TY  - JOUR
AU  - Stevanović, Milena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Kojić, Vesna
AU  - Stojanović, Jovica
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Rhee, Kyong Yop
AU  - Mišković-Stanković, Vesna
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4839
AB  - This paper describes a promising electrophoretic deposition (EPD) approach for developing composite coatings based on chitosan with the additional components of hydroxyapatite, graphene, and gentamicin on titanium substrate. Bioactive properties were investigated in vitro by immersing the coatings in simulated body fluid (SBF) at 37 degrees C. The newly formed biomimetic layer on the top of the deposited chitosan-based coatings on Ti was confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and electrochemical measurements, while coatings' bioactivity was proved by alkaline phosphatase activity assay in MRC-5 and L929 tested cell lines. The biocompatibility towards MRC-5 and L929 cell lines was investigated by dye exclusion test (DET) implying the non-cytotoxic effect of coatings. Gentamicin release studies were monitored during 21-day by high-performance liquid chromatography coupled with mass spectrometry, indicating rapid release of gentamicin (approximate to 40%) in the first 48 h and more than 60% after 14 days.
PB  - Elsevier B.V.
T2  - Journal of Materials Research and Technology
T1  - The chitosan-based bioactive composite coating on titanium
EP  - 4474
SP  - 4461
VL  - 15
DO  - 10.1016/j.jmrt.2021.10.072
ER  - 

@article{
author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Kojić, Vesna and Stojanović, Jovica and Grujić, Svetlana and Matić-Bujagić, Ivana and Rhee, Kyong Yop and Mišković-Stanković, Vesna",
year = "2021",
abstract = "This paper describes a promising electrophoretic deposition (EPD) approach for developing composite coatings based on chitosan with the additional components of hydroxyapatite, graphene, and gentamicin on titanium substrate. Bioactive properties were investigated in vitro by immersing the coatings in simulated body fluid (SBF) at 37 degrees C. The newly formed biomimetic layer on the top of the deposited chitosan-based coatings on Ti was confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and electrochemical measurements, while coatings' bioactivity was proved by alkaline phosphatase activity assay in MRC-5 and L929 tested cell lines. The biocompatibility towards MRC-5 and L929 cell lines was investigated by dye exclusion test (DET) implying the non-cytotoxic effect of coatings. Gentamicin release studies were monitored during 21-day by high-performance liquid chromatography coupled with mass spectrometry, indicating rapid release of gentamicin (approximate to 40%) in the first 48 h and more than 60% after 14 days.",
publisher = "Elsevier B.V.",
journal = "Journal of Materials Research and Technology",
title = "The chitosan-based bioactive composite coating on titanium",
pages = "4474-4461",
volume = "15",
doi = "10.1016/j.jmrt.2021.10.072"
}

Stevanović, M., Đošić, M., Janković, A., Kojić, V., Stojanović, J., Grujić, S., Matić-Bujagić, I., Rhee, K. Y.,& Mišković-Stanković, V.. (2021). The chitosan-based bioactive composite coating on titanium. in Journal of Materials Research and Technology
Elsevier B.V.., 15, 4461-4474.
https://doi.org/10.1016/j.jmrt.2021.10.072

Stevanović M, Đošić M, Janković A, Kojić V, Stojanović J, Grujić S, Matić-Bujagić I, Rhee KY, Mišković-Stanković V. The chitosan-based bioactive composite coating on titanium. in Journal of Materials Research and Technology. 2021;15:4461-4474.
doi:10.1016/j.jmrt.2021.10.072 .

Stevanović, Milena, Đošić, Marija, Janković, Ana, Kojić, Vesna, Stojanović, Jovica, Grujić, Svetlana, Matić-Bujagić, Ivana, Rhee, Kyong Yop, Mišković-Stanković, Vesna, "The chitosan-based bioactive composite coating on titanium" in Journal of Materials Research and Technology, 15 (2021):4461-4474,
https://doi.org/10.1016/j.jmrt.2021.10.072 . .

TY  - JOUR
AU  - Gvozdić, Eleonora
AU  - Matić Bujagić, Ivana
AU  - Đurkić, Tatjana
AU  - Grujić, Svetlana
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4395
PB  - Elsevier Inc.
T2  - Microchemical Journal
T1  - Trace analysis of artificial sweeteners in environmental waters, wastewater and river sediments by liquid chromatography-tandem mass spectrometry
SP  - 105071
VL  - 157
DO  - 10.1016/j.microc.2020.105071
ER  - 

@article{
author = "Gvozdić, Eleonora and Matić Bujagić, Ivana and Đurkić, Tatjana and Grujić, Svetlana",
year = "2020",
publisher = "Elsevier Inc.",
journal = "Microchemical Journal",
title = "Trace analysis of artificial sweeteners in environmental waters, wastewater and river sediments by liquid chromatography-tandem mass spectrometry",
pages = "105071",
volume = "157",
doi = "10.1016/j.microc.2020.105071"
}

Gvozdić, E., Matić Bujagić, I., Đurkić, T.,& Grujić, S.. (2020). Trace analysis of artificial sweeteners in environmental waters, wastewater and river sediments by liquid chromatography-tandem mass spectrometry. in Microchemical Journal
Elsevier Inc.., 157, 105071.
https://doi.org/10.1016/j.microc.2020.105071

Gvozdić E, Matić Bujagić I, Đurkić T, Grujić S. Trace analysis of artificial sweeteners in environmental waters, wastewater and river sediments by liquid chromatography-tandem mass spectrometry. in Microchemical Journal. 2020;157:105071.
doi:10.1016/j.microc.2020.105071 .

Gvozdić, Eleonora, Matić Bujagić, Ivana, Đurkić, Tatjana, Grujić, Svetlana, "Trace analysis of artificial sweeteners in environmental waters, wastewater and river sediments by liquid chromatography-tandem mass spectrometry" in Microchemical Journal, 157 (2020):105071,
https://doi.org/10.1016/j.microc.2020.105071 . .

TY  - JOUR
AU  - Stevanović, Milena
AU  - Đošić, Marija
AU  - Janković, Ana
AU  - Nešović, Katarina
AU  - Kojić, Vesna
AU  - Stojanović, Jovica
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Rhee, Kyong Yop
AU  - Mišković-Stanković, Vesna
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4498
AB  - The electrophoretic deposition process (EPD) was utilized to produce bioactive hydroxyapatite/chitosan (HAP/CS) and hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) coatings on titanium. The bioactivity of newly synthesized composite coatings was investigated in the simulated body fluid (SBF) and examined by X-ray diffraction, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy. The obtained results revealed carbonate-substituted hydroxyapatite after immersion in SBF, emphasizing the similarity of the biomimetically grown HAP with the naturally occurring apatite in the bone. The formation of biomimetic HAP was confirmed by electrochemical impedance spectroscopy and polarization measurements, through the decrease in corrosion current density and coating capacitance values after 28-day immersion in SBF. The osseointegration ability was further validated by measuring the alkaline phosphatase activity (ALP) indicating the favorable osseopromotive properties of deposited coatings (significant increase in ALP levels for both HAP/CS (3.206 U mL(-1)) and HAP/CS/Gent (4.039 U mL(-1)) coatings, compared to the control (0.900 U mL(-1))). Drug-release kinetics was investigated in deionized water at 37 degrees C by high-performance liquid chromatography coupled with mass spectrometry. Release profiles revealed the beneficial "burst-release effect" (similar to 21% of gentamicin released in the first 48 h) as a potentially promising solution against the biofilm formation in the initial period. When tested against human and mice fibroblast cells (MRC-5 and L929), both composite coatings showed a noncytotoxic effect (viability  gt 85%), providing a promising basis for further medical application trials.
PB  - Amer Chemical Soc, Washington
T2  - ACS Omega
T1  - Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate
EP  - 15445
IS  - 25
SP  - 15433
VL  - 5
DO  - 10.1021/acsomega.0c01583
ER  - 

@article{
author = "Stevanović, Milena and Đošić, Marija and Janković, Ana and Nešović, Katarina and Kojić, Vesna and Stojanović, Jovica and Grujić, Svetlana and Matić-Bujagić, Ivana and Rhee, Kyong Yop and Mišković-Stanković, Vesna",
year = "2020",
abstract = "The electrophoretic deposition process (EPD) was utilized to produce bioactive hydroxyapatite/chitosan (HAP/CS) and hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) coatings on titanium. The bioactivity of newly synthesized composite coatings was investigated in the simulated body fluid (SBF) and examined by X-ray diffraction, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy. The obtained results revealed carbonate-substituted hydroxyapatite after immersion in SBF, emphasizing the similarity of the biomimetically grown HAP with the naturally occurring apatite in the bone. The formation of biomimetic HAP was confirmed by electrochemical impedance spectroscopy and polarization measurements, through the decrease in corrosion current density and coating capacitance values after 28-day immersion in SBF. The osseointegration ability was further validated by measuring the alkaline phosphatase activity (ALP) indicating the favorable osseopromotive properties of deposited coatings (significant increase in ALP levels for both HAP/CS (3.206 U mL(-1)) and HAP/CS/Gent (4.039 U mL(-1)) coatings, compared to the control (0.900 U mL(-1))). Drug-release kinetics was investigated in deionized water at 37 degrees C by high-performance liquid chromatography coupled with mass spectrometry. Release profiles revealed the beneficial "burst-release effect" (similar to 21% of gentamicin released in the first 48 h) as a potentially promising solution against the biofilm formation in the initial period. When tested against human and mice fibroblast cells (MRC-5 and L929), both composite coatings showed a noncytotoxic effect (viability  gt 85%), providing a promising basis for further medical application trials.",
publisher = "Amer Chemical Soc, Washington",
journal = "ACS Omega",
title = "Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate",
pages = "15445-15433",
number = "25",
volume = "5",
doi = "10.1021/acsomega.0c01583"
}

Stevanović, M., Đošić, M., Janković, A., Nešović, K., Kojić, V., Stojanović, J., Grujić, S., Matić-Bujagić, I., Rhee, K. Y.,& Mišković-Stanković, V.. (2020). Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate. in ACS Omega
Amer Chemical Soc, Washington., 5(25), 15433-15445.
https://doi.org/10.1021/acsomega.0c01583

Stevanović M, Đošić M, Janković A, Nešović K, Kojić V, Stojanović J, Grujić S, Matić-Bujagić I, Rhee KY, Mišković-Stanković V. Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate. in ACS Omega. 2020;5(25):15433-15445.
doi:10.1021/acsomega.0c01583 .

Stevanović, Milena, Đošić, Marija, Janković, Ana, Nešović, Katarina, Kojić, Vesna, Stojanović, Jovica, Grujić, Svetlana, Matić-Bujagić, Ivana, Rhee, Kyong Yop, Mišković-Stanković, Vesna, "Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate" in ACS Omega, 5, no. 25 (2020):15433-15445,
https://doi.org/10.1021/acsomega.0c01583 . .

TY  - JOUR
AU  - Matić-Bujagić, Ivana
AU  - Grujić, Svetlana
AU  - Laušević, Mila
AU  - Hofmann, Thilo
AU  - Micić, Vesna
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4180
AB  - The Iron Gate I Reservoir is the largest impoundment on the Danube River. It retains  gt 50% of the incoming total suspended solids load and the associated organic contaminants. In the sediment core of the Iron Gate I Reservoir we report the presence and fate of four classes of emerging contaminants (pharmaceuticals, pesticides, steroids and perfluorinated compounds), predominantly not covered by the EU monitoring programs, but considered as future candidates. Based on contaminant's partitioning behavior in the water/sediment system and the suspected ecotoxicological potential asserted from the literature data, the risk of recorded concentrations for sediment-dwelling organisms was discussed. The high anticipated risk was associated with antibiotics sulfamethoxazole and erythromycin, and pesticides linuron and carbendazim (banned in the EU, but still approved for use in the investigated area) and malathion. This indicated the need for better control of release of these compounds into the river, and implied their inclusion in future regular monitoring. Higher concentrations of pharmaceuticals and most pesticides and sterols were recorded in the fragment of allochthonous coarser sediment, assumed to have entered the reservoir during a high discharge event. Only one perfluorinated compound was recorded in the upper part of the sediment core. The vertical concentration profiles of pesticides propazine and malathion indicated their uniform source, most likely atmospheric transport and deposition of particles deriving from agricultural land.
PB  - Elsevier, Amsterdam
T2  - Science of the Total Environment
T1  - Emerging contaminants in sediment core from the Iron Gate I Reservoir on the Danube River
EP  - 87
SP  - 77
VL  - 662
DO  - 10.1016/j.scitotenv.2019.01.205
ER  - 

@article{
author = "Matić-Bujagić, Ivana and Grujić, Svetlana and Laušević, Mila and Hofmann, Thilo and Micić, Vesna",
year = "2019",
abstract = "The Iron Gate I Reservoir is the largest impoundment on the Danube River. It retains  gt 50% of the incoming total suspended solids load and the associated organic contaminants. In the sediment core of the Iron Gate I Reservoir we report the presence and fate of four classes of emerging contaminants (pharmaceuticals, pesticides, steroids and perfluorinated compounds), predominantly not covered by the EU monitoring programs, but considered as future candidates. Based on contaminant's partitioning behavior in the water/sediment system and the suspected ecotoxicological potential asserted from the literature data, the risk of recorded concentrations for sediment-dwelling organisms was discussed. The high anticipated risk was associated with antibiotics sulfamethoxazole and erythromycin, and pesticides linuron and carbendazim (banned in the EU, but still approved for use in the investigated area) and malathion. This indicated the need for better control of release of these compounds into the river, and implied their inclusion in future regular monitoring. Higher concentrations of pharmaceuticals and most pesticides and sterols were recorded in the fragment of allochthonous coarser sediment, assumed to have entered the reservoir during a high discharge event. Only one perfluorinated compound was recorded in the upper part of the sediment core. The vertical concentration profiles of pesticides propazine and malathion indicated their uniform source, most likely atmospheric transport and deposition of particles deriving from agricultural land.",
publisher = "Elsevier, Amsterdam",
journal = "Science of the Total Environment",
title = "Emerging contaminants in sediment core from the Iron Gate I Reservoir on the Danube River",
pages = "87-77",
volume = "662",
doi = "10.1016/j.scitotenv.2019.01.205"
}

Matić-Bujagić, I., Grujić, S., Laušević, M., Hofmann, T.,& Micić, V.. (2019). Emerging contaminants in sediment core from the Iron Gate I Reservoir on the Danube River. in Science of the Total Environment
Elsevier, Amsterdam., 662, 77-87.
https://doi.org/10.1016/j.scitotenv.2019.01.205

Matić-Bujagić I, Grujić S, Laušević M, Hofmann T, Micić V. Emerging contaminants in sediment core from the Iron Gate I Reservoir on the Danube River. in Science of the Total Environment. 2019;662:77-87.
doi:10.1016/j.scitotenv.2019.01.205 .

Matić-Bujagić, Ivana, Grujić, Svetlana, Laušević, Mila, Hofmann, Thilo, Micić, Vesna, "Emerging contaminants in sediment core from the Iron Gate I Reservoir on the Danube River" in Science of the Total Environment, 662 (2019):77-87,
https://doi.org/10.1016/j.scitotenv.2019.01.205 . .

TY  - JOUR
AU  - Antanasijević, Davor
AU  - Matić-Bujagić, Ivana
AU  - Grujić, Svetlana
AU  - Laušević, Mila
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4020
AB  - In this paper, multivariate analysis of sterol concentrations detected in river sediment samples was performed. In order to remove co-dependence of values, concentrations of sterols were transformed using centered log-ratio (CLR) transformation. The main objective of the work was to point out the damaging effects of working in the wrong geometry on the principal component analysis (PCA) assessment of sterol pollution. In order to determine if the dimension lost have effect on the principal component analysis of sterols in sediments, we have performed the PCA using raw and log-ratio transformed sterol data. Additionally, two rounded zero replacement approaches, i.e. a simple-substitution method (DL/2, 0.55DL and DL/root 2) and multiplicative replacement strategy (0.65 DL), were compared in order to determine if the replacement values have an effect on PCA results and conclusions. Relevant differences were noted by comparing the results of the principal component analysis obtained with raw data and log-ratio transformed sterol data. Only the PC loadings obtained from the CLR PCA allowed the clear distinction between human-sourced pollution and biogenic sources of sterols, whereas in the case of PCA with raw data loadings were all grouped almost in a single quadrant. For the small proportion of rounded zeros (not more than 10%), two different replacement approaches did not have any effect on transformed PCA output. The results presented in this work have shown that the effect of "closure" in the sterol data can be easily observed from the PCA biplot, and that it obstructs the evaluation of human contribution to pollution of river sediments. Therefore, prior to the PCA, sterol concentrations must be CLR transformed in order to perform a reliable assessment of the sewage contamination.
PB  - Elsevier Science Bv, Amsterdam
T2  - Microchemical Journal
T1  - Effect of compositional data in the multivariate analysis of sterol concentrations in river sediments
EP  - 195
SP  - 188
VL  - 139
DO  - 10.1016/j.microc.2018.02.031
ER  - 

@article{
author = "Antanasijević, Davor and Matić-Bujagić, Ivana and Grujić, Svetlana and Laušević, Mila",
year = "2018",
abstract = "In this paper, multivariate analysis of sterol concentrations detected in river sediment samples was performed. In order to remove co-dependence of values, concentrations of sterols were transformed using centered log-ratio (CLR) transformation. The main objective of the work was to point out the damaging effects of working in the wrong geometry on the principal component analysis (PCA) assessment of sterol pollution. In order to determine if the dimension lost have effect on the principal component analysis of sterols in sediments, we have performed the PCA using raw and log-ratio transformed sterol data. Additionally, two rounded zero replacement approaches, i.e. a simple-substitution method (DL/2, 0.55DL and DL/root 2) and multiplicative replacement strategy (0.65 DL), were compared in order to determine if the replacement values have an effect on PCA results and conclusions. Relevant differences were noted by comparing the results of the principal component analysis obtained with raw data and log-ratio transformed sterol data. Only the PC loadings obtained from the CLR PCA allowed the clear distinction between human-sourced pollution and biogenic sources of sterols, whereas in the case of PCA with raw data loadings were all grouped almost in a single quadrant. For the small proportion of rounded zeros (not more than 10%), two different replacement approaches did not have any effect on transformed PCA output. The results presented in this work have shown that the effect of "closure" in the sterol data can be easily observed from the PCA biplot, and that it obstructs the evaluation of human contribution to pollution of river sediments. Therefore, prior to the PCA, sterol concentrations must be CLR transformed in order to perform a reliable assessment of the sewage contamination.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Microchemical Journal",
title = "Effect of compositional data in the multivariate analysis of sterol concentrations in river sediments",
pages = "195-188",
volume = "139",
doi = "10.1016/j.microc.2018.02.031"
}

Antanasijević, D., Matić-Bujagić, I., Grujić, S.,& Laušević, M.. (2018). Effect of compositional data in the multivariate analysis of sterol concentrations in river sediments. in Microchemical Journal
Elsevier Science Bv, Amsterdam., 139, 188-195.
https://doi.org/10.1016/j.microc.2018.02.031

Antanasijević D, Matić-Bujagić I, Grujić S, Laušević M. Effect of compositional data in the multivariate analysis of sterol concentrations in river sediments. in Microchemical Journal. 2018;139:188-195.
doi:10.1016/j.microc.2018.02.031 .

Antanasijević, Davor, Matić-Bujagić, Ivana, Grujić, Svetlana, Laušević, Mila, "Effect of compositional data in the multivariate analysis of sterol concentrations in river sediments" in Microchemical Journal, 139 (2018):188-195,
https://doi.org/10.1016/j.microc.2018.02.031 . .

TY  - JOUR
AU  - Jauković, Zorica D.
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Laušević, Mila
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3630
AB  - The development and optimization of an analytical method for simultaneous extraction, determination and reliable confirmation of twenty steroids from different classes (human/animal and plant sterols, and natural and synthetic steroid hormones) in environmental water and wastewater at ng L-1 levels are described. Water samples were prepared using solid-phase extraction and extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry. Improved instrumental method was developed for complete chromatographic separation of analytes with identical fragmentation reactions, based on the Use of a single C8 column and acetonitrile as organic solvent in the mobile phase. The optimized method provided high recoveries (70-114%) for both water matrices with the RSDs generally lower than 20%. Low limits of detection were achieved for both surface water (0.7-15.0 ng L-1) and wastewater (1.7-15.0 ng L-1). Method displayed good linearity in the tested concentration ranges. As a result of method application to real water samples, cholesterol was detected in all fifteen analyzed river water samples (in the concentration range 176-5162 ng L-1) and all seven wastewater samples (1092-4808 ng L-1). Also, coprostanol, stigmasterol, campesterol, beta-sitosterol and sitostanol were found in the investigated samples. Steroid hormones were not detected in any of the analyzed water samples.
PB  - Elsevier Science Bv, Amsterdam
T2  - Microchemical Journal
T1  - Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry
EP  - 47
SP  - 39
VL  - 135
DO  - 10.1016/j.microc.2017.07.011
ER  - 

@article{
author = "Jauković, Zorica D. and Grujić, Svetlana and Matić-Bujagić, Ivana and Laušević, Mila",
year = "2017",
abstract = "The development and optimization of an analytical method for simultaneous extraction, determination and reliable confirmation of twenty steroids from different classes (human/animal and plant sterols, and natural and synthetic steroid hormones) in environmental water and wastewater at ng L-1 levels are described. Water samples were prepared using solid-phase extraction and extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry. Improved instrumental method was developed for complete chromatographic separation of analytes with identical fragmentation reactions, based on the Use of a single C8 column and acetonitrile as organic solvent in the mobile phase. The optimized method provided high recoveries (70-114%) for both water matrices with the RSDs generally lower than 20%. Low limits of detection were achieved for both surface water (0.7-15.0 ng L-1) and wastewater (1.7-15.0 ng L-1). Method displayed good linearity in the tested concentration ranges. As a result of method application to real water samples, cholesterol was detected in all fifteen analyzed river water samples (in the concentration range 176-5162 ng L-1) and all seven wastewater samples (1092-4808 ng L-1). Also, coprostanol, stigmasterol, campesterol, beta-sitosterol and sitostanol were found in the investigated samples. Steroid hormones were not detected in any of the analyzed water samples.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Microchemical Journal",
title = "Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry",
pages = "47-39",
volume = "135",
doi = "10.1016/j.microc.2017.07.011"
}

Jauković, Z. D., Grujić, S., Matić-Bujagić, I.,& Laušević, M.. (2017). Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. in Microchemical Journal
Elsevier Science Bv, Amsterdam., 135, 39-47.
https://doi.org/10.1016/j.microc.2017.07.011

Jauković ZD, Grujić S, Matić-Bujagić I, Laušević M. Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. in Microchemical Journal. 2017;135:39-47.
doi:10.1016/j.microc.2017.07.011 .

Jauković, Zorica D., Grujić, Svetlana, Matić-Bujagić, Ivana, Laušević, Mila, "Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry" in Microchemical Journal, 135 (2017):39-47,
https://doi.org/10.1016/j.microc.2017.07.011 . .

TY  - JOUR
AU  - Matić-Bujagić, Ivana
AU  - Grujić, Svetlana
AU  - Jauković, Zorica D.
AU  - Laušević, Mila
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3285
AB  - In this work, source pollution tracing of the sediments of the Danube River and its tributaries in Serbia was performed using sterol ratios. Improved liquid chromatography-tandem mass spectrometry method, which enabled complete chromatographic separation of four analytes with identical fragmentation reactions (epicoprostanol, coprostanol, epicholestanol and cholestanol), was applied for the determination of steroid compounds (hormones, human/animal and plant sterols). A widespread occurrence of sterols was identified in all analyzed samples, whereas the only detected hormones were mestranol and 17 alpha-estradiol. A human-sourced sewage marker coprostanol was detected at the highest concentration (up to 1939 ng g(-1)). The ratios between the key sterol biomarkers, as well as the percentage of coprostanol relative to the total sterol amount, were applied with the aim of selecting the most reliable for distinction between human-sourced pollution and the sterols originated from the natural sources in river sediments. The coprostanol/(cholesterol + cholestanol) and coprostanol/epicoprostanol ratios do not distinguish between human and natural sources of sterols in the river sediments in Serbia. The most reliable sterol ratios for the sewage pollution assessment of river sediments in the studied area were found to be coprostanol/(coprostanol + cholestanol), coprostanol/cholesterol and epicoprostanol/coprostanol. For the majority of sediments, human-derived pollution was determined. Two sediment samples were identified as influenced by a combination of human and natural biogenic sources.
PB  - Elsevier Sci Ltd, Oxford
T2  - Environmental Pollution
T1  - Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia
EP  - 83
SP  - 76
VL  - 213
DO  - 10.1016/j.envpol.2015.12.036
ER  - 

@article{
author = "Matić-Bujagić, Ivana and Grujić, Svetlana and Jauković, Zorica D. and Laušević, Mila",
year = "2016",
abstract = "In this work, source pollution tracing of the sediments of the Danube River and its tributaries in Serbia was performed using sterol ratios. Improved liquid chromatography-tandem mass spectrometry method, which enabled complete chromatographic separation of four analytes with identical fragmentation reactions (epicoprostanol, coprostanol, epicholestanol and cholestanol), was applied for the determination of steroid compounds (hormones, human/animal and plant sterols). A widespread occurrence of sterols was identified in all analyzed samples, whereas the only detected hormones were mestranol and 17 alpha-estradiol. A human-sourced sewage marker coprostanol was detected at the highest concentration (up to 1939 ng g(-1)). The ratios between the key sterol biomarkers, as well as the percentage of coprostanol relative to the total sterol amount, were applied with the aim of selecting the most reliable for distinction between human-sourced pollution and the sterols originated from the natural sources in river sediments. The coprostanol/(cholesterol + cholestanol) and coprostanol/epicoprostanol ratios do not distinguish between human and natural sources of sterols in the river sediments in Serbia. The most reliable sterol ratios for the sewage pollution assessment of river sediments in the studied area were found to be coprostanol/(coprostanol + cholestanol), coprostanol/cholesterol and epicoprostanol/coprostanol. For the majority of sediments, human-derived pollution was determined. Two sediment samples were identified as influenced by a combination of human and natural biogenic sources.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Environmental Pollution",
title = "Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia",
pages = "83-76",
volume = "213",
doi = "10.1016/j.envpol.2015.12.036"
}

Matić-Bujagić, I., Grujić, S., Jauković, Z. D.,& Laušević, M.. (2016). Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. in Environmental Pollution
Elsevier Sci Ltd, Oxford., 213, 76-83.
https://doi.org/10.1016/j.envpol.2015.12.036

Matić-Bujagić I, Grujić S, Jauković ZD, Laušević M. Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. in Environmental Pollution. 2016;213:76-83.
doi:10.1016/j.envpol.2015.12.036 .

Matić-Bujagić, Ivana, Grujić, Svetlana, Jauković, Zorica D., Laušević, Mila, "Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia" in Environmental Pollution, 213 (2016):76-83,
https://doi.org/10.1016/j.envpol.2015.12.036 . .

TY  - CONF
AU  - Matić, Ivana V.
AU  - Tolić, Ljiljana M.
AU  - Grujić, Svetlana D.
AU  - Laušević, Mila D.
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7242
AB  - Cilj ovog rada bio je ispitivanje načina adsorpcije i raspodele odabranih lekova i pesticida između vodene faze i sedimenta, kao i određivanje stepena adsorpcije i desorpcije na sedimentu reke Dunav. Rezultati adsorpcije leka karbamazepina i pesticida atrazina, karbendazima i karbofurana pokazuju najbolje slaganje sa Frojndlihovom izotermom, što ukazuje na reverzibilnu adsorpciju. Zbog visokog procenta desorpcije karbamazepina, atrazina i karbendazima, njihovo prisustvo u sistemu voda-sediment je očekivano, dok se karbofuran očekuje u manjoj koncentraciji u vodi, zbog nižeg procenta desorpcije. Lengmirov model opisuje monoslojnu adsorpciju pesticida dimetoata. Ovaj pesticid pokazuje i mali stepen desorpcije, što ukazuje na to da se može akumulirati u sedimentima u visokoj koncentraciji. Adsorpcija lekova trimetoprima, metoprolola i lorazepama se može opisati linearnim modelom. Ovi analiti pokazuju veliki afinitet adsorpcije i mogu se vezati za sediment u koncentracijama većim od ispitivanih. Za razliku od metoprolola i lorazepama, trimetoprim se u velikom procentu desorbuje sa sedimenta, pa se ovaj analit očekuje u vodi. Lekovi bromazepam, eritromicin i amlodipin su pokazali skoro potpunu adsorpciju na sedimentu i veoma mali stepen desorpcije, pa je njihova akumulacija u sedimentima očekivana.
AB  - The aim of this study was investigation of the adsorption and distribution of the selected
pharmaceuticals and pesticides between water phase and sediment, as well as determination
of the adsorption and desorption extent using sediment of the Danube River. Adsorption
data of the drug carbamazepine and pesticides atrazine, carbendazim and carbofuran fit well
to Freundlich isotherm, implying reversible adsorption. Due to high desorption extent of
carbamazepine, atrazine and carbendazim, their presence in water-sediment system is
expected, whereas lower desorption level of carbofuran indicates lower expected
concentration of this pesticide in water. Langmuir model describes monolayer adsorption of
pesticide dimethoate. This pesticide also shows low desorption extent, indicating its high
accumulation in sediments. Adsorption data of pharmaceuticals trimethoprim, metoprolol
and lorazepam fit fine to the linear model. These analytes show high adsorption affinity and
can be adsorbed onto sediment at concentrations higher than tested. Unlike metoprolol and
lorazepam, trimethoprim exhibits higher desorption level, so it is expected in water.
Pharmaceuticals bromazepam, erythromycin and amlodipine displayed almost complete
adsorption onto sediment and extremely low desorption rate, so their accumulation in
sediments is expected.
PB  - Beograd : Srpsko hemijsko društvo
C3  - Knjiga radova / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29. i 30. maj 2015
T1  - Raspodela odabranih lekova i pesticida u sistemu voda-sediment
T1  - Distribution of selected pharmaceuticals and pesticides in water-sediment system
EP  - 62
SP  - 59
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7242
ER  - 

@conference{
author = "Matić, Ivana V. and Tolić, Ljiljana M. and Grujić, Svetlana D. and Laušević, Mila D.",
year = "2015",
abstract = "Cilj ovog rada bio je ispitivanje načina adsorpcije i raspodele odabranih lekova i pesticida između vodene faze i sedimenta, kao i određivanje stepena adsorpcije i desorpcije na sedimentu reke Dunav. Rezultati adsorpcije leka karbamazepina i pesticida atrazina, karbendazima i karbofurana pokazuju najbolje slaganje sa Frojndlihovom izotermom, što ukazuje na reverzibilnu adsorpciju. Zbog visokog procenta desorpcije karbamazepina, atrazina i karbendazima, njihovo prisustvo u sistemu voda-sediment je očekivano, dok se karbofuran očekuje u manjoj koncentraciji u vodi, zbog nižeg procenta desorpcije. Lengmirov model opisuje monoslojnu adsorpciju pesticida dimetoata. Ovaj pesticid pokazuje i mali stepen desorpcije, što ukazuje na to da se može akumulirati u sedimentima u visokoj koncentraciji. Adsorpcija lekova trimetoprima, metoprolola i lorazepama se može opisati linearnim modelom. Ovi analiti pokazuju veliki afinitet adsorpcije i mogu se vezati za sediment u koncentracijama većim od ispitivanih. Za razliku od metoprolola i lorazepama, trimetoprim se u velikom procentu desorbuje sa sedimenta, pa se ovaj analit očekuje u vodi. Lekovi bromazepam, eritromicin i amlodipin su pokazali skoro potpunu adsorpciju na sedimentu i veoma mali stepen desorpcije, pa je njihova akumulacija u sedimentima očekivana., The aim of this study was investigation of the adsorption and distribution of the selected
pharmaceuticals and pesticides between water phase and sediment, as well as determination
of the adsorption and desorption extent using sediment of the Danube River. Adsorption
data of the drug carbamazepine and pesticides atrazine, carbendazim and carbofuran fit well
to Freundlich isotherm, implying reversible adsorption. Due to high desorption extent of
carbamazepine, atrazine and carbendazim, their presence in water-sediment system is
expected, whereas lower desorption level of carbofuran indicates lower expected
concentration of this pesticide in water. Langmuir model describes monolayer adsorption of
pesticide dimethoate. This pesticide also shows low desorption extent, indicating its high
accumulation in sediments. Adsorption data of pharmaceuticals trimethoprim, metoprolol
and lorazepam fit fine to the linear model. These analytes show high adsorption affinity and
can be adsorbed onto sediment at concentrations higher than tested. Unlike metoprolol and
lorazepam, trimethoprim exhibits higher desorption level, so it is expected in water.
Pharmaceuticals bromazepam, erythromycin and amlodipine displayed almost complete
adsorption onto sediment and extremely low desorption rate, so their accumulation in
sediments is expected.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "Knjiga radova / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29. i 30. maj 2015",
title = "Raspodela odabranih lekova i pesticida u sistemu voda-sediment, Distribution of selected pharmaceuticals and pesticides in water-sediment system",
pages = "62-59",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7242"
}

Matić, I. V., Tolić, L. M., Grujić, S. D.,& Laušević, M. D.. (2015). Raspodela odabranih lekova i pesticida u sistemu voda-sediment. in Knjiga radova / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29. i 30. maj 2015
Beograd : Srpsko hemijsko društvo., 59-62.
https://hdl.handle.net/21.15107/rcub_technorep_7242

Matić IV, Tolić LM, Grujić SD, Laušević MD. Raspodela odabranih lekova i pesticida u sistemu voda-sediment. in Knjiga radova / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29. i 30. maj 2015. 2015;:59-62.
https://hdl.handle.net/21.15107/rcub_technorep_7242 .

Matić, Ivana V., Tolić, Ljiljana M., Grujić, Svetlana D., Laušević, Mila D., "Raspodela odabranih lekova i pesticida u sistemu voda-sediment" in Knjiga radova / 52. savetovanje Srpskog hemijskog društva, Novi Sad, 29. i 30. maj 2015 (2015):59-62,
https://hdl.handle.net/21.15107/rcub_technorep_7242 .

TY  - JOUR
AU  - Matić, Ivana
AU  - Grujić, Svetlana
AU  - Jauković, Zorica D.
AU  - Laušević, Mila
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2751
AB  - In this paper, development and optimization of new LC-MS method for determination of twenty selected hormones, human/animal and plant sterols in river sediments were described. Sediment samples were prepared using ultrasonic extraction and clean up with silica gel/anhydrous sodium sulphate cartridge. Extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry, with atmospheric pressure chemical ionization. The optimized extraction parameters were extraction solvent (methanol), weight of the sediment (2g) and time of ultrasonic extraction (3x 10 min). Successful chromatographic separation of hormones (estriol and estrone, 17 alpha- and 17 beta-estradiol) and four human/animal sterols (epicoprostanol, coprostanol, alpha-cholestanol and beta-cholestanol) that have identical fragmentation reactions was achieved. The developed and optimized method provided high recoveries (73-118%), low limits of detection (0.8-18 ng g(-1)) and quantification (2.5-60 ng g(-1)) with the RSDs generally lower than 20%. Applicability of the developed method was confirmed by analysis of six river sediment samples. A widespread occurrence of human/animal and plant sterols was found. The only detected hormone was mestranol in just one sediment sample.
PB  - Elsevier, Amsterdam
T2  - Journal of Chromatography A
T1  - Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry
EP  - 127
SP  - 117
VL  - 1364
DO  - 10.1016/j.chroma.2014.08.061
ER  - 

@article{
author = "Matić, Ivana and Grujić, Svetlana and Jauković, Zorica D. and Laušević, Mila",
year = "2014",
abstract = "In this paper, development and optimization of new LC-MS method for determination of twenty selected hormones, human/animal and plant sterols in river sediments were described. Sediment samples were prepared using ultrasonic extraction and clean up with silica gel/anhydrous sodium sulphate cartridge. Extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry, with atmospheric pressure chemical ionization. The optimized extraction parameters were extraction solvent (methanol), weight of the sediment (2g) and time of ultrasonic extraction (3x 10 min). Successful chromatographic separation of hormones (estriol and estrone, 17 alpha- and 17 beta-estradiol) and four human/animal sterols (epicoprostanol, coprostanol, alpha-cholestanol and beta-cholestanol) that have identical fragmentation reactions was achieved. The developed and optimized method provided high recoveries (73-118%), low limits of detection (0.8-18 ng g(-1)) and quantification (2.5-60 ng g(-1)) with the RSDs generally lower than 20%. Applicability of the developed method was confirmed by analysis of six river sediment samples. A widespread occurrence of human/animal and plant sterols was found. The only detected hormone was mestranol in just one sediment sample.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Chromatography A",
title = "Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry",
pages = "127-117",
volume = "1364",
doi = "10.1016/j.chroma.2014.08.061"
}

Matić, I., Grujić, S., Jauković, Z. D.,& Laušević, M.. (2014). Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. in Journal of Chromatography A
Elsevier, Amsterdam., 1364, 117-127.
https://doi.org/10.1016/j.chroma.2014.08.061

Matić I, Grujić S, Jauković ZD, Laušević M. Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. in Journal of Chromatography A. 2014;1364:117-127.
doi:10.1016/j.chroma.2014.08.061 .

Matić, Ivana, Grujić, Svetlana, Jauković, Zorica D., Laušević, Mila, "Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry" in Journal of Chromatography A, 1364 (2014):117-127,
https://doi.org/10.1016/j.chroma.2014.08.061 . .