TY  - JOUR
AU  - Knežević, Nikola Ž.
AU  - Mrdanović, Jasminka
AU  - Borisev, Ivana
AU  - Milenković, Sanja
AU  - Janaćković, Đorđe
AU  - Cunin, Frederique
AU  - Đorđević, Aleksandar
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3386
AB  - A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.
PB  - Royal Society of Chemistry
T2  - RSC Advances
T1  - Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy
EP  - 7065
IS  - 9
SP  - 7061
VL  - 6
DO  - 10.1039/c5ra22937e
ER  - 

@article{
author = "Knežević, Nikola Ž. and Mrdanović, Jasminka and Borisev, Ivana and Milenković, Sanja and Janaćković, Đorđe and Cunin, Frederique and Đorđević, Aleksandar",
year = "2016",
abstract = "A novel cancer-targeting drug delivery system is constructed and characterized, based on folic acid-functionalized mesoporous silica nanoparticles with pore-loaded anticancer drug vinblastine and pore-blocking fullerenol molecules. The selective treatment efficacy based on targeting of cancer-verexpressed folate receptors is demonstrated by comparison of cell viability upon the treatment of healthy MRC-5, breast cancer MCF-7 and cervical cancer HeLa cells, which are known to differ in the amount of folate receptors on their surfaces.",
publisher = "Royal Society of Chemistry",
journal = "RSC Advances",
title = "Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy",
pages = "7065-7061",
number = "9",
volume = "6",
doi = "10.1039/c5ra22937e"
}

Knežević, N. Ž., Mrdanović, J., Borisev, I., Milenković, S., Janaćković, Đ., Cunin, F.,& Đorđević, A.. (2016). Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. in RSC Advances
Royal Society of Chemistry., 6(9), 7061-7065.
https://doi.org/10.1039/c5ra22937e

Knežević NŽ, Mrdanović J, Borisev I, Milenković S, Janaćković Đ, Cunin F, Đorđević A. Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy. in RSC Advances. 2016;6(9):7061-7065.
doi:10.1039/c5ra22937e .

Knežević, Nikola Ž., Mrdanović, Jasminka, Borisev, Ivana, Milenković, Sanja, Janaćković, Đorđe, Cunin, Frederique, Đorđević, Aleksandar, "Hydroxylated fullerene-capped, vinblastine-loaded folic acid-functionalized mesoporous silica nanoparticles for targeted anticancer therapy" in RSC Advances, 6, no. 9 (2016):7061-7065,
https://doi.org/10.1039/c5ra22937e . .

TY  - JOUR
AU  - Knežević, Nikola Ž.
AU  - Milenković, Sanja
AU  - Jović, Danica
AU  - Lazarević, Slavica
AU  - Mrđanović, Jasminka
AU  - Đorđević, Aleksandar
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3130
AB  - Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.
PB  - Hindawi Ltd, London
T2  - Advances in Materials Science and Engineering
T1  - Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery
VL  - 2015
DO  - 10.1155/2015/567350
ER  - 

@article{
author = "Knežević, Nikola Ž. and Milenković, Sanja and Jović, Danica and Lazarević, Slavica and Mrđanović, Jasminka and Đorđević, Aleksandar",
year = "2015",
abstract = "Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.",
publisher = "Hindawi Ltd, London",
journal = "Advances in Materials Science and Engineering",
title = "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery",
volume = "2015",
doi = "10.1155/2015/567350"
}

Knežević, N. Ž., Milenković, S., Jović, D., Lazarević, S., Mrđanović, J.,& Đorđević, A.. (2015). Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering
Hindawi Ltd, London., 2015.
https://doi.org/10.1155/2015/567350

Knežević NŽ, Milenković S, Jović D, Lazarević S, Mrđanović J, Đorđević A. Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. in Advances in Materials Science and Engineering. 2015;2015.
doi:10.1155/2015/567350 .

Knežević, Nikola Ž., Milenković, Sanja, Jović, Danica, Lazarević, Slavica, Mrđanović, Jasminka, Đorđević, Aleksandar, "Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery" in Advances in Materials Science and Engineering, 2015 (2015),
https://doi.org/10.1155/2015/567350 . .