TY  - CONF
AU  - Mašulović, Aleksandra
AU  - Lađarević, Jelena
AU  - Veruševski, Vanja
AU  - Matović, Luka
AU  - Svetozarević, Milica
AU  - Mijin, Dušan
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6657
AB  - Considering a significant antioxidant activity of 6-hydroxy-6-methyl-2-pyridones, in this paper four series of arylazo pyridone dyes were subjected to antioxidant ABTS assay. Firstly, preliminary tests were conducted at concentration of 1 mg/ml in order to investigate the effects of different substituents on the dye activity. Based on the preliminary results, dyes with the highest activity were selected for further evaluation of IC50 values and these values were compared with IC50 value of ascorbic acid used as standard. It has been shown that five arylazo pyridone dyes exhibit more potent activity when compared to the ascorbic acid.
AB  - Uzimajući u obzir značajnu antioksidativnu aktivnost 6-hidroksi-4-metil-2-piridona, u okviru ovog rada ispitana je antioksidativna aktivnost četiri serije arilazo piridonskih azo boja pomoću ABTS testa. U prvom delu su urađeni preliminari testovi aktivnosti pri koncentracij od 1 mg/ml kako bi se ispitao uticaj različitih supstituenata na antioksidativnu aktivnost. Na osnovu ovih rezultata izabrane su boje sa najvećom antioksidativnom aktivnošću, i u drugom delu je za njih određena IC50 vrednost i upoređena sa vrednošću askorbinske kiseline koja je korišćena kao standard. Rezultati su pokazali da pet boja imaju značajniju aktivnost od askorbinske kiseline.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova / 35. Međunarodni kongres o procesnoj industriji, PROCESING '22, 1-3. jun 2022, Beograd
T1  - Investigation of antioxidant activity of 6-hydroxy-6-methyl-2-pyridones
T1  - Ispitivanje antioksidativne aktivnosti azo boja na bazi 6--hidroksi-4-metil-2-piridona
EP  - 40
SP  - 37
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6657
ER  - 

@conference{
author = "Mašulović, Aleksandra and Lađarević, Jelena and Veruševski, Vanja and Matović, Luka and Svetozarević, Milica and Mijin, Dušan",
year = "2022",
abstract = "Considering a significant antioxidant activity of 6-hydroxy-6-methyl-2-pyridones, in this paper four series of arylazo pyridone dyes were subjected to antioxidant ABTS assay. Firstly, preliminary tests were conducted at concentration of 1 mg/ml in order to investigate the effects of different substituents on the dye activity. Based on the preliminary results, dyes with the highest activity were selected for further evaluation of IC50 values and these values were compared with IC50 value of ascorbic acid used as standard. It has been shown that five arylazo pyridone dyes exhibit more potent activity when compared to the ascorbic acid., Uzimajući u obzir značajnu antioksidativnu aktivnost 6-hidroksi-4-metil-2-piridona, u okviru ovog rada ispitana je antioksidativna aktivnost četiri serije arilazo piridonskih azo boja pomoću ABTS testa. U prvom delu su urađeni preliminari testovi aktivnosti pri koncentracij od 1 mg/ml kako bi se ispitao uticaj različitih supstituenata na antioksidativnu aktivnost. Na osnovu ovih rezultata izabrane su boje sa najvećom antioksidativnom aktivnošću, i u drugom delu je za njih određena IC50 vrednost i upoređena sa vrednošću askorbinske kiseline koja je korišćena kao standard. Rezultati su pokazali da pet boja imaju značajniju aktivnost od askorbinske kiseline.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova / 35. Međunarodni kongres o procesnoj industriji, PROCESING '22, 1-3. jun 2022, Beograd",
title = "Investigation of antioxidant activity of 6-hydroxy-6-methyl-2-pyridones, Ispitivanje antioksidativne aktivnosti azo boja na bazi 6--hidroksi-4-metil-2-piridona",
pages = "40-37",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6657"
}

Mašulović, A., Lađarević, J., Veruševski, V., Matović, L., Svetozarević, M.,& Mijin, D.. (2022). Investigation of antioxidant activity of 6-hydroxy-6-methyl-2-pyridones. in Zbornik radova / 35. Međunarodni kongres o procesnoj industriji, PROCESING '22, 1-3. jun 2022, Beograd
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 37-40.
https://hdl.handle.net/21.15107/rcub_technorep_6657

Mašulović A, Lađarević J, Veruševski V, Matović L, Svetozarević M, Mijin D. Investigation of antioxidant activity of 6-hydroxy-6-methyl-2-pyridones. in Zbornik radova / 35. Međunarodni kongres o procesnoj industriji, PROCESING '22, 1-3. jun 2022, Beograd. 2022;:37-40.
https://hdl.handle.net/21.15107/rcub_technorep_6657 .

Mašulović, Aleksandra, Lađarević, Jelena, Veruševski, Vanja, Matović, Luka, Svetozarević, Milica, Mijin, Dušan, "Investigation of antioxidant activity of 6-hydroxy-6-methyl-2-pyridones" in Zbornik radova / 35. Međunarodni kongres o procesnoj industriji, PROCESING '22, 1-3. jun 2022, Beograd (2022):37-40,
https://hdl.handle.net/21.15107/rcub_technorep_6657 .

TY  - JOUR
AU  - Lunić, Tanja
AU  - Lađarević, Jelena
AU  - Mandić, Marija
AU  - Veruševski, Vanja
AU  - Božić-Nedeljković, Biljana
AU  - Mijin, Dušan
AU  - Božić, Bojan
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4728
AB  - Series of twenty-four 2-pyridone derivatives were screened and selected using the antioxidant ABTS assay
in order to find the most prominent compounds for further in vitro and in silico analyses. Seven derivatives with the highest antioxidant activities were selected and evaluated by β-carotene bleaching assay,
where all of the compounds exhibited better activities than standard antioxidant substance, vitamin C.
Furthermore, seven selected 2-pyridones exhibited significant anti-neuroinflammatory activity by reducing the production of pro-inflammatory mediators (ROS, NO, IL-6, and TNF-α) by LPS-stimulated BV2
microglial cells. Moreover, neuroprotective activity in microglia supernatant transfer model system on
SH-SY5Y neuronal cells has been observed. Anti-neuroinflammatory mechanisms of selected 2-pyridones
have been investigated by molecular docking studies of the TLR4 signaling pathway proteins as well as
inducible nitric oxide synthase. The present study suggests that selected 2-pyridone derivatives can alleviate neuroinflammation in microglial cells and protect the surrounding neuronal cells from damage,
which qualifies them for further investigations towards neurodegenerative diseases associated with inflammation.
PB  - Elsevier B.V.
T2  - Journal of Molecular Structure
T1  - Antioxidant and neuroprotective activities of selected 2-pyridones: In vitro and in silico study
SP  - 132546
VL  - 1256
DO  - 10.1016/j.molstruc.2022.132546
ER  - 

@article{
author = "Lunić, Tanja and Lađarević, Jelena and Mandić, Marija and Veruševski, Vanja and Božić-Nedeljković, Biljana and Mijin, Dušan and Božić, Bojan",
year = "2022",
abstract = "Series of twenty-four 2-pyridone derivatives were screened and selected using the antioxidant ABTS assay
in order to find the most prominent compounds for further in vitro and in silico analyses. Seven derivatives with the highest antioxidant activities were selected and evaluated by β-carotene bleaching assay,
where all of the compounds exhibited better activities than standard antioxidant substance, vitamin C.
Furthermore, seven selected 2-pyridones exhibited significant anti-neuroinflammatory activity by reducing the production of pro-inflammatory mediators (ROS, NO, IL-6, and TNF-α) by LPS-stimulated BV2
microglial cells. Moreover, neuroprotective activity in microglia supernatant transfer model system on
SH-SY5Y neuronal cells has been observed. Anti-neuroinflammatory mechanisms of selected 2-pyridones
have been investigated by molecular docking studies of the TLR4 signaling pathway proteins as well as
inducible nitric oxide synthase. The present study suggests that selected 2-pyridone derivatives can alleviate neuroinflammation in microglial cells and protect the surrounding neuronal cells from damage,
which qualifies them for further investigations towards neurodegenerative diseases associated with inflammation.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Structure",
title = "Antioxidant and neuroprotective activities of selected 2-pyridones: In vitro and in silico study",
pages = "132546",
volume = "1256",
doi = "10.1016/j.molstruc.2022.132546"
}

Lunić, T., Lađarević, J., Mandić, M., Veruševski, V., Božić-Nedeljković, B., Mijin, D.,& Božić, B.. (2022). Antioxidant and neuroprotective activities of selected 2-pyridones: In vitro and in silico study. in Journal of Molecular Structure
Elsevier B.V.., 1256, 132546.
https://doi.org/10.1016/j.molstruc.2022.132546

Lunić T, Lađarević J, Mandić M, Veruševski V, Božić-Nedeljković B, Mijin D, Božić B. Antioxidant and neuroprotective activities of selected 2-pyridones: In vitro and in silico study. in Journal of Molecular Structure. 2022;1256:132546.
doi:10.1016/j.molstruc.2022.132546 .

Lunić, Tanja, Lađarević, Jelena, Mandić, Marija, Veruševski, Vanja, Božić-Nedeljković, Biljana, Mijin, Dušan, Božić, Bojan, "Antioxidant and neuroprotective activities of selected 2-pyridones: In vitro and in silico study" in Journal of Molecular Structure, 1256 (2022):132546,
https://doi.org/10.1016/j.molstruc.2022.132546 . .