TY  - JOUR
AU  - Anojčić, Jasmina
AU  - Mijin, Dušan
AU  - Eraković Pantović, Sanja
AU  - Bogdanović, Aleksandra
AU  - Turuntaš, Nikola
AU  - Mutić, Sanja
AU  - Petrović, Slobodan
AU  - Avramov Ivić, Milka
PY  - 2024-03
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7278
AB  - The anticholinergic drug, solifenacin, is frequently used for the treatment of the urological tract for urinary incontinence, and urinary frequency. The development of reliable and effective solifenacin electrochemical sensors is of great importance for the pharmaceutical industry and clinical practice. In this work, the electrochemical behavior of solifenacin succinate (SOL) was studied using three different working electrodes: gold (Au), glassy carbon (GCE) and boron-doped diamond electrode (BDDE). The cyclic voltammetric (CV) measurements performed in 0.05 M NaHCO3 indicated that the SOL oxidation process is irreversible and diffusion-controlled at all investigated working electrodes. Afterwards, the testing of SOL electrochemical stability and the possibility of its electrochemical degradation was performed at the Au electrode by the cycling of the potential during 3 h and continuously to 6 h. It was shown that the SOL was electrochemically transformed into another electroactive species and its degradation was excluded. For electroanalytical application, the anodically pretreated BDDE (+2.0 V; 30 s) was selected. Various experimental parameters were optimized, including the pH of the aqueous Britton-Robinson (B-R) buffer as a supporting electrolyte (from pH 2.0 to 11.98) and the most intensive peak of the target analyte was at pH 11.0, so this pH value was chosen as the optimum for further measurements. Based on the correlation of the SOL peak intensity and different concentrations, the developed differential pulse voltammetric (DPV) method was characterized by a linear concentration range from 0.041 to 2.50 µM, with a correlation coefficient of 0.999, and a relative standard deviation of 0.3 %. Taking into account the sensitivity of the developed DPV method towards the electrochemical oxidation of SOL, a very low detection limit of 0.012 µM in the model system was achieved. The BDDE showed adequate selectivity for SOL in the presence of the investigated interferents. The obtained results indicate that the BDDE with an optimized DPV method could be applied for the trace-level electroanalytical determination of SOL in human urine sample with excellent recovery and reproducibility.
PB  - Elsevier B.V.
T2  - Journal of Electroanalytical Chemistry
T1  - Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination
SP  - 118113
VL  - 957
DO  - 10.1016/j.jelechem.2024.118113
ER  - 

@article{
author = "Anojčić, Jasmina and Mijin, Dušan and Eraković Pantović, Sanja and Bogdanović, Aleksandra and Turuntaš, Nikola and Mutić, Sanja and Petrović, Slobodan and Avramov Ivić, Milka",
year = "2024-03",
abstract = "The anticholinergic drug, solifenacin, is frequently used for the treatment of the urological tract for urinary incontinence, and urinary frequency. The development of reliable and effective solifenacin electrochemical sensors is of great importance for the pharmaceutical industry and clinical practice. In this work, the electrochemical behavior of solifenacin succinate (SOL) was studied using three different working electrodes: gold (Au), glassy carbon (GCE) and boron-doped diamond electrode (BDDE). The cyclic voltammetric (CV) measurements performed in 0.05 M NaHCO3 indicated that the SOL oxidation process is irreversible and diffusion-controlled at all investigated working electrodes. Afterwards, the testing of SOL electrochemical stability and the possibility of its electrochemical degradation was performed at the Au electrode by the cycling of the potential during 3 h and continuously to 6 h. It was shown that the SOL was electrochemically transformed into another electroactive species and its degradation was excluded. For electroanalytical application, the anodically pretreated BDDE (+2.0 V; 30 s) was selected. Various experimental parameters were optimized, including the pH of the aqueous Britton-Robinson (B-R) buffer as a supporting electrolyte (from pH 2.0 to 11.98) and the most intensive peak of the target analyte was at pH 11.0, so this pH value was chosen as the optimum for further measurements. Based on the correlation of the SOL peak intensity and different concentrations, the developed differential pulse voltammetric (DPV) method was characterized by a linear concentration range from 0.041 to 2.50 µM, with a correlation coefficient of 0.999, and a relative standard deviation of 0.3 %. Taking into account the sensitivity of the developed DPV method towards the electrochemical oxidation of SOL, a very low detection limit of 0.012 µM in the model system was achieved. The BDDE showed adequate selectivity for SOL in the presence of the investigated interferents. The obtained results indicate that the BDDE with an optimized DPV method could be applied for the trace-level electroanalytical determination of SOL in human urine sample with excellent recovery and reproducibility.",
publisher = "Elsevier B.V.",
journal = "Journal of Electroanalytical Chemistry",
title = "Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination",
pages = "118113",
volume = "957",
doi = "10.1016/j.jelechem.2024.118113"
}

Anojčić, J., Mijin, D., Eraković Pantović, S., Bogdanović, A., Turuntaš, N., Mutić, S., Petrović, S.,& Avramov Ivić, M.. (2024-03). Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination. in Journal of Electroanalytical Chemistry
Elsevier B.V.., 957, 118113.
https://doi.org/10.1016/j.jelechem.2024.118113

Anojčić J, Mijin D, Eraković Pantović S, Bogdanović A, Turuntaš N, Mutić S, Petrović S, Avramov Ivić M. Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination. in Journal of Electroanalytical Chemistry. 2024;957:118113.
doi:10.1016/j.jelechem.2024.118113 .

Anojčić, Jasmina, Mijin, Dušan, Eraković Pantović, Sanja, Bogdanović, Aleksandra, Turuntaš, Nikola, Mutić, Sanja, Petrović, Slobodan, Avramov Ivić, Milka, "Voltammetric behavior of solifenacin succinate on gold, glassy carbon and boron-doped diamond electrodes: Stability testing and determination" in Journal of Electroanalytical Chemistry, 957 (2024-03):118113,
https://doi.org/10.1016/j.jelechem.2024.118113 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov-Ivić, Milka
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5191
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
IS  - 7
SP  - 076507
VL  - 169
DO  - 10.1149/1945-7111/ac7e74
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov-Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
number = "7",
pages = "076507",
volume = "169",
doi = "10.1149/1945-7111/ac7e74"
}

Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov-Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society., 169(7), 076507.
https://doi.org/10.1149/1945-7111/ac7e74

Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov-Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;169(7):076507.
doi:10.1149/1945-7111/ac7e74 .

Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov-Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society, 169, no. 7 (2022):076507,
https://doi.org/10.1149/1945-7111/ac7e74 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5197
AB  - Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.
PB  - ESG
T2  - International Journal of Electrochemical Science
T1  - Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode
SP  - 220928
VL  - 17
DO  - 10.20964/2022.09.36
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2022",
abstract = "Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.",
publisher = "ESG",
journal = "International Journal of Electrochemical Science",
title = "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode",
pages = "220928",
volume = "17",
doi = "10.20964/2022.09.36"
}

Lović, J., Bogdanović, A., Mijin, D., Vuković, D., Petrović, S.,& Avramov-Ivić, M.. (2022). Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science
ESG., 17, 220928.
https://doi.org/10.20964/2022.09.36

Lović J, Bogdanović A, Mijin D, Vuković D, Petrović S, Avramov-Ivić M. Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science. 2022;17:220928.
doi:10.20964/2022.09.36 .

Lović, Jelena, Bogdanović, Aleksandra, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan, Avramov-Ivić, Milka, "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode" in International Journal of Electrochemical Science, 17 (2022):220928,
https://doi.org/10.20964/2022.09.36 . .

TY  - JOUR
AU  - Milentijevic, Goran
AU  - Marinković, Aleksandar
AU  - Rancic, Milica
AU  - Bogdanović, Aleksandra
AU  - Prlainović, Nevena
AU  - Markovic, Smiljana
AU  - Milosavljevic, Milutin
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4779
AB  - The specific objectives of the presented study were related to the optimization of the production process of N-alkyl-, N,N-dialkyl-, and N-cycloalkyl-O-isobutyl thiocarbamate; trial industrial production of N-ethyl-O-isobutyl thiocarbamate; and the evaluation of flotation efficiency of N-ethyl-O-isobutyl thiocarbamate using a real ore sample. The optimization of thiocarbamate syntheses were performed by varying the molar ratio of isobutyl alcohol, carbon disulfide, potassium hydroxide, reaction time, and reaction temperature. In the first step, one-pot reaction took place to produce alkyl xanthate and was followed with chlorination to give alkyl chloroformate (O-alkyl carbonochloridothioate); finally, thiocarbamates were obtained by the reaction with corresponding amines. N-alkyl-O-ethyl thiocarbamate was synthesized as a comparative flotation agent. The structure of the synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and MS instrumental methods, and the purity was determined by gas chromatographic method and elemental analysis. The optimized methods gave high-purity products in a significant yield that was also confirmed by semi-industrial production of N-ethyl-O-isobutyl thiocarbamate. The optimized thiocarbamate synthesis, without isolation of intermediates, is of great importance from the aspect of green technologies. Flotation efficiency test results, using real copper and zinc ores, showed the highest activity of N-ethyl-O-isobutyl thiocarbamate. The optimal one-pot thiocarbamate synthesis provides a simple procedure with a high conversion degree, and, thus, offers valuable technology applicable at the industrial scale.
T2  - Minerals
T1  - New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture
IS  - 12
VL  - 11
DO  - 10.3390/min11121346
ER  - 

@article{
author = "Milentijevic, Goran and Marinković, Aleksandar and Rancic, Milica and Bogdanović, Aleksandra and Prlainović, Nevena and Markovic, Smiljana and Milosavljevic, Milutin",
year = "2021",
abstract = "The specific objectives of the presented study were related to the optimization of the production process of N-alkyl-, N,N-dialkyl-, and N-cycloalkyl-O-isobutyl thiocarbamate; trial industrial production of N-ethyl-O-isobutyl thiocarbamate; and the evaluation of flotation efficiency of N-ethyl-O-isobutyl thiocarbamate using a real ore sample. The optimization of thiocarbamate syntheses were performed by varying the molar ratio of isobutyl alcohol, carbon disulfide, potassium hydroxide, reaction time, and reaction temperature. In the first step, one-pot reaction took place to produce alkyl xanthate and was followed with chlorination to give alkyl chloroformate (O-alkyl carbonochloridothioate); finally, thiocarbamates were obtained by the reaction with corresponding amines. N-alkyl-O-ethyl thiocarbamate was synthesized as a comparative flotation agent. The structure of the synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and MS instrumental methods, and the purity was determined by gas chromatographic method and elemental analysis. The optimized methods gave high-purity products in a significant yield that was also confirmed by semi-industrial production of N-ethyl-O-isobutyl thiocarbamate. The optimized thiocarbamate synthesis, without isolation of intermediates, is of great importance from the aspect of green technologies. Flotation efficiency test results, using real copper and zinc ores, showed the highest activity of N-ethyl-O-isobutyl thiocarbamate. The optimal one-pot thiocarbamate synthesis provides a simple procedure with a high conversion degree, and, thus, offers valuable technology applicable at the industrial scale.",
journal = "Minerals",
title = "New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture",
number = "12",
volume = "11",
doi = "10.3390/min11121346"
}

Milentijevic, G., Marinković, A., Rancic, M., Bogdanović, A., Prlainović, N., Markovic, S.,& Milosavljevic, M.. (2021). New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture. in Minerals, 11(12).
https://doi.org/10.3390/min11121346

Milentijevic G, Marinković A, Rancic M, Bogdanović A, Prlainović N, Markovic S, Milosavljevic M. New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture. in Minerals. 2021;11(12).
doi:10.3390/min11121346 .

Milentijevic, Goran, Marinković, Aleksandar, Rancic, Milica, Bogdanović, Aleksandra, Prlainović, Nevena, Markovic, Smiljana, Milosavljevic, Milutin, "New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture" in Minerals, 11, no. 12 (2021),
https://doi.org/10.3390/min11121346 . .

TY  - JOUR
AU  - Bogdanović, Aleksandra
AU  - Lazić, Anita
AU  - Grujic, Slavica
AU  - Dimkic, Ivica
AU  - Stankovic, Slavisa
AU  - Petrović, Slobodan
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4912
AB  - In this study we screened twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quantitative structure-activity relationship (QSAR) analysis based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans. Our compounds met all the screening criteria of Lipinski's rule of five (Ro5) as well as Veber's and Egan's methods for predicting biological activity. In antimicrobial activity tests, all chloroacetamides were effective against Gram-positive S. aureus and MRSA, less effective against the Gram-negative E. coli, and moderately effective against the yeast C. albicans. Our study confirmed that the biological activity of chloroacetamides varied with the position of substituents bound to the phenyl ring, which explains why some molecules were more effective against Gram-negative than Gram-positive bacteria or C. albicans. Bearing the halogenated p-substituted phenyl ring, N-(4-chlorophenyl), N-(4-fluorophenyl), and N-(3-bromophenyl) chloroacetamides were among the most active thanks to high lipophilicity, which allows them to pass rapidly through the phospholipid bilayer of the cell membrane. They are the most promising compounds for further investigation, particularly against Gram-positive bacteria and pathogenic yeasts.
T2  - Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology
T1  - Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests
EP  - 79
IS  - 1
SP  - 70
VL  - 72
DO  - 10.2478/aiht-2021-72-3483
ER  - 

@article{
author = "Bogdanović, Aleksandra and Lazić, Anita and Grujic, Slavica and Dimkic, Ivica and Stankovic, Slavisa and Petrović, Slobodan",
year = "2021",
abstract = "In this study we screened twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quantitative structure-activity relationship (QSAR) analysis based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans. Our compounds met all the screening criteria of Lipinski's rule of five (Ro5) as well as Veber's and Egan's methods for predicting biological activity. In antimicrobial activity tests, all chloroacetamides were effective against Gram-positive S. aureus and MRSA, less effective against the Gram-negative E. coli, and moderately effective against the yeast C. albicans. Our study confirmed that the biological activity of chloroacetamides varied with the position of substituents bound to the phenyl ring, which explains why some molecules were more effective against Gram-negative than Gram-positive bacteria or C. albicans. Bearing the halogenated p-substituted phenyl ring, N-(4-chlorophenyl), N-(4-fluorophenyl), and N-(3-bromophenyl) chloroacetamides were among the most active thanks to high lipophilicity, which allows them to pass rapidly through the phospholipid bilayer of the cell membrane. They are the most promising compounds for further investigation, particularly against Gram-positive bacteria and pathogenic yeasts.",
journal = "Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology",
title = "Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests",
pages = "79-70",
number = "1",
volume = "72",
doi = "10.2478/aiht-2021-72-3483"
}

Bogdanović, A., Lazić, A., Grujic, S., Dimkic, I., Stankovic, S.,& Petrović, S.. (2021). Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests. in Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology, 72(1), 70-79.
https://doi.org/10.2478/aiht-2021-72-3483

Bogdanović A, Lazić A, Grujic S, Dimkic I, Stankovic S, Petrović S. Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests. in Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology. 2021;72(1):70-79.
doi:10.2478/aiht-2021-72-3483 .

Bogdanović, Aleksandra, Lazić, Anita, Grujic, Slavica, Dimkic, Ivica, Stankovic, Slavisa, Petrović, Slobodan, "Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests" in Arhiv Za Higijenu Rada I Toksikologiju-Archives of Industrial Hygiene and Toxicology, 72, no. 1 (2021):70-79,
https://doi.org/10.2478/aiht-2021-72-3483 . .

TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Marinković, Aleksandar
AU  - Rančić, Milica
AU  - Milentijević, Goran
AU  - Bogdanović, Aleksandra
AU  - Cvijetić, Ilija
AU  - Gurešić, Dejan
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4528
AB  - An optimal laboratory two-step procedure was developed for sodium/potassium O-alkyl carbonodithioate (sodium/potassium alkyl xanthates) production in the form of aqueous solutions. Sodium isopropyl xanthate (Na-iPrX), as the most effective salt in a real ore flotation process, was also produced at an industrial level and introduced as a collector for copper ores. In order to reduce toxicity of the flotation process and improve sustainability by minimising environmental impacts, collector efficiency and selectivity in the flotation process were studied in relation to possible synergism of xanthates combined with the derived biomass and biodegradable green reagents levulinic acid, 5-hydroxymethyl-2-furanacrylic acid (HMFA), and condensation product of hydroxymethylfurfural and levulinic acid. Optimal content of 30% of HMFA in the collector pointed to the possibility of substitution of commercial xanthate collector without significantly affecting its efficiency/selectivity. The density functional theory (DFT) calculations provided insights into the interaction mechanism of Na-iPrX and HMFA with cooper. The benefits of the presented method highlight production simplicity, mild reaction conditions, high purity and yield of products, no by-products, and technological applicability on an industrial scale.
PB  - MDPI, Basel
T2  - Minerals
T1  - New Eco-Friendly Xanthate-Based Flotation Agents
IS  - 4
VL  - 10
DO  - 10.3390/min10040350
ER  - 

@article{
author = "Milosavljević, Milutin M. and Marinković, Aleksandar and Rančić, Milica and Milentijević, Goran and Bogdanović, Aleksandra and Cvijetić, Ilija and Gurešić, Dejan",
year = "2020",
abstract = "An optimal laboratory two-step procedure was developed for sodium/potassium O-alkyl carbonodithioate (sodium/potassium alkyl xanthates) production in the form of aqueous solutions. Sodium isopropyl xanthate (Na-iPrX), as the most effective salt in a real ore flotation process, was also produced at an industrial level and introduced as a collector for copper ores. In order to reduce toxicity of the flotation process and improve sustainability by minimising environmental impacts, collector efficiency and selectivity in the flotation process were studied in relation to possible synergism of xanthates combined with the derived biomass and biodegradable green reagents levulinic acid, 5-hydroxymethyl-2-furanacrylic acid (HMFA), and condensation product of hydroxymethylfurfural and levulinic acid. Optimal content of 30% of HMFA in the collector pointed to the possibility of substitution of commercial xanthate collector without significantly affecting its efficiency/selectivity. The density functional theory (DFT) calculations provided insights into the interaction mechanism of Na-iPrX and HMFA with cooper. The benefits of the presented method highlight production simplicity, mild reaction conditions, high purity and yield of products, no by-products, and technological applicability on an industrial scale.",
publisher = "MDPI, Basel",
journal = "Minerals",
title = "New Eco-Friendly Xanthate-Based Flotation Agents",
number = "4",
volume = "10",
doi = "10.3390/min10040350"
}

Milosavljević, M. M., Marinković, A., Rančić, M., Milentijević, G., Bogdanović, A., Cvijetić, I.,& Gurešić, D.. (2020). New Eco-Friendly Xanthate-Based Flotation Agents. in Minerals
MDPI, Basel., 10(4).
https://doi.org/10.3390/min10040350

Milosavljević MM, Marinković A, Rančić M, Milentijević G, Bogdanović A, Cvijetić I, Gurešić D. New Eco-Friendly Xanthate-Based Flotation Agents. in Minerals. 2020;10(4).
doi:10.3390/min10040350 .

Milosavljević, Milutin M., Marinković, Aleksandar, Rančić, Milica, Milentijević, Goran, Bogdanović, Aleksandra, Cvijetić, Ilija, Gurešić, Dejan, "New Eco-Friendly Xanthate-Based Flotation Agents" in Minerals, 10, no. 4 (2020),
https://doi.org/10.3390/min10040350 . .

TY  - JOUR
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Petrović, Slobodan
AU  - Skala, Dejan
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4543
AB  - Supercritical CO2 extraction was applied on fenugreek (Trigonella foenum-graecum L., Fabaceae) seeds with the aim to define optimal process conditions to obtain the maximal extract yields content of steroidal sapogenins. Central composite rotatable design (CCRD) combined with response surface methodology (RSM) was applied to determine optimal process conditions defined by the influence and interaction of pressure, temperature and time of extraction through consumption of SC CO2. Optimization experiments revealed that the pressure of 24.73 MPa, the temperature of 38.2 degrees C and the consumption of SC CO2 of 19.24 g/g(DM) were the best process conditions enabling the maximal yield of extract and gain of the highest content of sapogenins. The optimal values of pressure and temperature defined SC CO2 density of 885.47 kg/m(3), which provided the maximal yield of the extract with the highest content of steroidal sapogenins. The achieved yield of extract at these conditions was 0.073g/g(DM), with 0.774 mg/g(DM) diosgenin, 0.477 mg/g(DM) protodioscin, 0.713 mg/g(DM) sarsapogenin and 0.205 mg/g(DM) oleanolic and ursolic acid with a significant quantity of 2.475 mg/g(DM) in the obtained extract.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Supercritical CO2 extraction of steroidal sapogenins from fenugreek (tngonella foenum-graecum l.) Seed
EP  - 182
IS  - 2
SP  - 171
VL  - 26
DO  - 10.2298/CICEQ191001036B
ER  - 

@article{
author = "Bogdanović, Aleksandra and Tadić, Vanja and Petrović, Slobodan and Skala, Dejan",
year = "2020",
abstract = "Supercritical CO2 extraction was applied on fenugreek (Trigonella foenum-graecum L., Fabaceae) seeds with the aim to define optimal process conditions to obtain the maximal extract yields content of steroidal sapogenins. Central composite rotatable design (CCRD) combined with response surface methodology (RSM) was applied to determine optimal process conditions defined by the influence and interaction of pressure, temperature and time of extraction through consumption of SC CO2. Optimization experiments revealed that the pressure of 24.73 MPa, the temperature of 38.2 degrees C and the consumption of SC CO2 of 19.24 g/g(DM) were the best process conditions enabling the maximal yield of extract and gain of the highest content of sapogenins. The optimal values of pressure and temperature defined SC CO2 density of 885.47 kg/m(3), which provided the maximal yield of the extract with the highest content of steroidal sapogenins. The achieved yield of extract at these conditions was 0.073g/g(DM), with 0.774 mg/g(DM) diosgenin, 0.477 mg/g(DM) protodioscin, 0.713 mg/g(DM) sarsapogenin and 0.205 mg/g(DM) oleanolic and ursolic acid with a significant quantity of 2.475 mg/g(DM) in the obtained extract.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Supercritical CO2 extraction of steroidal sapogenins from fenugreek (tngonella foenum-graecum l.) Seed",
pages = "182-171",
number = "2",
volume = "26",
doi = "10.2298/CICEQ191001036B"
}

Bogdanović, A., Tadić, V., Petrović, S.,& Skala, D.. (2020). Supercritical CO2 extraction of steroidal sapogenins from fenugreek (tngonella foenum-graecum l.) Seed. in Chemical Industry & Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 26(2), 171-182.
https://doi.org/10.2298/CICEQ191001036B

Bogdanović A, Tadić V, Petrović S, Skala D. Supercritical CO2 extraction of steroidal sapogenins from fenugreek (tngonella foenum-graecum l.) Seed. in Chemical Industry & Chemical Engineering Quarterly. 2020;26(2):171-182.
doi:10.2298/CICEQ191001036B .

Bogdanović, Aleksandra, Tadić, Vanja, Petrović, Slobodan, Skala, Dejan, "Supercritical CO2 extraction of steroidal sapogenins from fenugreek (tngonella foenum-graecum l.) Seed" in Chemical Industry & Chemical Engineering Quarterly, 26, no. 2 (2020):171-182,
https://doi.org/10.2298/CICEQ191001036B . .

TY  - JOUR
AU  - Durdević, Sanja
AU  - Milovanović, Stoja
AU  - Šavikin, Katarina
AU  - Ristić, Mihailo S.
AU  - Menković, Nebojša
AU  - Pljevljakusić, Dejan
AU  - Petrović, Slobodan
AU  - Bogdanović, Aleksandra
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3715
AB  - Microwave radiation was suggested as a pretreatment technique to increase the yield of pomegranate seed oil. Seeds were pretreated at 100, 250 and 600 W during 2 and 6 min and then extracted by supercritical carbon dioxide (scCO(2)) in high pressure unit as well as by n-hexane in Soxhlet apparatus. Even at the lowest microwave pretreatment parameters applied (100 W for 2 min) increased the yield of seed oil obtained by both extraction techniques compared with untreated seeds (from 27.7 to 34.0% and from 21.6 to 25.5% for Soxhlet and scCO(2) extractions, respectively). Maximal oil yield in Soxhlet extraction (36.3%) was obtained with microwave radiation of 600 W for 6 min while for scCO(2) extraction maximal oil yield (27.2%) was with 250 W for 6 min microwave radiation pretreatment. The qualitative and quantitative composition of fatty acids of the obtained oils was determined by gas chromatography/flame ionization detection and gas chromatography/mass spectrometry. Punicic acid was the most abundant fatty acid in pomegranate seed oil ( gt  60%). Microwave pretreatment of seeds showed negligible influence on profile and the amount of fatty acids in obtained extracts, compared with its significant influence on extraction yield. Our results recognize microwave pretreatment as a promising technique for intensification of oil extraction from pomegranate seeds.
PB  - Elsevier, Amsterdam
T2  - Industrial Crops and Products
T1  - Improvement of supercritical CO2 and n-hexane extraction of wild growing pomegranate seed oil by microwave pretreatment
EP  - 27
SP  - 21
VL  - 104
DO  - 10.1016/j.indcrop.2017.04.024
ER  - 

@article{
author = "Durdević, Sanja and Milovanović, Stoja and Šavikin, Katarina and Ristić, Mihailo S. and Menković, Nebojša and Pljevljakusić, Dejan and Petrović, Slobodan and Bogdanović, Aleksandra",
year = "2017",
abstract = "Microwave radiation was suggested as a pretreatment technique to increase the yield of pomegranate seed oil. Seeds were pretreated at 100, 250 and 600 W during 2 and 6 min and then extracted by supercritical carbon dioxide (scCO(2)) in high pressure unit as well as by n-hexane in Soxhlet apparatus. Even at the lowest microwave pretreatment parameters applied (100 W for 2 min) increased the yield of seed oil obtained by both extraction techniques compared with untreated seeds (from 27.7 to 34.0% and from 21.6 to 25.5% for Soxhlet and scCO(2) extractions, respectively). Maximal oil yield in Soxhlet extraction (36.3%) was obtained with microwave radiation of 600 W for 6 min while for scCO(2) extraction maximal oil yield (27.2%) was with 250 W for 6 min microwave radiation pretreatment. The qualitative and quantitative composition of fatty acids of the obtained oils was determined by gas chromatography/flame ionization detection and gas chromatography/mass spectrometry. Punicic acid was the most abundant fatty acid in pomegranate seed oil ( gt  60%). Microwave pretreatment of seeds showed negligible influence on profile and the amount of fatty acids in obtained extracts, compared with its significant influence on extraction yield. Our results recognize microwave pretreatment as a promising technique for intensification of oil extraction from pomegranate seeds.",
publisher = "Elsevier, Amsterdam",
journal = "Industrial Crops and Products",
title = "Improvement of supercritical CO2 and n-hexane extraction of wild growing pomegranate seed oil by microwave pretreatment",
pages = "27-21",
volume = "104",
doi = "10.1016/j.indcrop.2017.04.024"
}

Durdević, S., Milovanović, S., Šavikin, K., Ristić, M. S., Menković, N., Pljevljakusić, D., Petrović, S.,& Bogdanović, A.. (2017). Improvement of supercritical CO2 and n-hexane extraction of wild growing pomegranate seed oil by microwave pretreatment. in Industrial Crops and Products
Elsevier, Amsterdam., 104, 21-27.
https://doi.org/10.1016/j.indcrop.2017.04.024

Durdević S, Milovanović S, Šavikin K, Ristić MS, Menković N, Pljevljakusić D, Petrović S, Bogdanović A. Improvement of supercritical CO2 and n-hexane extraction of wild growing pomegranate seed oil by microwave pretreatment. in Industrial Crops and Products. 2017;104:21-27.
doi:10.1016/j.indcrop.2017.04.024 .

Durdević, Sanja, Milovanović, Stoja, Šavikin, Katarina, Ristić, Mihailo S., Menković, Nebojša, Pljevljakusić, Dejan, Petrović, Slobodan, Bogdanović, Aleksandra, "Improvement of supercritical CO2 and n-hexane extraction of wild growing pomegranate seed oil by microwave pretreatment" in Industrial Crops and Products, 104 (2017):21-27,
https://doi.org/10.1016/j.indcrop.2017.04.024 . .

TY  - THES
AU  - Bogdanović, Aleksandra
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=4604
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:14730/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48702735
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4651
AB  - Synthetic hypolipemics nowdays have being replaced by natural ones due to the noticed deficiencies and side effects of synthetic drugs. Great effort is being devoted to the search for alternative and cheaper sources of natural hypolipemics, as well as to the development of efficient, selective and more convenient extraction techniques. Extraction with conventional solvents is characterized by poor selectivity and requires high temperatures, which could result in degradation of the desired compounds, and obtained extracts usually have solvent residues which is not convenient in medicinal use. Supercritical extraction (SCE) shows higher selectivity compared to conventional techniques of extraction. Selectivity of SCE towards some groups of compounds can be tuned by changing extraction conditions (pressure and temperature). According to easy and total separation of supercritical fluid from the extract achieved by lowering pressure, SCE presents type of extraction which allows obtaining extracts without residual solvents (for example for application in pharmaceutical, food and cosmetics industry). The aim of this study was the isolation of extracts of lemon balm (Melissae officinalis) and fenugreek (Trigonella foenum-graecum) rich in compounds that possess hypolipidemic activity according to literature data, using different extraction processes. The extracts rich in hypolipidemic substances were obtained by supercritical carbon dioxide extraction (SCE-CO2), hydrodistillation and ethanol extraction from plant material. Characterization and analysis of the obtained extracts as well as determination of contents of the components identified by the literature data as carriers of hypolipidemic activity, were performed . Identification and quantification of the active components in the extracts were performed using gas chromatography mass spectrometry (GC / MS) and liquid chromatography (HPLC). The research was based on the kinetic analysis and optimization of different extraction processes for obtaining extracts rich in components with hypolidemic activity. Kinetics of subcritical and supercritical extractions were analyzed, whereby, the influence of process parameters (pressure and temperature) as well as appropriate pretreatment of plant material on the yield of total extract and hypolipidemic compunds was examined...
AB  - Sintetski hipolipemici danas se sve više zamenjuju prirodnim hipolipemicima, usled utvrđenih nedostataka, nus-pojava i sporednih efekata sintetičkih lekova. Shodno tome, podstaknuta je povećana upotreba biljaka, odnosno njihovih aktivnih komponenata- sa hipolipemijskom aktivnošću. Zamena sintetskih jedinjenja prirodnim aktivnim komponentama usmerava istraživanja u pravcu ispitivanja različitih biljnih materijala i identifikovanja novih jedinjenja sa hipolipemijskim dejstvom koji se mogu iz njih izolovati. Zbog toga se veliki napori ulože u cilju dobijanja i izolovanja prirodnih hipolipemika, kao i za razvoj efikasnih i selektivnih tehnika ekstrakcije. Ekstrakciju konvencionalnim rastvaračima karakterišu niska selektivnost i visoke temperature, što može dovesti do degradacije željenih jedinjenja. Primenom natkritične ekstrakcije (NKE) koja se odvija na nižim temperaturama, sprečava se degradacija jedinjenja i dobija na kvalitetu ekstrakata shodno većoj koncentraciji komponenata sa željenim farmakološkim dejstvom. NKE je mnogo selektivnija od konvencionalnih načina ekstrakcije. Selektivnost prema pojedinim grupama jedinjenja se postiže podešavanjem uslova ekstrakcije (temperature i pritiska). Usled lake i potpune separacije natkritičnog fluida smanjenjem pritiska, ovaj vid ekstrakcije omogućava dobijanje ekstrakata bez tragova rastvarača (npr. za primenu u prehrambenoj, kozmetičkoj i farmaceutskoj industriji). Cilj ovog rada je bilo proučavanje frakcija ekstrakata matičnjaka (Melissae officinalis L., Lamiaceae) i grčkog semena (Trigonella foenum-graecum L., Fabaceae) bogatih supstancama sa hipolipemijskom aktivnosti, izolovanih primenom različitih metoda ekstrakcije, kao i optimizacija procesa njihovog dobijanja. Za dobijanje ekstrakata bogatih supstancama sa hipolipemijskim dejstvom, primenjena je subkritična (SKE) i NKE sa ugljenik (IV)-oksidom, hidrodestilacija i ekstrakcija etanolom. Na osnovu hemijskog profila dobijenih ekstrakata, identifikovane su supstance koje su u literaturi okarakterisane kao nosioci hipolipemijske aktivnosti i određivan je njihov sadržaj. Za identifikaciju i kvantifikaciju aktivnih komponenti u dobijenim ekstraktima korišćene su gasna hromatografija sa masenom spektrometrijom (GC/MS) i tečna hromatografije (HPLC). Cilj disertacije je bio ispitivanje kinetike izolacije ekstrakata bogatih komponenatama nosiocima hipolipemijskog dejstva, kao i analizi i optimizaciji različitih procesa ekstrakcije, pri čemu je glavni naglasak dat analizi kinetike procesa NKE, ispitivanjem uticaja variranja procesnih parametara (pritiska i temperature) subkritične i NKE i odgovarajućeg predtretmana biljnog materijala na prinos totalnog ekstrakta i u njemu sadržaj komponenata nosilaca hipolipemijskog dejstva...
PB  - Univerzitet u Beogradu, Tehnološko-metalurški fakultet
T1  - Obtaining, characterization and optimization of hypolipidemic extracts of lemon balm (Melissa officinalis) and fenugreek (Trigonella foenum-graecum) using supercritical carbon dioxide
T1  - Dobijanje, karakterizacija i optimizacija hipolipemijskih ekstrakata matičnjaka (Melissa officinalis) i grčkog semena (Trigonella foenum-graecum) natkritičnim ugljenik (IV)-oksidom
UR  - https://hdl.handle.net/21.15107/rcub_technorep_4651
ER  - 

@phdthesis{
author = "Bogdanović, Aleksandra",
year = "2016",
abstract = "Synthetic hypolipemics nowdays have being replaced by natural ones due to the noticed deficiencies and side effects of synthetic drugs. Great effort is being devoted to the search for alternative and cheaper sources of natural hypolipemics, as well as to the development of efficient, selective and more convenient extraction techniques. Extraction with conventional solvents is characterized by poor selectivity and requires high temperatures, which could result in degradation of the desired compounds, and obtained extracts usually have solvent residues which is not convenient in medicinal use. Supercritical extraction (SCE) shows higher selectivity compared to conventional techniques of extraction. Selectivity of SCE towards some groups of compounds can be tuned by changing extraction conditions (pressure and temperature). According to easy and total separation of supercritical fluid from the extract achieved by lowering pressure, SCE presents type of extraction which allows obtaining extracts without residual solvents (for example for application in pharmaceutical, food and cosmetics industry). The aim of this study was the isolation of extracts of lemon balm (Melissae officinalis) and fenugreek (Trigonella foenum-graecum) rich in compounds that possess hypolipidemic activity according to literature data, using different extraction processes. The extracts rich in hypolipidemic substances were obtained by supercritical carbon dioxide extraction (SCE-CO2), hydrodistillation and ethanol extraction from plant material. Characterization and analysis of the obtained extracts as well as determination of contents of the components identified by the literature data as carriers of hypolipidemic activity, were performed . Identification and quantification of the active components in the extracts were performed using gas chromatography mass spectrometry (GC / MS) and liquid chromatography (HPLC). The research was based on the kinetic analysis and optimization of different extraction processes for obtaining extracts rich in components with hypolidemic activity. Kinetics of subcritical and supercritical extractions were analyzed, whereby, the influence of process parameters (pressure and temperature) as well as appropriate pretreatment of plant material on the yield of total extract and hypolipidemic compunds was examined..., Sintetski hipolipemici danas se sve više zamenjuju prirodnim hipolipemicima, usled utvrđenih nedostataka, nus-pojava i sporednih efekata sintetičkih lekova. Shodno tome, podstaknuta je povećana upotreba biljaka, odnosno njihovih aktivnih komponenata- sa hipolipemijskom aktivnošću. Zamena sintetskih jedinjenja prirodnim aktivnim komponentama usmerava istraživanja u pravcu ispitivanja različitih biljnih materijala i identifikovanja novih jedinjenja sa hipolipemijskim dejstvom koji se mogu iz njih izolovati. Zbog toga se veliki napori ulože u cilju dobijanja i izolovanja prirodnih hipolipemika, kao i za razvoj efikasnih i selektivnih tehnika ekstrakcije. Ekstrakciju konvencionalnim rastvaračima karakterišu niska selektivnost i visoke temperature, što može dovesti do degradacije željenih jedinjenja. Primenom natkritične ekstrakcije (NKE) koja se odvija na nižim temperaturama, sprečava se degradacija jedinjenja i dobija na kvalitetu ekstrakata shodno većoj koncentraciji komponenata sa željenim farmakološkim dejstvom. NKE je mnogo selektivnija od konvencionalnih načina ekstrakcije. Selektivnost prema pojedinim grupama jedinjenja se postiže podešavanjem uslova ekstrakcije (temperature i pritiska). Usled lake i potpune separacije natkritičnog fluida smanjenjem pritiska, ovaj vid ekstrakcije omogućava dobijanje ekstrakata bez tragova rastvarača (npr. za primenu u prehrambenoj, kozmetičkoj i farmaceutskoj industriji). Cilj ovog rada je bilo proučavanje frakcija ekstrakata matičnjaka (Melissae officinalis L., Lamiaceae) i grčkog semena (Trigonella foenum-graecum L., Fabaceae) bogatih supstancama sa hipolipemijskom aktivnosti, izolovanih primenom različitih metoda ekstrakcije, kao i optimizacija procesa njihovog dobijanja. Za dobijanje ekstrakata bogatih supstancama sa hipolipemijskim dejstvom, primenjena je subkritična (SKE) i NKE sa ugljenik (IV)-oksidom, hidrodestilacija i ekstrakcija etanolom. Na osnovu hemijskog profila dobijenih ekstrakata, identifikovane su supstance koje su u literaturi okarakterisane kao nosioci hipolipemijske aktivnosti i određivan je njihov sadržaj. Za identifikaciju i kvantifikaciju aktivnih komponenti u dobijenim ekstraktima korišćene su gasna hromatografija sa masenom spektrometrijom (GC/MS) i tečna hromatografije (HPLC). Cilj disertacije je bio ispitivanje kinetike izolacije ekstrakata bogatih komponenatama nosiocima hipolipemijskog dejstva, kao i analizi i optimizaciji različitih procesa ekstrakcije, pri čemu je glavni naglasak dat analizi kinetike procesa NKE, ispitivanjem uticaja variranja procesnih parametara (pritiska i temperature) subkritične i NKE i odgovarajućeg predtretmana biljnog materijala na prinos totalnog ekstrakta i u njemu sadržaj komponenata nosilaca hipolipemijskog dejstva...",
publisher = "Univerzitet u Beogradu, Tehnološko-metalurški fakultet",
title = "Obtaining, characterization and optimization of hypolipidemic extracts of lemon balm (Melissa officinalis) and fenugreek (Trigonella foenum-graecum) using supercritical carbon dioxide, Dobijanje, karakterizacija i optimizacija hipolipemijskih ekstrakata matičnjaka (Melissa officinalis) i grčkog semena (Trigonella foenum-graecum) natkritičnim ugljenik (IV)-oksidom",
url = "https://hdl.handle.net/21.15107/rcub_technorep_4651"
}

Bogdanović, A.. (2016). Obtaining, characterization and optimization of hypolipidemic extracts of lemon balm (Melissa officinalis) and fenugreek (Trigonella foenum-graecum) using supercritical carbon dioxide. 
Univerzitet u Beogradu, Tehnološko-metalurški fakultet..
https://hdl.handle.net/21.15107/rcub_technorep_4651

Bogdanović A. Obtaining, characterization and optimization of hypolipidemic extracts of lemon balm (Melissa officinalis) and fenugreek (Trigonella foenum-graecum) using supercritical carbon dioxide. 2016;.
https://hdl.handle.net/21.15107/rcub_technorep_4651 .

Bogdanović, Aleksandra, "Obtaining, characterization and optimization of hypolipidemic extracts of lemon balm (Melissa officinalis) and fenugreek (Trigonella foenum-graecum) using supercritical carbon dioxide" (2016),
https://hdl.handle.net/21.15107/rcub_technorep_4651 .

TY  - JOUR
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Arsić, Ivana A.
AU  - Milovanović, Stoja
AU  - Petrović, Slobodan
AU  - Skala, Dejan
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3406
AB  - Analysis of yield and composition profile of Melissa officinalis (Lemon balm) extract obtained by two-step CO2 extraction at high pressure was analyzed. The first or essential oil fraction, collected at 10 MPa and 40 degrees C, contained mostly the high volatile and aromatic compounds. The second fraction was consenquently extracted at 30 MPa using different temperature: 25 degrees C (higher pressure than critical pressure but at temperature below the critical; HPCP-CO2), 40 degrees C or 100 degrees C (supercritical CO2; SC-CO2). Obtained yield of essential oil fraction was 0.45% at 10 MPa, while depending on applied extraction temperature (HPCP-CO2 or SC-CO2), the yields of the second fractions collected at 30 MPa varied from 0.44% to 0.94%. Within the study, the content of active substances in obtained extracts was analyzed, too. For comparison with CO2 extracts (HPCP or SC) the yield and characterization of essential oil obtained by hydrodistillation was accomplished, as well. A significant difference was noted not only between the essential oil isolated by hydrodistillation and SC-CO2 extraction (40 degrees C, 10 MPa) but also between total extracts obtained by HPCP-CO2 and SC-CO2 extraction. The pseudo kinetic model was applied to define SC-CO2 extraction of Lemon balm to describe the relation between the yield of extraction and CO2 consumption. Antioxidant activity of obtained extracts was determined by free radical scavenging capacity (RSC) and significant correlation of antioxidant capacity and composition profile between obtained extracts was observed.
PB  - Elsevier, Amsterdam
T2  - Journal of Supercritical Fluids
T1  - Supercritical and high pressure subcritical fluid extraction from Lemon balm (Melissa officinalis L., Lamiaceae)
EP  - 242
SP  - 234
VL  - 107
DO  - 10.1016/j.supflu.2015.09.008
ER  - 

@article{
author = "Bogdanović, Aleksandra and Tadić, Vanja and Arsić, Ivana A. and Milovanović, Stoja and Petrović, Slobodan and Skala, Dejan",
year = "2016",
abstract = "Analysis of yield and composition profile of Melissa officinalis (Lemon balm) extract obtained by two-step CO2 extraction at high pressure was analyzed. The first or essential oil fraction, collected at 10 MPa and 40 degrees C, contained mostly the high volatile and aromatic compounds. The second fraction was consenquently extracted at 30 MPa using different temperature: 25 degrees C (higher pressure than critical pressure but at temperature below the critical; HPCP-CO2), 40 degrees C or 100 degrees C (supercritical CO2; SC-CO2). Obtained yield of essential oil fraction was 0.45% at 10 MPa, while depending on applied extraction temperature (HPCP-CO2 or SC-CO2), the yields of the second fractions collected at 30 MPa varied from 0.44% to 0.94%. Within the study, the content of active substances in obtained extracts was analyzed, too. For comparison with CO2 extracts (HPCP or SC) the yield and characterization of essential oil obtained by hydrodistillation was accomplished, as well. A significant difference was noted not only between the essential oil isolated by hydrodistillation and SC-CO2 extraction (40 degrees C, 10 MPa) but also between total extracts obtained by HPCP-CO2 and SC-CO2 extraction. The pseudo kinetic model was applied to define SC-CO2 extraction of Lemon balm to describe the relation between the yield of extraction and CO2 consumption. Antioxidant activity of obtained extracts was determined by free radical scavenging capacity (RSC) and significant correlation of antioxidant capacity and composition profile between obtained extracts was observed.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Supercritical Fluids",
title = "Supercritical and high pressure subcritical fluid extraction from Lemon balm (Melissa officinalis L., Lamiaceae)",
pages = "242-234",
volume = "107",
doi = "10.1016/j.supflu.2015.09.008"
}

Bogdanović, A., Tadić, V., Arsić, I. A., Milovanović, S., Petrović, S.,& Skala, D.. (2016). Supercritical and high pressure subcritical fluid extraction from Lemon balm (Melissa officinalis L., Lamiaceae). in Journal of Supercritical Fluids
Elsevier, Amsterdam., 107, 234-242.
https://doi.org/10.1016/j.supflu.2015.09.008

Bogdanović A, Tadić V, Arsić IA, Milovanović S, Petrović S, Skala D. Supercritical and high pressure subcritical fluid extraction from Lemon balm (Melissa officinalis L., Lamiaceae). in Journal of Supercritical Fluids. 2016;107:234-242.
doi:10.1016/j.supflu.2015.09.008 .

Bogdanović, Aleksandra, Tadić, Vanja, Arsić, Ivana A., Milovanović, Stoja, Petrović, Slobodan, Skala, Dejan, "Supercritical and high pressure subcritical fluid extraction from Lemon balm (Melissa officinalis L., Lamiaceae)" in Journal of Supercritical Fluids, 107 (2016):234-242,
https://doi.org/10.1016/j.supflu.2015.09.008 . .

TY  - JOUR
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Stamenić, Marko
AU  - Petrović, Slobodan
AU  - Skala, Dejan
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3405
AB  - Pretreatment of fenugreek (Trigonella foenum-graecum L, Fabaceae) seeds was achieved using the step of defatting and acid hydrolysis. The obtained hydro-isolate (HI) was used as initial feed for diosgenin isolation by supercritical CO2 extraction (SC-CO2). Preliminary tests performed at conditions resulting in SC-CO2 density ranging from 800 to 920 kg/m(3) indicated that at some pressure, temperature as well as consumption of supercritical fluids the optimal working conditions for diosgenin isolation could be determined. For this purpose, the following range of working conditions of SC-CO2 were tested by using Central Composite Rotatable Design (CCRD) and Response Surface Methodology (RSM): pressure from 16.6 to 33.4 MPa, temperature from 30 to 50 degrees C and consumption of SC-CO2 from 11.6 to 28.4 g(co2)/g(dm). The result of this investigation indicated that maximum yield of 0.81 mg diosgenin from 1 g of fenugreek seeds on dry basis (about 1.3% of total extract) at 24.6 MPa, 43.5 degrees C, and 20.87 g(co2)/g(dm) could be obtained.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Supercritical Fluids
T1  - Supercritical carbon dioxide extraction of Trigonella foenum-graecum L. seeds: Process optimization using response surface methodology
EP  - 50
SP  - 44
VL  - 107
DO  - 10.1016/j.supflu.2015.08.003
ER  - 

@article{
author = "Bogdanović, Aleksandra and Tadić, Vanja and Stamenić, Marko and Petrović, Slobodan and Skala, Dejan",
year = "2016",
abstract = "Pretreatment of fenugreek (Trigonella foenum-graecum L, Fabaceae) seeds was achieved using the step of defatting and acid hydrolysis. The obtained hydro-isolate (HI) was used as initial feed for diosgenin isolation by supercritical CO2 extraction (SC-CO2). Preliminary tests performed at conditions resulting in SC-CO2 density ranging from 800 to 920 kg/m(3) indicated that at some pressure, temperature as well as consumption of supercritical fluids the optimal working conditions for diosgenin isolation could be determined. For this purpose, the following range of working conditions of SC-CO2 were tested by using Central Composite Rotatable Design (CCRD) and Response Surface Methodology (RSM): pressure from 16.6 to 33.4 MPa, temperature from 30 to 50 degrees C and consumption of SC-CO2 from 11.6 to 28.4 g(co2)/g(dm). The result of this investigation indicated that maximum yield of 0.81 mg diosgenin from 1 g of fenugreek seeds on dry basis (about 1.3% of total extract) at 24.6 MPa, 43.5 degrees C, and 20.87 g(co2)/g(dm) could be obtained.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Supercritical Fluids",
title = "Supercritical carbon dioxide extraction of Trigonella foenum-graecum L. seeds: Process optimization using response surface methodology",
pages = "50-44",
volume = "107",
doi = "10.1016/j.supflu.2015.08.003"
}

Bogdanović, A., Tadić, V., Stamenić, M., Petrović, S.,& Skala, D.. (2016). Supercritical carbon dioxide extraction of Trigonella foenum-graecum L. seeds: Process optimization using response surface methodology. in Journal of Supercritical Fluids
Elsevier Science Bv, Amsterdam., 107, 44-50.
https://doi.org/10.1016/j.supflu.2015.08.003

Bogdanović A, Tadić V, Stamenić M, Petrović S, Skala D. Supercritical carbon dioxide extraction of Trigonella foenum-graecum L. seeds: Process optimization using response surface methodology. in Journal of Supercritical Fluids. 2016;107:44-50.
doi:10.1016/j.supflu.2015.08.003 .

Bogdanović, Aleksandra, Tadić, Vanja, Stamenić, Marko, Petrović, Slobodan, Skala, Dejan, "Supercritical carbon dioxide extraction of Trigonella foenum-graecum L. seeds: Process optimization using response surface methodology" in Journal of Supercritical Fluids, 107 (2016):44-50,
https://doi.org/10.1016/j.supflu.2015.08.003 . .

TY  - JOUR
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Ristić, Mihailo S.
AU  - Petrović, Slobodan
AU  - Skala, Dejan
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3344
AB  - Supercritical CO2 (SC-CO2) extraction of fenugreek seeds (Trigonella foenum-graecum L, Fabaceae) was analyzed using different pressure and temperature (16.6-33.4 MPa and, 30-50 degrees C), which corresponded to SC-CO2 density between 779 and 957 kg/m(3). The yield of extract as well as its composition were determined and analyzed for different solvent consumption defined as mass of used CO2 for extraction per mass of dry fenugreek seeds. A central composite design (CCD) combined with response surface methodology (RSM) was used to study the best extraction conditions which determined that 27.0 MPa, 42.6 degrees C, and 24.6 gCO(2)/g(dm), were the optimal conditions for isolation of total extract. The calculated yield of extract at these conditions defined by SC-CO2 density of 890 kg/m3 could be 2.57% based on fenugreek seed. Moreover, the best extraction conditions for obtaining extract which contains the maximal amount of sterols, or maximal amount of vitamin E or vitamin D were also analyzed. These RSM optimizations showed that at slightly lower pressure (22.8-24.8 MPa), temperature (39.9-42.0 degrees C) and consumption of SC-CO2 (19.0-19.7 gCO(2)/g(dm)) is followed by smaller amount of isolated extract but with maximum content of sterols (16.28%), or vitamin E or vitamin D (1.44% and 0.71%, respectively) at these conditions. Calculation of molar solubility of total extract, and apparent solubility of sterols, vitamin E and D in SC-CO2 was performed at different pressure and temperature. They were correlated to density of SC-CO2, temperature at which extractions were performed and Hildebrand solubility parameter of solvent and solubility parameter of compounds which are the main constituents of extract. These calculations also show that the highest molar solubility of total extract and apparent molar solubility of its constituents could be obtained using optimal density of SC-CO2 (830-890 kg/m(3)) defined by corresponding values of temperature and pressure (310-320 K and 20-25 MPa).
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Supercritical Fluids
T1  - Optimization of supercritical CO2 extraction of fenugreek seed (Trigonella foenum-graecum L.) and calculating of extracts solubility
EP  - 307
SP  - 297
VL  - 117
DO  - 10.1016/j.supflu.2016.07.010
ER  - 

@article{
author = "Bogdanović, Aleksandra and Tadić, Vanja and Ristić, Mihailo S. and Petrović, Slobodan and Skala, Dejan",
year = "2016",
abstract = "Supercritical CO2 (SC-CO2) extraction of fenugreek seeds (Trigonella foenum-graecum L, Fabaceae) was analyzed using different pressure and temperature (16.6-33.4 MPa and, 30-50 degrees C), which corresponded to SC-CO2 density between 779 and 957 kg/m(3). The yield of extract as well as its composition were determined and analyzed for different solvent consumption defined as mass of used CO2 for extraction per mass of dry fenugreek seeds. A central composite design (CCD) combined with response surface methodology (RSM) was used to study the best extraction conditions which determined that 27.0 MPa, 42.6 degrees C, and 24.6 gCO(2)/g(dm), were the optimal conditions for isolation of total extract. The calculated yield of extract at these conditions defined by SC-CO2 density of 890 kg/m3 could be 2.57% based on fenugreek seed. Moreover, the best extraction conditions for obtaining extract which contains the maximal amount of sterols, or maximal amount of vitamin E or vitamin D were also analyzed. These RSM optimizations showed that at slightly lower pressure (22.8-24.8 MPa), temperature (39.9-42.0 degrees C) and consumption of SC-CO2 (19.0-19.7 gCO(2)/g(dm)) is followed by smaller amount of isolated extract but with maximum content of sterols (16.28%), or vitamin E or vitamin D (1.44% and 0.71%, respectively) at these conditions. Calculation of molar solubility of total extract, and apparent solubility of sterols, vitamin E and D in SC-CO2 was performed at different pressure and temperature. They were correlated to density of SC-CO2, temperature at which extractions were performed and Hildebrand solubility parameter of solvent and solubility parameter of compounds which are the main constituents of extract. These calculations also show that the highest molar solubility of total extract and apparent molar solubility of its constituents could be obtained using optimal density of SC-CO2 (830-890 kg/m(3)) defined by corresponding values of temperature and pressure (310-320 K and 20-25 MPa).",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Supercritical Fluids",
title = "Optimization of supercritical CO2 extraction of fenugreek seed (Trigonella foenum-graecum L.) and calculating of extracts solubility",
pages = "307-297",
volume = "117",
doi = "10.1016/j.supflu.2016.07.010"
}

Bogdanović, A., Tadić, V., Ristić, M. S., Petrović, S.,& Skala, D.. (2016). Optimization of supercritical CO2 extraction of fenugreek seed (Trigonella foenum-graecum L.) and calculating of extracts solubility. in Journal of Supercritical Fluids
Elsevier Science Bv, Amsterdam., 117, 297-307.
https://doi.org/10.1016/j.supflu.2016.07.010

Bogdanović A, Tadić V, Ristić MS, Petrović S, Skala D. Optimization of supercritical CO2 extraction of fenugreek seed (Trigonella foenum-graecum L.) and calculating of extracts solubility. in Journal of Supercritical Fluids. 2016;117:297-307.
doi:10.1016/j.supflu.2016.07.010 .

Bogdanović, Aleksandra, Tadić, Vanja, Ristić, Mihailo S., Petrović, Slobodan, Skala, Dejan, "Optimization of supercritical CO2 extraction of fenugreek seed (Trigonella foenum-graecum L.) and calculating of extracts solubility" in Journal of Supercritical Fluids, 117 (2016):297-307,
https://doi.org/10.1016/j.supflu.2016.07.010 . .

TY  - JOUR
AU  - Tadić, V.
AU  - Đorđević, S.
AU  - Žugić, Ana R.
AU  - Arsić, Ivana A.
AU  - Bogdanović, Aleksandra
AU  - Homsek, Irena J.
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2318
PB  - Elsevier Science Bv, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Sensitive HPLC Method for the Determination of Usnic Acid in Tablets
EP  - E206
SP  - E206
VL  - 50
UR  - https://hdl.handle.net/21.15107/rcub_technorep_2318
ER  - 

@article{
author = "Tadić, V. and Đorđević, S. and Žugić, Ana R. and Arsić, Ivana A. and Bogdanović, Aleksandra and Homsek, Irena J.",
year = "2013",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Sensitive HPLC Method for the Determination of Usnic Acid in Tablets",
pages = "E206-E206",
volume = "50",
url = "https://hdl.handle.net/21.15107/rcub_technorep_2318"
}

Tadić, V., Đorđević, S., Žugić, A. R., Arsić, I. A., Bogdanović, A.,& Homsek, I. J.. (2013). Sensitive HPLC Method for the Determination of Usnic Acid in Tablets. in European Journal of Pharmaceutical Sciences
Elsevier Science Bv, Amsterdam., 50, E206-E206.
https://hdl.handle.net/21.15107/rcub_technorep_2318

Tadić V, Đorđević S, Žugić AR, Arsić IA, Bogdanović A, Homsek IJ. Sensitive HPLC Method for the Determination of Usnic Acid in Tablets. in European Journal of Pharmaceutical Sciences. 2013;50:E206-E206.
https://hdl.handle.net/21.15107/rcub_technorep_2318 .

Tadić, V., Đorđević, S., Žugić, Ana R., Arsić, Ivana A., Bogdanović, Aleksandra, Homsek, Irena J., "Sensitive HPLC Method for the Determination of Usnic Acid in Tablets" in European Journal of Pharmaceutical Sciences, 50 (2013):E206-E206,
https://hdl.handle.net/21.15107/rcub_technorep_2318 .