TY  - JOUR
AU  - Dobić, Sava N.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2213
AB  - Hydrogels based on 2-hydroxyethyl methacrylate (HEMA), different poly(ethylene glycol) dimethacrylates (PEGDMA) and itaconic acid (IA) were prepared by free radical crosslinking copolymerization. The influence of different PEGDMA content and type, with PEG chain length of 550 and 875, on the structure, morphology, biocompatibility, swelling and release properties of P(HEMA/IA/550PEGDMA) and P(HEMA/IA/875PEGDMA) copolymeric hydrogels have been investigated. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line, indicated satisfactory cytocompatibility. Swelling studies were conducted for all samples in a physiological pH and temperature range, showing a noticeable pH sensitivity and temperature dependent equilibrium swelling. The characterization by Fourier transform infrared (FTIR) spectroscopy confirmed the presence of all monomers used in the gel structure, and morphology study, performed by scanning electron microscopy (SEM), revealed no significant differences between the samples with respect to pore size. In order to elucidate the release mechanism, drug release study was carried out in vitro using two forms of vitamin 6:3: nicotinamide (NAm) and nicotinic acid (NAc). The dissolution profiles were fitted to various mathematical models and the best fit was obtained for first order kinetics. The favorable swelling and drug release properties of P(HEMA/IA/PEGDMA) hydrogels make them good candidates to be used as biomaterials.
PB  - Elsevier Science Sa, Lausanne
T2  - Chemical Engineering Journal
T1  - Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels
EP  - 380
SP  - 372
VL  - 179
DO  - 10.1016/j.cej.2011.10.083
ER  - 

@article{
author = "Dobić, Sava N. and Filipović, Jovanka M. and Tomić, Simonida",
year = "2012",
abstract = "Hydrogels based on 2-hydroxyethyl methacrylate (HEMA), different poly(ethylene glycol) dimethacrylates (PEGDMA) and itaconic acid (IA) were prepared by free radical crosslinking copolymerization. The influence of different PEGDMA content and type, with PEG chain length of 550 and 875, on the structure, morphology, biocompatibility, swelling and release properties of P(HEMA/IA/550PEGDMA) and P(HEMA/IA/875PEGDMA) copolymeric hydrogels have been investigated. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line, indicated satisfactory cytocompatibility. Swelling studies were conducted for all samples in a physiological pH and temperature range, showing a noticeable pH sensitivity and temperature dependent equilibrium swelling. The characterization by Fourier transform infrared (FTIR) spectroscopy confirmed the presence of all monomers used in the gel structure, and morphology study, performed by scanning electron microscopy (SEM), revealed no significant differences between the samples with respect to pore size. In order to elucidate the release mechanism, drug release study was carried out in vitro using two forms of vitamin 6:3: nicotinamide (NAm) and nicotinic acid (NAc). The dissolution profiles were fitted to various mathematical models and the best fit was obtained for first order kinetics. The favorable swelling and drug release properties of P(HEMA/IA/PEGDMA) hydrogels make them good candidates to be used as biomaterials.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Chemical Engineering Journal",
title = "Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels",
pages = "380-372",
volume = "179",
doi = "10.1016/j.cej.2011.10.083"
}

Dobić, S. N., Filipović, J. M.,& Tomić, S.. (2012). Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels. in Chemical Engineering Journal
Elsevier Science Sa, Lausanne., 179, 372-380.
https://doi.org/10.1016/j.cej.2011.10.083

Dobić SN, Filipović JM, Tomić S. Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels. in Chemical Engineering Journal. 2012;179:372-380.
doi:10.1016/j.cej.2011.10.083 .

Dobić, Sava N., Filipović, Jovanka M., Tomić, Simonida, "Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels" in Chemical Engineering Journal, 179 (2012):372-380,
https://doi.org/10.1016/j.cej.2011.10.083 . .

TY  - JOUR
AU  - Dobić, Sava N.
AU  - Jovašević, Jovana S.
AU  - Vojisavljević, Marija D.
AU  - Tomić, Simonida
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1780
AB  - In this study a novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical cross-linking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revealed that the cell viability of all samples was in the range of 97-100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe, with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.
AB  - U radu je izvedena sinteza dva nova tipa kopolimernih hidrogelova na bazi 2- -hidroksietil (met)akrilata, itakonske kiseline i poli(etilen glikol) dimetakrilata, s ciljem primene ovih polimernih sistema u biomedicinske svrhe. Testirana je biokompatibilnost preko probe hemokompatibilnosti. Hemolitička aktivnost svih hidrogelova je bila u dozvoljenim granicama, prihvatljivim za biomedicinsku primenu. Studije bubrenja hidrogelova, izvedene u opsegu fizioloških pH i temperaturnih vrednosti, pokazale su da bubrenje zavisi od pH i temperature. Sintetisani hidrogelovi su pokazali sličan trend zavisnosti stepena bubrenja od pH i temperature. Sadržaj 550PEGDMA u hidrogelu utiče na stepen bubrenja, dok koncentracija 875PEGDMA komponente vrlo malo utiče na stepen bubrenja. Hidrogel sa 15 mol% 550PEGDMA manje bubri od uzoraka sa manjim sadržajem ove komponente (5 i 10 mol%), što ukazuje da pri toj koncentraciji preovladava umrežavajuće dejstvo ove komponente. Duži PEG lanci u 875PEGDMA su fleksibilniji, pa je efekat umrežavanja uravnotežen sa efektom fleksibilnosti lanca, što ima za posledicu slično bubrenje za sve uzorke u opsegu koncentracija koje su korišćene u ovom radu.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels
T1  - Proučavanje hemokompatibilnosti i bubrenja hidrogelova poli(2-hidroksietil metakrilat-ko-itakonska kiselina-ko-poli(etilen glikol) dimetakrilat)
EP  - 685
IS  - 6
SP  - 675
VL  - 65
DO  - 10.2298/HEMIND111005102D
ER  - 

@article{
author = "Dobić, Sava N. and Jovašević, Jovana S. and Vojisavljević, Marija D. and Tomić, Simonida",
year = "2011",
abstract = "In this study a novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical cross-linking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revealed that the cell viability of all samples was in the range of 97-100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe, with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials., U radu je izvedena sinteza dva nova tipa kopolimernih hidrogelova na bazi 2- -hidroksietil (met)akrilata, itakonske kiseline i poli(etilen glikol) dimetakrilata, s ciljem primene ovih polimernih sistema u biomedicinske svrhe. Testirana je biokompatibilnost preko probe hemokompatibilnosti. Hemolitička aktivnost svih hidrogelova je bila u dozvoljenim granicama, prihvatljivim za biomedicinsku primenu. Studije bubrenja hidrogelova, izvedene u opsegu fizioloških pH i temperaturnih vrednosti, pokazale su da bubrenje zavisi od pH i temperature. Sintetisani hidrogelovi su pokazali sličan trend zavisnosti stepena bubrenja od pH i temperature. Sadržaj 550PEGDMA u hidrogelu utiče na stepen bubrenja, dok koncentracija 875PEGDMA komponente vrlo malo utiče na stepen bubrenja. Hidrogel sa 15 mol% 550PEGDMA manje bubri od uzoraka sa manjim sadržajem ove komponente (5 i 10 mol%), što ukazuje da pri toj koncentraciji preovladava umrežavajuće dejstvo ove komponente. Duži PEG lanci u 875PEGDMA su fleksibilniji, pa je efekat umrežavanja uravnotežen sa efektom fleksibilnosti lanca, što ima za posledicu slično bubrenje za sve uzorke u opsegu koncentracija koje su korišćene u ovom radu.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels, Proučavanje hemokompatibilnosti i bubrenja hidrogelova poli(2-hidroksietil metakrilat-ko-itakonska kiselina-ko-poli(etilen glikol) dimetakrilat)",
pages = "685-675",
number = "6",
volume = "65",
doi = "10.2298/HEMIND111005102D"
}

Dobić, S. N., Jovašević, J. S., Vojisavljević, M. D.,& Tomić, S.. (2011). Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels. in Hemijska industrija
Association of Chemical Engineers of Serbia., 65(6), 675-685.
https://doi.org/10.2298/HEMIND111005102D

Dobić SN, Jovašević JS, Vojisavljević MD, Tomić S. Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels. in Hemijska industrija. 2011;65(6):675-685.
doi:10.2298/HEMIND111005102D .

Dobić, Sava N., Jovašević, Jovana S., Vojisavljević, Marija D., Tomić, Simonida, "Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels" in Hemijska industrija, 65, no. 6 (2011):675-685,
https://doi.org/10.2298/HEMIND111005102D . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Dobić, Sava N.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1707
AB  - pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Radiation Physics and Chemistry
T1  - Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
EP  - 649
IS  - 5
SP  - 643
VL  - 79
DO  - 10.1016/j.radphyschem.2009.11.015
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Dobić, Sava N. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Radiation Physics and Chemistry",
title = "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application",
pages = "649-643",
number = "5",
volume = "79",
doi = "10.1016/j.radphyschem.2009.11.015"
}

Tomić, S., Mićić, M. M., Dobić, S. N., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry
Pergamon-Elsevier Science Ltd, Oxford., 79(5), 643-649.
https://doi.org/10.1016/j.radphyschem.2009.11.015

Tomić S, Mićić MM, Dobić SN, Filipović JM, Suljovrujić EH. Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry. 2010;79(5):643-649.
doi:10.1016/j.radphyschem.2009.11.015 .

Tomić, Simonida, Mićić, Maja M., Dobić, Sava N., Filipović, Jovanka M., Suljovrujić, Edin H., "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application" in Radiation Physics and Chemistry, 79, no. 5 (2010):643-649,
https://doi.org/10.1016/j.radphyschem.2009.11.015 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Mićić, Maja M.
AU  - Krezović, Bojana D.
AU  - Dobić, Sava N.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1400
AB  - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
AB  - pH i temperaturno osetljivi hidrogelovi na bazi kopolimera 2-hidroksietilmetakrilata (HEMA) i itakonske kiseline (IK) sintetisani su upotrebom gama zračenja i karakterisani s ciljem ispitivanja njihove potencijalne primene kao biomaterijala. Ispitivan je uticaj odnosa komonomera u ovim inteligentnim polimernim biomaterijalima na morfologiju, mehanička svojstva, biokompatibilnost i penetraciju mikroba. Mehanička svojstva kopolimera su ispitivana dinamičko-mehaničkom analizom (DMA), dok je morfologija karakterisana skenirajućom elektronskom mikroskopijom (SEM). Pokazalo se da su morfologija i mehanička svojstva ovih hidrogelova odgovarajući za većinu biomedicinskih primena. In vitro analizom biokompatibilnosti P(HEMA/IK) hidrogelova potvrđeno je da nisu toksični za ćelije niti izazivaju značajnu hemolitičku aktivnost. Takođe, test mikrobne penetracije pokazao je da ni Staphylococcus aureus ni Escherichia coli ne prolaze kroz hidrogelne obloge; stoga se P(HEMA/IK) obloge mogu smatrati dobrom barijerom protiv mikroba, a radi održavanja sterilnosti okolne sredine. Svi rezultati pokazuju da P(HEMA/IK) hidrogelovi imaju veliku mogućnost primene u biomedicini, posebno kod tretmana kože i kao obloge za opekotine.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Smart hydrogels based on itaconic acid for biomedical application
T1  - Inteligentni hidrogelovi na bazi itakonske kiseline za biomedicinsku primenu
EP  - 610
IS  - 6
SP  - 603
VL  - 63
DO  - 10.2298/HEMIND0906603T
ER  - 

@article{
author = "Tomić, Simonida and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2009",
abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings., pH i temperaturno osetljivi hidrogelovi na bazi kopolimera 2-hidroksietilmetakrilata (HEMA) i itakonske kiseline (IK) sintetisani su upotrebom gama zračenja i karakterisani s ciljem ispitivanja njihove potencijalne primene kao biomaterijala. Ispitivan je uticaj odnosa komonomera u ovim inteligentnim polimernim biomaterijalima na morfologiju, mehanička svojstva, biokompatibilnost i penetraciju mikroba. Mehanička svojstva kopolimera su ispitivana dinamičko-mehaničkom analizom (DMA), dok je morfologija karakterisana skenirajućom elektronskom mikroskopijom (SEM). Pokazalo se da su morfologija i mehanička svojstva ovih hidrogelova odgovarajući za većinu biomedicinskih primena. In vitro analizom biokompatibilnosti P(HEMA/IK) hidrogelova potvrđeno je da nisu toksični za ćelije niti izazivaju značajnu hemolitičku aktivnost. Takođe, test mikrobne penetracije pokazao je da ni Staphylococcus aureus ni Escherichia coli ne prolaze kroz hidrogelne obloge; stoga se P(HEMA/IK) obloge mogu smatrati dobrom barijerom protiv mikroba, a radi održavanja sterilnosti okolne sredine. Svi rezultati pokazuju da P(HEMA/IK) hidrogelovi imaju veliku mogućnost primene u biomedicini, posebno kod tretmana kože i kao obloge za opekotine.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Smart hydrogels based on itaconic acid for biomedical application, Inteligentni hidrogelovi na bazi itakonske kiseline za biomedicinsku primenu",
pages = "610-603",
number = "6",
volume = "63",
doi = "10.2298/HEMIND0906603T"
}

Tomić, S., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart hydrogels based on itaconic acid for biomedical application. in Hemijska industrija
Association of Chemical Engineers of Serbia., 63(6), 603-610.
https://doi.org/10.2298/HEMIND0906603T

Tomić S, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart hydrogels based on itaconic acid for biomedical application. in Hemijska industrija. 2009;63(6):603-610.
doi:10.2298/HEMIND0906603T .

Tomić, Simonida, Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart hydrogels based on itaconic acid for biomedical application" in Hemijska industrija, 63, no. 6 (2009):603-610,
https://doi.org/10.2298/HEMIND0906603T . .