TY  - JOUR
AU  - Batinić, Petar
AU  - Jovanović, Aleksandra
AU  - Stojković, Dejan
AU  - Zengin, Gökhan
AU  - Cvijetić, Ilija
AU  - Gašić, Uroš
AU  - Čutović, Natalija
AU  - Pešić, Mirjana B.
AU  - Milinčić, Danijel D.
AU  - Carević, Tamara
AU  - Marinković, Aleksandar
AU  - Bugarski, Branko
AU  - Marković, Tatjana
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7457
AB  - Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia
IS  - 4
SP  - 518
VL  - 17
DO  - 10.3390/ph17040518
ER  - 

@article{
author = "Batinić, Petar and Jovanović, Aleksandra and Stojković, Dejan and Zengin, Gökhan and Cvijetić, Ilija and Gašić, Uroš and Čutović, Natalija and Pešić, Mirjana B. and Milinčić, Danijel D. and Carević, Tamara and Marinković, Aleksandar and Bugarski, Branko and Marković, Tatjana",
year = "2024",
abstract = "Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia",
number = "4",
pages = "518",
volume = "17",
doi = "10.3390/ph17040518"
}

Batinić, P., Jovanović, A., Stojković, D., Zengin, G., Cvijetić, I., Gašić, U., Čutović, N., Pešić, M. B., Milinčić, D. D., Carević, T., Marinković, A., Bugarski, B.,& Marković, T.. (2024). Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia. in Pharmaceuticals
MDPI., 17(4), 518.
https://doi.org/10.3390/ph17040518

Batinić P, Jovanović A, Stojković D, Zengin G, Cvijetić I, Gašić U, Čutović N, Pešić MB, Milinčić DD, Carević T, Marinković A, Bugarski B, Marković T. Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia. in Pharmaceuticals. 2024;17(4):518.
doi:10.3390/ph17040518 .

Batinić, Petar, Jovanović, Aleksandra, Stojković, Dejan, Zengin, Gökhan, Cvijetić, Ilija, Gašić, Uroš, Čutović, Natalija, Pešić, Mirjana B., Milinčić, Danijel D., Carević, Tamara, Marinković, Aleksandar, Bugarski, Branko, Marković, Tatjana, "Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia" in Pharmaceuticals, 17, no. 4 (2024):518,
https://doi.org/10.3390/ph17040518 . .

TY  - JOUR
AU  - Bošnjaković, Jovana M.
AU  - Bugarčić, Mladen D.
AU  - Čutović, Natalija
AU  - Jovanović, Aleksandar A.
AU  - Manasijević, Srećko
AU  - Marinković, Aleksandar D.
AU  - Veličković, Zlate S.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5179
AB  - Elderberry (Sambucus nigra) pith was modified with polyethyleneimine (PEI) in order to improve the adsorption properties. Characterization of both dried Sambucus nigra pith (DSNP) and amino modification of elderberry pith with branched PEI (PEI/DSNP) was performed by: Fourier-transform infrared spectroscopy (FTIR), optical microscopy, and porosity determination. The amine and ester number, as well as acid value, were determined on DSNP and PEI/DSNP samples using standard volumetric methods. The samples were used as adsorbents for Pb2+ ions from an aqueous solution in a batch system. The obtained results were fitted using suitable equilibrium isotherm and kinetic models. The maximum adsorption capacity for Pb2+ ions on DSNP and aminаted sample, obtained using Langmuir adsorption isotherm at 298 K, are 18.9 and 47.8 mg g-1, respectively. Based on the kinetic studies, the adsorption process follows the pseudo second-order model. Thermodynamic parameters showed that the adsorption process is endothermic and spontaneous. In general, the overall adsorption process was improved by modifying starting material with branched PEI modifier by introducing large numbers of amino functionalities having high affinity to cations.
PB  - Association of Metallurgical Engineers of Serbia
T2  - Metallurgical and Materials Engineering
T1  - ECO-FRIENDLY ELDERBERRY BASED SORBENT FOR REMOVING Pb2+ IONS FROM AQUEOUS SOLUTIONS
EP  - 401
IS  - 2
SP  - 391
VL  - 28
DO  - 10.30544/710
ER  - 

@article{
author = "Bošnjaković, Jovana M. and Bugarčić, Mladen D. and Čutović, Natalija and Jovanović, Aleksandar A. and Manasijević, Srećko and Marinković, Aleksandar D. and Veličković, Zlate S.",
year = "2022",
abstract = "Elderberry (Sambucus nigra) pith was modified with polyethyleneimine (PEI) in order to improve the adsorption properties. Characterization of both dried Sambucus nigra pith (DSNP) and amino modification of elderberry pith with branched PEI (PEI/DSNP) was performed by: Fourier-transform infrared spectroscopy (FTIR), optical microscopy, and porosity determination. The amine and ester number, as well as acid value, were determined on DSNP and PEI/DSNP samples using standard volumetric methods. The samples were used as adsorbents for Pb2+ ions from an aqueous solution in a batch system. The obtained results were fitted using suitable equilibrium isotherm and kinetic models. The maximum adsorption capacity for Pb2+ ions on DSNP and aminаted sample, obtained using Langmuir adsorption isotherm at 298 K, are 18.9 and 47.8 mg g-1, respectively. Based on the kinetic studies, the adsorption process follows the pseudo second-order model. Thermodynamic parameters showed that the adsorption process is endothermic and spontaneous. In general, the overall adsorption process was improved by modifying starting material with branched PEI modifier by introducing large numbers of amino functionalities having high affinity to cations.",
publisher = "Association of Metallurgical Engineers of Serbia",
journal = "Metallurgical and Materials Engineering",
title = "ECO-FRIENDLY ELDERBERRY BASED SORBENT FOR REMOVING Pb2+ IONS FROM AQUEOUS SOLUTIONS",
pages = "401-391",
number = "2",
volume = "28",
doi = "10.30544/710"
}

Bošnjaković, J. M., Bugarčić, M. D., Čutović, N., Jovanović, A. A., Manasijević, S., Marinković, A. D.,& Veličković, Z. S.. (2022). ECO-FRIENDLY ELDERBERRY BASED SORBENT FOR REMOVING Pb2+ IONS FROM AQUEOUS SOLUTIONS. in Metallurgical and Materials Engineering
Association of Metallurgical Engineers of Serbia., 28(2), 391-401.
https://doi.org/10.30544/710

Bošnjaković JM, Bugarčić MD, Čutović N, Jovanović AA, Manasijević S, Marinković AD, Veličković ZS. ECO-FRIENDLY ELDERBERRY BASED SORBENT FOR REMOVING Pb2+ IONS FROM AQUEOUS SOLUTIONS. in Metallurgical and Materials Engineering. 2022;28(2):391-401.
doi:10.30544/710 .

Bošnjaković, Jovana M., Bugarčić, Mladen D., Čutović, Natalija, Jovanović, Aleksandar A., Manasijević, Srećko, Marinković, Aleksandar D., Veličković, Zlate S., "ECO-FRIENDLY ELDERBERRY BASED SORBENT FOR REMOVING Pb2+ IONS FROM AQUEOUS SOLUTIONS" in Metallurgical and Materials Engineering, 28, no. 2 (2022):391-401,
https://doi.org/10.30544/710 . .

TY  - JOUR
AU  - Shwika, Salem Ibrahim
AU  - Omran, Kaled Mohamed Ben
AU  - Čutović, Natalija
AU  - Marinković, Aleksandar
AU  - Ranitović, Milisav
AU  - Vasilski, Dragana
AU  - Kamberović, Željko
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5178
AB  - Due to the rapidly increasing use of electrical devices, e-waste became one of the major threats to the environment. Waste printed circuit boards (WPCBs) are an integral part of electrical devices, thus the interest in their recycling is growing. Recycling of WPCBs can be performed by applying hydrometallurgical or pyrometallurgical processes, as well as vacuum pyrolysis. The main advantages of vacuum pyrolysis are eco-friendliness, economic viability and efficiency in extracting present noble metals, while pyrolysis oil occurs as a by-product. Pyrolysis oil poses a tremendous threat to the environment, due to the possibility of its spillage into water, as well as a potential release into the air and soil. Because of this, the pyrolysis oil was subjected to chemical treatment with different reagents, such as sodium hydroxide, calcium oxide, sulfuric acid and maleic anhydride, with the intent to solidify the material and remove unpleasant odors. Incorporation of the solidified materials into bitumen, at 2.5, 5, 7.5, and 10 wt.% addition, was performed to obtain waterproofing materials. The obtained solidified and bituminous water-resistant materials were subjected to various test methods: FTIR spectroscopy, physicochemical and mechanical properties of bitumen, etc. which showed that all the tested characteristics are in accordance with values prescribed by the current standard. Toxicity Leaching Procedure (TCLP) confirmed non-hazardous characteristics of the obtained materials, except for the ones with added solidified pyrolysis oil, with Sodium hydroxide, that showed higher leaching of the phenol constituent.
PB  - Association of Metallurgical Engineers of Serbia
T2  - Metallurgical and Materials Engineering
T1  - SUSTAINABLE DEVELOPMENT IN WPCBs TREATMENT FOR PRODUCTION OF BITUMINOUS WATERPROOFING MATERIALS
EP  - 390
IS  - 2
SP  - 381
VL  - 28
DO  - 10.30544/787
ER  - 

@article{
author = "Shwika, Salem Ibrahim and Omran, Kaled Mohamed Ben and Čutović, Natalija and Marinković, Aleksandar and Ranitović, Milisav and Vasilski, Dragana and Kamberović, Željko",
year = "2022",
abstract = "Due to the rapidly increasing use of electrical devices, e-waste became one of the major threats to the environment. Waste printed circuit boards (WPCBs) are an integral part of electrical devices, thus the interest in their recycling is growing. Recycling of WPCBs can be performed by applying hydrometallurgical or pyrometallurgical processes, as well as vacuum pyrolysis. The main advantages of vacuum pyrolysis are eco-friendliness, economic viability and efficiency in extracting present noble metals, while pyrolysis oil occurs as a by-product. Pyrolysis oil poses a tremendous threat to the environment, due to the possibility of its spillage into water, as well as a potential release into the air and soil. Because of this, the pyrolysis oil was subjected to chemical treatment with different reagents, such as sodium hydroxide, calcium oxide, sulfuric acid and maleic anhydride, with the intent to solidify the material and remove unpleasant odors. Incorporation of the solidified materials into bitumen, at 2.5, 5, 7.5, and 10 wt.% addition, was performed to obtain waterproofing materials. The obtained solidified and bituminous water-resistant materials were subjected to various test methods: FTIR spectroscopy, physicochemical and mechanical properties of bitumen, etc. which showed that all the tested characteristics are in accordance with values prescribed by the current standard. Toxicity Leaching Procedure (TCLP) confirmed non-hazardous characteristics of the obtained materials, except for the ones with added solidified pyrolysis oil, with Sodium hydroxide, that showed higher leaching of the phenol constituent.",
publisher = "Association of Metallurgical Engineers of Serbia",
journal = "Metallurgical and Materials Engineering",
title = "SUSTAINABLE DEVELOPMENT IN WPCBs TREATMENT FOR PRODUCTION OF BITUMINOUS WATERPROOFING MATERIALS",
pages = "390-381",
number = "2",
volume = "28",
doi = "10.30544/787"
}

Shwika, S. I., Omran, K. M. B., Čutović, N., Marinković, A., Ranitović, M., Vasilski, D.,& Kamberović, Ž.. (2022). SUSTAINABLE DEVELOPMENT IN WPCBs TREATMENT FOR PRODUCTION OF BITUMINOUS WATERPROOFING MATERIALS. in Metallurgical and Materials Engineering
Association of Metallurgical Engineers of Serbia., 28(2), 381-390.
https://doi.org/10.30544/787

Shwika SI, Omran KMB, Čutović N, Marinković A, Ranitović M, Vasilski D, Kamberović Ž. SUSTAINABLE DEVELOPMENT IN WPCBs TREATMENT FOR PRODUCTION OF BITUMINOUS WATERPROOFING MATERIALS. in Metallurgical and Materials Engineering. 2022;28(2):381-390.
doi:10.30544/787 .

Shwika, Salem Ibrahim, Omran, Kaled Mohamed Ben, Čutović, Natalija, Marinković, Aleksandar, Ranitović, Milisav, Vasilski, Dragana, Kamberović, Željko, "SUSTAINABLE DEVELOPMENT IN WPCBs TREATMENT FOR PRODUCTION OF BITUMINOUS WATERPROOFING MATERIALS" in Metallurgical and Materials Engineering, 28, no. 2 (2022):381-390,
https://doi.org/10.30544/787 . .

TY  - JOUR
AU  - Čutović, Natalija
AU  - Marković, Tatjana
AU  - Kostić, Marina
AU  - Gašić, Uroš
AU  - Prijić, Željana
AU  - Ren, Xiuxia
AU  - Lukić, Milan
AU  - Bugarski, Branko
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5298
AB  - Without being aware of its chemical makeup, many ancient societies have used Steppe peony in their traditional medicine. Given that modern phytopreparation intended for use on human skin requires, above all, knowledge of its chemical composition, the goal of this study was to make a screening of the composition of aqueous and methanolic extracts of the petals of P. tenuifolia L. and to examine them for various skin-beneficial properties. The extracts were prepared by maceration, ultrasound-assisted, and microwave-assisted extraction procedures. The chemical profiling was conducted by the use of UHPLC-LTQ-OrbiTrap MS and UHPLC/MS, and spectrophotometric methods for the determination of total polyphenol and total flavonoid contents. The biological activities entailed antioxidant ABTS, DPPH, CUPRAC (Cupric Ion Reducing Antioxidant Capacity), and FRAP (Ferric Reducing Antioxidant Power) assays, antimicrobial (antibacterial and antifungal) and antibiofilm activities, cytotoxicity, wound healing potential, as well as the adhesion and invasion of Staphylococcus lugdunensis. The results showed that the petals are rich in phenolic acids and flavonoids, which are commonly associated with numerous biological activities. The aqueous extracts were more efficient in the majority of the bioactivity assays then the methanolic ones, whereas the optimal extraction method varied between the assays. This study is the first step towards the safe use of the aqueous extracts of P. tenuifolia petals for therapeutic skin treatments.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Chemical Profile and Skin-Beneficial Activities of the Petal Extracts of Paeonia tenuifolia L. from Serbia
IS  - 12
SP  - 1537
VL  - 15
DO  - 10.3390/ph15121537
ER  - 

@article{
author = "Čutović, Natalija and Marković, Tatjana and Kostić, Marina and Gašić, Uroš and Prijić, Željana and Ren, Xiuxia and Lukić, Milan and Bugarski, Branko",
year = "2022",
abstract = "Without being aware of its chemical makeup, many ancient societies have used Steppe peony in their traditional medicine. Given that modern phytopreparation intended for use on human skin requires, above all, knowledge of its chemical composition, the goal of this study was to make a screening of the composition of aqueous and methanolic extracts of the petals of P. tenuifolia L. and to examine them for various skin-beneficial properties. The extracts were prepared by maceration, ultrasound-assisted, and microwave-assisted extraction procedures. The chemical profiling was conducted by the use of UHPLC-LTQ-OrbiTrap MS and UHPLC/MS, and spectrophotometric methods for the determination of total polyphenol and total flavonoid contents. The biological activities entailed antioxidant ABTS, DPPH, CUPRAC (Cupric Ion Reducing Antioxidant Capacity), and FRAP (Ferric Reducing Antioxidant Power) assays, antimicrobial (antibacterial and antifungal) and antibiofilm activities, cytotoxicity, wound healing potential, as well as the adhesion and invasion of Staphylococcus lugdunensis. The results showed that the petals are rich in phenolic acids and flavonoids, which are commonly associated with numerous biological activities. The aqueous extracts were more efficient in the majority of the bioactivity assays then the methanolic ones, whereas the optimal extraction method varied between the assays. This study is the first step towards the safe use of the aqueous extracts of P. tenuifolia petals for therapeutic skin treatments.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Chemical Profile and Skin-Beneficial Activities of the Petal Extracts of Paeonia tenuifolia L. from Serbia",
number = "12",
pages = "1537",
volume = "15",
doi = "10.3390/ph15121537"
}

Čutović, N., Marković, T., Kostić, M., Gašić, U., Prijić, Ž., Ren, X., Lukić, M.,& Bugarski, B.. (2022). Chemical Profile and Skin-Beneficial Activities of the Petal Extracts of Paeonia tenuifolia L. from Serbia. in Pharmaceuticals
MDPI., 15(12), 1537.
https://doi.org/10.3390/ph15121537

Čutović N, Marković T, Kostić M, Gašić U, Prijić Ž, Ren X, Lukić M, Bugarski B. Chemical Profile and Skin-Beneficial Activities of the Petal Extracts of Paeonia tenuifolia L. from Serbia. in Pharmaceuticals. 2022;15(12):1537.
doi:10.3390/ph15121537 .

Čutović, Natalija, Marković, Tatjana, Kostić, Marina, Gašić, Uroš, Prijić, Željana, Ren, Xiuxia, Lukić, Milan, Bugarski, Branko, "Chemical Profile and Skin-Beneficial Activities of the Petal Extracts of Paeonia tenuifolia L. from Serbia" in Pharmaceuticals, 15, no. 12 (2022):1537,
https://doi.org/10.3390/ph15121537 . .