TY  - CONF
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Vuković, Jovana
AU  - Perišić, Marija D.
AU  - Filipović, Vuk
AU  - Davidović, Slađana
AU  - Filipović, Jovanka M.
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3296
AB  - In this study, superporous hydrogels were synthesized by free radical polymerization of 2-hydroxyethyl methacrylate without and in the presence of gelatin. Highly porous hydrogel structures were obtained by two different techniques: using a gas blowing agent, sodium bicarbonate, and a cryogenic treatment followed by freeze-drying. After the gel synthesis, gelatin molecules were covalently immobilised onto PHEMA via glytaraldehyde activation. All samples were characterized for morphological, mechanical, swelling and antibacterial properties. The results obtained show that samples with gelatin show better properties in comparison with PHEMA samples, which make these materials highly attractive for developing hydrogel scaffolds for tissue regeneration.
PB  - Amer Inst Physics, Melville
C3  - VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology
T1  - 2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration
SP  - 4949668
VL  - 1736
DO  - 10.1063/1.4949668
ER  - 

@conference{
author = "Tomić, Simonida and Babić, Marija and Vuković, Jovana and Perišić, Marija D. and Filipović, Vuk and Davidović, Slađana and Filipović, Jovanka M.",
year = "2016",
abstract = "In this study, superporous hydrogels were synthesized by free radical polymerization of 2-hydroxyethyl methacrylate without and in the presence of gelatin. Highly porous hydrogel structures were obtained by two different techniques: using a gas blowing agent, sodium bicarbonate, and a cryogenic treatment followed by freeze-drying. After the gel synthesis, gelatin molecules were covalently immobilised onto PHEMA via glytaraldehyde activation. All samples were characterized for morphological, mechanical, swelling and antibacterial properties. The results obtained show that samples with gelatin show better properties in comparison with PHEMA samples, which make these materials highly attractive for developing hydrogel scaffolds for tissue regeneration.",
publisher = "Amer Inst Physics, Melville",
journal = "VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology",
title = "2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration",
pages = "4949668",
volume = "1736",
doi = "10.1063/1.4949668"
}

Tomić, S., Babić, M., Vuković, J., Perišić, M. D., Filipović, V., Davidović, S.,& Filipović, J. M.. (2016). 2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration. in VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology
Amer Inst Physics, Melville., 1736, 4949668.
https://doi.org/10.1063/1.4949668

Tomić S, Babić M, Vuković J, Perišić MD, Filipović V, Davidović S, Filipović JM. 2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration. in VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology. 2016;1736:4949668.
doi:10.1063/1.4949668 .

Tomić, Simonida, Babić, Marija, Vuković, Jovana, Perišić, Marija D., Filipović, Vuk, Davidović, Slađana, Filipović, Jovanka M., "2-Hydroxyethyl Metahcrylate/Gelatin based Superporous Hydrogels for Tissue Regeneration" in VIII International Conference on Times of Polymers and Composites: From Aerospace to Nanotechnology, 1736 (2016):4949668,
https://doi.org/10.1063/1.4949668 . .

TY  - JOUR
AU  - Babić, Marija
AU  - Božić, Bojan
AU  - Antić, Katarina
AU  - Jovašević-Vuković, Jovana J.
AU  - Perišić, Marija D.
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2970
AB  - Series of novel dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels were designed as multifunctional drug delivery system which can provide several advantages including drug protection, self-regulated oscillatory release and targeted delivery to a single entity. The hydrogels were synthesized by the free-radical crosslinking copolymerization and evaluated as carriers for hydrophobic drug, Oxaprozin, with specific controlled release properties. Structural, morphological, thermal, surface charge, swelling and antimicrobial properties of the hydrogels were investigated for unloaded and Oxaprozin-loaded samples. Swelling studies demonstrated pH- and temperature-sensitivity of drug-free and drug-loaded P(HPA/IA) hydrogels. The results of swelling and oscillatory swelling, and swelling behavior of drug-free, and drug-loaded hydrogels in simulated gastrointestinal conditions, and in vitro Oxaprozin release studies confirmed these hydrogels as a highly effective colon-specific drug delivery system with excellent performance of long-term controlled release. These unique properties make the P(HPA/IA) hydrogels highly attractive materials for developing multifunctional drug delivery systems.
PB  - Elsevier Science Bv, Amsterdam
T2  - Materials Letters
T1  - Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels
EP  - 68
SP  - 64
VL  - 147
DO  - 10.1016/j.matlet.2015.02.035
ER  - 

@article{
author = "Babić, Marija and Božić, Bojan and Antić, Katarina and Jovašević-Vuković, Jovana J. and Perišić, Marija D. and Filipović, Jovanka M. and Tomić, Simonida",
year = "2015",
abstract = "Series of novel dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels were designed as multifunctional drug delivery system which can provide several advantages including drug protection, self-regulated oscillatory release and targeted delivery to a single entity. The hydrogels were synthesized by the free-radical crosslinking copolymerization and evaluated as carriers for hydrophobic drug, Oxaprozin, with specific controlled release properties. Structural, morphological, thermal, surface charge, swelling and antimicrobial properties of the hydrogels were investigated for unloaded and Oxaprozin-loaded samples. Swelling studies demonstrated pH- and temperature-sensitivity of drug-free and drug-loaded P(HPA/IA) hydrogels. The results of swelling and oscillatory swelling, and swelling behavior of drug-free, and drug-loaded hydrogels in simulated gastrointestinal conditions, and in vitro Oxaprozin release studies confirmed these hydrogels as a highly effective colon-specific drug delivery system with excellent performance of long-term controlled release. These unique properties make the P(HPA/IA) hydrogels highly attractive materials for developing multifunctional drug delivery systems.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Materials Letters",
title = "Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels",
pages = "68-64",
volume = "147",
doi = "10.1016/j.matlet.2015.02.035"
}

Babić, M., Božić, B., Antić, K., Jovašević-Vuković, J. J., Perišić, M. D., Filipović, J. M.,& Tomić, S.. (2015). Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels. in Materials Letters
Elsevier Science Bv, Amsterdam., 147, 64-68.
https://doi.org/10.1016/j.matlet.2015.02.035

Babić M, Božić B, Antić K, Jovašević-Vuković JJ, Perišić MD, Filipović JM, Tomić S. Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels. in Materials Letters. 2015;147:64-68.
doi:10.1016/j.matlet.2015.02.035 .

Babić, Marija, Božić, Bojan, Antić, Katarina, Jovašević-Vuković, Jovana J., Perišić, Marija D., Filipović, Jovanka M., Tomić, Simonida, "Design of novel multifunctional Oxaprozin delivery system based on dual-sensitive poly(2-hydroxypropyl acrylate/itaconic acid) hydrogels" in Materials Letters, 147 (2015):64-68,
https://doi.org/10.1016/j.matlet.2015.02.035 . .

TY  - JOUR
AU  - Malešić, Neda B.
AU  - Rusmirović, Jelena
AU  - Jovašević, Jovana S.
AU  - Perišić, Marija D.
AU  - Dimitrijević, Suzana
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2595
AB  - The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time.
AB  - Cilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.
PB  - Savez inženjera i tehničara Srbije, Beograd
T2  - Tehnika
T1  - Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion
T1  - Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon
EP  - 568
IS  - 4
SP  - 563
VL  - 69
DO  - 10.5937/tehnika1404563M
ER  - 

@article{
author = "Malešić, Neda B. and Rusmirović, Jelena and Jovašević, Jovana S. and Perišić, Marija D. and Dimitrijević, Suzana and Filipović, Jovanka M. and Tomić, Simonida",
year = "2014",
abstract = "The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time., Cilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.",
publisher = "Savez inženjera i tehničara Srbije, Beograd",
journal = "Tehnika",
title = "Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion, Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon",
pages = "568-563",
number = "4",
volume = "69",
doi = "10.5937/tehnika1404563M"
}

Malešić, N. B., Rusmirović, J., Jovašević, J. S., Perišić, M. D., Dimitrijević, S., Filipović, J. M.,& Tomić, S.. (2014). Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion. in Tehnika
Savez inženjera i tehničara Srbije, Beograd., 69(4), 563-568.
https://doi.org/10.5937/tehnika1404563M

Malešić NB, Rusmirović J, Jovašević JS, Perišić MD, Dimitrijević S, Filipović JM, Tomić S. Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion. in Tehnika. 2014;69(4):563-568.
doi:10.5937/tehnika1404563M .

Malešić, Neda B., Rusmirović, Jelena, Jovašević, Jovana S., Perišić, Marija D., Dimitrijević, Suzana, Filipović, Jovanka M., Tomić, Simonida, "Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion" in Tehnika, 69, no. 4 (2014):563-568,
https://doi.org/10.5937/tehnika1404563M . .