TY  - JOUR
AU  - Milovanović, Stoja
AU  - Djuris, Jelena
AU  - Dapčević, Aleksandra
AU  - Lučić-Škorić, Marija
AU  - Medarevic, Đorđe
AU  - Pavlovic, Stefan M.
AU  - Ibric, Svetlana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4959
AB  - This study investigates pharmaceutical polymers (Soluplus((R)), HPMCAS, and Eudragit((R)) E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 degrees C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m(3). FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus((R)) and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit((R)) E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
T2  - Journal of Polymer Research
T1  - Preparation of floating polymer-valsartan delivery systems using supercritical CO2
IS  - 3
VL  - 28
DO  - 10.1007/s10965-021-02440-1
ER  - 

@article{
author = "Milovanović, Stoja and Djuris, Jelena and Dapčević, Aleksandra and Lučić-Škorić, Marija and Medarevic, Đorđe and Pavlovic, Stefan M. and Ibric, Svetlana",
year = "2021",
abstract = "This study investigates pharmaceutical polymers (Soluplus((R)), HPMCAS, and Eudragit((R)) E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 degrees C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m(3). FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus((R)) and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit((R)) E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.",
journal = "Journal of Polymer Research",
title = "Preparation of floating polymer-valsartan delivery systems using supercritical CO2",
number = "3",
volume = "28",
doi = "10.1007/s10965-021-02440-1"
}

Milovanović, S., Djuris, J., Dapčević, A., Lučić-Škorić, M., Medarevic, Đ., Pavlovic, S. M.,& Ibric, S.. (2021). Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research, 28(3).
https://doi.org/10.1007/s10965-021-02440-1

Milovanović S, Djuris J, Dapčević A, Lučić-Škorić M, Medarevic Đ, Pavlovic SM, Ibric S. Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research. 2021;28(3).
doi:10.1007/s10965-021-02440-1 .

Milovanović, Stoja, Djuris, Jelena, Dapčević, Aleksandra, Lučić-Škorić, Marija, Medarevic, Đorđe, Pavlovic, Stefan M., Ibric, Svetlana, "Preparation of floating polymer-valsartan delivery systems using supercritical CO2" in Journal of Polymer Research, 28, no. 3 (2021),
https://doi.org/10.1007/s10965-021-02440-1 . .

TY  - JOUR
AU  - Djuris, Jelena
AU  - Milovanovic, Stoja
AU  - Medarevic, Djordje
AU  - Dobricic, Vladimir
AU  - Dapčević, Aleksandra
AU  - Ibric, Svetlana
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5030
AB  - Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO 2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO 2 assisted method, solid dispersions of CARV with the selected (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δ p values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol  solid dispersions
EP  - 200
SP  - 190
VL  - 554
DO  - 10.1016/j.ijpharm.2018.11.015
ER  - 

@article{
author = "Djuris, Jelena and Milovanovic, Stoja and Medarevic, Djordje and Dobricic, Vladimir and Dapčević, Aleksandra and Ibric, Svetlana",
year = "2019",
abstract = "Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods. Miscibility analysis provides valuable guidance for selection of the most appropriate polymeric carrier for dispersion of the drug of interest. In addition to the increased drug release rate, solid dispersions should have proper mechanical attributes in order to be successfully formulated in the final solid dosage form such as tablet. Therefore, several pharmaceutical grade polymers have been selected for development of BCS Class II drug carvedilol (CARV) solid dispersions. They were compared based on behavior in supercritical CO 2 and affinity towards CARV calculated from the miscibility analysis. By utilization of the supercritical CO 2 assisted method, solid dispersions of CARV with the selected (co)polymers (polyvinylpyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), Soluplus® and Eudragit®) were obtained. Properties of the prepared CARV-polymer dispersions were observed by the polarizing and scanning electron microscopy and analyzed by differential scanning calorimetry and Fourier transform infrared spectroscopy. CARV was additionally characterized by X-ray powder diffraction. Furthermore, in vitro dissolution studies and dynamic compaction analysis were performed on the selected samples of solid dispersions. Among the studied polymers, PVP and HPMC have been identified as polymers with the highest affinity towards CARV, based on the calculated δ p values. This has been also confirmed with the highest dissolution efficiency of CARV-PVP and CARV-HPMC solid dispersions. Solid state characterization indicated that CARV was dispersed either molecularly, or in the amorphous form, depending on interactions with each polymer. Determination of CARV-PVP and CARV-HPMC mechanical properties revealed that CARV-PVP solid dispersion has superior compactibility and tabletability. Therefore, CARV-PVP solid dispersion has been highlighted as the most appropriate for the further development of tablets as the final dosage form. Presented study provides an example for efficient approach for development of poorly soluble drug solid dispersion with satisfactory tableting properties.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol  solid dispersions",
pages = "200-190",
volume = "554",
doi = "10.1016/j.ijpharm.2018.11.015"
}

Djuris, J., Milovanovic, S., Medarevic, D., Dobricic, V., Dapčević, A.,& Ibric, S.. (2019). Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol  solid dispersions. in International Journal of Pharmaceutics
Elsevier B.V.., 554, 190-200.
https://doi.org/10.1016/j.ijpharm.2018.11.015

Djuris J, Milovanovic S, Medarevic D, Dobricic V, Dapčević A, Ibric S. Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol  solid dispersions. in International Journal of Pharmaceutics. 2019;554:190-200.
doi:10.1016/j.ijpharm.2018.11.015 .

Djuris, Jelena, Milovanovic, Stoja, Medarevic, Djordje, Dobricic, Vladimir, Dapčević, Aleksandra, Ibric, Svetlana, "Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol  solid dispersions" in International Journal of Pharmaceutics, 554 (2019):190-200,
https://doi.org/10.1016/j.ijpharm.2018.11.015 . .