TY  - JOUR
AU  - Rajilić-Stojanović, Mirjana
AU  - Figueiredo, Ceu
AU  - Smet, Annemieke
AU  - Hansen, Richard
AU  - Kupcinskas, Juozas
AU  - Rokkas, Theo
AU  - Andersen, Leif
AU  - Machado, Jose C.
AU  - Ianiro, Gianluca
AU  - Gasbarrini, Antonio
AU  - Leja, Marcis
AU  - Gisbert, Javier P.
AU  - Hold, Georgina L.
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4478
AB  - Background Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty-five papers were eligible for inclusion. With the exception of H pylori-induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.
PB  - Wiley, Hoboken
T2  - Alimentary Pharmacology & Therapeutics
T1  - Systematic review: gastric microbiota in health and disease
EP  - 602
IS  - 6
SP  - 582
VL  - 51
DO  - 10.1111/apt.15650
ER  - 

@article{
author = "Rajilić-Stojanović, Mirjana and Figueiredo, Ceu and Smet, Annemieke and Hansen, Richard and Kupcinskas, Juozas and Rokkas, Theo and Andersen, Leif and Machado, Jose C. and Ianiro, Gianluca and Gasbarrini, Antonio and Leja, Marcis and Gisbert, Javier P. and Hold, Georgina L.",
year = "2020",
abstract = "Background Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty-five papers were eligible for inclusion. With the exception of H pylori-induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.",
publisher = "Wiley, Hoboken",
journal = "Alimentary Pharmacology & Therapeutics",
title = "Systematic review: gastric microbiota in health and disease",
pages = "602-582",
number = "6",
volume = "51",
doi = "10.1111/apt.15650"
}

Rajilić-Stojanović, M., Figueiredo, C., Smet, A., Hansen, R., Kupcinskas, J., Rokkas, T., Andersen, L., Machado, J. C., Ianiro, G., Gasbarrini, A., Leja, M., Gisbert, J. P.,& Hold, G. L.. (2020). Systematic review: gastric microbiota in health and disease. in Alimentary Pharmacology & Therapeutics
Wiley, Hoboken., 51(6), 582-602.
https://doi.org/10.1111/apt.15650

Rajilić-Stojanović M, Figueiredo C, Smet A, Hansen R, Kupcinskas J, Rokkas T, Andersen L, Machado JC, Ianiro G, Gasbarrini A, Leja M, Gisbert JP, Hold GL. Systematic review: gastric microbiota in health and disease. in Alimentary Pharmacology & Therapeutics. 2020;51(6):582-602.
doi:10.1111/apt.15650 .

Rajilić-Stojanović, Mirjana, Figueiredo, Ceu, Smet, Annemieke, Hansen, Richard, Kupcinskas, Juozas, Rokkas, Theo, Andersen, Leif, Machado, Jose C., Ianiro, Gianluca, Gasbarrini, Antonio, Leja, Marcis, Gisbert, Javier P., Hold, Georgina L., "Systematic review: gastric microbiota in health and disease" in Alimentary Pharmacology & Therapeutics, 51, no. 6 (2020):582-602,
https://doi.org/10.1111/apt.15650 . .