TY  - JOUR
AU  - Perić, Tamara
AU  - Marković, Dejan
AU  - Petrović, Bojan
AU  - Radojević, Vesna
AU  - Todorović, Tatjana
AU  - Anđelski-Radičević, Biljana
AU  - Jančić-Heinemann, Radmila
AU  - Susić, Gordana
AU  - Perić‐Popadić, Aleksandra
AU  - Tomić-Spirić, Vesna
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3101
AB  - The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome
EP  - 2165
IS  - 9
SP  - 2153
VL  - 19
DO  - 10.1007/s00784-015-1444-1
ER  - 

@article{
author = "Perić, Tamara and Marković, Dejan and Petrović, Bojan and Radojević, Vesna and Todorović, Tatjana and Anđelski-Radičević, Biljana and Jančić-Heinemann, Radmila and Susić, Gordana and Perić‐Popadić, Aleksandra and Tomić-Spirić, Vesna",
year = "2015",
abstract = "The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome",
pages = "2165-2153",
number = "9",
volume = "19",
doi = "10.1007/s00784-015-1444-1"
}

Perić, T., Marković, D., Petrović, B., Radojević, V., Todorović, T., Anđelski-Radičević, B., Jančić-Heinemann, R., Susić, G., Perić‐Popadić, A.,& Tomić-Spirić, V.. (2015). Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 19(9), 2153-2165.
https://doi.org/10.1007/s00784-015-1444-1

Perić T, Marković D, Petrović B, Radojević V, Todorović T, Anđelski-Radičević B, Jančić-Heinemann R, Susić G, Perić‐Popadić A, Tomić-Spirić V. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations. 2015;19(9):2153-2165.
doi:10.1007/s00784-015-1444-1 .

Perić, Tamara, Marković, Dejan, Petrović, Bojan, Radojević, Vesna, Todorović, Tatjana, Anđelski-Radičević, Biljana, Jančić-Heinemann, Radmila, Susić, Gordana, Perić‐Popadić, Aleksandra, Tomić-Spirić, Vesna, "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome" in Clinical Oral Investigations, 19, no. 9 (2015):2153-2165,
https://doi.org/10.1007/s00784-015-1444-1 . .

TY  - JOUR
AU  - Perić, Tamara
AU  - Marković, Dejan
AU  - Radojević, Vesna
AU  - Jančić-Heinemann, Radmila
AU  - Petrović, Bojan
AU  - Lamovec, Jelena
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2704
AB  - Purpose: The purpose of the study was to evaluate the surface characteristics of demineralized enamel after treatment with pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) and to compare their efficacy with that of 0.05% NaF. Methods: Following formation of the artificial carious lesion, enamel slabs were divided into 4 groups (CPP-ACP, CPP-ACFP, 0.05% NaF and control) and submitted to a chemical caries model. Remineralization potential was examined using scanning electron microscope, energy-dispersive spectroscopy (EDS) and microhardness test. Scanning electron microphotographs were analyzed for area, minimal, maximal and mean diameter, perimeter, roundness and number of enamel defects and percentage of tooth surface affected by defects. Results: Treatment with 0.05% NaF partly reduced the appearance of enamel defects when compared with irregular demineralized enamel. Treatment with CPP-ACP or CPP-ACFP resulted in occlusion of defects which produced more flattened enamel surface. Image analysis revealed reduction of the dimensions of the defects in the 3 experimental groups. Treatment with CPP-ACFP decreased the number of enamel defects when compared with demineralized enamel. The EDS analysis did not show differences in Ca/O, P/O and Ca/P ratios between the groups (P gt 0.05). Microhardness test revealed significant effects of CPP-ACP and CPP-ACFP (P lt 0.05). Conclusions: Pastes containing CPP-ACP or CPP-ACFP showed potential to remineralize enamel surface lesions.
PB  - Sage Publications Ltd, London
T2  - Journal of Applied Biomaterials & Functional Materials
T1  - Influence of pastes containing casein phosphopeptide-amorphous calcium phosphate on surface of demineralized enamel
EP  - 239
IS  - 3
SP  - 234
VL  - 12
DO  - 10.5301/jabfm.5000194
ER  - 

@article{
author = "Perić, Tamara and Marković, Dejan and Radojević, Vesna and Jančić-Heinemann, Radmila and Petrović, Bojan and Lamovec, Jelena",
year = "2014",
abstract = "Purpose: The purpose of the study was to evaluate the surface characteristics of demineralized enamel after treatment with pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) and to compare their efficacy with that of 0.05% NaF. Methods: Following formation of the artificial carious lesion, enamel slabs were divided into 4 groups (CPP-ACP, CPP-ACFP, 0.05% NaF and control) and submitted to a chemical caries model. Remineralization potential was examined using scanning electron microscope, energy-dispersive spectroscopy (EDS) and microhardness test. Scanning electron microphotographs were analyzed for area, minimal, maximal and mean diameter, perimeter, roundness and number of enamel defects and percentage of tooth surface affected by defects. Results: Treatment with 0.05% NaF partly reduced the appearance of enamel defects when compared with irregular demineralized enamel. Treatment with CPP-ACP or CPP-ACFP resulted in occlusion of defects which produced more flattened enamel surface. Image analysis revealed reduction of the dimensions of the defects in the 3 experimental groups. Treatment with CPP-ACFP decreased the number of enamel defects when compared with demineralized enamel. The EDS analysis did not show differences in Ca/O, P/O and Ca/P ratios between the groups (P gt 0.05). Microhardness test revealed significant effects of CPP-ACP and CPP-ACFP (P lt 0.05). Conclusions: Pastes containing CPP-ACP or CPP-ACFP showed potential to remineralize enamel surface lesions.",
publisher = "Sage Publications Ltd, London",
journal = "Journal of Applied Biomaterials & Functional Materials",
title = "Influence of pastes containing casein phosphopeptide-amorphous calcium phosphate on surface of demineralized enamel",
pages = "239-234",
number = "3",
volume = "12",
doi = "10.5301/jabfm.5000194"
}

Perić, T., Marković, D., Radojević, V., Jančić-Heinemann, R., Petrović, B.,& Lamovec, J.. (2014). Influence of pastes containing casein phosphopeptide-amorphous calcium phosphate on surface of demineralized enamel. in Journal of Applied Biomaterials & Functional Materials
Sage Publications Ltd, London., 12(3), 234-239.
https://doi.org/10.5301/jabfm.5000194

Perić T, Marković D, Radojević V, Jančić-Heinemann R, Petrović B, Lamovec J. Influence of pastes containing casein phosphopeptide-amorphous calcium phosphate on surface of demineralized enamel. in Journal of Applied Biomaterials & Functional Materials. 2014;12(3):234-239.
doi:10.5301/jabfm.5000194 .

Perić, Tamara, Marković, Dejan, Radojević, Vesna, Jančić-Heinemann, Radmila, Petrović, Bojan, Lamovec, Jelena, "Influence of pastes containing casein phosphopeptide-amorphous calcium phosphate on surface of demineralized enamel" in Journal of Applied Biomaterials & Functional Materials, 12, no. 3 (2014):234-239,
https://doi.org/10.5301/jabfm.5000194 . .