TY  - JOUR
AU  - Krezović, Bojana D.
AU  - Dimitrijević, Suzana
AU  - Filipović, Jovanka M.
AU  - Nikolić, Rajko R.
AU  - Tomić, Simonida
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2543
AB  - New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA, 5 mol%), in the presence of poly(vinyl pyrrolidone) (PVP, 2, 5, and 10 mol%), as an interpenetrating agent. The structure of the semi-IPNHs was confirmed by Fourier transform infrared spectroscopy, and morphology study was performed by scanning electron microscopy, which revealed the characteristic porous morphology. The results obtained by dynamic mechanical analysis showed the improvement of mechanical properties with increasing PVP content in semi-IPNs. The maximum swelling was observed for all studied systems at a slightly acidic media (around pH 6), so it can be said that the content of PVP has no influence on the swelling behavior, in the PVP range investigated. Along with the pH sensitivity, which was expected due to the presence of IA, semi-IPNHs showed temperature-sensitive swelling properties, with the lower critical solution temperature value around 41 degrees C, which is in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus, and C. albicans pathogens. It was noticed that the antimicrobial potential depends on type of microbes, time of exposure, and PVP content in the samples. Due to their good antimicrobial and mechanical properties these stimuli-sensitive semi-IPNHs have potential to be used as biomaterials for the applications in medicine and pharmacy.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels
EP  - 819
IS  - 3
SP  - 809
VL  - 70
DO  - 10.1007/s00289-012-0830-y
ER  - 

@article{
author = "Krezović, Bojana D. and Dimitrijević, Suzana and Filipović, Jovanka M. and Nikolić, Rajko R. and Tomić, Simonida",
year = "2013",
abstract = "New semi-interpenetrating networks (semi-IPNHs) (P(HEMA/IA)/PVP) were prepared by free radical crosslinking copolymerization of 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA, 5 mol%), in the presence of poly(vinyl pyrrolidone) (PVP, 2, 5, and 10 mol%), as an interpenetrating agent. The structure of the semi-IPNHs was confirmed by Fourier transform infrared spectroscopy, and morphology study was performed by scanning electron microscopy, which revealed the characteristic porous morphology. The results obtained by dynamic mechanical analysis showed the improvement of mechanical properties with increasing PVP content in semi-IPNs. The maximum swelling was observed for all studied systems at a slightly acidic media (around pH 6), so it can be said that the content of PVP has no influence on the swelling behavior, in the PVP range investigated. Along with the pH sensitivity, which was expected due to the presence of IA, semi-IPNHs showed temperature-sensitive swelling properties, with the lower critical solution temperature value around 41 degrees C, which is in the physiologically interesting interval. The antimicrobial activity of the samples was tested using E. coli, S. aureus, and C. albicans pathogens. It was noticed that the antimicrobial potential depends on type of microbes, time of exposure, and PVP content in the samples. Due to their good antimicrobial and mechanical properties these stimuli-sensitive semi-IPNHs have potential to be used as biomaterials for the applications in medicine and pharmacy.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels",
pages = "819-809",
number = "3",
volume = "70",
doi = "10.1007/s00289-012-0830-y"
}

Krezović, B. D., Dimitrijević, S., Filipović, J. M., Nikolić, R. R.,& Tomić, S.. (2013). Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels. in Polymer Bulletin
Springer, New York., 70(3), 809-819.
https://doi.org/10.1007/s00289-012-0830-y

Krezović BD, Dimitrijević S, Filipović JM, Nikolić RR, Tomić S. Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels. in Polymer Bulletin. 2013;70(3):809-819.
doi:10.1007/s00289-012-0830-y .

Krezović, Bojana D., Dimitrijević, Suzana, Filipović, Jovanka M., Nikolić, Rajko R., Tomić, Simonida, "Antimicrobial P(HEMA/IA)/PVP semi-interpenetrating network hydrogels" in Polymer Bulletin, 70, no. 3 (2013):809-819,
https://doi.org/10.1007/s00289-012-0830-y . .