TY  - JOUR
AU  - Barbara, Giovanni
AU  - Grover, Madhusudan
AU  - Bercik, Premysl
AU  - Corsetti, Maura
AU  - Ghoshal, Uday C.
AU  - Ohman, Lena
AU  - Rajilić-Stojanović, Mirjana
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4322
AB  - BACKGROUND & AIMS: The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team report to summarize the available evidence on the pathophysiology of PI-IBS and provide guidance for diagnosis and treatment, based on findings reported in the literature and clinical experience. METHODS: The working team conducted an evidence-based review of publication databases for articles describing the clinical features (diagnosis), pathophysiology (intestinal sensorimotor function, microbiota, immune dysregulation, barrier dysfunction, enteroendocrine pathways, and genetics), and animal models of PI-IBS. We used a Delphi-based consensus system to create guidelines for management of PI-IBS and a developed treatment algorithm based on published findings and experiences of team members. RESULTS: PI-IBS develops in about 10% of patients with infectious enteritis. Risk factors include female sex, younger age, psychological distress during or before acute gastroenteritis, and severity of the acute episode. The pathogenesis of PI-PBS appears to involve changes in the intestinal microbiome as well as epithelial, serotonergic, and immune system factors. However, these mechanisms are incompletely understood. There are no evidence-based, effective pharmacologic strategies for treatment of PI-IBS. We provide a consensus-based treatment algorithm, based on clinical presentation and potential disease mechanisms. CONCLUSIONS: Based on a systematic review of the literature and team experience, we summarize the clinical features, pathophysiology (from animal models and human studies), and progression of PI-IBS. Based on these findings, we present an algorithm for diagnosis and treatment of PI-IBS based on team consensus. We also propose areas for future investigation.
PB  - W B Saunders Co-Elsevier Inc, Philadelphia
T2  - Gastroenterology
T1  - Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome
EP  - 58.e7
IS  - 1
SP  - 46
VL  - 156
DO  - 10.1053/j.gastro.2018.07.011
ER  - 

@article{
author = "Barbara, Giovanni and Grover, Madhusudan and Bercik, Premysl and Corsetti, Maura and Ghoshal, Uday C. and Ohman, Lena and Rajilić-Stojanović, Mirjana",
year = "2019",
abstract = "BACKGROUND & AIMS: The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team report to summarize the available evidence on the pathophysiology of PI-IBS and provide guidance for diagnosis and treatment, based on findings reported in the literature and clinical experience. METHODS: The working team conducted an evidence-based review of publication databases for articles describing the clinical features (diagnosis), pathophysiology (intestinal sensorimotor function, microbiota, immune dysregulation, barrier dysfunction, enteroendocrine pathways, and genetics), and animal models of PI-IBS. We used a Delphi-based consensus system to create guidelines for management of PI-IBS and a developed treatment algorithm based on published findings and experiences of team members. RESULTS: PI-IBS develops in about 10% of patients with infectious enteritis. Risk factors include female sex, younger age, psychological distress during or before acute gastroenteritis, and severity of the acute episode. The pathogenesis of PI-PBS appears to involve changes in the intestinal microbiome as well as epithelial, serotonergic, and immune system factors. However, these mechanisms are incompletely understood. There are no evidence-based, effective pharmacologic strategies for treatment of PI-IBS. We provide a consensus-based treatment algorithm, based on clinical presentation and potential disease mechanisms. CONCLUSIONS: Based on a systematic review of the literature and team experience, we summarize the clinical features, pathophysiology (from animal models and human studies), and progression of PI-IBS. Based on these findings, we present an algorithm for diagnosis and treatment of PI-IBS based on team consensus. We also propose areas for future investigation.",
publisher = "W B Saunders Co-Elsevier Inc, Philadelphia",
journal = "Gastroenterology",
title = "Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome",
pages = "58.e7-46",
number = "1",
volume = "156",
doi = "10.1053/j.gastro.2018.07.011"
}

Barbara, G., Grover, M., Bercik, P., Corsetti, M., Ghoshal, U. C., Ohman, L.,& Rajilić-Stojanović, M.. (2019). Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome. in Gastroenterology
W B Saunders Co-Elsevier Inc, Philadelphia., 156(1), 46-58.e7.
https://doi.org/10.1053/j.gastro.2018.07.011

Barbara G, Grover M, Bercik P, Corsetti M, Ghoshal UC, Ohman L, Rajilić-Stojanović M. Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome. in Gastroenterology. 2019;156(1):46-58.e7.
doi:10.1053/j.gastro.2018.07.011 .

Barbara, Giovanni, Grover, Madhusudan, Bercik, Premysl, Corsetti, Maura, Ghoshal, Uday C., Ohman, Lena, Rajilić-Stojanović, Mirjana, "Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome" in Gastroenterology, 156, no. 1 (2019):46-58.e7,
https://doi.org/10.1053/j.gastro.2018.07.011 . .

TY  - JOUR
AU  - Enck, Paul
AU  - Aziz, Qasim
AU  - Barbara, Giovanni
AU  - Farmer, Adam D.
AU  - Fukudo, Shin
AU  - Mayer, Emeran A.
AU  - Niesler, Beate
AU  - Quigley, Eamonn M. M.
AU  - Rajilić-Stojanović, Mirjana
AU  - Schemann, Michael
AU  - Schwille-Kiuntke, Juliane
AU  - Simren, Magnus
AU  - Zipfel, Stephan
AU  - Spiller, Robin C.
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3234
AB  - Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain-gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.
PB  - Nature Research, Berlin
T2  - Nature Reviews Disease Primers
T1  - Irritable bowel syndrome
VL  - 2
DO  - 10.1038/nrdp.2016.14
ER  - 

@article{
author = "Enck, Paul and Aziz, Qasim and Barbara, Giovanni and Farmer, Adam D. and Fukudo, Shin and Mayer, Emeran A. and Niesler, Beate and Quigley, Eamonn M. M. and Rajilić-Stojanović, Mirjana and Schemann, Michael and Schwille-Kiuntke, Juliane and Simren, Magnus and Zipfel, Stephan and Spiller, Robin C.",
year = "2016",
abstract = "Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain-gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.",
publisher = "Nature Research, Berlin",
journal = "Nature Reviews Disease Primers",
title = "Irritable bowel syndrome",
volume = "2",
doi = "10.1038/nrdp.2016.14"
}

Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M., Schemann, M., Schwille-Kiuntke, J., Simren, M., Zipfel, S.,& Spiller, R. C.. (2016). Irritable bowel syndrome. in Nature Reviews Disease Primers
Nature Research, Berlin., 2.
https://doi.org/10.1038/nrdp.2016.14

Enck P, Aziz Q, Barbara G, Farmer AD, Fukudo S, Mayer EA, Niesler B, Quigley EMM, Rajilić-Stojanović M, Schemann M, Schwille-Kiuntke J, Simren M, Zipfel S, Spiller RC. Irritable bowel syndrome. in Nature Reviews Disease Primers. 2016;2.
doi:10.1038/nrdp.2016.14 .

Enck, Paul, Aziz, Qasim, Barbara, Giovanni, Farmer, Adam D., Fukudo, Shin, Mayer, Emeran A., Niesler, Beate, Quigley, Eamonn M. M., Rajilić-Stojanović, Mirjana, Schemann, Michael, Schwille-Kiuntke, Juliane, Simren, Magnus, Zipfel, Stephan, Spiller, Robin C., "Irritable bowel syndrome" in Nature Reviews Disease Primers, 2 (2016),
https://doi.org/10.1038/nrdp.2016.14 . .