TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša
AU  - Nikolić, Vesna
AU  - Petrović, Slobodan
AU  - Oro, Violeta
AU  - Mitić, Žarko
AU  - Najman, Stevo
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4899
AB  - In this study, poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate) hydrogels were synthesized using free radical initiated copolymerization method. Four hydrogels with different cross-linker concentrations were prepared. Semi-crystalline, cross-linked copolymer networks were confirmed by FTIR, SEM and XRD analysis. Variation of swelling behaviour was monitored gravimetrically and thermo-responsiveness has been noticed. An application of synthesized thermo-responsive hydrogels as carriers for the modulated release of anti-inflammatory model drug was investigated. Moreover, naproxen loading into these hydrogels was also determined using FTIR, SEM and XRD techniques and release was analyzed using HPLC method at simulated physiological conditions. Swelling kinetic and mechanism of water transport, as well as diffusion of naproxen through the hydrogels were analyzed. Thus, the aim of this work was to study various compositions of obtained hydrogels and their possibility of application as a thermo-responsive carrier for prolonged naproxen release in order to evaluate as a potential candidate for drug carrier in future pharmaceutical applications.
T2  - Pharmaceutics
T1  - Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study
IS  - 2
VL  - 13
DO  - 10.3390/pharmaceutics13020158
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša and Nikolić, Vesna and Petrović, Slobodan and Oro, Violeta and Mitić, Žarko and Najman, Stevo",
year = "2021",
abstract = "In this study, poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate) hydrogels were synthesized using free radical initiated copolymerization method. Four hydrogels with different cross-linker concentrations were prepared. Semi-crystalline, cross-linked copolymer networks were confirmed by FTIR, SEM and XRD analysis. Variation of swelling behaviour was monitored gravimetrically and thermo-responsiveness has been noticed. An application of synthesized thermo-responsive hydrogels as carriers for the modulated release of anti-inflammatory model drug was investigated. Moreover, naproxen loading into these hydrogels was also determined using FTIR, SEM and XRD techniques and release was analyzed using HPLC method at simulated physiological conditions. Swelling kinetic and mechanism of water transport, as well as diffusion of naproxen through the hydrogels were analyzed. Thus, the aim of this work was to study various compositions of obtained hydrogels and their possibility of application as a thermo-responsive carrier for prolonged naproxen release in order to evaluate as a potential candidate for drug carrier in future pharmaceutical applications.",
journal = "Pharmaceutics",
title = "Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study",
number = "2",
volume = "13",
doi = "10.3390/pharmaceutics13020158"
}

Ilić-Stojanović, S., Nikolić, L., Nikolić, V., Petrović, S., Oro, V., Mitić, Ž.,& Najman, S.. (2021). Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study. in Pharmaceutics, 13(2).
https://doi.org/10.3390/pharmaceutics13020158

Ilić-Stojanović S, Nikolić L, Nikolić V, Petrović S, Oro V, Mitić Ž, Najman S. Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study. in Pharmaceutics. 2021;13(2).
doi:10.3390/pharmaceutics13020158 .

Ilić-Stojanović, Snežana, Nikolić, Ljubiša, Nikolić, Vesna, Petrović, Slobodan, Oro, Violeta, Mitić, Žarko, Najman, Stevo, "Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study" in Pharmaceutics, 13, no. 2 (2021),
https://doi.org/10.3390/pharmaceutics13020158 . .

TY  - JOUR
AU  - Nikolic, L
AU  - Skala, Dejan
AU  - Nikolić, Vladimir M.
AU  - Stamenkovic, J
AU  - Babić, Dragan
AU  - Ilic-Stojanovic, S
PY  - 2004
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5403
AB  - In this work the synthesis of a crosslinked macroporous copolymer was effected from methyl methacrylate and acrylamide. The synthesis process began with emulsion prepolymerization, followed by sol-gel copolymerization until a hard block was obtained. Determination of the properties of the obtained material was carried out by FTIR, mercury porosimetry, and SEM microscopy. The material was characterized by a porous structure with open pores. The macroporous copolymer obtained can be used for polymer-analog reactions and the transformation of amide and ester groups into acyl azide groups. It can be used as a hard inert support for the immobilization of enzymes, or other proteins, by condensation of acyl azide group on poly-mer with the free amino group from the base amino acid of enzyme/protein. For the immobilization of microorganisms it can be used by vacuum diffusion of microorganism suspension into the porous structure, without active group transformation reactions. With microorganisms in the polymer pores, microorganism colonies form within the copolymer by microbial fermentation. (C) 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 387-395, 2004.
T2  - Journal of Applied Polymer Science
T1  - Methyl methacrylate and acrylamide crosslinked macroporous copolymers
EP  - 395
IS  - 1
SP  - 387
VL  - 91
DO  - 10.1002/app.13113
ER  - 

@article{
author = "Nikolic, L and Skala, Dejan and Nikolić, Vladimir M. and Stamenkovic, J and Babić, Dragan and Ilic-Stojanovic, S",
year = "2004",
abstract = "In this work the synthesis of a crosslinked macroporous copolymer was effected from methyl methacrylate and acrylamide. The synthesis process began with emulsion prepolymerization, followed by sol-gel copolymerization until a hard block was obtained. Determination of the properties of the obtained material was carried out by FTIR, mercury porosimetry, and SEM microscopy. The material was characterized by a porous structure with open pores. The macroporous copolymer obtained can be used for polymer-analog reactions and the transformation of amide and ester groups into acyl azide groups. It can be used as a hard inert support for the immobilization of enzymes, or other proteins, by condensation of acyl azide group on poly-mer with the free amino group from the base amino acid of enzyme/protein. For the immobilization of microorganisms it can be used by vacuum diffusion of microorganism suspension into the porous structure, without active group transformation reactions. With microorganisms in the polymer pores, microorganism colonies form within the copolymer by microbial fermentation. (C) 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 387-395, 2004.",
journal = "Journal of Applied Polymer Science",
title = "Methyl methacrylate and acrylamide crosslinked macroporous copolymers",
pages = "395-387",
number = "1",
volume = "91",
doi = "10.1002/app.13113"
}

Nikolic, L., Skala, D., Nikolić, V. M., Stamenkovic, J., Babić, D.,& Ilic-Stojanovic, S.. (2004). Methyl methacrylate and acrylamide crosslinked macroporous copolymers. in Journal of Applied Polymer Science, 91(1), 387-395.
https://doi.org/10.1002/app.13113

Nikolic L, Skala D, Nikolić VM, Stamenkovic J, Babić D, Ilic-Stojanovic S. Methyl methacrylate and acrylamide crosslinked macroporous copolymers. in Journal of Applied Polymer Science. 2004;91(1):387-395.
doi:10.1002/app.13113 .

Nikolic, L, Skala, Dejan, Nikolić, Vladimir M., Stamenkovic, J, Babić, Dragan, Ilic-Stojanovic, S, "Methyl methacrylate and acrylamide crosslinked macroporous copolymers" in Journal of Applied Polymer Science, 91, no. 1 (2004):387-395,
https://doi.org/10.1002/app.13113 . .