TY  - CONF
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6737
AB  - Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced.
AB  - Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
T1  - Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine
T1  - Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina
EP  - 187
SP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6737
ER  - 

@conference{
author = "Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Pantić, Olga J. and Panić, Vesna V.",
year = "2023",
abstract = "Modern society are faced with lot of challenges in the treatment of many diseases, especially
with serious ones such as cancer. Safer and more efficient treatment of the cancer patients are main
goals which researchers are aiming. One of the good approaches can be drug delivery systems.
Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled release
can be quite challenging. Present study is focused to improve drug delivery system based on
hydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-soluble
caffeine, which has been developed through our previous research. The hydrogels with 1.6mol% of
crosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-
4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed in
two environments which simulate human stomach and intestines. It is also investigated how the
change in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,
affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The results
show that controlled release of caffeine is improved, therefore overall therapy can be enhanced., Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac",
title = "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine, Biohidrogelovi poli(metakrilne kiseline): bubrenje i kontrolisano otpuštanje kofeina",
pages = "187-181",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6737"
}

Marković, M. D., Spasojević, P. M., Savić, S. I., Pantić, O. J.,& Panić, V. V.. (2023). Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 181-187.
https://hdl.handle.net/21.15107/rcub_technorep_6737

Marković MD, Spasojević PM, Savić SI, Pantić OJ, Panić VV. Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine. in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac. 2023;:181-187.
https://hdl.handle.net/21.15107/rcub_technorep_6737 .

Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Pantić, Olga J., Panić, Vesna V., "Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine" in Zbornik radova / 36. Međunarodni kongres o procesnoj industriji, PROCESING '23, 1 i 2. jun 2023, Šabac (2023):181-187,
https://hdl.handle.net/21.15107/rcub_technorep_6737 .

TY  - JOUR
AU  - Pantic, Olga J.
AU  - Pjanovic, Rada V.
AU  - Panić, Vesna V.
AU  - Savic, Sanja I.
AU  - Spasojevic, Pavle M.
AU  - Marković, Maja D.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5479
AB  - Drug delivery system is an amazing tool which is widely used for drug
protection and its controlled release in order to enhance drug bioavailability,
reduce side effects and therefore to improve overall therapy. Hydrogels have
been attracted great attention as drug carriers due to their great physicochemical
properties, similarity to the living tissues and biocompatibility. One group of
pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These
non-toxic hydrogels are used as drug delivery system because they swell as
a response to the change in pH of external environment and drug is being
released during the process. In present study, in order to improve the control of
drug release rate, caffeine was encapsulated in liposomes which were further
embedded into PMC hydrogel (PMCL). It was investigated how the change in
neutralization degree of methacrylic acid affect the swelling degree of PMCL
hydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 M
hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as
a simulation of pH environment in human stomach and intestines, respectively.
Obtained results show that PMCL hydrogels have great potential for controlled
release of poorly water-soluble drugs in human intestines.
PB  - the Faculty of Technology, University of Banja Luka
T2  - Journal of Chemists, Technologists and Environmentalists
T1  - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
EP  - 5
IS  - 1
SP  - 1
VL  - 3
DO  - 10.7251/JCTE2203001P
ER  - 

@article{
author = "Pantic, Olga J. and Pjanovic, Rada V. and Panić, Vesna V. and Savic, Sanja I. and Spasojevic, Pavle M. and Marković, Maja D.",
year = "2022",
abstract = "Drug delivery system is an amazing tool which is widely used for drug
protection and its controlled release in order to enhance drug bioavailability,
reduce side effects and therefore to improve overall therapy. Hydrogels have
been attracted great attention as drug carriers due to their great physicochemical
properties, similarity to the living tissues and biocompatibility. One group of
pH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). These
non-toxic hydrogels are used as drug delivery system because they swell as
a response to the change in pH of external environment and drug is being
released during the process. In present study, in order to improve the control of
drug release rate, caffeine was encapsulated in liposomes which were further
embedded into PMC hydrogel (PMCL). It was investigated how the change in
neutralization degree of methacrylic acid affect the swelling degree of PMCL
hydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 M
hydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), as
a simulation of pH environment in human stomach and intestines, respectively.
Obtained results show that PMCL hydrogels have great potential for controlled
release of poorly water-soluble drugs in human intestines.",
publisher = "the Faculty of Technology, University of Banja Luka",
journal = "Journal of Chemists, Technologists and Environmentalists",
title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release",
pages = "5-1",
number = "1",
volume = "3",
doi = "10.7251/JCTE2203001P"
}

Pantic, O. J., Pjanovic, R. V., Panić, V. V., Savic, S. I., Spasojevic, P. M.,& Marković, M. D.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists
the Faculty of Technology, University of Banja Luka., 3(1), 1-5.
https://doi.org/10.7251/JCTE2203001P

Pantic OJ, Pjanovic RV, Panić VV, Savic SI, Spasojevic PM, Marković MD. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists. 2022;3(1):1-5.
doi:10.7251/JCTE2203001P .

Pantic, Olga J., Pjanovic, Rada V., Panić, Vesna V., Savic, Sanja I., Spasojevic, Pavle M., Marković, Maja D., "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Journal of Chemists, Technologists and Environmentalists, 3, no. 1 (2022):1-5,
https://doi.org/10.7251/JCTE2203001P . .