TY  - CONF
AU  - Veljović, Đorđe
AU  - Janaćković, Đorđe
AU  - Petrović, Rada
AU  - Radovanović, Željko
AU  - Ugrinović, Vukašin
AU  - Matić, Tamara
AU  - Milivojević, Marija
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7439
AB  - Bioactive  materials  for  the repairand  regeneration  of human bone  tissue,  as  well  as  for  the restoration  of  teeth,  are  the focus of  numerous  studies  in  the  field  of  biomaterials.Orthopaedic  surgeons  anticipate that  bioactive materialshave  the  potential  to  facilitate  the  formation  of  new  apatite-like  crystals  upon  contact  with body fluids, promoting the development of new bone tissue under in vivoconditions. On the other hand, dentists expect that bioactive  materials  have  the  potential  for  remineralization  of  partially  demineralized  enamel  and  dentin. In  the preceding years, the Bioceramic Materials Group, founded within the Department of Inorganic Chemical Technology at the  Faculty  of  Technology  and  Metallurgy,  University  of  Belgrade (FTM-UB),  conducted  extensive  research  on  the advancement of bioactive and biocompatible materials with adequate mechanical properties, designed for applicationin dentistry, orthopaedics, maxillofacial surgery, and also bone tissue engineering(BTE).
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - The current trend in innovative bioactive materials for dental and orthopedic applications
IS  - 1S
SP  - 37
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7439
ER  - 

@conference{
author = "Veljović, Đorđe and Janaćković, Đorđe and Petrović, Rada and Radovanović, Željko and Ugrinović, Vukašin and Matić, Tamara and Milivojević, Marija",
year = "2024",
abstract = "Bioactive  materials  for  the repairand  regeneration  of human bone  tissue,  as  well  as  for  the restoration  of  teeth,  are  the focus of  numerous  studies  in  the  field  of  biomaterials.Orthopaedic  surgeons  anticipate that  bioactive materialshave  the  potential  to  facilitate  the  formation  of  new  apatite-like  crystals  upon  contact  with body fluids, promoting the development of new bone tissue under in vivoconditions. On the other hand, dentists expect that bioactive  materials  have  the  potential  for  remineralization  of  partially  demineralized  enamel  and  dentin. In  the preceding years, the Bioceramic Materials Group, founded within the Department of Inorganic Chemical Technology at the  Faculty  of  Technology  and  Metallurgy,  University  of  Belgrade (FTM-UB),  conducted  extensive  research  on  the advancement of bioactive and biocompatible materials with adequate mechanical properties, designed for applicationin dentistry, orthopaedics, maxillofacial surgery, and also bone tissue engineering(BTE).",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "The current trend in innovative bioactive materials for dental and orthopedic applications",
number = "1S",
pages = "37",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7439"
}

Veljović, Đ., Janaćković, Đ., Petrović, R., Radovanović, Ž., Ugrinović, V., Matić, T.,& Milivojević, M.. (2024). The current trend in innovative bioactive materials for dental and orthopedic applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 37.
https://hdl.handle.net/21.15107/rcub_technorep_7439

Veljović Đ, Janaćković Đ, Petrović R, Radovanović Ž, Ugrinović V, Matić T, Milivojević M. The current trend in innovative bioactive materials for dental and orthopedic applications. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):37.
https://hdl.handle.net/21.15107/rcub_technorep_7439 .

Veljović, Đorđe, Janaćković, Đorđe, Petrović, Rada, Radovanović, Željko, Ugrinović, Vukašin, Matić, Tamara, Milivojević, Marija, "The current trend in innovative bioactive materials for dental and orthopedic applications" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):37,
https://hdl.handle.net/21.15107/rcub_technorep_7439 .

TY  - JOUR
AU  - Milivojević, Marija
AU  - Chen, Ke
AU  - Radovanović, Željko
AU  - Petrović, Rada
AU  - Dimitrijević-Branković, Suzana
AU  - Kojić, Vesna
AU  - Marković, Danica
AU  - Janaćković, Đorđe
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6803
AB  - The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth ofEscherichia coliandStaphylococcus aureusfor 4-6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.
PB  - IOP Publishing
T2  - Biomedical Materials
T1  - Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects
IS  - 6
SP  - 065020
VL  - 18
DO  - 10.1088/1748-605X/ad02d2
ER  - 

@article{
author = "Milivojević, Marija and Chen, Ke and Radovanović, Željko and Petrović, Rada and Dimitrijević-Branković, Suzana and Kojić, Vesna and Marković, Danica and Janaćković, Đorđe",
year = "2023",
abstract = "The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth ofEscherichia coliandStaphylococcus aureusfor 4-6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.",
publisher = "IOP Publishing",
journal = "Biomedical Materials",
title = "Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects",
number = "6",
pages = "065020",
volume = "18",
doi = "10.1088/1748-605X/ad02d2"
}

Milivojević, M., Chen, K., Radovanović, Ž., Petrović, R., Dimitrijević-Branković, S., Kojić, V., Marković, D.,& Janaćković, Đ.. (2023). Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects. in Biomedical Materials
IOP Publishing., 18(6), 065020.
https://doi.org/10.1088/1748-605X/ad02d2

Milivojević M, Chen K, Radovanović Ž, Petrović R, Dimitrijević-Branković S, Kojić V, Marković D, Janaćković Đ. Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects. in Biomedical Materials. 2023;18(6):065020.
doi:10.1088/1748-605X/ad02d2 .

Milivojević, Marija, Chen, Ke, Radovanović, Željko, Petrović, Rada, Dimitrijević-Branković, Suzana, Kojić, Vesna, Marković, Danica, Janaćković, Đorđe, "Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects" in Biomedical Materials, 18, no. 6 (2023):065020,
https://doi.org/10.1088/1748-605X/ad02d2 . .

TY  - JOUR
AU  - Radunović, Milena
AU  - Pavić, Aleksandar
AU  - Ivanović, Vera
AU  - Milivojević, Marija
AU  - Radović, Igor
AU  - Di Carlo, Roberta
AU  - Pilato, Serena
AU  - Fontana, Antonella
AU  - Piattelli, Adriano
AU  - Petrović, Sanja
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5144
AB  - The aims of the study were: 1) to evaluate the effect on biofilm formation of barrier membranes and titanium surfaces coated with graphene-oxide (GO); 2) to analyze the connection between the superficial topography of the tested materials and the amount of bacterial accumulation on them and 3) to analyze the biocompatibility of GO functionalized discs using the zebrafish model. Methods: Single species bacterial biofilms (Streptococcus oralis, Veilonella parvula, Fusobacterium nucleatum, Porphyomonas gingivalis) were grown on GO-free membranes, membranes coated with 2 and 10 μg/ml of GO, GO-free and GO-coated titanium discs. The biofilms were analyzed by determining the CFU count and by Scanning Electron Microscopy (SEM) and the materials’ topography by Atomic Force Microscopy (AFM). Zebrafish model was used to determine the materials’ toxicity and inflammatory effects. Results: AFM showed similar roughness of control and GO-coated materials. CFU counts on GO-coated discs were significantly lower than on control discs for all species. CFU counts of S. oralis, V. parvula and P. gingivalis were lower on biofilms grown on both types of GO-coated membranes than on GO-free membrane. SEM analysis showed different formation of single species biofilm of S. oralis on control and GO-coated materials. GO-functionalized titanium discs do not induce toxic or inflammatory effects. Significance: Titanium implant surfaces functionalized with GO have shown to be biocompatible and less susceptible to biofilm formation. These results encourage further in vivo investigation of the tested materials on infection prevention, specifically in prevention and reduction of peri-implant mucositis and periimplantitis incidence.
PB  - Elsevier Inc.
T2  - Dental Materials
T1  - Biocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranes
EP  - 1127
IS  - 7
SP  - 1117
VL  - 38
DO  - 10.1016/j.dental.2022.04.024
ER  - 

@article{
author = "Radunović, Milena and Pavić, Aleksandar and Ivanović, Vera and Milivojević, Marija and Radović, Igor and Di Carlo, Roberta and Pilato, Serena and Fontana, Antonella and Piattelli, Adriano and Petrović, Sanja",
year = "2022",
abstract = "The aims of the study were: 1) to evaluate the effect on biofilm formation of barrier membranes and titanium surfaces coated with graphene-oxide (GO); 2) to analyze the connection between the superficial topography of the tested materials and the amount of bacterial accumulation on them and 3) to analyze the biocompatibility of GO functionalized discs using the zebrafish model. Methods: Single species bacterial biofilms (Streptococcus oralis, Veilonella parvula, Fusobacterium nucleatum, Porphyomonas gingivalis) were grown on GO-free membranes, membranes coated with 2 and 10 μg/ml of GO, GO-free and GO-coated titanium discs. The biofilms were analyzed by determining the CFU count and by Scanning Electron Microscopy (SEM) and the materials’ topography by Atomic Force Microscopy (AFM). Zebrafish model was used to determine the materials’ toxicity and inflammatory effects. Results: AFM showed similar roughness of control and GO-coated materials. CFU counts on GO-coated discs were significantly lower than on control discs for all species. CFU counts of S. oralis, V. parvula and P. gingivalis were lower on biofilms grown on both types of GO-coated membranes than on GO-free membrane. SEM analysis showed different formation of single species biofilm of S. oralis on control and GO-coated materials. GO-functionalized titanium discs do not induce toxic or inflammatory effects. Significance: Titanium implant surfaces functionalized with GO have shown to be biocompatible and less susceptible to biofilm formation. These results encourage further in vivo investigation of the tested materials on infection prevention, specifically in prevention and reduction of peri-implant mucositis and periimplantitis incidence.",
publisher = "Elsevier Inc.",
journal = "Dental Materials",
title = "Biocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranes",
pages = "1127-1117",
number = "7",
volume = "38",
doi = "10.1016/j.dental.2022.04.024"
}

Radunović, M., Pavić, A., Ivanović, V., Milivojević, M., Radović, I., Di Carlo, R., Pilato, S., Fontana, A., Piattelli, A.,& Petrović, S.. (2022). Biocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranes. in Dental Materials
Elsevier Inc.., 38(7), 1117-1127.
https://doi.org/10.1016/j.dental.2022.04.024

Radunović M, Pavić A, Ivanović V, Milivojević M, Radović I, Di Carlo R, Pilato S, Fontana A, Piattelli A, Petrović S. Biocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranes. in Dental Materials. 2022;38(7):1117-1127.
doi:10.1016/j.dental.2022.04.024 .

Radunović, Milena, Pavić, Aleksandar, Ivanović, Vera, Milivojević, Marija, Radović, Igor, Di Carlo, Roberta, Pilato, Serena, Fontana, Antonella, Piattelli, Adriano, Petrović, Sanja, "Biocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranes" in Dental Materials, 38, no. 7 (2022):1117-1127,
https://doi.org/10.1016/j.dental.2022.04.024 . .