TY  - JOUR
AU  - Pejić, Biljana
AU  - Medović-Baralić, Adela
AU  - Kojić, Zvezdana
AU  - Škundrić, Petar
AU  - Kostić, Mirjana
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2983
AB  - Oxidized cellulose has a long history of safe and effective use in medical applications. In this paper, research has been directed towards obtaining hormone-active cellulose fibers in the form of an artificial insulin depot, and examination of its biocompatibility regarding cytotoxicity, sensitization, and irritation. The procedure of obtaining the fibrous insulin depot is based on the modification of cotton fibers with sodium periodate, followed by chemisorption of insulin from insulin aqueous solutions. In order to optimize the insulin chemisorption process, the influence of the fiber structure parameters, i.e. the aldehyde group content and iodine sorption value (ISV) on the chemisorption capacity was examined. The obtained artificial depot, containing approximate to 55 mg insulin/g of fibers, has been characterized in vitro by investigation of the desorption kinetics of the insulin from the fibrous depot. It has been shown that insulin is controllably released in quantities of 1.3-1.6 mg of insulin during 24 hours, in the course of 20 days. The results of biocompatibility tests have shown that the examined artificial depot neither shows irritating effects nor provokes sensitizing or cytotoxic effects. Therefore, these materials are acceptable for use in a direct contact with tissue of a living organism.
PB  - Korean Fiber Soc, Seoul
T2  - Fibers and Polymers
T1  - Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility
EP  - 1004
IS  - 5
SP  - 997
VL  - 16
DO  - 10.1007/s12221-015-0997-6
ER  - 

@article{
author = "Pejić, Biljana and Medović-Baralić, Adela and Kojić, Zvezdana and Škundrić, Petar and Kostić, Mirjana",
year = "2015",
abstract = "Oxidized cellulose has a long history of safe and effective use in medical applications. In this paper, research has been directed towards obtaining hormone-active cellulose fibers in the form of an artificial insulin depot, and examination of its biocompatibility regarding cytotoxicity, sensitization, and irritation. The procedure of obtaining the fibrous insulin depot is based on the modification of cotton fibers with sodium periodate, followed by chemisorption of insulin from insulin aqueous solutions. In order to optimize the insulin chemisorption process, the influence of the fiber structure parameters, i.e. the aldehyde group content and iodine sorption value (ISV) on the chemisorption capacity was examined. The obtained artificial depot, containing approximate to 55 mg insulin/g of fibers, has been characterized in vitro by investigation of the desorption kinetics of the insulin from the fibrous depot. It has been shown that insulin is controllably released in quantities of 1.3-1.6 mg of insulin during 24 hours, in the course of 20 days. The results of biocompatibility tests have shown that the examined artificial depot neither shows irritating effects nor provokes sensitizing or cytotoxic effects. Therefore, these materials are acceptable for use in a direct contact with tissue of a living organism.",
publisher = "Korean Fiber Soc, Seoul",
journal = "Fibers and Polymers",
title = "Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility",
pages = "1004-997",
number = "5",
volume = "16",
doi = "10.1007/s12221-015-0997-6"
}

Pejić, B., Medović-Baralić, A., Kojić, Z., Škundrić, P.,& Kostić, M.. (2015). Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility. in Fibers and Polymers
Korean Fiber Soc, Seoul., 16(5), 997-1004.
https://doi.org/10.1007/s12221-015-0997-6

Pejić B, Medović-Baralić A, Kojić Z, Škundrić P, Kostić M. Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility. in Fibers and Polymers. 2015;16(5):997-1004.
doi:10.1007/s12221-015-0997-6 .

Pejić, Biljana, Medović-Baralić, Adela, Kojić, Zvezdana, Škundrić, Petar, Kostić, Mirjana, "Oxidized Cotton as a Substrate for the Preparation of Hormone-Active Fibers-Characterization, Efficiency and Biocompatibility" in Fibers and Polymers, 16, no. 5 (2015):997-1004,
https://doi.org/10.1007/s12221-015-0997-6 . .

TY  - JOUR
AU  - Simović, Ljiljana
AU  - Škundrić, Petar
AU  - Medović-Baralić, Adela
AU  - Pajić-Lijaković, Ivana
AU  - Milutinović-Nikolić, Aleksandra
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2238
AB  - In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Biomedical Materials Research Part A
T1  - Characterization and behavior of anesthetic bioactive textile complex in vitro condition
EP  - 6
IS  - 1
SP  - 1
VL  - 100A
DO  - 10.1002/jbm.a.33234
ER  - 

@article{
author = "Simović, Ljiljana and Škundrić, Petar and Medović-Baralić, Adela and Pajić-Lijaković, Ivana and Milutinović-Nikolić, Aleksandra",
year = "2012",
abstract = "In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Biomedical Materials Research Part A",
title = "Characterization and behavior of anesthetic bioactive textile complex in vitro condition",
pages = "6-1",
number = "1",
volume = "100A",
doi = "10.1002/jbm.a.33234"
}

Simović, L., Škundrić, P., Medović-Baralić, A., Pajić-Lijaković, I.,& Milutinović-Nikolić, A.. (2012). Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A
Wiley-Blackwell, Malden., 100A(1), 1-6.
https://doi.org/10.1002/jbm.a.33234

Simović L, Škundrić P, Medović-Baralić A, Pajić-Lijaković I, Milutinović-Nikolić A. Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A. 2012;100A(1):1-6.
doi:10.1002/jbm.a.33234 .

Simović, Ljiljana, Škundrić, Petar, Medović-Baralić, Adela, Pajić-Lijaković, Ivana, Milutinović-Nikolić, Aleksandra, "Characterization and behavior of anesthetic bioactive textile complex in vitro condition" in Journal of Biomedical Materials Research Part A, 100A, no. 1 (2012):1-6,
https://doi.org/10.1002/jbm.a.33234 . .