TY  - JOUR
AU  - Lopičić, Srđan
AU  - Svirčev, Zorica
AU  - Palanački Malešević, Tamara
AU  - Kopitović, Aleksandar
AU  - Ivanovska, Aleksandra
AU  - Meriluoto, Jussi
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5294
AB  - In the present review we have discussed the occurrence of β-N-methylamino-L-alanine (BMAA) and its natural isomers, and the organisms and sample types in which the toxin(s) have been detected. Further, the review discusses general pathogenic mechanisms of neurodegenerative diseases, and how modes of action of BMAA fit in those mechanisms. The biogeography of BMAA occurrence presented here contributes to the planning of epidemiological research based on the geographical distribution of BMAA and human exposure. Analysis of BMAA mechanisms in relation to pathogenic processes of neurodegeneration is used to critically assess the potential significance of the amino acid as well as to identify gaps in our understanding. Taken together, these two approaches provide the basis for the discussion on the potential role of BMAA as a secondary factor in neurodegenerative diseases, the rationale for further research and possible directions the research can take, which are outlined in the conclusions.
PB  - MDPI
T2  - Microorganisms
T1  - Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases
IS  - 12
SP  - 2418
VL  - 10
DO  - 10.3390/microorganisms10122418
ER  - 

@article{
author = "Lopičić, Srđan and Svirčev, Zorica and Palanački Malešević, Tamara and Kopitović, Aleksandar and Ivanovska, Aleksandra and Meriluoto, Jussi",
year = "2022",
abstract = "In the present review we have discussed the occurrence of β-N-methylamino-L-alanine (BMAA) and its natural isomers, and the organisms and sample types in which the toxin(s) have been detected. Further, the review discusses general pathogenic mechanisms of neurodegenerative diseases, and how modes of action of BMAA fit in those mechanisms. The biogeography of BMAA occurrence presented here contributes to the planning of epidemiological research based on the geographical distribution of BMAA and human exposure. Analysis of BMAA mechanisms in relation to pathogenic processes of neurodegeneration is used to critically assess the potential significance of the amino acid as well as to identify gaps in our understanding. Taken together, these two approaches provide the basis for the discussion on the potential role of BMAA as a secondary factor in neurodegenerative diseases, the rationale for further research and possible directions the research can take, which are outlined in the conclusions.",
publisher = "MDPI",
journal = "Microorganisms",
title = "Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases",
number = "12",
pages = "2418",
volume = "10",
doi = "10.3390/microorganisms10122418"
}

Lopičić, S., Svirčev, Z., Palanački Malešević, T., Kopitović, A., Ivanovska, A.,& Meriluoto, J.. (2022). Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases. in Microorganisms
MDPI., 10(12), 2418.
https://doi.org/10.3390/microorganisms10122418

Lopičić S, Svirčev Z, Palanački Malešević T, Kopitović A, Ivanovska A, Meriluoto J. Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases. in Microorganisms. 2022;10(12):2418.
doi:10.3390/microorganisms10122418 .

Lopičić, Srđan, Svirčev, Zorica, Palanački Malešević, Tamara, Kopitović, Aleksandar, Ivanovska, Aleksandra, Meriluoto, Jussi, "Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases" in Microorganisms, 10, no. 12 (2022):2418,
https://doi.org/10.3390/microorganisms10122418 . .