TY  - JOUR
AU  - Rajilić-Stojanović, Mirjana
AU  - Figueiredo, Ceu
AU  - Smet, Annemieke
AU  - Hansen, Richard
AU  - Kupcinskas, Juozas
AU  - Rokkas, Theo
AU  - Andersen, Leif
AU  - Machado, Jose C.
AU  - Ianiro, Gianluca
AU  - Gasbarrini, Antonio
AU  - Leja, Marcis
AU  - Gisbert, Javier P.
AU  - Hold, Georgina L.
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4478
AB  - Background Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty-five papers were eligible for inclusion. With the exception of H pylori-induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.
PB  - Wiley, Hoboken
T2  - Alimentary Pharmacology & Therapeutics
T1  - Systematic review: gastric microbiota in health and disease
EP  - 602
IS  - 6
SP  - 582
VL  - 51
DO  - 10.1111/apt.15650
ER  - 

@article{
author = "Rajilić-Stojanović, Mirjana and Figueiredo, Ceu and Smet, Annemieke and Hansen, Richard and Kupcinskas, Juozas and Rokkas, Theo and Andersen, Leif and Machado, Jose C. and Ianiro, Gianluca and Gasbarrini, Antonio and Leja, Marcis and Gisbert, Javier P. and Hold, Georgina L.",
year = "2020",
abstract = "Background Helicobacter pylori is the most infamous constituent of the gastric microbiota and its presence is the strongest risk factor for gastric cancer and other gastroduodenal diseases. Although historically the healthy stomach was considered a sterile organ, we now know it is colonised with a complex microbiota. However, its role in health and disease is not well understood. Aim To systematically explore the literature on the gastric microbiota in health and disease as well as the gut microbiota after bariatric surgery. Methods A systematic search of online bibliographic databases MEDLINE/EMBASE was performed between 1966 and February 2019 with screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Randomised controlled trials, cohort studies and observational studies were included if they reported next-generation sequencing derived microbiota analysis on gastric aspirate/tissue or stool samples (bariatric surgical outcomes). Results Sixty-five papers were eligible for inclusion. With the exception of H pylori-induced conditions, overarching gastric microbiota signatures of health or disease could not be determined. Gastric carcinogenesis induces a progressively altered microbiota with an enrichment of oral and intestinal taxa as well as significant changes in host gastric mucin expression. Proton pump inhibitors usage increases gastric microbiota richness. Bariatric surgery is associated with an increase in potentially pathogenic proteobacterial species in patient stool samples. Conclusion While H pylori remains the single most important risk factor for gastric disease, its capacity to shape the collective gastric microbiota remains to be fully elucidated. Further studies are needed to explore the intricate host/microbial and microbial/microbial interplay.",
publisher = "Wiley, Hoboken",
journal = "Alimentary Pharmacology & Therapeutics",
title = "Systematic review: gastric microbiota in health and disease",
pages = "602-582",
number = "6",
volume = "51",
doi = "10.1111/apt.15650"
}

Rajilić-Stojanović, M., Figueiredo, C., Smet, A., Hansen, R., Kupcinskas, J., Rokkas, T., Andersen, L., Machado, J. C., Ianiro, G., Gasbarrini, A., Leja, M., Gisbert, J. P.,& Hold, G. L.. (2020). Systematic review: gastric microbiota in health and disease. in Alimentary Pharmacology & Therapeutics
Wiley, Hoboken., 51(6), 582-602.
https://doi.org/10.1111/apt.15650

Rajilić-Stojanović M, Figueiredo C, Smet A, Hansen R, Kupcinskas J, Rokkas T, Andersen L, Machado JC, Ianiro G, Gasbarrini A, Leja M, Gisbert JP, Hold GL. Systematic review: gastric microbiota in health and disease. in Alimentary Pharmacology & Therapeutics. 2020;51(6):582-602.
doi:10.1111/apt.15650 .

Rajilić-Stojanović, Mirjana, Figueiredo, Ceu, Smet, Annemieke, Hansen, Richard, Kupcinskas, Juozas, Rokkas, Theo, Andersen, Leif, Machado, Jose C., Ianiro, Gianluca, Gasbarrini, Antonio, Leja, Marcis, Gisbert, Javier P., Hold, Georgina L., "Systematic review: gastric microbiota in health and disease" in Alimentary Pharmacology & Therapeutics, 51, no. 6 (2020):582-602,
https://doi.org/10.1111/apt.15650 . .

TY  - JOUR
AU  - Cammarota, Giovanni
AU  - Ianiro, Gianluca
AU  - Tilg, Herbert
AU  - Rajilić-Stojanović, Mirjana
AU  - Kump, Patrizia
AU  - Satokari, Reetta
AU  - Sokol, Harry
AU  - Arkkila, Perttu
AU  - Pintus, Cristina
AU  - Hart, Ailsa
AU  - Segal, Jonathan
AU  - Aloi, Marina
AU  - Masucci, Luca
AU  - Molinaro, Antonio
AU  - Scaldaferri, Franco
AU  - Gasbarrini, Giovanni
AU  - Lopez-Sanroman, Antonio
AU  - Link, Alexander
AU  - De Groot, Pieter
AU  - de Vos, Willem M.
AU  - Hoegenauer, Christoph
AU  - Malfertheiner, Peter
AU  - Mattila, Eero
AU  - Milosavljević, Tomica
AU  - Nieuwdorp, Max
AU  - Sanguinetti, Maurizio
AU  - Simren, Magnus
AU  - Gasbarrini, Antonio
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3706
AB  - Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.
PB  - Bmj Publishing Group, London
T2  - GUT
T1  - European consensus conference on faecal microbiota transplantation in clinical practice
EP  - 580
IS  - 4
SP  - 569
VL  - 66
DO  - 10.1136/gutjnl-2016-313017
ER  - 

@article{
author = "Cammarota, Giovanni and Ianiro, Gianluca and Tilg, Herbert and Rajilić-Stojanović, Mirjana and Kump, Patrizia and Satokari, Reetta and Sokol, Harry and Arkkila, Perttu and Pintus, Cristina and Hart, Ailsa and Segal, Jonathan and Aloi, Marina and Masucci, Luca and Molinaro, Antonio and Scaldaferri, Franco and Gasbarrini, Giovanni and Lopez-Sanroman, Antonio and Link, Alexander and De Groot, Pieter and de Vos, Willem M. and Hoegenauer, Christoph and Malfertheiner, Peter and Mattila, Eero and Milosavljević, Tomica and Nieuwdorp, Max and Sanguinetti, Maurizio and Simren, Magnus and Gasbarrini, Antonio",
year = "2017",
abstract = "Faecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium difficile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of C. difficile infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.",
publisher = "Bmj Publishing Group, London",
journal = "GUT",
title = "European consensus conference on faecal microbiota transplantation in clinical practice",
pages = "580-569",
number = "4",
volume = "66",
doi = "10.1136/gutjnl-2016-313017"
}

Cammarota, G., Ianiro, G., Tilg, H., Rajilić-Stojanović, M., Kump, P., Satokari, R., Sokol, H., Arkkila, P., Pintus, C., Hart, A., Segal, J., Aloi, M., Masucci, L., Molinaro, A., Scaldaferri, F., Gasbarrini, G., Lopez-Sanroman, A., Link, A., De Groot, P., de Vos, W. M., Hoegenauer, C., Malfertheiner, P., Mattila, E., Milosavljević, T., Nieuwdorp, M., Sanguinetti, M., Simren, M.,& Gasbarrini, A.. (2017). European consensus conference on faecal microbiota transplantation in clinical practice. in GUT
Bmj Publishing Group, London., 66(4), 569-580.
https://doi.org/10.1136/gutjnl-2016-313017

Cammarota G, Ianiro G, Tilg H, Rajilić-Stojanović M, Kump P, Satokari R, Sokol H, Arkkila P, Pintus C, Hart A, Segal J, Aloi M, Masucci L, Molinaro A, Scaldaferri F, Gasbarrini G, Lopez-Sanroman A, Link A, De Groot P, de Vos WM, Hoegenauer C, Malfertheiner P, Mattila E, Milosavljević T, Nieuwdorp M, Sanguinetti M, Simren M, Gasbarrini A. European consensus conference on faecal microbiota transplantation in clinical practice. in GUT. 2017;66(4):569-580.
doi:10.1136/gutjnl-2016-313017 .

Cammarota, Giovanni, Ianiro, Gianluca, Tilg, Herbert, Rajilić-Stojanović, Mirjana, Kump, Patrizia, Satokari, Reetta, Sokol, Harry, Arkkila, Perttu, Pintus, Cristina, Hart, Ailsa, Segal, Jonathan, Aloi, Marina, Masucci, Luca, Molinaro, Antonio, Scaldaferri, Franco, Gasbarrini, Giovanni, Lopez-Sanroman, Antonio, Link, Alexander, De Groot, Pieter, de Vos, Willem M., Hoegenauer, Christoph, Malfertheiner, Peter, Mattila, Eero, Milosavljević, Tomica, Nieuwdorp, Max, Sanguinetti, Maurizio, Simren, Magnus, Gasbarrini, Antonio, "European consensus conference on faecal microbiota transplantation in clinical practice" in GUT, 66, no. 4 (2017):569-580,
https://doi.org/10.1136/gutjnl-2016-313017 . .