TY  - CONF
AU  - Tolić, Ljiljana
AU  - Grujić, Svetlana
AU  - Laušević, Mila
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7256
AB  - U cilju poboljšanja kvaliteta leka i unapređenja sigurnosti njegovog korišćenja, potrebno je praćenje stabilnosti i određivanje degradacionih proizvoda koji mogu nastati tokom proizvodnje, rukovanja ili čuvanja leka. Cilj ovog rada je ispitivanje stabilnosti i praćenje degradacije višefun-kcionalnog leka anizomicina. Stabilnost anizomicina je ispitivana sprovođenjem studija forsirane degradacije, koje obuhvataju ispitivanje osetljivosti leka na hidrolizu (kiselu, baznu i neutralnu), oksidaciju, svetlost (vidljivu i UV) i povišenu temperaturu, u skladu sa ICH (eng. International Conference on Harmonization) smernicama. Za praćenje degradacije leka i identifikaciju degradacionih prozvoda korišćena je metoda tečne hromatografije sa tandem masenom spek-trometrijom. Pokazano je da je anizomicin stabilan u prisustvu oksidacionog sredstva i svetlosti, umereno stabilan u kiseloj i neutralnoj sredini, jako nestabilan u baznoj sredini i termo-degradabilan. Deacetilanizomicin je identifikovan kao glavni proizvod degradacije anisomicina.
AB  - In order to improve the quality of a drug and its safety usage, it is necessary to monitor stability
of a drug and to determine degradation products that may form during production, usage and
storage. Aim of this work was to investigate stability and monitor degradation of the
multifunctional drug anisomycin. Stability of anisomycin was studied by performing force
degradation that includes investigation of susceptibility of the drug to hydrolysis (acidic, alkaline
and neutral), oxidation, light (visible and UV) and temperature, in accordance with ICH
(International Conference on Harmonization) guidelines. Liquid chromatography coupled to
tandem mass spectrometry was used for investigation of the drug degradation and identification
of the degradation products. It was shown that anisomycin was stable in the presence of
oxidizing agent and light, moderately stable under acidic and neutral conditions, very unstable
under alkaline conditions and thermodegradable. Deacetylanisomycin was identified as the
principal degradation product of anisomycin.
PB  - Belgrade : Serbian Chemical Society
C3  - Book of Abstracts / Fourth Conference of Young Chemists of Serbia, Belgrade, Serbia, November 5, 2016
T1  - Ispitivanje stabilnosti anizomicina metodom tečne hromatografije sa tandem masenom spektrometrijom
T1  - Investigation of anisomycin stability using liquid chromatography coupled to tandem mass spectrometry
SP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7256
ER  - 

@conference{
author = "Tolić, Ljiljana and Grujić, Svetlana and Laušević, Mila",
year = "2016",
abstract = "U cilju poboljšanja kvaliteta leka i unapređenja sigurnosti njegovog korišćenja, potrebno je praćenje stabilnosti i određivanje degradacionih proizvoda koji mogu nastati tokom proizvodnje, rukovanja ili čuvanja leka. Cilj ovog rada je ispitivanje stabilnosti i praćenje degradacije višefun-kcionalnog leka anizomicina. Stabilnost anizomicina je ispitivana sprovođenjem studija forsirane degradacije, koje obuhvataju ispitivanje osetljivosti leka na hidrolizu (kiselu, baznu i neutralnu), oksidaciju, svetlost (vidljivu i UV) i povišenu temperaturu, u skladu sa ICH (eng. International Conference on Harmonization) smernicama. Za praćenje degradacije leka i identifikaciju degradacionih prozvoda korišćena je metoda tečne hromatografije sa tandem masenom spek-trometrijom. Pokazano je da je anizomicin stabilan u prisustvu oksidacionog sredstva i svetlosti, umereno stabilan u kiseloj i neutralnoj sredini, jako nestabilan u baznoj sredini i termo-degradabilan. Deacetilanizomicin je identifikovan kao glavni proizvod degradacije anisomicina., In order to improve the quality of a drug and its safety usage, it is necessary to monitor stability
of a drug and to determine degradation products that may form during production, usage and
storage. Aim of this work was to investigate stability and monitor degradation of the
multifunctional drug anisomycin. Stability of anisomycin was studied by performing force
degradation that includes investigation of susceptibility of the drug to hydrolysis (acidic, alkaline
and neutral), oxidation, light (visible and UV) and temperature, in accordance with ICH
(International Conference on Harmonization) guidelines. Liquid chromatography coupled to
tandem mass spectrometry was used for investigation of the drug degradation and identification
of the degradation products. It was shown that anisomycin was stable in the presence of
oxidizing agent and light, moderately stable under acidic and neutral conditions, very unstable
under alkaline conditions and thermodegradable. Deacetylanisomycin was identified as the
principal degradation product of anisomycin.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Book of Abstracts / Fourth Conference of Young Chemists of Serbia, Belgrade, Serbia, November 5, 2016",
title = "Ispitivanje stabilnosti anizomicina metodom tečne hromatografije sa tandem masenom spektrometrijom, Investigation of anisomycin stability using liquid chromatography coupled to tandem mass spectrometry",
pages = "30",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7256"
}

Tolić, L., Grujić, S.,& Laušević, M.. (2016). Ispitivanje stabilnosti anizomicina metodom tečne hromatografije sa tandem masenom spektrometrijom. in Book of Abstracts / Fourth Conference of Young Chemists of Serbia, Belgrade, Serbia, November 5, 2016
Belgrade : Serbian Chemical Society., 30.
https://hdl.handle.net/21.15107/rcub_technorep_7256

Tolić L, Grujić S, Laušević M. Ispitivanje stabilnosti anizomicina metodom tečne hromatografije sa tandem masenom spektrometrijom. in Book of Abstracts / Fourth Conference of Young Chemists of Serbia, Belgrade, Serbia, November 5, 2016. 2016;:30.
https://hdl.handle.net/21.15107/rcub_technorep_7256 .

Tolić, Ljiljana, Grujić, Svetlana, Laušević, Mila, "Ispitivanje stabilnosti anizomicina metodom tečne hromatografije sa tandem masenom spektrometrijom" in Book of Abstracts / Fourth Conference of Young Chemists of Serbia, Belgrade, Serbia, November 5, 2016 (2016):30,
https://hdl.handle.net/21.15107/rcub_technorep_7256 .

TY  - JOUR
AU  - Jovanović, Zoran M.
AU  - Pašti, Igor A.
AU  - Kalijadis, Ana
AU  - Lausevic, Mila
AU  - Mentus, Slavko V.
AU  - Laušević, Zoran
PY  - 2011
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5649
AB  - We report a particular method of Pt/glassy carbon (GC) surface formation, based on a 15 key H(+/-) ion beam irradiation of thin H(2)PtCl(6)xnH(2)O layer placed over the GC surface. Hydrogen-ion beam irradiation provided an excellent adherence of Pt deposit, unlike to any other Pt-deposition method. Furthermore, the morphology and electrochemical activity of GC/Pt catalyst obtained at the fluence of 5 x 10(17) cm(-2) was found to be sensitive to the sign of charge of hydrogen ions. The electrochemical activity of such obtained Pt/GC surface toward oxygen reduction and ethanol oxidation was compared with the activity of the Pt deposits obtained by other more common reduction procedures. (C) 2011 Elsevier B.V. All rights reserved.
T2  - Materials Letters
T1  - Platinum deposition from hydrogen-ion beam irradiated solid precursor
EP  - 2657
IS  - 17-18
SP  - 2655
VL  - 65
DO  - 10.1016/j.matlet.2011.05.015
ER  - 

@article{
author = "Jovanović, Zoran M. and Pašti, Igor A. and Kalijadis, Ana and Lausevic, Mila and Mentus, Slavko V. and Laušević, Zoran",
year = "2011",
abstract = "We report a particular method of Pt/glassy carbon (GC) surface formation, based on a 15 key H(+/-) ion beam irradiation of thin H(2)PtCl(6)xnH(2)O layer placed over the GC surface. Hydrogen-ion beam irradiation provided an excellent adherence of Pt deposit, unlike to any other Pt-deposition method. Furthermore, the morphology and electrochemical activity of GC/Pt catalyst obtained at the fluence of 5 x 10(17) cm(-2) was found to be sensitive to the sign of charge of hydrogen ions. The electrochemical activity of such obtained Pt/GC surface toward oxygen reduction and ethanol oxidation was compared with the activity of the Pt deposits obtained by other more common reduction procedures. (C) 2011 Elsevier B.V. All rights reserved.",
journal = "Materials Letters",
title = "Platinum deposition from hydrogen-ion beam irradiated solid precursor",
pages = "2657-2655",
number = "17-18",
volume = "65",
doi = "10.1016/j.matlet.2011.05.015"
}

Jovanović, Z. M., Pašti, I. A., Kalijadis, A., Lausevic, M., Mentus, S. V.,& Laušević, Z.. (2011). Platinum deposition from hydrogen-ion beam irradiated solid precursor. in Materials Letters, 65(17-18), 2655-2657.
https://doi.org/10.1016/j.matlet.2011.05.015

Jovanović ZM, Pašti IA, Kalijadis A, Lausevic M, Mentus SV, Laušević Z. Platinum deposition from hydrogen-ion beam irradiated solid precursor. in Materials Letters. 2011;65(17-18):2655-2657.
doi:10.1016/j.matlet.2011.05.015 .

Jovanović, Zoran M., Pašti, Igor A., Kalijadis, Ana, Lausevic, Mila, Mentus, Slavko V., Laušević, Zoran, "Platinum deposition from hydrogen-ion beam irradiated solid precursor" in Materials Letters, 65, no. 17-18 (2011):2655-2657,
https://doi.org/10.1016/j.matlet.2011.05.015 . .