TY  - JOUR
AU  - Đukić, Tamara
AU  - Drvenica, Ivana
AU  - Kovačić, Marijana
AU  - Milanović, Slađan
AU  - Majerič, Dragana
AU  - Šefik-Bukilica, Mirjana
AU  - Miletić, Maja
AU  - Bugarski, Branko
AU  - Ilić, Vesna
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7411
AB  - The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and IgM were found in all analyzed CICs, but more IgA and IgG were found in RA than in control CICs. In both control and RA CICs, DLS detected 50 particles that differed in size and clustered around two size groups: with a 7.5–164 nm radius and with a 342–1718 nm radius. An increased level of IgA in RA CICs, compared to control ones, was associated with more than 50% of CIC particles. In RA, compared to the control, a higher number of CICs with 28.2 nm, 531 nm, 712 nm, and 1718 nm particles and a lower number of CICs with 78.8 nm particles were detected. This particle distribution pattern did not reflect the changes in the CIC immunoglobulin level. Thus, RA elevated CIC IgA was linked with all these particles (except the 1718 nm particle), the IgM increase was linked with 43.8 nm and 712 nm particles, and the IgG increase was linked with the 712 nm particle only. This study provides the very first data on the association between CIC particles’ size, CIC immunoglobulin level, and RA. It opens the possibility that the size of CICs determined by DLS can be used as a criterion in RA diagnosis or monitoring after a large-scale study confirmation.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients
IS  - 6
SP  - 3138
VL  - 25
DO  - 10.3390/ijms25063138
ER  - 

@article{
author = "Đukić, Tamara and Drvenica, Ivana and Kovačić, Marijana and Milanović, Slađan and Majerič, Dragana and Šefik-Bukilica, Mirjana and Miletić, Maja and Bugarski, Branko and Ilić, Vesna",
year = "2024",
abstract = "The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and IgM were found in all analyzed CICs, but more IgA and IgG were found in RA than in control CICs. In both control and RA CICs, DLS detected 50 particles that differed in size and clustered around two size groups: with a 7.5–164 nm radius and with a 342–1718 nm radius. An increased level of IgA in RA CICs, compared to control ones, was associated with more than 50% of CIC particles. In RA, compared to the control, a higher number of CICs with 28.2 nm, 531 nm, 712 nm, and 1718 nm particles and a lower number of CICs with 78.8 nm particles were detected. This particle distribution pattern did not reflect the changes in the CIC immunoglobulin level. Thus, RA elevated CIC IgA was linked with all these particles (except the 1718 nm particle), the IgM increase was linked with 43.8 nm and 712 nm particles, and the IgG increase was linked with the 712 nm particle only. This study provides the very first data on the association between CIC particles’ size, CIC immunoglobulin level, and RA. It opens the possibility that the size of CICs determined by DLS can be used as a criterion in RA diagnosis or monitoring after a large-scale study confirmation.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients",
number = "6",
pages = "3138",
volume = "25",
doi = "10.3390/ijms25063138"
}

Đukić, T., Drvenica, I., Kovačić, M., Milanović, S., Majerič, D., Šefik-Bukilica, M., Miletić, M., Bugarski, B.,& Ilić, V.. (2024). Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients. in International Journal of Molecular Sciences
MDPI., 25(6), 3138.
https://doi.org/10.3390/ijms25063138

Đukić T, Drvenica I, Kovačić M, Milanović S, Majerič D, Šefik-Bukilica M, Miletić M, Bugarski B, Ilić V. Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients. in International Journal of Molecular Sciences. 2024;25(6):3138.
doi:10.3390/ijms25063138 .

Đukić, Tamara, Drvenica, Ivana, Kovačić, Marijana, Milanović, Slađan, Majerič, Dragana, Šefik-Bukilica, Mirjana, Miletić, Maja, Bugarski, Branko, Ilić, Vesna, "Exploring the Link between Hydrodynamic Size and Immunoglobulins of Circulating Immune Complexes in Rheumatoid Arthritis Patients" in International Journal of Molecular Sciences, 25, no. 6 (2024):3138,
https://doi.org/10.3390/ijms25063138 . .

TY  - CHAP
AU  - Đorđević, Verica
AU  - Belščak-Cvitanović, Ana
AU  - Drvenica, Ivana
AU  - Komes, Draženka
AU  - Nedović, Viktor A.
AU  - Bugarski, Branko M.
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6177
AB  - This chapter gives an overview of nanoencapsulation technologies that can be used by food manufacturers to develop effective nutrient delivery systems. The direct use of essential nutrients (vitamins, minerals, polyunsaturated fatty acids, peptides, amino acids, etc.) in food production and their biological activity on consumption are restricted by various physicochemical and biological constraints. The first part of the chapter summarizes encapsulation benefits (increased stability against physical, chemical or enzymatic degradation, reduction of undesired tastes/odors, conversion of liquids to solid forms, controlled release, etc.) with a special focus on increased bioavailability. Then, the physicochemical and physiological conditions prevailing in different regions of gastrointestinal tract (GIT) are described in relation to the impact of encapsulation on the bioaccessibility of nutrients. The main part of the chapter refers to different techniques used to fabricate nanoparticulate encapsulates, described from the engineering aspect, that is, the impact of process conditions on nanoparticle properties. Advantages and limitations of nanoencapsulation technologies versus common microencapsulation technologies are emphasized to get a critical point of view on perspectives for industrial applications. Finally, characteristics (composition, structure, dimensions, interfacial properties, loading, and stability) of different nanoparticle-based delivery systems (micelles, nanoemulsions, complexes, lipid-based nanoparticles, and biopolymer-based nanoparticles) are compared with a special focus on release properties.
PB  - Academic Press
T2  - Nutrient Delivery: Nanotechnology in the Agri-Food Industry
T1  - Nanoscale nutrient delivery systems
EP  - 139
SP  - 87
VL  - 5
DO  - 10.1016/B978-0-12-804304-2.00003-2
ER  - 

@inbook{
author = "Đorđević, Verica and Belščak-Cvitanović, Ana and Drvenica, Ivana and Komes, Draženka and Nedović, Viktor A. and Bugarski, Branko M.",
year = "2017",
abstract = "This chapter gives an overview of nanoencapsulation technologies that can be used by food manufacturers to develop effective nutrient delivery systems. The direct use of essential nutrients (vitamins, minerals, polyunsaturated fatty acids, peptides, amino acids, etc.) in food production and their biological activity on consumption are restricted by various physicochemical and biological constraints. The first part of the chapter summarizes encapsulation benefits (increased stability against physical, chemical or enzymatic degradation, reduction of undesired tastes/odors, conversion of liquids to solid forms, controlled release, etc.) with a special focus on increased bioavailability. Then, the physicochemical and physiological conditions prevailing in different regions of gastrointestinal tract (GIT) are described in relation to the impact of encapsulation on the bioaccessibility of nutrients. The main part of the chapter refers to different techniques used to fabricate nanoparticulate encapsulates, described from the engineering aspect, that is, the impact of process conditions on nanoparticle properties. Advantages and limitations of nanoencapsulation technologies versus common microencapsulation technologies are emphasized to get a critical point of view on perspectives for industrial applications. Finally, characteristics (composition, structure, dimensions, interfacial properties, loading, and stability) of different nanoparticle-based delivery systems (micelles, nanoemulsions, complexes, lipid-based nanoparticles, and biopolymer-based nanoparticles) are compared with a special focus on release properties.",
publisher = "Academic Press",
journal = "Nutrient Delivery: Nanotechnology in the Agri-Food Industry",
booktitle = "Nanoscale nutrient delivery systems",
pages = "139-87",
volume = "5",
doi = "10.1016/B978-0-12-804304-2.00003-2"
}

Đorđević, V., Belščak-Cvitanović, A., Drvenica, I., Komes, D., Nedović, V. A.,& Bugarski, B. M.. (2017). Nanoscale nutrient delivery systems. in Nutrient Delivery: Nanotechnology in the Agri-Food Industry
Academic Press., 5, 87-139.
https://doi.org/10.1016/B978-0-12-804304-2.00003-2

Đorđević V, Belščak-Cvitanović A, Drvenica I, Komes D, Nedović VA, Bugarski BM. Nanoscale nutrient delivery systems. in Nutrient Delivery: Nanotechnology in the Agri-Food Industry. 2017;5:87-139.
doi:10.1016/B978-0-12-804304-2.00003-2 .

Đorđević, Verica, Belščak-Cvitanović, Ana, Drvenica, Ivana, Komes, Draženka, Nedović, Viktor A., Bugarski, Branko M., "Nanoscale nutrient delivery systems" in Nutrient Delivery: Nanotechnology in the Agri-Food Industry, 5 (2017):87-139,
https://doi.org/10.1016/B978-0-12-804304-2.00003-2 . .