TY  - JOUR
AU  - Malešić, Neda B.
AU  - Rusmirović, Jelena
AU  - Jovašević, Jovana S.
AU  - Perišić, Marija D.
AU  - Dimitrijević, Suzana
AU  - Filipović, Jovanka M.
AU  - Tomić, Simonida
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2595
AB  - The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time.
AB  - Cilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.
PB  - Savez inženjera i tehničara Srbije, Beograd
T2  - Tehnika
T1  - Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion
T1  - Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon
EP  - 568
IS  - 4
SP  - 563
VL  - 69
DO  - 10.5937/tehnika1404563M
ER  - 

@article{
author = "Malešić, Neda B. and Rusmirović, Jelena and Jovašević, Jovana S. and Perišić, Marija D. and Dimitrijević, Suzana and Filipović, Jovanka M. and Tomić, Simonida",
year = "2014",
abstract = "The objective of our study was to develop new antimicrobial hydrogels silver/poly(2-hydroxyethyl methacrylate/ itaconic acid) (Ag/P(HEMA/IA)). The P(HEMA/IA) samples, with different HEMA/IA ratio, were prepared by free radical crosslinking copolymerization. Ag ion were introduced in hydrogels by immersing dried P(HEMA/IA) disks in silver(I) salt solution, which was confirmed by FTIR spectroscopy. The in vitro controlled release of silver(I) ion from (Ag/P(HEMA/IA)) gels, and antimicrobial activity during the release period were also studied. The release profiles have shown a two-phase exponential profile, with fast initial phase, followed by a much slower release rate. Kinetic parameters determined, have indicated Fickian transport of Ag(I) ion in the initial phase. It is perceived that the antimicrobial activity of the Ag/P(HEMA/IA) depends on IA content. Excellent antimicrobial potential was maintained during the entire release time., Cilj našeg istraživanja je bio da se razviju novi antimikrobni hidrogelovi. Srebro/poli(2-hidroksietil metakrilat/itakonska kiselina) (Ag/P(HEMA/IK)) hidrogelovi su sintetisani, i proučavano je kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IK) hidrogelova, kao i njihov antimikrobni potencijal. P(HEMA/IK) uzorci, sa različitim odnosima monomera HEMA/IK, dobijeni su radikalnom kopolimerizacijom/ umrežavanjem. Ag/P(HEMA/IK) hidrogelovi su formirani potapanjem suvih diskova gelova u srebro(I) so, što je i potvrđeno FTIR spektroskopijom. Ispitani su kontrolisano otpuštanje srebro(I) jona iz Ag/P(HEMA/IA) gelova in vitro, kao i antimikrobna aktivnost tokom perioda otpuštanja. Profili otpuštanja su pokazali dve faze (eksponencijalni rast), sa brzom početnom fazom, a zatim sporijom brzinom otpuštanja. Antimikrobna aktivnost u toku otpuštanja u maloj meri zavisi od sadržaja IA i vremena otpuštanja. Odličan antimikrobni potencijal se održava tokom celog vremena otpuštanja. Na osnovu dobijenih rezultata proizilazi da se Ag/P(HEMA/IK) hidrogelovi mogu koristiti u širokom spektru biomedicinskih primena.",
publisher = "Savez inženjera i tehničara Srbije, Beograd",
journal = "Tehnika",
title = "Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion, Antimikrobni hidrogelovi na bazi 2-hidroksietil metakrilata i itakonske kiseline koji sadrže srebro(I) jon",
pages = "568-563",
number = "4",
volume = "69",
doi = "10.5937/tehnika1404563M"
}

Malešić, N. B., Rusmirović, J., Jovašević, J. S., Perišić, M. D., Dimitrijević, S., Filipović, J. M.,& Tomić, S.. (2014). Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion. in Tehnika
Savez inženjera i tehničara Srbije, Beograd., 69(4), 563-568.
https://doi.org/10.5937/tehnika1404563M

Malešić NB, Rusmirović J, Jovašević JS, Perišić MD, Dimitrijević S, Filipović JM, Tomić S. Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion. in Tehnika. 2014;69(4):563-568.
doi:10.5937/tehnika1404563M .

Malešić, Neda B., Rusmirović, Jelena, Jovašević, Jovana S., Perišić, Marija D., Dimitrijević, Suzana, Filipović, Jovanka M., Tomić, Simonida, "Antimicrobial hydrogels based on 2-hydroxyethyl methacrylate and itaconic acid containing silver(I) ion" in Tehnika, 69, no. 4 (2014):563-568,
https://doi.org/10.5937/tehnika1404563M . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Antić, Katarina
AU  - Jovašević-Vuković, Jovana J.
AU  - Malešić, Neda B.
AU  - Filipović, Jovanka M.
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2719
AB  - Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.
PB  - Polymer Soc Korea, Seoul
T2  - Macromolecular Research
T1  - pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid
EP  - 1213
IS  - 11
SP  - 1203
VL  - 22
DO  - 10.1007/s13233-014-2172-0
ER  - 

@article{
author = "Tomić, Simonida and Babić, Marija and Antić, Katarina and Jovašević-Vuković, Jovana J. and Malešić, Neda B. and Filipović, Jovanka M.",
year = "2014",
abstract = "Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly (alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influence of different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG) and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties of P(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM) samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower than the value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed a marked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leading to a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogel properties were significantly dependent on the PAGM component, meaning that the type of side chains can be used to tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogels applicable in biomedical and biotechnological fields and controlled drug delivery.",
publisher = "Polymer Soc Korea, Seoul",
journal = "Macromolecular Research",
title = "pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid",
pages = "1213-1203",
number = "11",
volume = "22",
doi = "10.1007/s13233-014-2172-0"
}

Tomić, S., Babić, M., Antić, K., Jovašević-Vuković, J. J., Malešić, N. B.,& Filipović, J. M.. (2014). pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid. in Macromolecular Research
Polymer Soc Korea, Seoul., 22(11), 1203-1213.
https://doi.org/10.1007/s13233-014-2172-0

Tomić S, Babić M, Antić K, Jovašević-Vuković JJ, Malešić NB, Filipović JM. pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid. in Macromolecular Research. 2014;22(11):1203-1213.
doi:10.1007/s13233-014-2172-0 .

Tomić, Simonida, Babić, Marija, Antić, Katarina, Jovašević-Vuković, Jovana J., Malešić, Neda B., Filipović, Jovanka M., "pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid" in Macromolecular Research, 22, no. 11 (2014):1203-1213,
https://doi.org/10.1007/s13233-014-2172-0 . .