TY  - JOUR
AU  - Petkovska, Jovana
AU  - Geskovski, Nikola
AU  - Marković, Darka
AU  - Dimova, Vesna
AU  - Mirakovski, Dejan
AU  - Radetić, Maja
AU  - Jordanov, Igor
PY  - 2024-01
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7155
AB  - Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH.
PB  - Elsevier Ltd.
T2  - Carbohydrate Polymer Technologies and Applications
T1  - Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization
SP  - 100438
VL  - 7
DO  - 10.1016/j.carpta.2024.100438
ER  - 

@article{
author = "Petkovska, Jovana and Geskovski, Nikola and Marković, Darka and Dimova, Vesna and Mirakovski, Dejan and Radetić, Maja and Jordanov, Igor",
year = "2024-01",
abstract = "Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH.",
publisher = "Elsevier Ltd.",
journal = "Carbohydrate Polymer Technologies and Applications",
title = "Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization",
pages = "100438",
volume = "7",
doi = "10.1016/j.carpta.2024.100438"
}

Petkovska, J., Geskovski, N., Marković, D., Dimova, V., Mirakovski, D., Radetić, M.,& Jordanov, I.. (2024-01). Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization. in Carbohydrate Polymer Technologies and Applications
Elsevier Ltd.., 7, 100438.
https://doi.org/10.1016/j.carpta.2024.100438

Petkovska J, Geskovski N, Marković D, Dimova V, Mirakovski D, Radetić M, Jordanov I. Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization. in Carbohydrate Polymer Technologies and Applications. 2024;7:100438.
doi:10.1016/j.carpta.2024.100438 .

Petkovska, Jovana, Geskovski, Nikola, Marković, Darka, Dimova, Vesna, Mirakovski, Dejan, Radetić, Maja, Jordanov, Igor, "Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization" in Carbohydrate Polymer Technologies and Applications, 7 (2024-01):100438,
https://doi.org/10.1016/j.carpta.2024.100438 . .