@conference{
author = "Lazić, Anita and Gak, Kristina and Valentić, Nataša and Rogan, Jelena and Radovanović, Lidija and Đukić, Maja and Matović, Zoran and Trišović, Nemanja",
year = "2019",
abstract = "U okviru proučavanja uticaja strukture na farmakološku aktivnost derivata hidantoina,
5-(3-metilfenil)-5-metilhidantoin (1) i 5-(4-metoksifenil)-5-metilhidantoin (2) su sintetisani i
potpuno strukturno okarakterisani određivanjem temperature topljenje, FTIR, 1H i 13C NMR
spektroskopskim metodama. Određene su njihove kristalne strukture i izvršena je analiza
kristalnog pakovanja sa aspekta međumolekulskih interakcija i strukturnih motiva. U
kristalnom pakovanju oba jedinjenja uspostavljaju se jake intermolekulske N-H···O vodonične
veze između njihovih R i S izomera. Vezivanje proučavanih jedinjenja za DNK i serum humanog
albumina (HSA) proučavano je merenjem gašenja fluerescencije triptofana. Pokazano je da 2
ima viši afinitet vezivanja i za DNK i HSA od 1. Predstavljeno istraživanje pruža smernice za
dizajniranje novih derivata hidantoina sa poboljšanim farmakološkim svojstvima., Within the framework of the investigation of the structure–activity relationship of
hydantoin derivatives, 5-(3-methylphenyl)-5-methylhydantoin (1) and 5-(4-methoxyphe-
nyl)-5-methylhydantoin (2) were synthesized and structurally characterized by determi-
nation of their melting points, FTIR, 1H and 13C spectroscopic techniques. Their crystal
structures were determined and the analysis of the crystal packings in terms of the
contributing intermolecular interactions and structural motifs was performed. In the crystal
packing of both compounds, strong intermolecular N-H···O hydrogen bonds were observed
between their R and S isomers. Binding of the investigated compounds to DNA and to
human serum albumin (HSA) was studied by measuring quenching of the fluorescence of
tryptophan. It was shown that 2 has a higher binding affinity for both DNA and HSA than 1.
The presented investigation provide guidance for design of novel hydantoin derivatives with
improved pharmacological properties.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Kratki izvodi radova = Book of Abstracts / 56. savetovanje Srpskog hemijskog društva , Niš 7. i 8. juni 2019. = 56th meeting of the Serbian chemical society, Niš, Serbia, June 7-8, 2019",
title = "Proučavanje kristalne strukture i interakcija 5-(3- i 4-supstituisanih)-5-metilhidantoina sa albuminom humanog seruma i DNK, Study of the crystal structure and interactions of 5-(3- and 4-substituted)-5-methylhydantoins with human serum albumin and DNA",
pages = "92",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7405"
}
