Batinić, Petar

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Authority KeyName Variants
orcid::0000-0001-5647-2590
  • Batinić, Petar (5)
Projects
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200135 (University of Belgrade, Faculty of Technology and Metallurgy) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200287 (Innovation Center of the Faculty of Technology and Metallurgy)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200003 (Institute for Medicinal Plant Research 'Dr. Josif Pančić ', Belgrade) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200019 (University of Belgrade, Institute for the Application of Nuclear Energy - INEP)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200116 (University of Belgrade, Faculty of Agriculture)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry) FUNPRO - Functional products based on goat's milk proteins and bioactive compounds extracted from grape pomace and edible mushrooms
MultiPromis - Multifunctional leaf protein and assembled nanocarrier structures delivered by enzyme technology Ministry of Science, Technological Development, and Innovation of the Republic of Serbia (#Grant Nos: 451-03-1202/2021-09/3)

Author's Bibliography

Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia

Batinić, Petar; Jovanović, Aleksandra; Stojković, Dejan; Zengin, Gökhan; Cvijetić, Ilija; Gašić, Uroš; Čutović, Natalija; Pešić, Mirjana B.; Milinčić, Danijel D.; Carević, Tamara; Marinković, Aleksandar; Bugarski, Branko; Marković, Tatjana

(MDPI, 2024)

TY  - JOUR
AU  - Batinić, Petar
AU  - Jovanović, Aleksandra
AU  - Stojković, Dejan
AU  - Zengin, Gökhan
AU  - Cvijetić, Ilija
AU  - Gašić, Uroš
AU  - Čutović, Natalija
AU  - Pešić, Mirjana B.
AU  - Milinčić, Danijel D.
AU  - Carević, Tamara
AU  - Marinković, Aleksandar
AU  - Bugarski, Branko
AU  - Marković, Tatjana
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7457
AB  - Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia
IS  - 4
SP  - 518
VL  - 17
DO  - 10.3390/ph17040518
ER  - 
@article{
author = "Batinić, Petar and Jovanović, Aleksandra and Stojković, Dejan and Zengin, Gökhan and Cvijetić, Ilija and Gašić, Uroš and Čutović, Natalija and Pešić, Mirjana B. and Milinčić, Danijel D. and Carević, Tamara and Marinković, Aleksandar and Bugarski, Branko and Marković, Tatjana",
year = "2024",
abstract = "Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia",
number = "4",
pages = "518",
volume = "17",
doi = "10.3390/ph17040518"
}
Batinić, P., Jovanović, A., Stojković, D., Zengin, G., Cvijetić, I., Gašić, U., Čutović, N., Pešić, M. B., Milinčić, D. D., Carević, T., Marinković, A., Bugarski, B.,& Marković, T.. (2024). Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia. in Pharmaceuticals
MDPI., 17(4), 518.
https://doi.org/10.3390/ph17040518
Batinić P, Jovanović A, Stojković D, Zengin G, Cvijetić I, Gašić U, Čutović N, Pešić MB, Milinčić DD, Carević T, Marinković A, Bugarski B, Marković T. Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia. in Pharmaceuticals. 2024;17(4):518.
doi:10.3390/ph17040518 .
Batinić, Petar, Jovanović, Aleksandra, Stojković, Dejan, Zengin, Gökhan, Cvijetić, Ilija, Gašić, Uroš, Čutović, Natalija, Pešić, Mirjana B., Milinčić, Danijel D., Carević, Tamara, Marinković, Aleksandar, Bugarski, Branko, Marković, Tatjana, "Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia" in Pharmaceuticals, 17, no. 4 (2024):518,
https://doi.org/10.3390/ph17040518 . .

Optimization of the extraction process from Satureja montana L.: physicochemical characterization of the extracts

Čutović, Natalija; Batinić, Petar; Marković, Tatjana; Radanović, Dragoja; Marinković, Aleksandar; Bugarski, Branko; Jovanović, Aleksandra A.

(Savez hemijskih inženjera Srbije, 2023)

TY  - JOUR
AU  - Čutović, Natalija
AU  - Batinić, Petar
AU  - Marković, Tatjana
AU  - Radanović, Dragoja
AU  - Marinković, Aleksandar
AU  - Bugarski, Branko
AU  - Jovanović, Aleksandra A.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7041
AB  - The presented study aimed to optimize polyphenol extraction from Satureja montana L. obtained from the experimental field of the Institute for Medicinal Plants Research ”Dr Josif Pančić”, Serbia, by varying the most important parameters for maceration, solid-to-solvent ratio, and extraction time. The obtained extracts were characterized regarding the total polyphenol content (TPC), total flavonoid content (TFC), antioxidant potential, extraction yield, conductivity, density, surface tension, and viscosity. The TPC and TFC were ~7 to 92 mg GAE (gallic acid equivalent)/g and 3.7 to 10.9 mg CE (catechin equivalent)/g, respectively. The highest extraction yield (86 %) as well as the highest antioxidant activities were obtained for the extracts prepared using a solid-to-solvent ratio of 1 g:50 cm3. On the other hand, the extraction time did not have a significant influence. The highest conductivity was measured in the extract prepared at a 1 g:10 cm3 ratio, while the highest density and surface tension were in the extract prepared at a 1 g:40 cm3 ratio (941 kg m-3 and 29.0 mN m-1, respectively). The highest viscosity was measured in the extract prepared at a 1 g: 20 cm3 ratio (2.89 mPa∙s). Our study shows the possibilities for the production of polyphenol-rich extract of S. montana which might be used in pharmaceutical, food, or cosmetic products.
AB  - Prikazana  studija  je  imala  za  cilj  da  optimizuje  ekstrakciju  polifenola  izbiljkeSatureja  montanaL.  sa oglednog  polja  Instituta  za proučavanjelekovitog bilja „Dr Josif Pančić“, Srbija, variranjem najvažnijih parametara  maceracije,  odnosa biljnog materijala i rastvarača,i  ekstrakcionogvremena.  Dobijeni ekstrakti su okarakterisani u pogleduukupnog sadržaja polifenola (engl.total total polyphenol content, TPC), ukupnog sadržaja flavonoida (engl.total  flavonoid  content,TFC),  antioksidativnog  potencijala, prinosa  ekstrakcije,  provodljivosti,  gustine,  površinskog  napona  i  viskoznosti. Vrednostiukupnog sadržaja polifenola(engl.Total  Polyphenol  Content -TPC)iukupnog sadržaja flavonoida (engl.Total Flavonoid  Content -TFC)su  bile  u  opsezima7,2-92,2  mg ekvivalenta  galne  kiseline  (engl.gallic  acid equivalentGAE) /g i 3,7-10,9 mgekvivalenta katehina(engl.catechinequivalentCE)/g, redom. Najveće antioksidativne  aktivnosti dobijenesu  u  ekstraktima  pripremljenim  u  odnosu biljnog  materijala  i rastvarača1g :50cm-3. Najveći prinos ekstrakcije takođe je dobijenu tom ekstraktu (86,0%), dok vreme ekstrakcije nije imalo značajan uticaj. Najveća  provodljivost  izmerena  je  u  ekstraktu  pripremljenom  u odnosu biljnog materijala i rastvarača1g :10cm-3. Najvećagustina i površinski napon su bili u ekstraktu pripremljenom u odnosu 1g :40cm-3(941 kg m-3i 29,0 mNm-1, redom). Najvećaviskoznostje izmerenau  ekstraktu  pripremljenom  u  odnosu  1g :20cm-3(2,89 mPa∙s). Naša studija pokazuje mogućnosti  za proizvodnju  polifenolima  bogatog  ekstraktabiljkeS.  montanakoji se može koristiti u farmaceutskim, prehrambenim ili kozmetičkim proizvodima.
PB  - Savez hemijskih inženjera Srbije
T2  - Hemijska industrija
T1  - Optimization of the extraction process from Satureja montana L.: physicochemical characterization of the extracts
T1  - Optimizacija procesa ekstrakcije iz biljke Satureja montanal.: fizičkohemijska karakterizacija ekstrakata
EP  - 263
IS  - 4
SP  - 251
VL  - 77
DO  - 10.2298/HEMIND221213020C
ER  - 
@article{
author = "Čutović, Natalija and Batinić, Petar and Marković, Tatjana and Radanović, Dragoja and Marinković, Aleksandar and Bugarski, Branko and Jovanović, Aleksandra A.",
year = "2023",
abstract = "The presented study aimed to optimize polyphenol extraction from Satureja montana L. obtained from the experimental field of the Institute for Medicinal Plants Research ”Dr Josif Pančić”, Serbia, by varying the most important parameters for maceration, solid-to-solvent ratio, and extraction time. The obtained extracts were characterized regarding the total polyphenol content (TPC), total flavonoid content (TFC), antioxidant potential, extraction yield, conductivity, density, surface tension, and viscosity. The TPC and TFC were ~7 to 92 mg GAE (gallic acid equivalent)/g and 3.7 to 10.9 mg CE (catechin equivalent)/g, respectively. The highest extraction yield (86 %) as well as the highest antioxidant activities were obtained for the extracts prepared using a solid-to-solvent ratio of 1 g:50 cm3. On the other hand, the extraction time did not have a significant influence. The highest conductivity was measured in the extract prepared at a 1 g:10 cm3 ratio, while the highest density and surface tension were in the extract prepared at a 1 g:40 cm3 ratio (941 kg m-3 and 29.0 mN m-1, respectively). The highest viscosity was measured in the extract prepared at a 1 g: 20 cm3 ratio (2.89 mPa∙s). Our study shows the possibilities for the production of polyphenol-rich extract of S. montana which might be used in pharmaceutical, food, or cosmetic products., Prikazana  studija  je  imala  za  cilj  da  optimizuje  ekstrakciju  polifenola  izbiljkeSatureja  montanaL.  sa oglednog  polja  Instituta  za proučavanjelekovitog bilja „Dr Josif Pančić“, Srbija, variranjem najvažnijih parametara  maceracije,  odnosa biljnog materijala i rastvarača,i  ekstrakcionogvremena.  Dobijeni ekstrakti su okarakterisani u pogleduukupnog sadržaja polifenola (engl.total total polyphenol content, TPC), ukupnog sadržaja flavonoida (engl.total  flavonoid  content,TFC),  antioksidativnog  potencijala, prinosa  ekstrakcije,  provodljivosti,  gustine,  površinskog  napona  i  viskoznosti. Vrednostiukupnog sadržaja polifenola(engl.Total  Polyphenol  Content -TPC)iukupnog sadržaja flavonoida (engl.Total Flavonoid  Content -TFC)su  bile  u  opsezima7,2-92,2  mg ekvivalenta  galne  kiseline  (engl.gallic  acid equivalentGAE) /g i 3,7-10,9 mgekvivalenta katehina(engl.catechinequivalentCE)/g, redom. Najveće antioksidativne  aktivnosti dobijenesu  u  ekstraktima  pripremljenim  u  odnosu biljnog  materijala  i rastvarača1g :50cm-3. Najveći prinos ekstrakcije takođe je dobijenu tom ekstraktu (86,0%), dok vreme ekstrakcije nije imalo značajan uticaj. Najveća  provodljivost  izmerena  je  u  ekstraktu  pripremljenom  u odnosu biljnog materijala i rastvarača1g :10cm-3. Najvećagustina i površinski napon su bili u ekstraktu pripremljenom u odnosu 1g :40cm-3(941 kg m-3i 29,0 mNm-1, redom). Najvećaviskoznostje izmerenau  ekstraktu  pripremljenom  u  odnosu  1g :20cm-3(2,89 mPa∙s). Naša studija pokazuje mogućnosti  za proizvodnju  polifenolima  bogatog  ekstraktabiljkeS.  montanakoji se može koristiti u farmaceutskim, prehrambenim ili kozmetičkim proizvodima.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija",
title = "Optimization of the extraction process from Satureja montana L.: physicochemical characterization of the extracts, Optimizacija procesa ekstrakcije iz biljke Satureja montanal.: fizičkohemijska karakterizacija ekstrakata",
pages = "263-251",
number = "4",
volume = "77",
doi = "10.2298/HEMIND221213020C"
}
Čutović, N., Batinić, P., Marković, T., Radanović, D., Marinković, A., Bugarski, B.,& Jovanović, A. A.. (2023). Optimization of the extraction process from Satureja montana L.: physicochemical characterization of the extracts. in Hemijska industrija
Savez hemijskih inženjera Srbije., 77(4), 251-263.
https://doi.org/10.2298/HEMIND221213020C
Čutović N, Batinić P, Marković T, Radanović D, Marinković A, Bugarski B, Jovanović AA. Optimization of the extraction process from Satureja montana L.: physicochemical characterization of the extracts. in Hemijska industrija. 2023;77(4):251-263.
doi:10.2298/HEMIND221213020C .
Čutović, Natalija, Batinić, Petar, Marković, Tatjana, Radanović, Dragoja, Marinković, Aleksandar, Bugarski, Branko, Jovanović, Aleksandra A., "Optimization of the extraction process from Satureja montana L.: physicochemical characterization of the extracts" in Hemijska industrija, 77, no. 4 (2023):251-263,
https://doi.org/10.2298/HEMIND221213020C . .

Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release

Batinić, Petar; Đorđević, Verica; Balanč, Bojana; Bošković, Stefan; Bugarski, Branko

(Zvornik : Faculty of Technology, 2021)

TY  - CONF
AU  - Batinić, Petar
AU  - Đorđević, Verica
AU  - Balanč, Bojana
AU  - Bošković, Stefan
AU  - Bugarski, Branko
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7368
AB  - In this study liposomes were investigated regarding the ability to encapsulate vitamins, vitamin E and folic acid. Liposomes were prepared using commercial mixture based on the soybean lecithin (Phospholipon 90 G) by the proliposome technique. High entrapment efficiency (85-90%) was achieved for both types of vitamins, while the size was dependent on the vitamin type (350 and 630 nm for vitamin E- and folic acid-containing liposomes). Physical stability expressed via changes of the size, polydispersity and zeta potential during storage was confirmed for the period of one month in case liposomes with folic acid and two months for the liposomes with vitamin E. The release study, done using Franc diffusion cell, under skin conditions (pH=5.5), showed that the release rate was determined by solubility of the vitamins.
PB  - Zvornik : Faculty of Technology
C3  - Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021
T1  - Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release
EP  - 234
SP  - 227
DO  - 10.7251/EEMEN2101227B
ER  - 
@conference{
author = "Batinić, Petar and Đorđević, Verica and Balanč, Bojana and Bošković, Stefan and Bugarski, Branko",
year = "2021",
abstract = "In this study liposomes were investigated regarding the ability to encapsulate vitamins, vitamin E and folic acid. Liposomes were prepared using commercial mixture based on the soybean lecithin (Phospholipon 90 G) by the proliposome technique. High entrapment efficiency (85-90%) was achieved for both types of vitamins, while the size was dependent on the vitamin type (350 and 630 nm for vitamin E- and folic acid-containing liposomes). Physical stability expressed via changes of the size, polydispersity and zeta potential during storage was confirmed for the period of one month in case liposomes with folic acid and two months for the liposomes with vitamin E. The release study, done using Franc diffusion cell, under skin conditions (pH=5.5), showed that the release rate was determined by solubility of the vitamins.",
publisher = "Zvornik : Faculty of Technology",
journal = "Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021",
title = "Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release",
pages = "234-227",
doi = "10.7251/EEMEN2101227B"
}
Batinić, P., Đorđević, V., Balanč, B., Bošković, S.,& Bugarski, B.. (2021). Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release. in Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021
Zvornik : Faculty of Technology., 227-234.
https://doi.org/10.7251/EEMEN2101227B
Batinić P, Đorđević V, Balanč B, Bošković S, Bugarski B. Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release. in Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021. 2021;:227-234.
doi:10.7251/EEMEN2101227B .
Batinić, Petar, Đorđević, Verica, Balanč, Bojana, Bošković, Stefan, Bugarski, Branko, "Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release" in Proceedings / VII International Congress "Engineering, Environment and Materials in Process Industry" EEM2021, Jahorina, March 17-19, 2021 (2021):227-234,
https://doi.org/10.7251/EEMEN2101227B . .

Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin

Batinić, Petar; Đorđević, Verica; Stevanović, Sanja; Balanč, Bojana; Marković, Smilja; Luković, Nevena; Mijin, Dušan; Bugarski, Branko

(Elsevier, Amsterdam, 2020)

TY  - JOUR
AU  - Batinić, Petar
AU  - Đorđević, Verica
AU  - Stevanović, Sanja
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Luković, Nevena
AU  - Mijin, Dušan
AU  - Bugarski, Branko
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4359
AB  - In this study, development of folic acid-loaded liposomes using a basic amino acid, histidine as a solubilizing agent for folic acid was presented, which tackled the poor solubility of this vitamin. The effect of the liposomal membrane modifiers, cholesterol and SPAN 20 on the characteristics of the final formulations was examined. Liposomes prepared from a commercially available purified soybean lecithin (Phospholipon 90G) by proliposome method were between 503 and 877 nm in average diameter, where cholesterol induced enlargement and SPAN.20 reduction of vesicles. High encapsulation efficiency of 84% and drug loading of 0.123 mg g(-1) were achieved, irrespective to the composition. According to AFM images, folic acid-loaded liposomes of a fraction with a nano size were flattened compared to globular empty liposomes. FTIR analysis revealed possible interactions between phospholipids and histidine, while DSC study suggested interactions between folic acid and lipids during heating. Release study done by a Franz diffusion cell showed prolonged release of folic acid from liposomes and the release rate was determined by folic acid solubility.
PB  - Elsevier, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin
VL  - 59
DO  - 10.1016/j.jddst.2020.101920
ER  - 
@article{
author = "Batinić, Petar and Đorđević, Verica and Stevanović, Sanja and Balanč, Bojana and Marković, Smilja and Luković, Nevena and Mijin, Dušan and Bugarski, Branko",
year = "2020",
abstract = "In this study, development of folic acid-loaded liposomes using a basic amino acid, histidine as a solubilizing agent for folic acid was presented, which tackled the poor solubility of this vitamin. The effect of the liposomal membrane modifiers, cholesterol and SPAN 20 on the characteristics of the final formulations was examined. Liposomes prepared from a commercially available purified soybean lecithin (Phospholipon 90G) by proliposome method were between 503 and 877 nm in average diameter, where cholesterol induced enlargement and SPAN.20 reduction of vesicles. High encapsulation efficiency of 84% and drug loading of 0.123 mg g(-1) were achieved, irrespective to the composition. According to AFM images, folic acid-loaded liposomes of a fraction with a nano size were flattened compared to globular empty liposomes. FTIR analysis revealed possible interactions between phospholipids and histidine, while DSC study suggested interactions between folic acid and lipids during heating. Release study done by a Franz diffusion cell showed prolonged release of folic acid from liposomes and the release rate was determined by folic acid solubility.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin",
volume = "59",
doi = "10.1016/j.jddst.2020.101920"
}
Batinić, P., Đorđević, V., Stevanović, S., Balanč, B., Marković, S., Luković, N., Mijin, D.,& Bugarski, B.. (2020). Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin. in Journal of Drug Delivery Science and Technology
Elsevier, Amsterdam., 59.
https://doi.org/10.1016/j.jddst.2020.101920
Batinić P, Đorđević V, Stevanović S, Balanč B, Marković S, Luković N, Mijin D, Bugarski B. Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin. in Journal of Drug Delivery Science and Technology. 2020;59.
doi:10.1016/j.jddst.2020.101920 .
Batinić, Petar, Đorđević, Verica, Stevanović, Sanja, Balanč, Bojana, Marković, Smilja, Luković, Nevena, Mijin, Dušan, Bugarski, Branko, "Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin" in Journal of Drug Delivery Science and Technology, 59 (2020),
https://doi.org/10.1016/j.jddst.2020.101920 . .
14
2
17

Supplementary data for the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: https://doi.org/10.1016/j.jddst.2020.101920

Batinić, Petar; Đorđević, Verica; Stevanović, Sanja; Balanč, Bojana; Marković, Smilja; Luković, Nevena; Mijin, Dušan; Bugarski, Branko

(Elsevier, 2020)

TY  - DATA
AU  - Batinić, Petar
AU  - Đorđević, Verica
AU  - Stevanović, Sanja
AU  - Balanč, Bojana
AU  - Marković, Smilja
AU  - Luković, Nevena
AU  - Mijin, Dušan
AU  - Bugarski, Branko
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4425
AB  - Figure S1. The spectrum of folic acid; Figure S2. The spectrum of histidine; Figure S3. The spectrum of phospholipon 90 G; Figure S4. The spectrum of cholesterol; Figure S5. The spectrum of SPAN 20
PB  - Elsevier
T2  - Journal of Drug Delivery Science and Technology
T1  - Supplementary data for the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: https://doi.org/10.1016/j.jddst.2020.101920
SP  - 101920
VL  - 59
UR  - https://hdl.handle.net/21.15107/rcub_dais_9518
ER  - 
@misc{
author = "Batinić, Petar and Đorđević, Verica and Stevanović, Sanja and Balanč, Bojana and Marković, Smilja and Luković, Nevena and Mijin, Dušan and Bugarski, Branko",
year = "2020",
abstract = "Figure S1. The spectrum of folic acid; Figure S2. The spectrum of histidine; Figure S3. The spectrum of phospholipon 90 G; Figure S4. The spectrum of cholesterol; Figure S5. The spectrum of SPAN 20",
publisher = "Elsevier",
journal = "Journal of Drug Delivery Science and Technology",
title = "Supplementary data for the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: https://doi.org/10.1016/j.jddst.2020.101920",
pages = "101920",
volume = "59",
url = "https://hdl.handle.net/21.15107/rcub_dais_9518"
}
Batinić, P., Đorđević, V., Stevanović, S., Balanč, B., Marković, S., Luković, N., Mijin, D.,& Bugarski, B.. (2020). Supplementary data for the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: https://doi.org/10.1016/j.jddst.2020.101920. in Journal of Drug Delivery Science and Technology
Elsevier., 59, 101920.
https://hdl.handle.net/21.15107/rcub_dais_9518
Batinić P, Đorđević V, Stevanović S, Balanč B, Marković S, Luković N, Mijin D, Bugarski B. Supplementary data for the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: https://doi.org/10.1016/j.jddst.2020.101920. in Journal of Drug Delivery Science and Technology. 2020;59:101920.
https://hdl.handle.net/21.15107/rcub_dais_9518 .
Batinić, Petar, Đorđević, Verica, Stevanović, Sanja, Balanč, Bojana, Marković, Smilja, Luković, Nevena, Mijin, Dušan, Bugarski, Branko, "Supplementary data for the article: P.M. Batinić, V.B. Đorđević, S.I. Stevanović, B.D. Balanč, S.B. Marković, N.D. Luković, D.Ž. Mijin, B.M. Bugarski, Formulation and characterization of novel liposomes containing histidine for encapsulation of a poorly soluble vitamin, Journal of Drug Delivery Science and Technology, 2020, 59, 101920, doi: https://doi.org/10.1016/j.jddst.2020.101920" in Journal of Drug Delivery Science and Technology, 59 (2020):101920,
https://hdl.handle.net/21.15107/rcub_dais_9518 .