Miloradović, Zoran

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  • Miloradović, Zoran (5)
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Author's Bibliography

Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats

Vajić, Una-Jovana; Grujić-Milanović, Jelica; Miloradović, Zoran; Jovović, Đurđica; Ivanov, Milan; Karanović, Danijela; Šavikin, Katarina; Bugarski, Branko; Mihailović-Stanojević, Nevena

(Elsevier Gmbh, Urban & Fischer Verlag, Jena, 2018)

TY  - JOUR
AU  - Vajić, Una-Jovana
AU  - Grujić-Milanović, Jelica
AU  - Miloradović, Zoran
AU  - Jovović, Đurđica
AU  - Ivanov, Milan
AU  - Karanović, Danijela
AU  - Šavikin, Katarina
AU  - Bugarski, Branko
AU  - Mihailović-Stanojević, Nevena
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3880
AB  - Background: Urtica dioica L. (Stinging nettle) has been used for centuries for the treatment of numerous health issues. Purpose: This study investigates the antioxidant capacity and the most abundant phenolic compounds of Urtica dioica L. leaf extract (UE), and its antihypertensive and antioxidative effects in vivo. Study design: Spontaneously hypertensive rats were supplemented with 10, 50, and 200 mg/kg/day of UE and 10 mg/kg/day of losartan during 4-week period. Methods: In this study, HPLC analysis of UE was performed, as well as the determination of antioxidant capacity, superoxide radical scavenging activity, and metal chelating ability. Hemodynamic parameters were measured directly in anesthetized rats. Also, antioxidant enzyme activity and concentration in erythrocytes were determined, as well as systemic oxidative stress and plasma antioxidant status. Results: UE showed higher ferric reducing antioxidant power and Trolox equivalent antioxidant capacity than BHT, but lower than vitamin C. Furthermore, UE showed good metal chelating ability, but weak superoxide radical scavenging activity. All three tested UE doses managed to reduce systolic and diastolic blood pressure, as well as cardiac index, and to improve the antioxidative defense by increasing the activity of superoxide dismutase and catalase, without changing the concentration of the enzymes. Moreover, UE supplementation increased plasma antioxidant capacity and reduced systemic oxidative stress. Conclusion: Chronic UE dietary supplementation had beneficial effects in the experimental model of essential hypertension.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Phytomedicine
T1  - Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats
EP  - 45
SP  - 39
VL  - 46
DO  - 10.1016/j.phymed.2018.04.037
ER  - 
@article{
author = "Vajić, Una-Jovana and Grujić-Milanović, Jelica and Miloradović, Zoran and Jovović, Đurđica and Ivanov, Milan and Karanović, Danijela and Šavikin, Katarina and Bugarski, Branko and Mihailović-Stanojević, Nevena",
year = "2018",
abstract = "Background: Urtica dioica L. (Stinging nettle) has been used for centuries for the treatment of numerous health issues. Purpose: This study investigates the antioxidant capacity and the most abundant phenolic compounds of Urtica dioica L. leaf extract (UE), and its antihypertensive and antioxidative effects in vivo. Study design: Spontaneously hypertensive rats were supplemented with 10, 50, and 200 mg/kg/day of UE and 10 mg/kg/day of losartan during 4-week period. Methods: In this study, HPLC analysis of UE was performed, as well as the determination of antioxidant capacity, superoxide radical scavenging activity, and metal chelating ability. Hemodynamic parameters were measured directly in anesthetized rats. Also, antioxidant enzyme activity and concentration in erythrocytes were determined, as well as systemic oxidative stress and plasma antioxidant status. Results: UE showed higher ferric reducing antioxidant power and Trolox equivalent antioxidant capacity than BHT, but lower than vitamin C. Furthermore, UE showed good metal chelating ability, but weak superoxide radical scavenging activity. All three tested UE doses managed to reduce systolic and diastolic blood pressure, as well as cardiac index, and to improve the antioxidative defense by increasing the activity of superoxide dismutase and catalase, without changing the concentration of the enzymes. Moreover, UE supplementation increased plasma antioxidant capacity and reduced systemic oxidative stress. Conclusion: Chronic UE dietary supplementation had beneficial effects in the experimental model of essential hypertension.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Phytomedicine",
title = "Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats",
pages = "45-39",
volume = "46",
doi = "10.1016/j.phymed.2018.04.037"
}
Vajić, U., Grujić-Milanović, J., Miloradović, Z., Jovović, Đ., Ivanov, M., Karanović, D., Šavikin, K., Bugarski, B.,& Mihailović-Stanojević, N.. (2018). Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats. in Phytomedicine
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 46, 39-45.
https://doi.org/10.1016/j.phymed.2018.04.037
Vajić U, Grujić-Milanović J, Miloradović Z, Jovović Đ, Ivanov M, Karanović D, Šavikin K, Bugarski B, Mihailović-Stanojević N. Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats. in Phytomedicine. 2018;46:39-45.
doi:10.1016/j.phymed.2018.04.037 .
Vajić, Una-Jovana, Grujić-Milanović, Jelica, Miloradović, Zoran, Jovović, Đurđica, Ivanov, Milan, Karanović, Danijela, Šavikin, Katarina, Bugarski, Branko, Mihailović-Stanojević, Nevena, "Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats" in Phytomedicine, 46 (2018):39-45,
https://doi.org/10.1016/j.phymed.2018.04.037 . .
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33

Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress

Mihailović-Stanojević, Nevena; Miloradović, Zoran; Ivanov, Milan; Bugarski, Branko; Jovović, Đurđica; Karanović, Danijela; Vajić, Una-Jovana; Komes, Drazenka; Grujić-Milanović, Jelica

(Hindawi Ltd, London, 2016)

TY  - JOUR
AU  - Mihailović-Stanojević, Nevena
AU  - Miloradović, Zoran
AU  - Ivanov, Milan
AU  - Bugarski, Branko
AU  - Jovović, Đurđica
AU  - Karanović, Danijela
AU  - Vajić, Una-Jovana
AU  - Komes, Drazenka
AU  - Grujić-Milanović, Jelica
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3363
AB  - High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress
VL  - 2016
DO  - 10.1155/2016/1458793
ER  - 
@article{
author = "Mihailović-Stanojević, Nevena and Miloradović, Zoran and Ivanov, Milan and Bugarski, Branko and Jovović, Đurđica and Karanović, Danijela and Vajić, Una-Jovana and Komes, Drazenka and Grujić-Milanović, Jelica",
year = "2016",
abstract = "High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress",
volume = "2016",
doi = "10.1155/2016/1458793"
}
Mihailović-Stanojević, N., Miloradović, Z., Ivanov, M., Bugarski, B., Jovović, Đ., Karanović, D., Vajić, U., Komes, D.,& Grujić-Milanović, J.. (2016). Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London., 2016.
https://doi.org/10.1155/2016/1458793
Mihailović-Stanojević N, Miloradović Z, Ivanov M, Bugarski B, Jovović Đ, Karanović D, Vajić U, Komes D, Grujić-Milanović J. Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress. in Oxidative Medicine and Cellular Longevity. 2016;2016.
doi:10.1155/2016/1458793 .
Mihailović-Stanojević, Nevena, Miloradović, Zoran, Ivanov, Milan, Bugarski, Branko, Jovović, Đurđica, Karanović, Danijela, Vajić, Una-Jovana, Komes, Drazenka, Grujić-Milanović, Jelica, "Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress" in Oxidative Medicine and Cellular Longevity, 2016 (2016),
https://doi.org/10.1155/2016/1458793 . .
26
10
7
11

Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology

Vajić, Una-Jovana; Grujić-Milanović, Jelica; Živković, Jelena Č.; Šavikin, Katarina; Gođevac, Dejan; Miloradović, Zoran; Bugarski, Branko; Mihailović-Stanojević, Nevena

(Elsevier, Amsterdam, 2015)

TY  - JOUR
AU  - Vajić, Una-Jovana
AU  - Grujić-Milanović, Jelica
AU  - Živković, Jelena Č.
AU  - Šavikin, Katarina
AU  - Gođevac, Dejan
AU  - Miloradović, Zoran
AU  - Bugarski, Branko
AU  - Mihailović-Stanojević, Nevena
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3145
AB  - A full three level factorial design was implemented for optimization of extraction parameters in order to maximize total phenolic (TP) yield from stinging nettle leaf. Factors considered were percentage of methanol in solvent (X-1 : 50-100% methanol) and extraction time (X-2: 30-90 min), and maceration was used as extraction method. A second-order polynomial model was applied for fitting experimental data and predicting the response, and this mathematical model produced a satisfactory fit (R-2 = 0.993,p lt 0.01). The optimal extraction conditions were 54% aqueous methanol and 38 min extraction time, while maximal theoretical TP yield was 8.9 mg GAE/g DW. Solvent composition significantly affected extraction efficiency causing decrease of TP yield with increase of methanol percentage. On the other hand, extraction time did not influence significantly efficiency of extraction. Using LC/MS and HPLC analysis we detected and quantified three most abundant phenolic compounds: 2-O-caffeoyl malic acid, chlorogenic acid, and rutin. Comparison between maceration and ultrasound-assisted extraction (UAE) obtained extracts based on TP content as well as antiradical activity and HPLC results, showed that UAE have a better extraction capability affecting yield and time of extraction. Of all tested extracts, 54% aqueous methanolic extracts obtained with UAE and 38 min extraction time had the highest TP content.
PB  - Elsevier, Amsterdam
T2  - Industrial Crops and Products
T1  - Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology
EP  - 917
SP  - 912
VL  - 74
DO  - 10.1016/j.indcrop.2015.06.032
ER  - 
@article{
author = "Vajić, Una-Jovana and Grujić-Milanović, Jelica and Živković, Jelena Č. and Šavikin, Katarina and Gođevac, Dejan and Miloradović, Zoran and Bugarski, Branko and Mihailović-Stanojević, Nevena",
year = "2015",
abstract = "A full three level factorial design was implemented for optimization of extraction parameters in order to maximize total phenolic (TP) yield from stinging nettle leaf. Factors considered were percentage of methanol in solvent (X-1 : 50-100% methanol) and extraction time (X-2: 30-90 min), and maceration was used as extraction method. A second-order polynomial model was applied for fitting experimental data and predicting the response, and this mathematical model produced a satisfactory fit (R-2 = 0.993,p lt 0.01). The optimal extraction conditions were 54% aqueous methanol and 38 min extraction time, while maximal theoretical TP yield was 8.9 mg GAE/g DW. Solvent composition significantly affected extraction efficiency causing decrease of TP yield with increase of methanol percentage. On the other hand, extraction time did not influence significantly efficiency of extraction. Using LC/MS and HPLC analysis we detected and quantified three most abundant phenolic compounds: 2-O-caffeoyl malic acid, chlorogenic acid, and rutin. Comparison between maceration and ultrasound-assisted extraction (UAE) obtained extracts based on TP content as well as antiradical activity and HPLC results, showed that UAE have a better extraction capability affecting yield and time of extraction. Of all tested extracts, 54% aqueous methanolic extracts obtained with UAE and 38 min extraction time had the highest TP content.",
publisher = "Elsevier, Amsterdam",
journal = "Industrial Crops and Products",
title = "Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology",
pages = "917-912",
volume = "74",
doi = "10.1016/j.indcrop.2015.06.032"
}
Vajić, U., Grujić-Milanović, J., Živković, J. Č., Šavikin, K., Gođevac, D., Miloradović, Z., Bugarski, B.,& Mihailović-Stanojević, N.. (2015). Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology. in Industrial Crops and Products
Elsevier, Amsterdam., 74, 912-917.
https://doi.org/10.1016/j.indcrop.2015.06.032
Vajić U, Grujić-Milanović J, Živković JČ, Šavikin K, Gođevac D, Miloradović Z, Bugarski B, Mihailović-Stanojević N. Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology. in Industrial Crops and Products. 2015;74:912-917.
doi:10.1016/j.indcrop.2015.06.032 .
Vajić, Una-Jovana, Grujić-Milanović, Jelica, Živković, Jelena Č., Šavikin, Katarina, Gođevac, Dejan, Miloradović, Zoran, Bugarski, Branko, Mihailović-Stanojević, Nevena, "Optimization of extraction of stinging nettle leaf phenolic compounds using response surface methodology" in Industrial Crops and Products, 74 (2015):912-917,
https://doi.org/10.1016/j.indcrop.2015.06.032 . .
65
53
70

The effect of wild thyme polyphenols on haemodynamic parameters and plasma lipides in spontaneously hypertensive rats

Mihailović-Stanojević, Nevena; Bugarski, Branko; Komes, Drazenka; Grujić-Milanović, Jelica; Ivanov, Milan; Jovović, Đurđica; Bugarski, Diana; Miloradović, Zoran

(Lippincott Williams & Wilkins, Philadelphia, 2010)

TY  - JOUR
AU  - Mihailović-Stanojević, Nevena
AU  - Bugarski, Branko
AU  - Komes, Drazenka
AU  - Grujić-Milanović, Jelica
AU  - Ivanov, Milan
AU  - Jovović, Đurđica
AU  - Bugarski, Diana
AU  - Miloradović, Zoran
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1730
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Hypertension
T1  - The effect of wild thyme polyphenols on haemodynamic parameters and plasma lipides in spontaneously hypertensive rats
EP  - E495
SP  - E495
VL  - 28
UR  - https://hdl.handle.net/21.15107/rcub_technorep_1730
ER  - 
@article{
author = "Mihailović-Stanojević, Nevena and Bugarski, Branko and Komes, Drazenka and Grujić-Milanović, Jelica and Ivanov, Milan and Jovović, Đurđica and Bugarski, Diana and Miloradović, Zoran",
year = "2010",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Hypertension",
title = "The effect of wild thyme polyphenols on haemodynamic parameters and plasma lipides in spontaneously hypertensive rats",
pages = "E495-E495",
volume = "28",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1730"
}
Mihailović-Stanojević, N., Bugarski, B., Komes, D., Grujić-Milanović, J., Ivanov, M., Jovović, Đ., Bugarski, D.,& Miloradović, Z.. (2010). The effect of wild thyme polyphenols on haemodynamic parameters and plasma lipides in spontaneously hypertensive rats. in Journal of Hypertension
Lippincott Williams & Wilkins, Philadelphia., 28, E495-E495.
https://hdl.handle.net/21.15107/rcub_technorep_1730
Mihailović-Stanojević N, Bugarski B, Komes D, Grujić-Milanović J, Ivanov M, Jovović Đ, Bugarski D, Miloradović Z. The effect of wild thyme polyphenols on haemodynamic parameters and plasma lipides in spontaneously hypertensive rats. in Journal of Hypertension. 2010;28:E495-E495.
https://hdl.handle.net/21.15107/rcub_technorep_1730 .
Mihailović-Stanojević, Nevena, Bugarski, Branko, Komes, Drazenka, Grujić-Milanović, Jelica, Ivanov, Milan, Jovović, Đurđica, Bugarski, Diana, Miloradović, Zoran, "The effect of wild thyme polyphenols on haemodynamic parameters and plasma lipides in spontaneously hypertensive rats" in Journal of Hypertension, 28 (2010):E495-E495,
https://hdl.handle.net/21.15107/rcub_technorep_1730 .

Thyme extract improves blood pressure and oxidative stress in spontaneously hypertensive rats

Miloradović, Zoran; Bugarski, Branko; Komes, Drazenka; Grujić-Milanović, Jelica; Ivanov, Milan; Jovović, Đurđica; Mihailović-Stanojević, Nevena

(Lippincott Williams & Wilkins, Philadelphia, 2010)

TY  - JOUR
AU  - Miloradović, Zoran
AU  - Bugarski, Branko
AU  - Komes, Drazenka
AU  - Grujić-Milanović, Jelica
AU  - Ivanov, Milan
AU  - Jovović, Đurđica
AU  - Mihailović-Stanojević, Nevena
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1729
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Hypertension
T1  - Thyme extract improves blood pressure and oxidative stress in spontaneously hypertensive rats
EP  - E496
SP  - E496
VL  - 28
UR  - https://hdl.handle.net/21.15107/rcub_technorep_1729
ER  - 
@article{
author = "Miloradović, Zoran and Bugarski, Branko and Komes, Drazenka and Grujić-Milanović, Jelica and Ivanov, Milan and Jovović, Đurđica and Mihailović-Stanojević, Nevena",
year = "2010",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Hypertension",
title = "Thyme extract improves blood pressure and oxidative stress in spontaneously hypertensive rats",
pages = "E496-E496",
volume = "28",
url = "https://hdl.handle.net/21.15107/rcub_technorep_1729"
}
Miloradović, Z., Bugarski, B., Komes, D., Grujić-Milanović, J., Ivanov, M., Jovović, Đ.,& Mihailović-Stanojević, N.. (2010). Thyme extract improves blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Hypertension
Lippincott Williams & Wilkins, Philadelphia., 28, E496-E496.
https://hdl.handle.net/21.15107/rcub_technorep_1729
Miloradović Z, Bugarski B, Komes D, Grujić-Milanović J, Ivanov M, Jovović Đ, Mihailović-Stanojević N. Thyme extract improves blood pressure and oxidative stress in spontaneously hypertensive rats. in Journal of Hypertension. 2010;28:E496-E496.
https://hdl.handle.net/21.15107/rcub_technorep_1729 .
Miloradović, Zoran, Bugarski, Branko, Komes, Drazenka, Grujić-Milanović, Jelica, Ivanov, Milan, Jovović, Đurđica, Mihailović-Stanojević, Nevena, "Thyme extract improves blood pressure and oxidative stress in spontaneously hypertensive rats" in Journal of Hypertension, 28 (2010):E496-E496,
https://hdl.handle.net/21.15107/rcub_technorep_1729 .