TY  - JOUR
AU  - Jovanović, Aleksandra A.
AU  - Balanč, Bojana
AU  - Volić, Mina
AU  - Pećinar, Ilinka
AU  - Živković, Jelena
AU  - Šavikin, Katarina P.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6629
AB  - In the present study, rosehip (Rosa canina L.) extract was successfully encapsulated in phospholipid liposomes using a single-step procedure named the proliposome method. Part of the obtained liposomes was subjected to UV irradiation and non-treated (native) and UV-irradiated liposomes were further characterized in terms of encapsulation efficiency, chemical composition (HPLC analysis), antioxidant capacity, particle size, PDI, zeta potential, conductivity, mobility, and antioxidant capacity. Raman spectroscopy as well as DSC analysis were applied to evaluate the influence of UV irradiation on the physicochemical properties of liposomes. The encapsulation efficiency of extract-loaded liposomes was higher than 90%; the average size was 251.5 nm; the zeta potential was −22.4 mV; and the conductivity was found to be 0.007 mS/cm. UV irradiation did not cause a change in the mentioned parameters. In addition, irradiation did not affect the antioxidant potential of the liposome–extract system. Raman spectroscopy indicated that the extract was completely covered by the lipid membrane during liposome entrapment, and the peroxidation process was minimized by the presence of rosehip extract in liposomes. These results may guide the potential application of rosehip extract-loaded liposomes in the food, pharmaceutical, or cosmetic industries, particularly when liposomal sterilization is needed.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Plants
T1  - Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes
IS  - 17
SP  - 3063
VL  - 12
DO  - 10.3390/plants12173063
ER  - 

@article{
author = "Jovanović, Aleksandra A. and Balanč, Bojana and Volić, Mina and Pećinar, Ilinka and Živković, Jelena and Šavikin, Katarina P.",
year = "2023",
abstract = "In the present study, rosehip (Rosa canina L.) extract was successfully encapsulated in phospholipid liposomes using a single-step procedure named the proliposome method. Part of the obtained liposomes was subjected to UV irradiation and non-treated (native) and UV-irradiated liposomes were further characterized in terms of encapsulation efficiency, chemical composition (HPLC analysis), antioxidant capacity, particle size, PDI, zeta potential, conductivity, mobility, and antioxidant capacity. Raman spectroscopy as well as DSC analysis were applied to evaluate the influence of UV irradiation on the physicochemical properties of liposomes. The encapsulation efficiency of extract-loaded liposomes was higher than 90%; the average size was 251.5 nm; the zeta potential was −22.4 mV; and the conductivity was found to be 0.007 mS/cm. UV irradiation did not cause a change in the mentioned parameters. In addition, irradiation did not affect the antioxidant potential of the liposome–extract system. Raman spectroscopy indicated that the extract was completely covered by the lipid membrane during liposome entrapment, and the peroxidation process was minimized by the presence of rosehip extract in liposomes. These results may guide the potential application of rosehip extract-loaded liposomes in the food, pharmaceutical, or cosmetic industries, particularly when liposomal sterilization is needed.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Plants",
title = "Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes",
number = "17",
pages = "3063",
volume = "12",
doi = "10.3390/plants12173063"
}

Jovanović, A. A., Balanč, B., Volić, M., Pećinar, I., Živković, J.,& Šavikin, K. P.. (2023). Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes. in Plants
Multidisciplinary Digital Publishing Institute (MDPI)., 12(17), 3063.
https://doi.org/10.3390/plants12173063

Jovanović AA, Balanč B, Volić M, Pećinar I, Živković J, Šavikin KP. Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes. in Plants. 2023;12(17):3063.
doi:10.3390/plants12173063 .

Jovanović, Aleksandra A., Balanč, Bojana, Volić, Mina, Pećinar, Ilinka, Živković, Jelena, Šavikin, Katarina P., "Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes" in Plants, 12, no. 17 (2023):3063,
https://doi.org/10.3390/plants12173063 . .

TY  - CONF
AU  - Jovanović, Aleksandra A.
AU  - Đorđević, Verica
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina P.
AU  - Trifković, Kata
AU  - Jovanović, Jelena R.
AU  - Nedović, Viktor
AU  - Bugarski, Branko M.
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6444
AB  - Aromatic plant species of family Lamiaceae are important medicinal plants because of their antioxidant, antimicrobial, antispasmodic, expectorant, stimulant and diuretic properties. In this study T. serpyllum herba was evaluated as a source of polyphenolic compounds, which are extracted by the application of ultrasound probe instead of the traditional solvent extraction. Ultrasound extraction has become a good alternative extraction method when compared to classical methods due to its high efficiency, low energy and solvent consumption. Ultrasound assisted extraction is a well established method in the processing of plant material, particularly to extract bioactive substances such as polyphenols. Optimization of the extraction was carried out through varying degrees of fragmentation (0.3, 0.7 and 1.5), time of extraction (3, 7 and 10 minutes) and ratio drugs:solvent (1:10, 1:20 and 1:30) in 30% ethanol as an extraction medium. Extraction efficiency was expressed via total polyphenols content (Folin-Ciocalteu method) and antioxidant activity (DPPH method). The highest total polyphenols content and antioxidant activity were recorded in extract with a degree of fragmentation of 0.3 and ratio drug:solvent 1:30 after 3 minutes, 23.03 mg/L GA and IC50 3.00 mg/ml, respectively. The lowest total polyphenols content and antioxidant capacity were obtained in extract with a degree of fragmentation of 1.5 and ratio drug:solvent 1:10 (12.06 mg/L GA and IC50 4.78 mg/ml, respectively). This study found that both total polyphenols and antioxidant activities determined were significantly affected by the degree of fragmentation and ratio drugs:solvent. Also, the levels of total soluble phenolic compounds were positively correlated with free radical scavenging activities against DPPH radicals.
PB  - School of Chemical Engineering, Athens
C3  - 29th EFFoST International Conference, Food Science Research and Innovation: Delivering sustainable solutions to the global economy and society
T1  - Ultrasound Extraction of Polyphenolic Compounds from Thymus serpyllum
EP  - 1368
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6444
ER  - 

@conference{
author = "Jovanović, Aleksandra A. and Đorđević, Verica and Zdunić, Gordana and Šavikin, Katarina P. and Trifković, Kata and Jovanović, Jelena R. and Nedović, Viktor and Bugarski, Branko M.",
year = "2015",
abstract = "Aromatic plant species of family Lamiaceae are important medicinal plants because of their antioxidant, antimicrobial, antispasmodic, expectorant, stimulant and diuretic properties. In this study T. serpyllum herba was evaluated as a source of polyphenolic compounds, which are extracted by the application of ultrasound probe instead of the traditional solvent extraction. Ultrasound extraction has become a good alternative extraction method when compared to classical methods due to its high efficiency, low energy and solvent consumption. Ultrasound assisted extraction is a well established method in the processing of plant material, particularly to extract bioactive substances such as polyphenols. Optimization of the extraction was carried out through varying degrees of fragmentation (0.3, 0.7 and 1.5), time of extraction (3, 7 and 10 minutes) and ratio drugs:solvent (1:10, 1:20 and 1:30) in 30% ethanol as an extraction medium. Extraction efficiency was expressed via total polyphenols content (Folin-Ciocalteu method) and antioxidant activity (DPPH method). The highest total polyphenols content and antioxidant activity were recorded in extract with a degree of fragmentation of 0.3 and ratio drug:solvent 1:30 after 3 minutes, 23.03 mg/L GA and IC50 3.00 mg/ml, respectively. The lowest total polyphenols content and antioxidant capacity were obtained in extract with a degree of fragmentation of 1.5 and ratio drug:solvent 1:10 (12.06 mg/L GA and IC50 4.78 mg/ml, respectively). This study found that both total polyphenols and antioxidant activities determined were significantly affected by the degree of fragmentation and ratio drugs:solvent. Also, the levels of total soluble phenolic compounds were positively correlated with free radical scavenging activities against DPPH radicals.",
publisher = "School of Chemical Engineering, Athens",
journal = "29th EFFoST International Conference, Food Science Research and Innovation: Delivering sustainable solutions to the global economy and society",
title = "Ultrasound Extraction of Polyphenolic Compounds from Thymus serpyllum",
pages = "1368",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6444"
}

Jovanović, A. A., Đorđević, V., Zdunić, G., Šavikin, K. P., Trifković, K., Jovanović, J. R., Nedović, V.,& Bugarski, B. M.. (2015). Ultrasound Extraction of Polyphenolic Compounds from Thymus serpyllum. in 29th EFFoST International Conference, Food Science Research and Innovation: Delivering sustainable solutions to the global economy and society
School of Chemical Engineering, Athens..
https://hdl.handle.net/21.15107/rcub_technorep_6444

Jovanović AA, Đorđević V, Zdunić G, Šavikin KP, Trifković K, Jovanović JR, Nedović V, Bugarski BM. Ultrasound Extraction of Polyphenolic Compounds from Thymus serpyllum. in 29th EFFoST International Conference, Food Science Research and Innovation: Delivering sustainable solutions to the global economy and society. 2015;:null-1368.
https://hdl.handle.net/21.15107/rcub_technorep_6444 .

Jovanović, Aleksandra A., Đorđević, Verica, Zdunić, Gordana, Šavikin, Katarina P., Trifković, Kata, Jovanović, Jelena R., Nedović, Viktor, Bugarski, Branko M., "Ultrasound Extraction of Polyphenolic Compounds from Thymus serpyllum" in 29th EFFoST International Conference, Food Science Research and Innovation: Delivering sustainable solutions to the global economy and society (2015),
https://hdl.handle.net/21.15107/rcub_technorep_6444 .

TY  - CONF
AU  - Jovanović, Aleksandra A.
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina
AU  - Pravilović, Radoslava
AU  - Đorđević, Verica
AU  - Isailović, Bojana
AU  - Bugarski, Branko
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6445
AB  - Wild Thyme (Thymus serpyllum) is perennial, herbaceous plant of Lamiaceae family. It has
aromatic, antioxidant, antiseptic, anthelmintic, repelent, antirheumatic, expectorant,
antispasmotic, carminative, sedative and diuretic properties. Optimization of the extraction by
maceration of T. serpyllum was carried out through varying degrees of fragmentation (0.3, 0.7
and 1.5) and the type of solvent (water, ethanol and mixtures of those in weight ratio 50:50 and
70:30). Extraction efficiency was expressed via total polyphenols content and antioxidant
activity. The highest total polyphenols content and antioxidant activity were recorded in 50%
ethanolic extract, with a degree of fragmentation of 0.3, 921,51 mg GA/g DW and 0,538 mM
Trolox/g DW, respectively. No significant differences were observed between total polyphenols
and antioxidant activity in water and in 70% ethanolic extracts. The lowest total polyphenols
content and antioxidant activity were obtained in 96% ethanolic extract (70.73 mg GA/g DW and
0,142 mM Trolox/g DW, respectively).
PB  - Faculty of Technology, Zvornik
C3  - IV International Congress of Engineering, Environment and Materials in Processing Industry
T1  - Effects of solvent and degree of fragmentation on total polyphenols and antioxidant activity of Thymus serpyllum extracts
EP  - 459
SP  - 453
DO  - 10.7251/EEMSR1501453
ER  - 

@conference{
author = "Jovanović, Aleksandra A. and Zdunić, Gordana and Šavikin, Katarina and Pravilović, Radoslava and Đorđević, Verica and Isailović, Bojana and Bugarski, Branko",
year = "2015",
abstract = "Wild Thyme (Thymus serpyllum) is perennial, herbaceous plant of Lamiaceae family. It has
aromatic, antioxidant, antiseptic, anthelmintic, repelent, antirheumatic, expectorant,
antispasmotic, carminative, sedative and diuretic properties. Optimization of the extraction by
maceration of T. serpyllum was carried out through varying degrees of fragmentation (0.3, 0.7
and 1.5) and the type of solvent (water, ethanol and mixtures of those in weight ratio 50:50 and
70:30). Extraction efficiency was expressed via total polyphenols content and antioxidant
activity. The highest total polyphenols content and antioxidant activity were recorded in 50%
ethanolic extract, with a degree of fragmentation of 0.3, 921,51 mg GA/g DW and 0,538 mM
Trolox/g DW, respectively. No significant differences were observed between total polyphenols
and antioxidant activity in water and in 70% ethanolic extracts. The lowest total polyphenols
content and antioxidant activity were obtained in 96% ethanolic extract (70.73 mg GA/g DW and
0,142 mM Trolox/g DW, respectively).",
publisher = "Faculty of Technology, Zvornik",
journal = "IV International Congress of Engineering, Environment and Materials in Processing Industry",
title = "Effects of solvent and degree of fragmentation on total polyphenols and antioxidant activity of Thymus serpyllum extracts",
pages = "459-453",
doi = "10.7251/EEMSR1501453"
}

Jovanović, A. A., Zdunić, G., Šavikin, K., Pravilović, R., Đorđević, V., Isailović, B.,& Bugarski, B.. (2015). Effects of solvent and degree of fragmentation on total polyphenols and antioxidant activity of Thymus serpyllum extracts. in IV International Congress of Engineering, Environment and Materials in Processing Industry
Faculty of Technology, Zvornik., 453-459.
https://doi.org/10.7251/EEMSR1501453

Jovanović AA, Zdunić G, Šavikin K, Pravilović R, Đorđević V, Isailović B, Bugarski B. Effects of solvent and degree of fragmentation on total polyphenols and antioxidant activity of Thymus serpyllum extracts. in IV International Congress of Engineering, Environment and Materials in Processing Industry. 2015;:453-459.
doi:10.7251/EEMSR1501453 .

Jovanović, Aleksandra A., Zdunić, Gordana, Šavikin, Katarina, Pravilović, Radoslava, Đorđević, Verica, Isailović, Bojana, Bugarski, Branko, "Effects of solvent and degree of fragmentation on total polyphenols and antioxidant activity of Thymus serpyllum extracts" in IV International Congress of Engineering, Environment and Materials in Processing Industry (2015):453-459,
https://doi.org/10.7251/EEMSR1501453 . .