@conference{
author = "Radovanović, Lidija and Lađarević, Jelena and Božić, Bojan and Kasalović, Marijana and Pantelić, Nebojša and Mijin, Dušan and Rogan, Jelena",
year = "2022",
abstract = "2-Quinolones represent important structural motifs in the numerous biologically active compounds
and naturally occurring alkaloids. Their derivatives show remarkable diversity of pharmalogical
properties such as antibacterial, antifungal, anticancer, antitubercular, anti-inflammatory, and
antihypertensive and play a significant role in the development of the new pharmaceuticals. On the
other hand, propanoic acid derivatives are known for their uniqe terapeutic activity. In an effort to
merge these two structural motifs, two-step synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic
acid, 1, was performed. The obtained compound was characterized by melting point, FTIR and
NMR spectra. The single crystals of molecule 1, was prepared by slow evaporation from the ethyl
acetate solution. The single crystal X-ray analysis revealed that molecule 1 crystallizes in
monoclinic P21/c space group with Z = 4. The main structural feature is pseudo wavy layer formed
by O–H···O and C–H···O interactions between adjacent molecules, whereas among the layers π···π
stacking and C–H···π interactions were observed, resulting in the formation of supramolecular
network. The main crystallographic data for 1: C13H13NO3, a = 9.2414(4), b = 9.0128(3),
c = 13.6567(6) Å, β = 109.676(4) °, V = 1071.06(8) Å
3
. The refinement based on F
2
(156
parameters) yielded: R1 = 0.0456, wR2 = 0.1287, S = 1.068 for all data, and R1 = 0.0433 for 1765
reflections with I ≥ 2σ(I).",
publisher = "Banja Luka : University in Banjaluka, Faculty of Technology",
journal = "Book of Abstracts / XIV Conference of Chemists, Technologists and Environmentalists of Republic of Srpska, Banja Luka, October 21-22, 2022",
title = "Synthesis, characterization and crystal structure of the 2-quinolone derivative",
pages = "22",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6724"
}