TY  - JOUR
AU  - Lukić, Ivana
AU  - Vulić, Jelena
AU  - Ivanović, Jasna
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4561
AB  - Present study was aimed to produce biodegradable films with antioxidant activity for active food packaging. Films of poly(lactic acid) (PLA) with 5 wt% of poly(ε-caprolactone) (PCL), denoted as PLA-5, were loaded with thymol, carvacrol and their mixture using supercritical CO2 at 40 °C and 10 MPa for 5 h, with 27.53, 21.18, and 21.49 % of loading achieved, respectively. Morphological, structural and mechanical properties of the obtained PLA-5 films were analyzed. The highest total polyphenol content and the best antioxidant activity as well as good storage stability, acceptable physical properties and the lowest release rate (44.51 mg/L released after 6 weeks) were observed for PLA-5 film loaded with thymol and carvacrol mixture. Mixture of thymol and carvacrol loaded into PLA-5 film showed synergy and low percentage of migration into distilled water, revealing great potential for application as a food packaging material with aim to decrease requirements for amount of the active ingredients.
T2  - Food Packaging and Shelf Life
T1  - Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO2 for active food packaging
VL  - 26
DO  - 10.1016/j.fpsl.2020.100578
ER  - 

@article{
author = "Lukić, Ivana and Vulić, Jelena and Ivanović, Jasna",
year = "2020",
abstract = "Present study was aimed to produce biodegradable films with antioxidant activity for active food packaging. Films of poly(lactic acid) (PLA) with 5 wt% of poly(ε-caprolactone) (PCL), denoted as PLA-5, were loaded with thymol, carvacrol and their mixture using supercritical CO2 at 40 °C and 10 MPa for 5 h, with 27.53, 21.18, and 21.49 % of loading achieved, respectively. Morphological, structural and mechanical properties of the obtained PLA-5 films were analyzed. The highest total polyphenol content and the best antioxidant activity as well as good storage stability, acceptable physical properties and the lowest release rate (44.51 mg/L released after 6 weeks) were observed for PLA-5 film loaded with thymol and carvacrol mixture. Mixture of thymol and carvacrol loaded into PLA-5 film showed synergy and low percentage of migration into distilled water, revealing great potential for application as a food packaging material with aim to decrease requirements for amount of the active ingredients.",
journal = "Food Packaging and Shelf Life",
title = "Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO2 for active food packaging",
volume = "26",
doi = "10.1016/j.fpsl.2020.100578"
}

Lukić, I., Vulić, J.,& Ivanović, J.. (2020). Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO2 for active food packaging. in Food Packaging and Shelf Life, 26.
https://doi.org/10.1016/j.fpsl.2020.100578

Lukić I, Vulić J, Ivanović J. Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO2 for active food packaging. in Food Packaging and Shelf Life. 2020;26.
doi:10.1016/j.fpsl.2020.100578 .

Lukić, Ivana, Vulić, Jelena, Ivanović, Jasna, "Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO2 for active food packaging" in Food Packaging and Shelf Life, 26 (2020),
https://doi.org/10.1016/j.fpsl.2020.100578 . .

TY  - JOUR
AU  - Kovačević, Strahinja
AU  - Karadzić-Banjac, Milica
AU  - Podunavac-Kuzmanović, Sanja
AU  - Milošević, Nataša
AU  - Curcić, Jelena
AU  - Vulić, Jelena
AU  - Seregelj, Vanja
AU  - Banjac, Nebojša
AU  - Ušćumlić, Gordana
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5885
AB  - The present study is focused on a series of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimide derivatives, as potential anticonvulsants. The retention behavior of eleven succinimide derivatives was determined by using reversed phase high performance liquid chromatography (RP-HPLC) and reversed phase high performance thin layer chromatography (RP-HPTLC). The estimated retention behavior was correlated with partition (logP) and distribution coefficients (logD). These high correlations pointed out that the determined retention parameters (logK(0) and R-M(0)) can be considered chromatographic (anisotropic) lipophilicity of the studied succinimide derivatives. The structural properties, which dominantly affect the chromatographic lipophilicity, were determined as well. The significant correlations between the chromatographic lipophilicity and plasma protein binding (PPB), Madin-Darby Canine Kidney (MDCK) cells permeability, volume of distribution (Vd) and absorption constant (Ka) indicate the strong influence of lipophilicity on pharmacokinetics of 1-aryl-3-ethyl-3-methylsuccinimide derivatives. These derivatives have also been tested applying Comprehensive Medicinal Chemistry (CMC) drug-like rules which confirmed their drug-like properties. Besides, their blood-brain penetration (BBB) ability has been estimated applying the set of Clark's rules and by using Pre-ADMET software. Regarding toxicity, it was predicted that only one compound from the set might have toxic effects by blocking the hERG potassium channel. The present study reveals which molecular features in the structure of novel succinimide derivatives could be crucial for their lipophilicity, and consequently for their pharmacokinetic properties. The results indicate that the newly synthesized series of succinimide derivatives should be further considered in design of novel anticonvulsants.
PB  - Elsevier Sci Ltd, Oxford
T2  - Computational Biology and Chemistry
T1  - Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides
VL  - 84
DO  - 10.1016/j.compbiolchem.2019.107161
ER  - 

@article{
author = "Kovačević, Strahinja and Karadzić-Banjac, Milica and Podunavac-Kuzmanović, Sanja and Milošević, Nataša and Curcić, Jelena and Vulić, Jelena and Seregelj, Vanja and Banjac, Nebojša and Ušćumlić, Gordana",
year = "2020",
abstract = "The present study is focused on a series of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimide derivatives, as potential anticonvulsants. The retention behavior of eleven succinimide derivatives was determined by using reversed phase high performance liquid chromatography (RP-HPLC) and reversed phase high performance thin layer chromatography (RP-HPTLC). The estimated retention behavior was correlated with partition (logP) and distribution coefficients (logD). These high correlations pointed out that the determined retention parameters (logK(0) and R-M(0)) can be considered chromatographic (anisotropic) lipophilicity of the studied succinimide derivatives. The structural properties, which dominantly affect the chromatographic lipophilicity, were determined as well. The significant correlations between the chromatographic lipophilicity and plasma protein binding (PPB), Madin-Darby Canine Kidney (MDCK) cells permeability, volume of distribution (Vd) and absorption constant (Ka) indicate the strong influence of lipophilicity on pharmacokinetics of 1-aryl-3-ethyl-3-methylsuccinimide derivatives. These derivatives have also been tested applying Comprehensive Medicinal Chemistry (CMC) drug-like rules which confirmed their drug-like properties. Besides, their blood-brain penetration (BBB) ability has been estimated applying the set of Clark's rules and by using Pre-ADMET software. Regarding toxicity, it was predicted that only one compound from the set might have toxic effects by blocking the hERG potassium channel. The present study reveals which molecular features in the structure of novel succinimide derivatives could be crucial for their lipophilicity, and consequently for their pharmacokinetic properties. The results indicate that the newly synthesized series of succinimide derivatives should be further considered in design of novel anticonvulsants.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Computational Biology and Chemistry",
title = "Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides",
volume = "84",
doi = "10.1016/j.compbiolchem.2019.107161"
}

Kovačević, S., Karadzić-Banjac, M., Podunavac-Kuzmanović, S., Milošević, N., Curcić, J., Vulić, J., Seregelj, V., Banjac, N.,& Ušćumlić, G.. (2020). Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides. in Computational Biology and Chemistry
Elsevier Sci Ltd, Oxford., 84.
https://doi.org/10.1016/j.compbiolchem.2019.107161

Kovačević S, Karadzić-Banjac M, Podunavac-Kuzmanović S, Milošević N, Curcić J, Vulić J, Seregelj V, Banjac N, Ušćumlić G. Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides. in Computational Biology and Chemistry. 2020;84.
doi:10.1016/j.compbiolchem.2019.107161 .

Kovačević, Strahinja, Karadzić-Banjac, Milica, Podunavac-Kuzmanović, Sanja, Milošević, Nataša, Curcić, Jelena, Vulić, Jelena, Seregelj, Vanja, Banjac, Nebojša, Ušćumlić, Gordana, "Chromatographic and computational screening of anisotropic lipophilicity and pharmacokinetics of newly synthesized 1-aryl-3-ethyl-3-methylsuccinimides" in Computational Biology and Chemistry, 84 (2020),
https://doi.org/10.1016/j.compbiolchem.2019.107161 . .

TY  - JOUR
AU  - Stamenić, Marko
AU  - Vulić, Jelena
AU  - Đilas, Sonja
AU  - Mišić, Dušan
AU  - Tadić, Vanja
AU  - Petrović, Slobodan
AU  - Žižović, Irena
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2655
AB  - The antioxidant and antibacterial properties of Greek oregano extracts obtained by fractional supercritical fluid extraction (SFE) with carbon dioxide were investigated and compared with the properties of essential oil obtained by hydrodistillation. According to DPPH., hydroxyl radical and superoxide anion radical scavenging activity assays, the supercritical extracts expressed stronger antioxidant activity comparing to the essential oil. The most effective was the supercritical extract obtained by fractional extraction at 30 MPa and 100 degrees C after the volatile fraction had been extracted at lower pressure. At the same time this extract showed strong antibacterial activity against staphylococci, including MASA strain, but did not affect Escherichia coli of normal intestinal flora. The essential oil obtained by hydrodistillation showed stronger antibacterial activity against E. coli, Salmonella and Klebsiella pneumoniae, comparing to the supercritical extracts but at the same affected the normal gut flora.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Free-radical scavenging activity and antibacterial impact of Greek oregano isolates obtained by SFE
EP  - 315
SP  - 307
VL  - 165
DO  - 10.1016/j.foodchem.2014.05.091
ER  - 

@article{
author = "Stamenić, Marko and Vulić, Jelena and Đilas, Sonja and Mišić, Dušan and Tadić, Vanja and Petrović, Slobodan and Žižović, Irena",
year = "2014",
abstract = "The antioxidant and antibacterial properties of Greek oregano extracts obtained by fractional supercritical fluid extraction (SFE) with carbon dioxide were investigated and compared with the properties of essential oil obtained by hydrodistillation. According to DPPH., hydroxyl radical and superoxide anion radical scavenging activity assays, the supercritical extracts expressed stronger antioxidant activity comparing to the essential oil. The most effective was the supercritical extract obtained by fractional extraction at 30 MPa and 100 degrees C after the volatile fraction had been extracted at lower pressure. At the same time this extract showed strong antibacterial activity against staphylococci, including MASA strain, but did not affect Escherichia coli of normal intestinal flora. The essential oil obtained by hydrodistillation showed stronger antibacterial activity against E. coli, Salmonella and Klebsiella pneumoniae, comparing to the supercritical extracts but at the same affected the normal gut flora.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Free-radical scavenging activity and antibacterial impact of Greek oregano isolates obtained by SFE",
pages = "315-307",
volume = "165",
doi = "10.1016/j.foodchem.2014.05.091"
}

Stamenić, M., Vulić, J., Đilas, S., Mišić, D., Tadić, V., Petrović, S.,& Žižović, I.. (2014). Free-radical scavenging activity and antibacterial impact of Greek oregano isolates obtained by SFE. in Food Chemistry
Elsevier Sci Ltd, Oxford., 165, 307-315.
https://doi.org/10.1016/j.foodchem.2014.05.091

Stamenić M, Vulić J, Đilas S, Mišić D, Tadić V, Petrović S, Žižović I. Free-radical scavenging activity and antibacterial impact of Greek oregano isolates obtained by SFE. in Food Chemistry. 2014;165:307-315.
doi:10.1016/j.foodchem.2014.05.091 .

Stamenić, Marko, Vulić, Jelena, Đilas, Sonja, Mišić, Dušan, Tadić, Vanja, Petrović, Slobodan, Žižović, Irena, "Free-radical scavenging activity and antibacterial impact of Greek oregano isolates obtained by SFE" in Food Chemistry, 165 (2014):307-315,
https://doi.org/10.1016/j.foodchem.2014.05.091 . .