Bjelović, Miloš

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23a0d720-3f99-4961-ba48-e932b4c643bb
  • Bjelović, Miloš (2)
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Author's Bibliography

Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release

Milosević, Miljan; Stojanović, Dušica; Simić, Vladimir; Grković, Mirjana; Bjelović, Miloš; Uskoković, Petar; Kojić, Miloš

(Nature Publishing Group, London, 2020)

TY  - JOUR
AU  - Milosević, Miljan
AU  - Stojanović, Dušica
AU  - Simić, Vladimir
AU  - Grković, Mirjana
AU  - Bjelović, Miloš
AU  - Uskoković, Petar
AU  - Kojić, Miloš
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4388
AB  - The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
IS  - 1
VL  - 10
DO  - 10.1038/s41598-020-68117-9
ER  - 
@article{
author = "Milosević, Miljan and Stojanović, Dušica and Simić, Vladimir and Grković, Mirjana and Bjelović, Miloš and Uskoković, Petar and Kojić, Miloš",
year = "2020",
abstract = "The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release",
number = "1",
volume = "10",
doi = "10.1038/s41598-020-68117-9"
}
Milosević, M., Stojanović, D., Simić, V., Grković, M., Bjelović, M., Uskoković, P.,& Kojić, M.. (2020). Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release. in Scientific Reports
Nature Publishing Group, London., 10(1).
https://doi.org/10.1038/s41598-020-68117-9
Milosević M, Stojanović D, Simić V, Grković M, Bjelović M, Uskoković P, Kojić M. Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release. in Scientific Reports. 2020;10(1).
doi:10.1038/s41598-020-68117-9 .
Milosević, Miljan, Stojanović, Dušica, Simić, Vladimir, Grković, Mirjana, Bjelović, Miloš, Uskoković, Petar, Kojić, Miloš, "Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release" in Scientific Reports, 10, no. 1 (2020),
https://doi.org/10.1038/s41598-020-68117-9 . .
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Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers

Grković, Mirjana; Stojanović, Dušica; Pavlović, Vladimir B.; Rajilić-Stojanović, Mirjana; Bjelović, Miloš; Uskoković, Petar

(Elsevier Sci Ltd, Oxford, 2017)

TY  - JOUR
AU  - Grković, Mirjana
AU  - Stojanović, Dušica
AU  - Pavlović, Vladimir B.
AU  - Rajilić-Stojanović, Mirjana
AU  - Bjelović, Miloš
AU  - Uskoković, Petar
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3558
AB  - In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.
PB  - Elsevier Sci Ltd, Oxford
T2  - Composites Part B-Engineering
T1  - Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers
EP  - 67
SP  - 58
VL  - 121
DO  - 10.1016/j.compositesb.2017.03.024
ER  - 
@article{
author = "Grković, Mirjana and Stojanović, Dušica and Pavlović, Vladimir B. and Rajilić-Stojanović, Mirjana and Bjelović, Miloš and Uskoković, Petar",
year = "2017",
abstract = "In this study conditions for green crosslinking with citric acid of chitosan/PEO (polyethylene oxide) nanofibers were evaluated. The thermal in situ crosslinking enabled penetration of crosslinking agent into the matrix providing an improvement of antibacterial activity, thermal stability and mechanical properties of the prepared material. With an increase of temperature above 80 degrees C antibacterial activity against Staphylococcus aureus and Escherichia coil, inversely decreased. Moreover crosslinking provided prolonged controlled drug release with outstanding increase of mechanical properties observed by nanoindentation measurements. Results of the investigation indicated crosslinking as an important parameter for producing material with multifunctional characteristics suitable for drug delivery and tissue engineering.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Composites Part B-Engineering",
title = "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers",
pages = "67-58",
volume = "121",
doi = "10.1016/j.compositesb.2017.03.024"
}
Grković, M., Stojanović, D., Pavlović, V. B., Rajilić-Stojanović, M., Bjelović, M.,& Uskoković, P.. (2017). Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering
Elsevier Sci Ltd, Oxford., 121, 58-67.
https://doi.org/10.1016/j.compositesb.2017.03.024
Grković M, Stojanović D, Pavlović VB, Rajilić-Stojanović M, Bjelović M, Uskoković P. Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers. in Composites Part B-Engineering. 2017;121:58-67.
doi:10.1016/j.compositesb.2017.03.024 .
Grković, Mirjana, Stojanović, Dušica, Pavlović, Vladimir B., Rajilić-Stojanović, Mirjana, Bjelović, Miloš, Uskoković, Petar, "Improvement of mechanical properties and antibacterial activity of crosslinked electrospun chitosan/poly (ethylene oxide) nanofibers" in Composites Part B-Engineering, 121 (2017):58-67,
https://doi.org/10.1016/j.compositesb.2017.03.024 . .
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