HEMA/BIS) i CEX/P(HEA/IA).Utvrđeno je da veliki uticaj na difuziju leka imaju interakcije koje se odigravaju između funkcionalnih grupa leka i polimerne mreže.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid
T1  - Difuzija lekova u hidrogelovima na bazi (met)akrilata, poli(alkilenglikol)-(met)akrilata i itakonske kiseline
EP  - 829
IS  - 6
SP  - 823
VL  - 66
DO  - 10.2298/HEMIND120406073B
ER  - 

@article{
author = "Babić, Marija and Jovašević, Jovana S. and Filipović, Jovanka M. and Tomić, Simonida",
year = "2012",
abstract = "The aim of this paper is to propose equations for the diffusion of drugs for investigated drug/hydrogel systems using the parameters affecting the transport of drug through poly- (2-hydroxyethylmethacrylate/itaconic acid) (P(HEMA/IA)), poly(2-hydroxyethylacrylate/ita- conic acid) (P(HEA/IA)), and poly(2-hydroxyethylmethacrylate/poly(alkyleneglycol) (meth)- acrylates) (P(HEMA/BIS)) copolymeric hydrogels. Different monomer types, as well as the variable content of some components in hydrogel composition (the amount of ionizable comonomer (IA) and different type of nonionic poly(alkyleneglycol) (meth)acrylates), ultimately defined the pore size available for drug diffusion. The hydrogels synthesized ranged from nonporous to microporous, based on the classification in accordance to the pore size, and could be classified as hydrogels that contain ionic groups and hydrogels without ionic groups. The drugs selected for this study are bronchodilators-theophylline (TPH), fenethylline hydrochloride (FE), and antibiotic cephalexin (CEX). Results of in vitro drug release tests defined the release systems based on the drug type, as well as the type of hydrogel used. The diffusion coefficient of drugs and the restriction coefficient, λ, defined as the ratio of solute to 'pore' radius (rs/rζ) that describes the ease of drug release from the gels, were used as factors that govern the release process., Cilj ove studije je da se predlože difuzione jednačine za ispitivane sisteme lek/hidrogel. Korišćeni su hidrogelovi poli(2-hidroksietilmetakrilat/itakonska kiselina) (P(HEMA/IK)), poli(2-hidroksietilakrilat/itakonska kiselina) (P(HEA/IK)) i poli-(2-hidroksietilmetakrilat/poli(alkilenglikol)-(met)akrilati) (P(HEMA/BIS)). Komponenta koja se menja u sastavu hidrogela HEMA, HEA, kao i udeo komponente sa promenljivim sadržajem (udeo jonizujućeg komonomera (IK) i tip BIS komponente) definiše veličinu pora koja je dostupna za difuziju leka. U ovoj studiji su korišćeni lekovi bronhodilatori teofilin (TPH) i fenetilin-hidrohlorid (FE), i antibiotik cefaleksin (CEX). Ovi gelovi su klasifikovani u režimu poroznosti kao neporozni i mikroporozni, sa veličinom pora u opsegu 0,18-24,9 nm. Kontrolisano otpuštanje lekova je izvedeno u in vitro uslovima u puferu pH 7,40 i na 37 °C, da bi se odredili difuzioni koeficijenti leka u hidrogelovima. Na osnovu toga su predložene jednačine difuzije leka kroz hidrogel za svaki sistem lek/hidrogel. Rezultati dobijeni fitovanjem eksperimentalnih podataka su pokazali da difuzija leka zavisi od hemijske strukture i morfologije hidrogela i parametra λ, koji predstavlja odnos prečnika leka i veličine pora. Eksponencijalna zavisnost koeficijenta restrikcije od normalizovanog koeficijenta difuzije je dobijena za sisteme TPH/P(HEMA/IA), FE/P(HEMA/ /IA), CEX/P(HEMA/BIS) i CEX/P(HEA/IA).Utvrđeno je da veliki uticaj na difuziju leka imaju interakcije koje se odigravaju između funkcionalnih grupa leka i polimerne mreže.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid, Difuzija lekova u hidrogelovima na bazi (met)akrilata, poli(alkilenglikol)-(met)akrilata i itakonske kiseline",
pages = "829-823",
number = "6",
volume = "66",
doi = "10.2298/HEMIND120406073B"
}

Babić, M., Jovašević, J. S., Filipović, J. M.,& Tomić, S.. (2012). Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid. in Hemijska industrija
Association of Chemical Engineers of Serbia., 66(6), 823-829.
https://doi.org/10.2298/HEMIND120406073B

Babić M, Jovašević JS, Filipović JM, Tomić S. Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid. in Hemijska industrija. 2012;66(6):823-829.
doi:10.2298/HEMIND120406073B .

Babić, Marija, Jovašević, Jovana S., Filipović, Jovanka M., Tomić, Simonida, "Diffusion of drugs in hydrogels based on (meth)acrylates, poly(alkylene glycol) (meth)acrylates and itaconic acid" in Hemijska industrija, 66, no. 6 (2012):823-829,
https://doi.org/10.2298/HEMIND120406073B . .

TY  - CONF
AU  - Tomić, Simonida
AU  - Jovašević, Jovana S.
AU  - Perić-Grujić, Aleksandra
AU  - Dimitrijević, Suzana
AU  - Filipović, Jovanka M.
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2184
PB  - Springer, New York
C3  - 5th European Conference of the International Federation for Medical and Biological Engineering, Pts
T1  - Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels
EP  - 974
SP  - 974
VL  - 37
UR  - https://hdl.handle.net/21.15107/rcub_technorep_2184
ER  - 

@conference{
author = "Tomić, Simonida and Jovašević, Jovana S. and Perić-Grujić, Aleksandra and Dimitrijević, Suzana and Filipović, Jovanka M.",
year = "2012",
publisher = "Springer, New York",
journal = "5th European Conference of the International Federation for Medical and Biological Engineering, Pts",
title = "Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels",
pages = "974-974",
volume = "37",
url = "https://hdl.handle.net/21.15107/rcub_technorep_2184"
}

Tomić, S., Jovašević, J. S., Perić-Grujić, A., Dimitrijević, S.,& Filipović, J. M.. (2012). Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels. in 5th European Conference of the International Federation for Medical and Biological Engineering, Pts
Springer, New York., 37, 974-974.
https://hdl.handle.net/21.15107/rcub_technorep_2184

Tomić S, Jovašević JS, Perić-Grujić A, Dimitrijević S, Filipović JM. Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels. in 5th European Conference of the International Federation for Medical and Biological Engineering, Pts. 2012;37:974-974.
https://hdl.handle.net/21.15107/rcub_technorep_2184 .

Tomić, Simonida, Jovašević, Jovana S., Perić-Grujić, Aleksandra, Dimitrijević, Suzana, Filipović, Jovanka M., "Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels" in 5th European Conference of the International Federation for Medical and Biological Engineering, Pts, 37 (2012):974-974,
https://hdl.handle.net/21.15107/rcub_technorep_2184 .