TY  - JOUR
AU  - Mijin, Dušan
AU  - Božić-Nedeljković, Biljana
AU  - Božić, Bojan
AU  - Kovrlija, Ilijana
AU  - Lađarević, Jelena
AU  - Ušćumlić, Gordana
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4008
AB  - New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and H-1 and C-13 NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed. An MTT (3,4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test was performed to prove the biocompatibility of the investigated dyes. The investigated dyes exhibited satisfying antiproliferative activities against both tumor cell lines, MDA-MB-231 and HCT-116, demonstrating the potent capacity for treatment of tumors.
PB  - Scientific Technical Research Council Turkey-Tubitak, Ankara
T2  - Turkish Journal of Chemistry
T1  - Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties
EP  - 907
IS  - 3
SP  - 896
VL  - 42
DO  - 10.3906/kim-1711-97
ER  - 

@article{
author = "Mijin, Dušan and Božić-Nedeljković, Biljana and Božić, Bojan and Kovrlija, Ilijana and Lađarević, Jelena and Ušćumlić, Gordana",
year = "2018",
abstract = "New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and H-1 and C-13 NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed. An MTT (3,4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test was performed to prove the biocompatibility of the investigated dyes. The investigated dyes exhibited satisfying antiproliferative activities against both tumor cell lines, MDA-MB-231 and HCT-116, demonstrating the potent capacity for treatment of tumors.",
publisher = "Scientific Technical Research Council Turkey-Tubitak, Ankara",
journal = "Turkish Journal of Chemistry",
title = "Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties",
pages = "907-896",
number = "3",
volume = "42",
doi = "10.3906/kim-1711-97"
}

Mijin, D., Božić-Nedeljković, B., Božić, B., Kovrlija, I., Lađarević, J.,& Ušćumlić, G.. (2018). Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties. in Turkish Journal of Chemistry
Scientific Technical Research Council Turkey-Tubitak, Ankara., 42(3), 896-907.
https://doi.org/10.3906/kim-1711-97

Mijin D, Božić-Nedeljković B, Božić B, Kovrlija I, Lađarević J, Ušćumlić G. Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties. in Turkish Journal of Chemistry. 2018;42(3):896-907.
doi:10.3906/kim-1711-97 .

Mijin, Dušan, Božić-Nedeljković, Biljana, Božić, Bojan, Kovrlija, Ilijana, Lađarević, Jelena, Ušćumlić, Gordana, "Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties" in Turkish Journal of Chemistry, 42, no. 3 (2018):896-907,
https://doi.org/10.3906/kim-1711-97 . .