TY  - JOUR
AU  - Ilić, Jovana M.
AU  - Grujić, Aleksandar
AU  - Stijepović, Mirko
AU  - Stajić-Trošić, Jasna
AU  - Bugarski, Branko
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2906
AB  - The aim of this paper is to obtain microbeads of natural polymers such as alginate and chitosan. These microbeads were used as potential carriers for the active ingredients so that in this study the diffusion of various substances from them is analyzed. Alginate microbeads were obtained by electrostatic droplet method. In the resulting microbeads was performed absorption of three tracer indicators with different molecular weight (acridine orange, blue dextran, methylene blue). The goal of the experiment is to monitor indicators release kinetics from microbeads. Based on these measurements the layoffs curve should give an answer on the impact of the molecular size of the three indicators on the diffusion rate of microbeads. In order to achieve the slow release of indicators alginate microbeads were coated with chitosan. Chitosan has an impact on reducing the porosity of gel, which further led to lower release tracer indicators of microbeads. Comparative analysis of the obtained layoffs curves answers about the impact on the process of obtaining micro diffusion rate indicator.
AB  - U ovom radu je prikazan proces sinteze mikročestica od prirodnih polimera, alginata i hitozana, kao i neka njihova svojstva. Osnovna primena ovih mikročestica je da se koriste kao potencijalni nosači za aktivne supstance. U tom smislu je ispitivana i difuzija različitih supstanci iz njih. Na alginatne mikročestice dobijene metodom elektrostatičke ekstruzije vršena je apsorpcija tri trejserska indikatora sa različitim molekulskim masama: akridin oranž, plavi dekstran i metilensko plavo. Praćenjem kinetike otpuštanja indikatora iz mikročestica konstruisane su krive otpuštanja koje daju informaciju o uticaju veličine molekula svakog od indikatora na brzinu difuzije iz mikročestica. Da bi se postiglo što sporije otpuštanje indikatora alginatne mikročestice su oblagane hitozanom. Hitozan ima uticaj na smanjenje poroznosti gela, što dovodi do sporijeg otpuštanja trejsersikh indikatora iz mikročestica. Uporedna analiza dobijenih krivih otpuštanja daje odgovor o uticaju postupka dobijanja mikročestica na brzinu difuzije indikatora.
PB  - Savez inženjera i tehničara Srbije, Beograd
T2  - Tehnika
T1  - Effect of tracers molecular weight on the release process from alginate microbeads
T1  - Uticaj molekulske mase trejserskih indikatora na kontrolisano otpuštanje iz alginatnih mikročestica
EP  - 405
IS  - 3
SP  - 401
VL  - 70
DO  - 10.5937/tehnika1503401I
ER  - 

@article{
author = "Ilić, Jovana M. and Grujić, Aleksandar and Stijepović, Mirko and Stajić-Trošić, Jasna and Bugarski, Branko",
year = "2015",
abstract = "The aim of this paper is to obtain microbeads of natural polymers such as alginate and chitosan. These microbeads were used as potential carriers for the active ingredients so that in this study the diffusion of various substances from them is analyzed. Alginate microbeads were obtained by electrostatic droplet method. In the resulting microbeads was performed absorption of three tracer indicators with different molecular weight (acridine orange, blue dextran, methylene blue). The goal of the experiment is to monitor indicators release kinetics from microbeads. Based on these measurements the layoffs curve should give an answer on the impact of the molecular size of the three indicators on the diffusion rate of microbeads. In order to achieve the slow release of indicators alginate microbeads were coated with chitosan. Chitosan has an impact on reducing the porosity of gel, which further led to lower release tracer indicators of microbeads. Comparative analysis of the obtained layoffs curves answers about the impact on the process of obtaining micro diffusion rate indicator., U ovom radu je prikazan proces sinteze mikročestica od prirodnih polimera, alginata i hitozana, kao i neka njihova svojstva. Osnovna primena ovih mikročestica je da se koriste kao potencijalni nosači za aktivne supstance. U tom smislu je ispitivana i difuzija različitih supstanci iz njih. Na alginatne mikročestice dobijene metodom elektrostatičke ekstruzije vršena je apsorpcija tri trejserska indikatora sa različitim molekulskim masama: akridin oranž, plavi dekstran i metilensko plavo. Praćenjem kinetike otpuštanja indikatora iz mikročestica konstruisane su krive otpuštanja koje daju informaciju o uticaju veličine molekula svakog od indikatora na brzinu difuzije iz mikročestica. Da bi se postiglo što sporije otpuštanje indikatora alginatne mikročestice su oblagane hitozanom. Hitozan ima uticaj na smanjenje poroznosti gela, što dovodi do sporijeg otpuštanja trejsersikh indikatora iz mikročestica. Uporedna analiza dobijenih krivih otpuštanja daje odgovor o uticaju postupka dobijanja mikročestica na brzinu difuzije indikatora.",
publisher = "Savez inženjera i tehničara Srbije, Beograd",
journal = "Tehnika",
title = "Effect of tracers molecular weight on the release process from alginate microbeads, Uticaj molekulske mase trejserskih indikatora na kontrolisano otpuštanje iz alginatnih mikročestica",
pages = "405-401",
number = "3",
volume = "70",
doi = "10.5937/tehnika1503401I"
}

Ilić, J. M., Grujić, A., Stijepović, M., Stajić-Trošić, J.,& Bugarski, B.. (2015). Effect of tracers molecular weight on the release process from alginate microbeads. in Tehnika
Savez inženjera i tehničara Srbije, Beograd., 70(3), 401-405.
https://doi.org/10.5937/tehnika1503401I

Ilić JM, Grujić A, Stijepović M, Stajić-Trošić J, Bugarski B. Effect of tracers molecular weight on the release process from alginate microbeads. in Tehnika. 2015;70(3):401-405.
doi:10.5937/tehnika1503401I .

Ilić, Jovana M., Grujić, Aleksandar, Stijepović, Mirko, Stajić-Trošić, Jasna, Bugarski, Branko, "Effect of tracers molecular weight on the release process from alginate microbeads" in Tehnika, 70, no. 3 (2015):401-405,
https://doi.org/10.5937/tehnika1503401I . .