TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Petrović, Slobodan
AU  - Živković, Predrag M.
AU  - Mijin, Dušan
AU  - Drljević, Katica
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1671
AB  - Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 to 8.96; from 8.40 to 8.77 in the presence of erythromycin A, and from 8.40 to 9.18 in the presence of azithromycin, indicating the reaction of the hydrogen species with antibiotics. This effect has been confirmed by using the phenolphthalein indicator and by analysing colours of the solutions by UV-Vis, as well as by FTIR spectroscopy. Under the identical experimental conditions at the gold electrode, in contrast to azithromycin dihydrate and erythromycin A, roxithromycin and midecamycin electroactivity promotion has been obtained during the first forward sweep starting from the area of a double layer region.
AB  - Metodom ciklične voltametrije je pokazano da je izdvajanje vodonika na elektrodi od zlata neophodno za elektrohemijsku aktivaciju azitromicin-dihidrata i eritromicina A. Četiri sata držanja potencijala na vrednosti 1,2 V vs. SCE je rezultovalo u promeni pH elektrolita sa 8,40 na 8,96; sa 8,40 na 8,77 u prisustvu eritromicina A, i sa 8,40 na 9,18 u prisustvu azitromicina, ukazujući na reakciju čestica izdvojenog vodonika sa antibioticima. Efekat je potvrđen upotrebom fenolftalein indikatora i analizom boje elektrolita UV-Vis spektroskopijom, a molekula antibiotika FTIR spektroskopijom. Pod istim eksperimentalnim uslovima na elektrodi od zlata, u suprotnosti sa ponašanjem azitromicin-dihidrata i eritromicina A, elektroaktivnost roksitromicina i midekamicina je uočena počevši od oblasti formiranja dvojnog sloja, tj. bez ikakvog učešća čestica izdvojenog vodonika.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution
T1  - Ispitivanje katalitičke uloge elektrode od zlata u elektrohemijskoj aktivaciji četiri makrolidna antibiotika u natrijum-bikarbonatnom elektrolitu
EP  - 116
IS  - 2
SP  - 111
VL  - 16
DO  - 10.2298/CICEQ091211017A
ER  - 

@article{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Živković, Predrag M. and Mijin, Dušan and Drljević, Katica",
year = "2010",
abstract = "Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 to 8.96; from 8.40 to 8.77 in the presence of erythromycin A, and from 8.40 to 9.18 in the presence of azithromycin, indicating the reaction of the hydrogen species with antibiotics. This effect has been confirmed by using the phenolphthalein indicator and by analysing colours of the solutions by UV-Vis, as well as by FTIR spectroscopy. Under the identical experimental conditions at the gold electrode, in contrast to azithromycin dihydrate and erythromycin A, roxithromycin and midecamycin electroactivity promotion has been obtained during the first forward sweep starting from the area of a double layer region., Metodom ciklične voltametrije je pokazano da je izdvajanje vodonika na elektrodi od zlata neophodno za elektrohemijsku aktivaciju azitromicin-dihidrata i eritromicina A. Četiri sata držanja potencijala na vrednosti 1,2 V vs. SCE je rezultovalo u promeni pH elektrolita sa 8,40 na 8,96; sa 8,40 na 8,77 u prisustvu eritromicina A, i sa 8,40 na 9,18 u prisustvu azitromicina, ukazujući na reakciju čestica izdvojenog vodonika sa antibioticima. Efekat je potvrđen upotrebom fenolftalein indikatora i analizom boje elektrolita UV-Vis spektroskopijom, a molekula antibiotika FTIR spektroskopijom. Pod istim eksperimentalnim uslovima na elektrodi od zlata, u suprotnosti sa ponašanjem azitromicin-dihidrata i eritromicina A, elektroaktivnost roksitromicina i midekamicina je uočena počevši od oblasti formiranja dvojnog sloja, tj. bez ikakvog učešća čestica izdvojenog vodonika.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution, Ispitivanje katalitičke uloge elektrode od zlata u elektrohemijskoj aktivaciji četiri makrolidna antibiotika u natrijum-bikarbonatnom elektrolitu",
pages = "116-111",
number = "2",
volume = "16",
doi = "10.2298/CICEQ091211017A"
}

Avramov-Ivić, M., Petrović, S., Živković, P. M., Mijin, D.,& Drljević, K.. (2010). A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 16(2), 111-116.
https://doi.org/10.2298/CICEQ091211017A

Avramov-Ivić M, Petrović S, Živković PM, Mijin D, Drljević K. A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution. in Chemical Industry & Chemical Engineering Quarterly. 2010;16(2):111-116.
doi:10.2298/CICEQ091211017A .

Avramov-Ivić, Milka, Petrović, Slobodan, Živković, Predrag M., Mijin, Dušan, Drljević, Katica, "A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution" in Chemical Industry & Chemical Engineering Quarterly, 16, no. 2 (2010):111-116,
https://doi.org/10.2298/CICEQ091211017A . .

TY  - CONF
AU  - Avramov-Ivić, Milka
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
AU  - Drljević, Katica
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1556
AB  - A gold electrode was applied in the voltammetric determination of oseltamivir phosphate standard in 0.05 M NaHCO3. Oseltamivir phosphate as a standard and as a component of Tamiflu capsule exhibited the identycal cyclic voltammogram. The electrochemical method for the qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry was developed.
PB  - Serbian Chemical Society, Belgrade
C3  - Second Regional Symposium on Electrochemistry South-East Europe, RSE-SEE, Program and Book of Abstra
T1  - The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry with simultaneous HPLC determination
EP  - 111
SP  - 111
UR  - https://hdl.handle.net/21.15107/rcub_technorep_1556
ER  - 

@conference{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan and Drljević, Katica",
year = "2010",
abstract = "A gold electrode was applied in the voltammetric determination of oseltamivir phosphate standard in 0.05 M NaHCO3. Oseltamivir phosphate as a standard and as a component of Tamiflu capsule exhibited the identycal cyclic voltammogram. The electrochemical method for the qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry was developed.",
publisher = "Serbian Chemical Society, Belgrade",
journal = "Second Regional Symposium on Electrochemistry South-East Europe, RSE-SEE, Program and Book of Abstra",
title = "The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry with simultaneous HPLC determination",
pages = "111-111",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1556"
}

Avramov-Ivić, M., Petrović, S., Mijin, D.,& Drljević, K.. (2010). The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry with simultaneous HPLC determination. in Second Regional Symposium on Electrochemistry South-East Europe, RSE-SEE, Program and Book of Abstra
Serbian Chemical Society, Belgrade., 111-111.
https://hdl.handle.net/21.15107/rcub_technorep_1556

Avramov-Ivić M, Petrović S, Mijin D, Drljević K. The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry with simultaneous HPLC determination. in Second Regional Symposium on Electrochemistry South-East Europe, RSE-SEE, Program and Book of Abstra. 2010;:111-111.
https://hdl.handle.net/21.15107/rcub_technorep_1556 .

Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, Drljević, Katica, "The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry with simultaneous HPLC determination" in Second Regional Symposium on Electrochemistry South-East Europe, RSE-SEE, Program and Book of Abstra (2010):111-111,
https://hdl.handle.net/21.15107/rcub_technorep_1556 .

TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Petrović, Slobodan
AU  - Vonmoos, F.
AU  - Mijin, Dušan
AU  - Živković, Predrag M.
AU  - Drljević, Katica
PY  - 2008
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1249
AB  - The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.
PB  - Pleiades Publishing Inc, Moscow
T2  - Russian Journal of Electrochemistry
T1  - The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes
EP  - 936
IS  - 8
SP  - 931
VL  - 44
DO  - 10.1134/S1023193508080089
ER  - 

@article{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljević, Katica",
year = "2008",
abstract = "The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.",
publisher = "Pleiades Publishing Inc, Moscow",
journal = "Russian Journal of Electrochemistry",
title = "The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes",
pages = "936-931",
number = "8",
volume = "44",
doi = "10.1134/S1023193508080089"
}

Avramov-Ivić, M., Petrović, S., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljević, K.. (2008). The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes. in Russian Journal of Electrochemistry
Pleiades Publishing Inc, Moscow., 44(8), 931-936.
https://doi.org/10.1134/S1023193508080089

Avramov-Ivić M, Petrović S, Vonmoos F, Mijin D, Živković PM, Drljević K. The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes. in Russian Journal of Electrochemistry. 2008;44(8):931-936.
doi:10.1134/S1023193508080089 .

Avramov-Ivić, Milka, Petrović, Slobodan, Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljević, Katica, "The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes" in Russian Journal of Electrochemistry, 44, no. 8 (2008):931-936,
https://doi.org/10.1134/S1023193508080089 . .

TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Petrović, Slobodan
AU  - Vonmoos, F.
AU  - Mijin, Dušan
AU  - Živković, Predrag M.
AU  - Drljević, Katica
PY  - 2007
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1160
AB  - The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.
PB  - Elsevier Science Inc, New York
T2  - Electrochemistry Communications
T1  - The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode
EP  - 1647
IS  - 7
SP  - 1643
VL  - 9
DO  - 10.1016/j.elecom.2007.03.011
ER  - 

@article{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljević, Katica",
year = "2007",
abstract = "The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.",
publisher = "Elsevier Science Inc, New York",
journal = "Electrochemistry Communications",
title = "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode",
pages = "1647-1643",
number = "7",
volume = "9",
doi = "10.1016/j.elecom.2007.03.011"
}

Avramov-Ivić, M., Petrović, S., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljević, K.. (2007). The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications
Elsevier Science Inc, New York., 9(7), 1643-1647.
https://doi.org/10.1016/j.elecom.2007.03.011

Avramov-Ivić M, Petrović S, Vonmoos F, Mijin D, Živković PM, Drljević K. The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications. 2007;9(7):1643-1647.
doi:10.1016/j.elecom.2007.03.011 .

Avramov-Ivić, Milka, Petrović, Slobodan, Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljević, Katica, "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode" in Electrochemistry Communications, 9, no. 7 (2007):1643-1647,
https://doi.org/10.1016/j.elecom.2007.03.011 . .

TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
AU  - Živković, Predrag M.
AU  - Kosović, IM
AU  - Drljević, Katica
AU  - Jovanović, Mica B.
PY  - 2006
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/863
AB  - The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of azithromycin and on the azithromycin/lactose, separation.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte
EP  - 2416
IS  - 12
SP  - 2407
VL  - 51
DO  - 10.1016/j.electacta.2005.07.032
ER  - 

@article{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan and Živković, Predrag M. and Kosović, IM and Drljević, Katica and Jovanović, Mica B.",
year = "2006",
abstract = "The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of azithromycin and on the azithromycin/lactose, separation.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte",
pages = "2416-2407",
number = "12",
volume = "51",
doi = "10.1016/j.electacta.2005.07.032"
}

Avramov-Ivić, M., Petrović, S., Mijin, D., Živković, P. M., Kosović, I., Drljević, K.,& Jovanović, M. B.. (2006). Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 51(12), 2407-2416.
https://doi.org/10.1016/j.electacta.2005.07.032

Avramov-Ivić M, Petrović S, Mijin D, Živković PM, Kosović I, Drljević K, Jovanović MB. Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte. in Electrochimica Acta. 2006;51(12):2407-2416.
doi:10.1016/j.electacta.2005.07.032 .

Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, Živković, Predrag M., Kosović, IM, Drljević, Katica, Jovanović, Mica B., "Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte" in Electrochimica Acta, 51, no. 12 (2006):2407-2416,
https://doi.org/10.1016/j.electacta.2005.07.032 . .