TY  - JOUR
AU  - Milošević, Nataša
AU  - Janjić, Nataša
AU  - Milić, Nataša
AU  - Milanović, Maja
AU  - Popović, Jovan
AU  - Antonović, Dušan
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5782
AB  - Herbicides, which are ubiquitously present in soil and food, have been proven to cause human health hazard effects, hence development of new herbicide-active compounds is recommended. In this paper, nine 2,4-bis(cycloalkyl)-6-chloro-s-triazines were considered as herbicide candidates and their pharmacokinetics and toxicity were reviewed on the basis of in silico descriptors. Both, pharmacokinetic and toxicity predictors were presented as functions of their lipophilicity, quantified with retention constants that were obtained by liquid chromatography. None of the candidates investigated has functional groups for genotoxicity hazards and endocrine disruptions; they have acceptable toxicity and favorable pharmacokinetic properties based on computer-aided analyses. Two candidates have been selected as lead compounds for further research.
PB  - American Chemical Society
T2  - Journal of Agricultural and Food Chemistry
T1  - Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants
EP  - 8585
IS  - 34
SP  - 8579
VL  - 62
DO  - 10.1021/jf502405k
ER  - 

@article{
author = "Milošević, Nataša and Janjić, Nataša and Milić, Nataša and Milanović, Maja and Popović, Jovan and Antonović, Dušan",
year = "2014",
abstract = "Herbicides, which are ubiquitously present in soil and food, have been proven to cause human health hazard effects, hence development of new herbicide-active compounds is recommended. In this paper, nine 2,4-bis(cycloalkyl)-6-chloro-s-triazines were considered as herbicide candidates and their pharmacokinetics and toxicity were reviewed on the basis of in silico descriptors. Both, pharmacokinetic and toxicity predictors were presented as functions of their lipophilicity, quantified with retention constants that were obtained by liquid chromatography. None of the candidates investigated has functional groups for genotoxicity hazards and endocrine disruptions; they have acceptable toxicity and favorable pharmacokinetic properties based on computer-aided analyses. Two candidates have been selected as lead compounds for further research.",
publisher = "American Chemical Society",
journal = "Journal of Agricultural and Food Chemistry",
title = "Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants",
pages = "8585-8579",
number = "34",
volume = "62",
doi = "10.1021/jf502405k"
}

Milošević, N., Janjić, N., Milić, N., Milanović, M., Popović, J.,& Antonović, D.. (2014). Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants. in Journal of Agricultural and Food Chemistry
American Chemical Society., 62(34), 8579-8585.
https://doi.org/10.1021/jf502405k

Milošević N, Janjić N, Milić N, Milanović M, Popović J, Antonović D. Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants. in Journal of Agricultural and Food Chemistry. 2014;62(34):8579-8585.
doi:10.1021/jf502405k .

Milošević, Nataša, Janjić, Nataša, Milić, Nataša, Milanović, Maja, Popović, Jovan, Antonović, Dušan, "Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants" in Journal of Agricultural and Food Chemistry, 62, no. 34 (2014):8579-8585,
https://doi.org/10.1021/jf502405k . .