Avramov-Ivić, Milka

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Authority KeyName Variants
orcid::0000-0001-6127-1216
  • Avramov-Ivić, Milka (54)
  • Avramov Ivić, Milka (2)
Projects
Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds New approach in designing materials for energy conversion and energy storage systems
Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200135 (University of Belgrade, Faculty of Technology and Metallurgy) CEEPUSIII network [CZ-0212-09-1516]
CEEPUSIII network [CZ-0212-131920] Development and Application of Methods and Materials for Monitoring New Organic Contaminants, Toxic Compounds and Heavy Metals
Sustainable and green chemistry approach for environmental friendly analytical methods and energy storage Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200125 (University of Novi Sad, Faculty of Science) Synthesis, processing and applications of nanostructured multifunctional materials with defined properties
Reinforcing of Nanotechnology and Functional Materials Centre Modeling and Numerical Simulations of Complex Many-Body Systems
Design, synthesis, characterization and assessment of practical applications of coordination and organometallic compounds Electrochemical synthesis and characterization of nanostructured functional materials for application in new technologies
Noncovalent interactions of pi-systems and their role in molecular recognition Biomarkers of organ damage and dysfunction
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200287 (Innovation Center of the Faculty of Technology and Metallurgy) Development of embedded systems with connected services and digital technology
Magnetic and radionuclide labeled nanostructured materials for medical applications Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness
Ministry of Science and Environmental Protection of Serbia for financial support (Project 1694). Research Fund of Serbia, Belgrade, Yugoslavia is gratefully acknowledged. We would also like to thank Dr N. Anastasijevic for helpful discussions leading to improvements of the manuscript.

Author's Bibliography

Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study

Mašulović, Aleksandra; Lović, Jelena D.; Lađarević, Jelena; Vitnik, Vesna; Vitnik, Željko; Avramov Ivić, Milka; Mijin, Dušan

(MDPI, 2023)

TY  - JOUR
AU  - Mašulović, Aleksandra
AU  - Lović, Jelena D.
AU  - Lađarević, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6601
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6686
AB  - In this work, the electrooxidation ability of nine pyridones was evaluated using cyclic(CV) and square-wave voltammetry (SWV) in Britton–Robinson (BR) aqueous buffer solutions on aglassy carbon electrode (GC). The dependence of electrochemical activity on pyridone structure waselucidated by means of experimentally obtained spectra and quantum chemical calculations. Firstly, itwas shown that electrochemical activity is determined by the –OH group as a substituent in position6 of the pyridone ring. By coupling the experimentally obtained UV-Vis spectra and DFT calculations,the most stable forms, both protonated and deprotonated, were defined. The calculated values areconsistent with the electrochemical behavior observed, indicating that the deprotonated anionic formwas the most electrochemically active. Moreover, the impact of the substituent in position 3 of thepyridone scaffold was discussed
PB  - MDPI
T2  - Applied Sciences
T1  - Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study
IS  - 18
SP  - 10276
VL  - 13
DO  - 10.3390/app131810276
ER  - 
@article{
author = "Mašulović, Aleksandra and Lović, Jelena D. and Lađarević, Jelena and Vitnik, Vesna and Vitnik, Željko and Avramov Ivić, Milka and Mijin, Dušan",
year = "2023",
abstract = "In this work, the electrooxidation ability of nine pyridones was evaluated using cyclic(CV) and square-wave voltammetry (SWV) in Britton–Robinson (BR) aqueous buffer solutions on aglassy carbon electrode (GC). The dependence of electrochemical activity on pyridone structure waselucidated by means of experimentally obtained spectra and quantum chemical calculations. Firstly, itwas shown that electrochemical activity is determined by the –OH group as a substituent in position6 of the pyridone ring. By coupling the experimentally obtained UV-Vis spectra and DFT calculations,the most stable forms, both protonated and deprotonated, were defined. The calculated values areconsistent with the electrochemical behavior observed, indicating that the deprotonated anionic formwas the most electrochemically active. Moreover, the impact of the substituent in position 3 of thepyridone scaffold was discussed",
publisher = "MDPI",
journal = "Applied Sciences",
title = "Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study",
number = "18",
pages = "10276",
volume = "13",
doi = "10.3390/app131810276"
}
Mašulović, A., Lović, J. D., Lađarević, J., Vitnik, V., Vitnik, Ž., Avramov Ivić, M.,& Mijin, D.. (2023). Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study. in Applied Sciences
MDPI., 13(18), 10276.
https://doi.org/10.3390/app131810276
Mašulović A, Lović JD, Lađarević J, Vitnik V, Vitnik Ž, Avramov Ivić M, Mijin D. Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study. in Applied Sciences. 2023;13(18):10276.
doi:10.3390/app131810276 .
Mašulović, Aleksandra, Lović, Jelena D., Lađarević, Jelena, Vitnik, Vesna, Vitnik, Željko, Avramov Ivić, Milka, Mijin, Dušan, "Structure-Dependent Electrochemical Behavior of 2-Pyridone Derivatives: A Combined Experimental and Theoretical Study" in Applied Sciences, 13, no. 18 (2023):10276,
https://doi.org/10.3390/app131810276 . .

Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation

Lović, Jelena; Bogdanović, Aleksandra; Tadić, Vanja; Mijin, Dušan; Vuković, Dragan; Petrović, Slobodan D.; Avramov-Ivić, Milka

(The Electrochemical Society, 2022)

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov-Ivić, Milka
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5191
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
IS  - 7
SP  - 076507
VL  - 169
DO  - 10.1149/1945-7111/ac7e74
ER  - 
@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov-Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DULstandard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidationat the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standardconcentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DULconcentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons andelectrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes wereproposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DULquantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquidchromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
number = "7",
pages = "076507",
volume = "169",
doi = "10.1149/1945-7111/ac7e74"
}
Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov-Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society., 169(7), 076507.
https://doi.org/10.1149/1945-7111/ac7e74
Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov-Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;169(7):076507.
doi:10.1149/1945-7111/ac7e74 .
Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov-Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society, 169, no. 7 (2022):076507,
https://doi.org/10.1149/1945-7111/ac7e74 . .
1

Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode

Lović, Jelena; Bogdanović, Aleksandra; Mijin, Dušan; Vuković, Dragan; Petrović, Slobodan; Avramov-Ivić, Milka

(ESG, 2022)

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5197
AB  - Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.
PB  - ESG
T2  - International Journal of Electrochemical Science
T1  - Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode
SP  - 220928
VL  - 17
DO  - 10.20964/2022.09.36
ER  - 
@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2022",
abstract = "Ticagrelor hydrochloride (TCG) is effective in platelet inhibition and useful for preventing cardiovascular death, myocardial infarction, or ischaemic stroke. The drug standard was investigated by cyclic voltammetry (CV) and quantitatively determined using differential pulse voltammetry (DPV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs. TCG standard concentrations in the range from 3 x 10-7 mol l-1 to 10-5 mol l-1 with the values of the limit of detection (LOD) and the limit of quantification: 0.288 μmol l-1 and 0.96 μmol l-1, respectively. Using the constructed and validated calibration curve, the values of unknown ticagrelor concentrations in Ticagrex® tablets and in human serum spiked with the standard were determined. Mechanistic study suggests that the oxidation proceeds at sulfur atom by removal of one electron as the rate determining step. In the next, fast step, formed radical cation loose another electron and sulfoxide is formed (with water molecule as nucleophile). The study of TCG degradation showed that at the Au, after 4.5 h of potential cycling, degradation occurs, which was confirmed by UV spectroscopy.",
publisher = "ESG",
journal = "International Journal of Electrochemical Science",
title = "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode",
pages = "220928",
volume = "17",
doi = "10.20964/2022.09.36"
}
Lović, J., Bogdanović, A., Mijin, D., Vuković, D., Petrović, S.,& Avramov-Ivić, M.. (2022). Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science
ESG., 17, 220928.
https://doi.org/10.20964/2022.09.36
Lović J, Bogdanović A, Mijin D, Vuković D, Petrović S, Avramov-Ivić M. Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode. in International Journal of Electrochemical Science. 2022;17:220928.
doi:10.20964/2022.09.36 .
Lović, Jelena, Bogdanović, Aleksandra, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan, Avramov-Ivić, Milka, "Ticagrelor Determination via Its Electrooxidation as the Standard, in Tablets and the Spiked Human Serum at Au Solid Electrode" in International Journal of Electrochemical Science, 17 (2022):220928,
https://doi.org/10.20964/2022.09.36 . .

Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations

Vajdle, Olga; Šekuljica, Sanja; Guzsvány, Valéria; Nagy, László; Kónya, Zoltán; Avramov-Ivić, Milka; Mijin, Dušan; Petrović, Slobodan; Anojčić, Jasmina

(Elsevier B.V., 2020)

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov-Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Anojčić, Jasmina
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4726
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.
PB  - Elsevier B.V.
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
VL  - 873
DO  - 10.1016/j.jelechem.2020.114324
ER  - 
@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov-Ivić, Milka and Mijin, Dušan and Petrović, Slobodan and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.",
publisher = "Elsevier B.V.",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
volume = "873",
doi = "10.1016/j.jelechem.2020.114324"
}
Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov-Ivić, M., Mijin, D., Petrović, S.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier B.V.., 873.
https://doi.org/10.1016/j.jelechem.2020.114324
Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov-Ivić M, Mijin D, Petrović S, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873.
doi:10.1016/j.jelechem.2020.114324 .
Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov-Ivić, Milka, Mijin, Dušan, Petrović, Slobodan, Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020),
https://doi.org/10.1016/j.jelechem.2020.114324 . .
6
17
4
16

Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations

Vajdle, Olga; Šekuljica, Sanja; Guzsvány, Valéria; Nagy, László; Kónya, Zoltán; Avramov-Ivić, Milka; Mijin, Dušan; Petrović, Slobodan; Anojčić, Jasmina

(Elsevier B.V., 2020)

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov-Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Anojčić, Jasmina
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4392
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.
PB  - Elsevier B.V.
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
SP  - 114324
VL  - 873
DO  - 10.1016/j.jelechem.2020.114324
ER  - 
@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov-Ivić, Milka and Mijin, Dušan and Petrović, Slobodan and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticics (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin cthylsuccinate (EIS), azithromycin (A7.1), clarithromycin (OA) and roxithromycin (ROX) determination. The surface of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nm diameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH  gt = 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CIA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low mu g mL(-1) concentration ranges with relative standard deviations (RSDs) lower than 6% and achieved detection limits (1.0Ds) as 0.18, 0.045, 1.43 and 0.30 mu g mL(-1) for EES, AZI, CLA and ROX, respectively. In the case of AZ1 and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPF. or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac (R) and Ilemomycine, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of H PLC-DAD measurements.",
publisher = "Elsevier B.V.",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
pages = "114324",
volume = "873",
doi = "10.1016/j.jelechem.2020.114324"
}
Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov-Ivić, M., Mijin, D., Petrović, S.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier B.V.., 873, 114324.
https://doi.org/10.1016/j.jelechem.2020.114324
Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov-Ivić M, Mijin D, Petrović S, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324.
doi:10.1016/j.jelechem.2020.114324 .
Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov-Ivić, Milka, Mijin, Dušan, Petrović, Slobodan, Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324,
https://doi.org/10.1016/j.jelechem.2020.114324 . .
6
17
4
13

Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin

Lović, Jelena; Avramov-Ivić, Milka; Božić, Bojan; Lađarević, Jelena; Mijin, Dušan

(Slovensko Kemijsko Drustvo, Ljubljana, 2019)

TY  - JOUR
AU  - Lović, Jelena
AU  - Avramov-Ivić, Milka
AU  - Božić, Bojan
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4182
AB  - The inclusion complexes of the selected, potentially biologically active, succinimides with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD) were prepared. The formation of the inclusion complexes of the investigated monophenyl and diphenyl succinimide derivatives was confirmed using attenuated total reflection (ATR) study. Their electrochemical behavior was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV) in 0.05 M NaHCO3 on a gold electrode. The stability constants for compound 1 were determined by cyclic voltammetry and calculated as K-beta CD = 350.87 M-1 and K-HP(beta CD) = 250.67 M-1. The SWV measurements reveal well defined peak at potential E-p = similar to 60 mV and the higher currents at E-p for both inclusion complex of the succinimides compared to the free compounds. The impact of chlorine atom in the phenyl moiety of succinimide derivatives on the activity in electro oxidation reaction is presented. Among the studied succinimides, according to SWV measurements, the most active is the monophenyl succinimide derivative (compound 1) in complex with beta CD. The difference of peak current of compound 1 + beta CD compared to compound 1 + HP beta CD and free compound is 6.3 and 35.2 mu A cm(-2), respectively.
PB  - Slovensko Kemijsko Drustvo, Ljubljana
T2  - Acta Chimica Slovenica
T1  - Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin
EP  - 189
IS  - 1
SP  - 182
VL  - 66
DO  - 10.17344/acsi.2018.4767
ER  - 
@article{
author = "Lović, Jelena and Avramov-Ivić, Milka and Božić, Bojan and Lađarević, Jelena and Mijin, Dušan",
year = "2019",
abstract = "The inclusion complexes of the selected, potentially biologically active, succinimides with beta-cyclodextrin (beta CD) and (2-hydroxypropyl)-beta-cyclodextrin (HP beta CD) were prepared. The formation of the inclusion complexes of the investigated monophenyl and diphenyl succinimide derivatives was confirmed using attenuated total reflection (ATR) study. Their electrochemical behavior was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV) in 0.05 M NaHCO3 on a gold electrode. The stability constants for compound 1 were determined by cyclic voltammetry and calculated as K-beta CD = 350.87 M-1 and K-HP(beta CD) = 250.67 M-1. The SWV measurements reveal well defined peak at potential E-p = similar to 60 mV and the higher currents at E-p for both inclusion complex of the succinimides compared to the free compounds. The impact of chlorine atom in the phenyl moiety of succinimide derivatives on the activity in electro oxidation reaction is presented. Among the studied succinimides, according to SWV measurements, the most active is the monophenyl succinimide derivative (compound 1) in complex with beta CD. The difference of peak current of compound 1 + beta CD compared to compound 1 + HP beta CD and free compound is 6.3 and 35.2 mu A cm(-2), respectively.",
publisher = "Slovensko Kemijsko Drustvo, Ljubljana",
journal = "Acta Chimica Slovenica",
title = "Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin",
pages = "189-182",
number = "1",
volume = "66",
doi = "10.17344/acsi.2018.4767"
}
Lović, J., Avramov-Ivić, M., Božić, B., Lađarević, J.,& Mijin, D.. (2019). Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo, Ljubljana., 66(1), 182-189.
https://doi.org/10.17344/acsi.2018.4767
Lović J, Avramov-Ivić M, Božić B, Lađarević J, Mijin D. Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin. in Acta Chimica Slovenica. 2019;66(1):182-189.
doi:10.17344/acsi.2018.4767 .
Lović, Jelena, Avramov-Ivić, Milka, Božić, Bojan, Lađarević, Jelena, Mijin, Dušan, "Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with beta-Cyclodextrin and (2-Hydroxypropyl)-beta-Cyclodextrin" in Acta Chimica Slovenica, 66, no. 1 (2019):182-189,
https://doi.org/10.17344/acsi.2018.4767 . .
2
2
2

Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes

Lović, Jelena; Lađarević, Jelena; Mijin, Dušan; Jadranin, Milka; Petrović, Slobodan; Avramov-Ivić, Milka

(Srpsko hemijsko društvo, Beograd, 2019)

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4102
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
EP  - 1327
IS  - 11
SP  - 1319
VL  - 84
DO  - 10.2298/JSC190731091L
ER  - 
@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes",
pages = "1327-1319",
number = "11",
volume = "84",
doi = "10.2298/JSC190731091L"
}
Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S.,& Avramov-Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L
Lović J, Lađarević J, Mijin D, Jadranin M, Petrović S, Avramov-Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .
Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .
2
2

Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation

Avramov-Ivić, Milka; Lović, Jelena; Stevanović, Sanja; Nikolić, Nebojša; Trišović, Nemanja; Lađarević, Jelena; Vuković, Dragan; Drmanić, Saša; Mladenović, Aleksandar R.; Jadranin, Milka; Petrović, Slobodan; Mijin, Dušan

(Elsevier Science Sa, Lausanne, 2019)

TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Vuković, Dragan
AU  - Drmanić, Saša
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4306
AB  - Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 mu g mL(-1) with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 mu g mL(-1), respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 gm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation
VL  - 848
DO  - 10.1016/j.jelechem.2019.113303
ER  - 
@article{
author = "Avramov-Ivić, Milka and Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša and Trišović, Nemanja and Lađarević, Jelena and Vuković, Dragan and Drmanić, Saša and Mladenović, Aleksandar R. and Jadranin, Milka and Petrović, Slobodan and Mijin, Dušan",
year = "2019",
abstract = "Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 mu g mL(-1) with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 mu g mL(-1), respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 gm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation",
volume = "848",
doi = "10.1016/j.jelechem.2019.113303"
}
Avramov-Ivić, M., Lović, J., Stevanović, S., Nikolić, N., Trišović, N., Lađarević, J., Vuković, D., Drmanić, S., Mladenović, A. R., Jadranin, M., Petrović, S.,& Mijin, D.. (2019). Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry
Elsevier Science Sa, Lausanne., 848.
https://doi.org/10.1016/j.jelechem.2019.113303
Avramov-Ivić M, Lović J, Stevanović S, Nikolić N, Trišović N, Lađarević J, Vuković D, Drmanić S, Mladenović AR, Jadranin M, Petrović S, Mijin D. Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry. 2019;848.
doi:10.1016/j.jelechem.2019.113303 .
Avramov-Ivić, Milka, Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša, Trišović, Nemanja, Lađarević, Jelena, Vuković, Dragan, Drmanić, Saša, Mladenović, Aleksandar R., Jadranin, Milka, Petrović, Slobodan, Mijin, Dušan, "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation" in Journal of Electroanalytical Chemistry, 848 (2019),
https://doi.org/10.1016/j.jelechem.2019.113303 . .
8
7
9

Voltammetric and Quantum Investigation of Selected Succinimides

Božić, Bojan; Lović, Jelena; Banjac, Nebojša; Vitnik, Željko; Vitnik, Vesna; Mijin, Dušan; Ušćumlić, Gordana; Avramov-Ivić, Milka

(Electrochemical Science Group, Beograd, 2018)

TY  - JOUR
AU  - Božić, Bojan
AU  - Lović, Jelena
AU  - Banjac, Nebojša
AU  - Vitnik, Željko
AU  - Vitnik, Vesna
AU  - Mijin, Dušan
AU  - Ušćumlić, Gordana
AU  - Avramov-Ivić, Milka
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3871
AB  - A series of succinimide derivatives were studied using the cyclic and square wave voltammetry. Density function theory was used in order to determinate which of the structural parameters influence the electrochemical activity. The quantum chemical calculations of the investigated succinimides were linked with the experimental electrochemical data and used to propose the oxidation mechanism. The most active among studied succinimides is 1,3-diphenylsuccinimide. The results obtained from the cyclic and square wave voltammetry and quantum chemical calculations indicate that the investigated compounds undergo oxidation by irreversible, diffusion controlled process including transfer of 1e(-) and 1 proton. The voltammetric and DFT results signify that the mechanism of electrochemical oxidation of all compounds involve the conversion of carbonyl-methyne-phenyl segment or methylene group in free radical. This conversion proceeds by the loss of one proton one electron process.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Voltammetric and Quantum Investigation of Selected Succinimides
EP  - 4297
IS  - 5
SP  - 4285
VL  - 13
DO  - 10.20964/2018.05.54
ER  - 
@article{
author = "Božić, Bojan and Lović, Jelena and Banjac, Nebojša and Vitnik, Željko and Vitnik, Vesna and Mijin, Dušan and Ušćumlić, Gordana and Avramov-Ivić, Milka",
year = "2018",
abstract = "A series of succinimide derivatives were studied using the cyclic and square wave voltammetry. Density function theory was used in order to determinate which of the structural parameters influence the electrochemical activity. The quantum chemical calculations of the investigated succinimides were linked with the experimental electrochemical data and used to propose the oxidation mechanism. The most active among studied succinimides is 1,3-diphenylsuccinimide. The results obtained from the cyclic and square wave voltammetry and quantum chemical calculations indicate that the investigated compounds undergo oxidation by irreversible, diffusion controlled process including transfer of 1e(-) and 1 proton. The voltammetric and DFT results signify that the mechanism of electrochemical oxidation of all compounds involve the conversion of carbonyl-methyne-phenyl segment or methylene group in free radical. This conversion proceeds by the loss of one proton one electron process.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Voltammetric and Quantum Investigation of Selected Succinimides",
pages = "4297-4285",
number = "5",
volume = "13",
doi = "10.20964/2018.05.54"
}
Božić, B., Lović, J., Banjac, N., Vitnik, Ž., Vitnik, V., Mijin, D., Ušćumlić, G.,& Avramov-Ivić, M.. (2018). Voltammetric and Quantum Investigation of Selected Succinimides. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 13(5), 4285-4297.
https://doi.org/10.20964/2018.05.54
Božić B, Lović J, Banjac N, Vitnik Ž, Vitnik V, Mijin D, Ušćumlić G, Avramov-Ivić M. Voltammetric and Quantum Investigation of Selected Succinimides. in International Journal of Electrochemical Science. 2018;13(5):4285-4297.
doi:10.20964/2018.05.54 .
Božić, Bojan, Lović, Jelena, Banjac, Nebojša, Vitnik, Željko, Vitnik, Vesna, Mijin, Dušan, Ušćumlić, Gordana, Avramov-Ivić, Milka, "Voltammetric and Quantum Investigation of Selected Succinimides" in International Journal of Electrochemical Science, 13, no. 5 (2018):4285-4297,
https://doi.org/10.20964/2018.05.54 . .
1
1

Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection

Avramov Ivić, Milka; Lović, Jelena; Lađarević, Jelena; Mijin, Dušan; Stevanović, Sanja; Nikolić, Nebojša; Vuković, Dragan; Petrović, Slobodan

(Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine, 2018)

TY  - CONF
AU  - Avramov Ivić, Milka
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6746
AB  - Esomeprazole has been shown to be the most effective oral PPI for controlling intragastric pH. The persistence of esomeprasole in environmental systems could be solved by different types of its degradation. In this work electrocatalytic degradation of esomeprasole has been investigated in the presence of sodium sulfate and sodium chloride using IrOx electrode and was monitored using UV-Vis spectrophotometer at 303 nm. Also the electro degradation process was examined and on Au electrode. NanoScope III A (Veeco, USA) microscope was used to study the morphology of Esomeprazole on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface was studied as well.
AB  - Ezomeprazol je poznat kao najefikasniji lek , tj. inhibitor protonske pumpe u
kontroli intragastricne vrednosti pH. Njegovo prisustvo u vodenim tokovima i
zemljištu se resava osmišljavanjem novih postupaka degradacije. U ovom radu
elektrokatalitiþka degradacija ezomeprazola je prouþavana u natrijum sulfatu i
natrijum hloridu na IrOx elektrodi. Reakcija je praüena korišüenjem UV-Vis
spektrofotometra na 303 nm. Takoÿe je prouþavana degradacija ezomeprazola
na elektrodi od zlata. NanoScope III A (Veeco, USA) mikroskop je korišüen u
prouþavanju morfologije ezomeprazola na površini eelektrode od zlata
mikroskopijom mneÿuatomskih sila. Optiþkom mikroskopijom je ispitivana
morfologija ezomeprazola na površini eelektrode od zlata u prisustvu humanog
seruma.
PB  - Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine
C3  - Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine
T1  - Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection
T1  - Elektrohemijska degradacija esomeprazola na različitim elektrodama u cilju zaštite životne sredine
EP  - 65
SP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6746
ER  - 
@conference{
author = "Avramov Ivić, Milka and Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Stevanović, Sanja and Nikolić, Nebojša and Vuković, Dragan and Petrović, Slobodan",
year = "2018",
abstract = "Esomeprazole has been shown to be the most effective oral PPI for controlling intragastric pH. The persistence of esomeprasole in environmental systems could be solved by different types of its degradation. In this work electrocatalytic degradation of esomeprasole has been investigated in the presence of sodium sulfate and sodium chloride using IrOx electrode and was monitored using UV-Vis spectrophotometer at 303 nm. Also the electro degradation process was examined and on Au electrode. NanoScope III A (Veeco, USA) microscope was used to study the morphology of Esomeprazole on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface was studied as well., Ezomeprazol je poznat kao najefikasniji lek , tj. inhibitor protonske pumpe u
kontroli intragastricne vrednosti pH. Njegovo prisustvo u vodenim tokovima i
zemljištu se resava osmišljavanjem novih postupaka degradacije. U ovom radu
elektrokatalitiþka degradacija ezomeprazola je prouþavana u natrijum sulfatu i
natrijum hloridu na IrOx elektrodi. Reakcija je praüena korišüenjem UV-Vis
spektrofotometra na 303 nm. Takoÿe je prouþavana degradacija ezomeprazola
na elektrodi od zlata. NanoScope III A (Veeco, USA) mikroskop je korišüen u
prouþavanju morfologije ezomeprazola na površini eelektrode od zlata
mikroskopijom mneÿuatomskih sila. Optiþkom mikroskopijom je ispitivana
morfologija ezomeprazola na površini eelektrode od zlata u prisustvu humanog
seruma.",
publisher = "Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine",
journal = "Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine",
title = "Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection, Elektrohemijska degradacija esomeprazola na različitim elektrodama u cilju zaštite životne sredine",
pages = "65-61",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6746"
}
Avramov Ivić, M., Lović, J., Lađarević, J., Mijin, D., Stevanović, S., Nikolić, N., Vuković, D.,& Petrović, S.. (2018). Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection. in Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine
Podgorica : Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine., 61-65.
https://hdl.handle.net/21.15107/rcub_technorep_6746
Avramov Ivić M, Lović J, Lađarević J, Mijin D, Stevanović S, Nikolić N, Vuković D, Petrović S. Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection. in Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine. 2018;:61-65.
https://hdl.handle.net/21.15107/rcub_technorep_6746 .
Avramov Ivić, Milka, Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Stevanović, Sanja, Nikolić, Nebojša, Vuković, Dragan, Petrović, Slobodan, "Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection" in Knjiga radova / Četvrti Međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara = Proceedings / Fourth International symposium on corrosion and materials protection, environmental protection and protection against fire, Bar, 18-21. septembar 2018. godine (2018):61-65,
https://hdl.handle.net/21.15107/rcub_technorep_6746 .

Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode

Lović, Jelena; Stevanović, Sanja; Anđelković, Boban D.; Petrović, Slobodan; Vuković, Dragan; Prlainović, Nevena; Mijin, Dušan; Nikolić, Nebojša; Avramov-Ivić, Milka

(Electrochemical Science Group, Beograd, 2018)

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Anđelković, Boban D.
AU  - Petrović, Slobodan
AU  - Vuković, Dragan
AU  - Prlainović, Nevena
AU  - Mijin, Dušan
AU  - Nikolić, Nebojša
AU  - Avramov-Ivić, Milka
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3907
AB  - Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode
EP  - 12348
IS  - 12
SP  - 12340
VL  - 13
DO  - 10.20964/2018.12.59
ER  - 
@article{
author = "Lović, Jelena and Stevanović, Sanja and Anđelković, Boban D. and Petrović, Slobodan and Vuković, Dragan and Prlainović, Nevena and Mijin, Dušan and Nikolić, Nebojša and Avramov-Ivić, Milka",
year = "2018",
abstract = "Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode",
pages = "12348-12340",
number = "12",
volume = "13",
doi = "10.20964/2018.12.59"
}
Lović, J., Stevanović, S., Anđelković, B. D., Petrović, S., Vuković, D., Prlainović, N., Mijin, D., Nikolić, N.,& Avramov-Ivić, M.. (2018). Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 13(12), 12340-12348.
https://doi.org/10.20964/2018.12.59
Lović J, Stevanović S, Anđelković BD, Petrović S, Vuković D, Prlainović N, Mijin D, Nikolić N, Avramov-Ivić M. Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science. 2018;13(12):12340-12348.
doi:10.20964/2018.12.59 .
Lović, Jelena, Stevanović, Sanja, Anđelković, Boban D., Petrović, Slobodan, Vuković, Dragan, Prlainović, Nevena, Mijin, Dušan, Nikolić, Nebojša, Avramov-Ivić, Milka, "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode" in International Journal of Electrochemical Science, 13, no. 12 (2018):12340-12348,
https://doi.org/10.20964/2018.12.59 . .
7
1
7

Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution

Lović, Jelena; Trišović, Nemanja; Antanasijević, Jelena; Avramov-Ivić, Milka

(Int Assoc Physical Chemists-Iapc, Zagreb, 2018)

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijević, Jelena
AU  - Avramov-Ivić, Milka
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4009
AB  - Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (AulCys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10(-3), 10(-2) 0.1, 0.5, 1 mu M and on Au/Cys in a range: 10(-3), 10(-2) 0.05, 0.1 mu M. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.
PB  - Int Assoc Physical Chemists-Iapc, Zagreb
T2  - Journal of Electrochemical Science and Engineering
T1  - Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution
EP  - 170
IS  - 2
SP  - 163
VL  - 8
DO  - 10.5599/jese.481
ER  - 
@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijević, Jelena and Avramov-Ivić, Milka",
year = "2018",
abstract = "Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (AulCys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10(-3), 10(-2) 0.1, 0.5, 1 mu M and on Au/Cys in a range: 10(-3), 10(-2) 0.05, 0.1 mu M. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.",
publisher = "Int Assoc Physical Chemists-Iapc, Zagreb",
journal = "Journal of Electrochemical Science and Engineering",
title = "Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution",
pages = "170-163",
number = "2",
volume = "8",
doi = "10.5599/jese.481"
}
Lović, J., Trišović, N., Antanasijević, J.,& Avramov-Ivić, M.. (2018). Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution. in Journal of Electrochemical Science and Engineering
Int Assoc Physical Chemists-Iapc, Zagreb., 8(2), 163-170.
https://doi.org/10.5599/jese.481
Lović J, Trišović N, Antanasijević J, Avramov-Ivić M. Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution. in Journal of Electrochemical Science and Engineering. 2018;8(2):163-170.
doi:10.5599/jese.481 .
Lović, Jelena, Trišović, Nemanja, Antanasijević, Jelena, Avramov-Ivić, Milka, "Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution" in Journal of Electrochemical Science and Engineering, 8, no. 2 (2018):163-170,
https://doi.org/10.5599/jese.481 . .
3
3

Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode

Lović, Jelena; Stevanović, Sanja; Nikolić, Nebojša; Petrović, Slobodan; Vuković, Dragan; Prlainović, Nevena; Mijin, Dušan; Avramov-Ivić, Milka

(Electrochemical Science Group, Beograd, 2017)

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša
AU  - Petrović, Slobodan
AU  - Vuković, Dragan
AU  - Prlainović, Nevena
AU  - Mijin, Dušan
AU  - Avramov-Ivić, Milka
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3570
AB  - The method to develop a stable glucose biosensor with successive attachment of cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is presented. The cyclic voltammetry (CV) suggests the diffusion control of the glucose oxidation. The obtained biosensor shows a fast electron transfer of k(0) = 20.4 s(-1), high affinity for glucose with the apparent MichaelisMenten constant K-M(app) = 1.15 mM, a low detection limit of 0.94 mM in a linear range 1.5-7 mM. This biosensor exhibits good stability and reproducibility. Good biocompatibility of modified electrode surface, which enhances the covalent bonded enzyme and consequently glucose oxidation, resulted in biosensor with excellent performances. Biosensor was tested in samples containing human serum.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode
EP  - 5817
IS  - 7
SP  - 5806
VL  - 12
DO  - 10.20964/2017.07.65
ER  - 
@article{
author = "Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša and Petrović, Slobodan and Vuković, Dragan and Prlainović, Nevena and Mijin, Dušan and Avramov-Ivić, Milka",
year = "2017",
abstract = "The method to develop a stable glucose biosensor with successive attachment of cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is presented. The cyclic voltammetry (CV) suggests the diffusion control of the glucose oxidation. The obtained biosensor shows a fast electron transfer of k(0) = 20.4 s(-1), high affinity for glucose with the apparent MichaelisMenten constant K-M(app) = 1.15 mM, a low detection limit of 0.94 mM in a linear range 1.5-7 mM. This biosensor exhibits good stability and reproducibility. Good biocompatibility of modified electrode surface, which enhances the covalent bonded enzyme and consequently glucose oxidation, resulted in biosensor with excellent performances. Biosensor was tested in samples containing human serum.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode",
pages = "5817-5806",
number = "7",
volume = "12",
doi = "10.20964/2017.07.65"
}
Lović, J., Stevanović, S., Nikolić, N., Petrović, S., Vuković, D., Prlainović, N., Mijin, D.,& Avramov-Ivić, M.. (2017). Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 12(7), 5806-5817.
https://doi.org/10.20964/2017.07.65
Lović J, Stevanović S, Nikolić N, Petrović S, Vuković D, Prlainović N, Mijin D, Avramov-Ivić M. Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode. in International Journal of Electrochemical Science. 2017;12(7):5806-5817.
doi:10.20964/2017.07.65 .
Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša, Petrović, Slobodan, Vuković, Dragan, Prlainović, Nevena, Mijin, Dušan, Avramov-Ivić, Milka, "Glucose Sensing Using Glucose Oxidase-GlutaraldehydeCysteine Modified Gold Electrode" in International Journal of Electrochemical Science, 12, no. 7 (2017):5806-5817,
https://doi.org/10.20964/2017.07.65 . .
13
6
12

Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis

Radosavljević, Kristina D.; Lović, Jelena; Mijin, Dušan; Petrović, Slobodan; Jadranin, Milka; Mladenović, Aleksandar R.; Avramov-Ivić, Milka

(Springer International Publishing Ag, Cham, 2017)

TY  - JOUR
AU  - Radosavljević, Kristina D.
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
AU  - Jadranin, Milka
AU  - Mladenović, Aleksandar R.
AU  - Avramov-Ivić, Milka
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3685
AB  - The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.
PB  - Springer International Publishing Ag, Cham
T2  - Chemical Papers
T1  - Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis
EP  - 1224
IS  - 7
SP  - 1217
VL  - 71
DO  - 10.1007/s11696-016-0115-2
ER  - 
@article{
author = "Radosavljević, Kristina D. and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan and Jadranin, Milka and Mladenović, Aleksandar R. and Avramov-Ivić, Milka",
year = "2017",
abstract = "The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.",
publisher = "Springer International Publishing Ag, Cham",
journal = "Chemical Papers",
title = "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis",
pages = "1224-1217",
number = "7",
volume = "71",
doi = "10.1007/s11696-016-0115-2"
}
Radosavljević, K. D., Lović, J., Mijin, D., Petrović, S., Jadranin, M., Mladenović, A. R.,& Avramov-Ivić, M.. (2017). Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers
Springer International Publishing Ag, Cham., 71(7), 1217-1224.
https://doi.org/10.1007/s11696-016-0115-2
Radosavljević KD, Lović J, Mijin D, Petrović S, Jadranin M, Mladenović AR, Avramov-Ivić M. Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers. 2017;71(7):1217-1224.
doi:10.1007/s11696-016-0115-2 .
Radosavljević, Kristina D., Lović, Jelena, Mijin, Dušan, Petrović, Slobodan, Jadranin, Milka, Mladenović, Aleksandar R., Avramov-Ivić, Milka, "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis" in Chemical Papers, 71, no. 7 (2017):1217-1224,
https://doi.org/10.1007/s11696-016-0115-2 . .
10
8
11

Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode

Vajdle, Olga; Guzsvány, Valéria; Skorić, Dušan; Csanadi, Janos; Petković, Miloš; Avramov-Ivić, Milka; Kónya, Zoltán; Petrović, Slobodan; Bobrowski, Andrzej

(Pergamon-Elsevier Science Ltd, Oxford, 2017)

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Skorić, Dušan
AU  - Csanadi, Janos
AU  - Petković, Miloš
AU  - Avramov-Ivić, Milka
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan
AU  - Bobrowski, Andrzej
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3681
AB  - The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range. During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from -0.75 V to -2.00V vs SCE, either one or two reduction peaks were obtained in the potential range from -1.5 to -1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CIA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed H-1 NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mu gmL(-1), 1.96-28.6 mu gmL(-1) and 1.48-25.9 mu gmL(-1) for AZI, CIA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mu gmL(-1), 0.05-0.99 mu gmL(-1) and 0.10-0.99 mu gmL(-1), for AZI, CIA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode
EP  - 344
SP  - 334
VL  - 229
DO  - 10.1016/j.electacta.2017.01.146
ER  - 
@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Skorić, Dušan and Csanadi, Janos and Petković, Miloš and Avramov-Ivić, Milka and Kónya, Zoltán and Petrović, Slobodan and Bobrowski, Andrzej",
year = "2017",
abstract = "The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range. During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from -0.75 V to -2.00V vs SCE, either one or two reduction peaks were obtained in the potential range from -1.5 to -1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CIA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed H-1 NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mu gmL(-1), 1.96-28.6 mu gmL(-1) and 1.48-25.9 mu gmL(-1) for AZI, CIA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mu gmL(-1), 0.05-0.99 mu gmL(-1) and 0.10-0.99 mu gmL(-1), for AZI, CIA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode",
pages = "344-334",
volume = "229",
doi = "10.1016/j.electacta.2017.01.146"
}
Vajdle, O., Guzsvány, V., Skorić, D., Csanadi, J., Petković, M., Avramov-Ivić, M., Kónya, Z., Petrović, S.,& Bobrowski, A.. (2017). Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 229, 334-344.
https://doi.org/10.1016/j.electacta.2017.01.146
Vajdle O, Guzsvány V, Skorić D, Csanadi J, Petković M, Avramov-Ivić M, Kónya Z, Petrović S, Bobrowski A. Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode. in Electrochimica Acta. 2017;229:334-344.
doi:10.1016/j.electacta.2017.01.146 .
Vajdle, Olga, Guzsvány, Valéria, Skorić, Dušan, Csanadi, Janos, Petković, Miloš, Avramov-Ivić, Milka, Kónya, Zoltán, Petrović, Slobodan, Bobrowski, Andrzej, "Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode" in Electrochimica Acta, 229 (2017):334-344,
https://doi.org/10.1016/j.electacta.2017.01.146 . .
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24
35

A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode

Avramov-Ivić, Milka; Antanasijević, Jelena; Trišović, Nemanja; Antanasijević, Davor; Lović, Jelena; Mijin, Dušan; Petrović, Slobodan

(Electrochemical Science Group, Beograd, 2016)

TY  - JOUR
AU  - Avramov-Ivić, Milka
AU  - Antanasijević, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijević, Davor
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Petrović, Slobodan
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3358
AB  - The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
PB  - Electrochemical Science Group, Beograd
T2  - International Journal of Electrochemical Science
T1  - A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode
EP  - 5951
IS  - 7
SP  - 5935
VL  - 11
DO  - 10.20964/2016.07.48
ER  - 
@article{
author = "Avramov-Ivić, Milka and Antanasijević, Jelena and Trišović, Nemanja and Antanasijević, Davor and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan",
year = "2016",
abstract = "The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.",
publisher = "Electrochemical Science Group, Beograd",
journal = "International Journal of Electrochemical Science",
title = "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode",
pages = "5951-5935",
number = "7",
volume = "11",
doi = "10.20964/2016.07.48"
}
Avramov-Ivić, M., Antanasijević, J., Trišović, N., Antanasijević, D., Lović, J., Mijin, D.,& Petrović, S.. (2016). A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science
Electrochemical Science Group, Beograd., 11(7), 5935-5951.
https://doi.org/10.20964/2016.07.48
Avramov-Ivić M, Antanasijević J, Trišović N, Antanasijević D, Lović J, Mijin D, Petrović S. A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science. 2016;11(7):5935-5951.
doi:10.20964/2016.07.48 .
Avramov-Ivić, Milka, Antanasijević, Jelena, Trišović, Nemanja, Antanasijević, Davor, Lović, Jelena, Mijin, Dušan, Petrović, Slobodan, "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode" in International Journal of Electrochemical Science, 11, no. 7 (2016):5935-5951,
https://doi.org/10.20964/2016.07.48 . .
3
7
4
9

Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals

Avramov-Ivić, Milka; Petrović, Slobodan; Mijin, Dušan

(Springer Science and Business Media LLC, 2016)

TY  - CHAP
AU  - Avramov-Ivić, Milka
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3181
AB  - Electrochemistry is rapidly growing area with a number of possible applications in the pharmaceutical analysis. Modern electrochemical methods are selective, sensitive, rapid, and provide easy techniques applicable to analyses in the pharmaceutical fi eld. It is evident that the electroanalytical techniques at varying levels of sensitivity are required to solve analytical–pharmaceutical problems. The advantages of electrochemical methods are the simple procedures of the sample preparation and in most cases lack of interferences from excipients in the pharmaceutical dosage forms.
PB  - Springer Science and Business Media LLC
T2  - Modern Aspects of Electrochemistry
T1  - Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals
EP  - 195
SP  - 89
VL  - 60
DO  - 10.1007/978-3-319-31849-3_2
ER  - 
@inbook{
author = "Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan",
year = "2016",
abstract = "Electrochemistry is rapidly growing area with a number of possible applications in the pharmaceutical analysis. Modern electrochemical methods are selective, sensitive, rapid, and provide easy techniques applicable to analyses in the pharmaceutical fi eld. It is evident that the electroanalytical techniques at varying levels of sensitivity are required to solve analytical–pharmaceutical problems. The advantages of electrochemical methods are the simple procedures of the sample preparation and in most cases lack of interferences from excipients in the pharmaceutical dosage forms.",
publisher = "Springer Science and Business Media LLC",
journal = "Modern Aspects of Electrochemistry",
booktitle = "Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals",
pages = "195-89",
volume = "60",
doi = "10.1007/978-3-319-31849-3_2"
}
Avramov-Ivić, M., Petrović, S.,& Mijin, D.. (2016). Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. in Modern Aspects of Electrochemistry
Springer Science and Business Media LLC., 60, 89-195.
https://doi.org/10.1007/978-3-319-31849-3_2
Avramov-Ivić M, Petrović S, Mijin D. Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. in Modern Aspects of Electrochemistry. 2016;60:89-195.
doi:10.1007/978-3-319-31849-3_2 .
Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, "Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals" in Modern Aspects of Electrochemistry, 60 (2016):89-195,
https://doi.org/10.1007/978-3-319-31849-3_2 . .
4

An investigation of tebuconazole degradation using a gold electrode

Lović, Jelena; Mijin, Dušan; Jovanović, Mica B.; Glavaski, Olivera; Zeremski, Tijana; Petrović, Slobodan; Avramov-Ivić, Milka

(Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, 2016)

TY  - JOUR
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Jovanović, Mica B.
AU  - Glavaski, Olivera
AU  - Zeremski, Tijana
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3350
AB  - Tebuconazole, a pesticide that presents risks for ecosystems, groundwater and human health, was degraded on a gold electrode as the catalyst in 0.05 M NaHCO3 using cyclic voltammetry (CV). First, tebuconazole was characterized on the gold electrode using CV and square wave voltammetry (SWV). The gold electrode, being highly sensitive, provided linear relationships (currents vs. concentrations) in the range: (0.076-0.76 mu mol dm(-3)). Based on the CV measurements, the investigated process is irreversible and diffusion controlled. The observed catalytic role of the Au electrode in the oxidation of tebuconazole and the data obtained from CV and SWV provided the experimental conditions for the degradation of tebuconazole. The degradation was performed by continuous cycling followed by gas chromatography mass spectroscopy (GC MS) analysis. This enabled the catalytic elimination of tebuconazole for 60 min, which promoted the use of a gold electrode as the catalyst for the degradation of environmental pollutants. The scheme of the possible mechanism of tebuconazole degradation is given.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - Comptes Rendus Chimie
T1  - An investigation of tebuconazole degradation using a gold electrode
EP  - 645
IS  - 5
SP  - 639
VL  - 19
DO  - 10.1016/j.crci.2016.01.014
ER  - 
@article{
author = "Lović, Jelena and Mijin, Dušan and Jovanović, Mica B. and Glavaski, Olivera and Zeremski, Tijana and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2016",
abstract = "Tebuconazole, a pesticide that presents risks for ecosystems, groundwater and human health, was degraded on a gold electrode as the catalyst in 0.05 M NaHCO3 using cyclic voltammetry (CV). First, tebuconazole was characterized on the gold electrode using CV and square wave voltammetry (SWV). The gold electrode, being highly sensitive, provided linear relationships (currents vs. concentrations) in the range: (0.076-0.76 mu mol dm(-3)). Based on the CV measurements, the investigated process is irreversible and diffusion controlled. The observed catalytic role of the Au electrode in the oxidation of tebuconazole and the data obtained from CV and SWV provided the experimental conditions for the degradation of tebuconazole. The degradation was performed by continuous cycling followed by gas chromatography mass spectroscopy (GC MS) analysis. This enabled the catalytic elimination of tebuconazole for 60 min, which promoted the use of a gold electrode as the catalyst for the degradation of environmental pollutants. The scheme of the possible mechanism of tebuconazole degradation is given.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "Comptes Rendus Chimie",
title = "An investigation of tebuconazole degradation using a gold electrode",
pages = "645-639",
number = "5",
volume = "19",
doi = "10.1016/j.crci.2016.01.014"
}
Lović, J., Mijin, D., Jovanović, M. B., Glavaski, O., Zeremski, T., Petrović, S.,& Avramov-Ivić, M.. (2016). An investigation of tebuconazole degradation using a gold electrode. in Comptes Rendus Chimie
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 19(5), 639-645.
https://doi.org/10.1016/j.crci.2016.01.014
Lović J, Mijin D, Jovanović MB, Glavaski O, Zeremski T, Petrović S, Avramov-Ivić M. An investigation of tebuconazole degradation using a gold electrode. in Comptes Rendus Chimie. 2016;19(5):639-645.
doi:10.1016/j.crci.2016.01.014 .
Lović, Jelena, Mijin, Dušan, Jovanović, Mica B., Glavaski, Olivera, Zeremski, Tijana, Petrović, Slobodan, Avramov-Ivić, Milka, "An investigation of tebuconazole degradation using a gold electrode" in Comptes Rendus Chimie, 19, no. 5 (2016):639-645,
https://doi.org/10.1016/j.crci.2016.01.014 . .
14
9
13

Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode

Lović, Jelena; Trišović, Nemanja; Antanasijević, Jelena; Nikolić, Nebojša; Stevanović, Sanja; Mijin, Dušan; Vuković, Dragan; Mladenović, Aleksandar R.; Petrović, Slobodan; Avramov-Ivić, Milka

(Elsevier Science Sa, Lausanne, 2016)

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijević, Jelena
AU  - Nikolić, Nebojša
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3312
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
EP  - 107
SP  - 103
VL  - 782
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 
@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijević, Jelena and Nikolić, Nebojša and Stevanović, Sanja and Mijin, Dušan and Vuković, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
pages = "107-103",
volume = "782",
doi = "10.1016/j.jelechem.2016.10.022"
}
Lović, J., Trišović, N., Antanasijević, J., Nikolić, N., Stevanović, S., Mijin, D., Vuković, D., Mladenović, A. R., Petrović, S.,& Avramov-Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier Science Sa, Lausanne., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022
Lović J, Trišović N, Antanasijević J, Nikolić N, Stevanović S, Mijin D, Vuković D, Mladenović AR, Petrović S, Avramov-Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .
Lović, Jelena, Trišović, Nemanja, Antanasijević, Jelena, Nikolić, Nebojša, Stevanović, Sanja, Mijin, Dušan, Vuković, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .
10
7
11

Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation

Vajdle, Olga; Guzsvány, Valéria; Skorić, Dušan; Anojčić, Jasmina; Jovanov, Pavle; Avramov-Ivić, Milka; Csanadi, Janos; Kónya, Zoltán; Petrović, Slobodan; Bobrowski, Andrzej

(Pergamon-Elsevier Science Ltd, Oxford, 2016)

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Skorić, Dušan
AU  - Anojčić, Jasmina
AU  - Jovanov, Pavle
AU  - Avramov-Ivić, Milka
AU  - Csanadi, Janos
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan
AU  - Bobrowski, Andrzej
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3465
AB  - Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation
EP  - 54
SP  - 44
VL  - 191
DO  - 10.1016/j.electacta.2015.12.207
ER  - 
@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Skorić, Dušan and Anojčić, Jasmina and Jovanov, Pavle and Avramov-Ivić, Milka and Csanadi, Janos and Kónya, Zoltán and Petrović, Slobodan and Bobrowski, Andrzej",
year = "2016",
abstract = "Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation",
pages = "54-44",
volume = "191",
doi = "10.1016/j.electacta.2015.12.207"
}
Vajdle, O., Guzsvány, V., Skorić, D., Anojčić, J., Jovanov, P., Avramov-Ivić, M., Csanadi, J., Kónya, Z., Petrović, S.,& Bobrowski, A.. (2016). Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 191, 44-54.
https://doi.org/10.1016/j.electacta.2015.12.207
Vajdle O, Guzsvány V, Skorić D, Anojčić J, Jovanov P, Avramov-Ivić M, Csanadi J, Kónya Z, Petrović S, Bobrowski A. Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta. 2016;191:44-54.
doi:10.1016/j.electacta.2015.12.207 .
Vajdle, Olga, Guzsvány, Valéria, Skorić, Dušan, Anojčić, Jasmina, Jovanov, Pavle, Avramov-Ivić, Milka, Csanadi, Janos, Kónya, Zoltán, Petrović, Slobodan, Bobrowski, Andrzej, "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation" in Electrochimica Acta, 191 (2016):44-54,
https://doi.org/10.1016/j.electacta.2015.12.207 . .
20
17
21

Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis

Tolić, Ljiljana; Lović, Jelena; Petrović, Slobodan; Mijin, Dušan; Grujić, Svetlana; Laušević, Mila; Avramov-Ivić, Milka

(Elsevier Science Inc, New York, 2015)

TY  - JOUR
AU  - Tolić, Ljiljana
AU  - Lović, Jelena
AU  - Petrović, Slobodan
AU  - Mijin, Dušan
AU  - Grujić, Svetlana
AU  - Laušević, Mila
AU  - Avramov-Ivić, Milka
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3148
AB  - Anisomycin is an immunosuppressant in low doses ( lt 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).
PB  - Elsevier Science Inc, New York
T2  - Electrochemistry Communications
T1  - Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis
EP  - 24
SP  - 20
VL  - 58
DO  - 10.1016/j.elecom.2015.05.017
ER  - 
@article{
author = "Tolić, Ljiljana and Lović, Jelena and Petrović, Slobodan and Mijin, Dušan and Grujić, Svetlana and Laušević, Mila and Avramov-Ivić, Milka",
year = "2015",
abstract = "Anisomycin is an immunosuppressant in low doses ( lt 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).",
publisher = "Elsevier Science Inc, New York",
journal = "Electrochemistry Communications",
title = "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis",
pages = "24-20",
volume = "58",
doi = "10.1016/j.elecom.2015.05.017"
}
Tolić, L., Lović, J., Petrović, S., Mijin, D., Grujić, S., Laušević, M.,& Avramov-Ivić, M.. (2015). Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications
Elsevier Science Inc, New York., 58, 20-24.
https://doi.org/10.1016/j.elecom.2015.05.017
Tolić L, Lović J, Petrović S, Mijin D, Grujić S, Laušević M, Avramov-Ivić M. Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications. 2015;58:20-24.
doi:10.1016/j.elecom.2015.05.017 .
Tolić, Ljiljana, Lović, Jelena, Petrović, Slobodan, Mijin, Dušan, Grujić, Svetlana, Laušević, Mila, Avramov-Ivić, Milka, "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis" in Electrochemistry Communications, 58 (2015):20-24,
https://doi.org/10.1016/j.elecom.2015.05.017 . .
3
3
2

Electrochemical characterization of phenytoin and its derivatives on bare gold electrode

Trišović, Nemanja; Božić, Bojan; Lović, Jelena; Vitnik, Vesna; Vitnik, Željko; Petrović, Slobodan; Avramov-Ivić, Milka

(Pergamon-Elsevier Science Ltd, Oxford, 2015)

TY  - JOUR
AU  - Trišović, Nemanja
AU  - Božić, Bojan
AU  - Lović, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Petrović, Slobodan
AU  - Avramov-Ivić, Milka
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2976
AB  - Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Electrochemical characterization of phenytoin and its derivatives on bare gold electrode
EP  - 387
SP  - 378
VL  - 161
DO  - 10.1016/j.electacta.2015.02.114
ER  - 
@article{
author = "Trišović, Nemanja and Božić, Bojan and Lović, Jelena and Vitnik, Vesna and Vitnik, Željko and Petrović, Slobodan and Avramov-Ivić, Milka",
year = "2015",
abstract = "Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode",
pages = "387-378",
volume = "161",
doi = "10.1016/j.electacta.2015.02.114"
}
Trišović, N., Božić, B., Lović, J., Vitnik, V., Vitnik, Ž., Petrović, S.,& Avramov-Ivić, M.. (2015). Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 161, 378-387.
https://doi.org/10.1016/j.electacta.2015.02.114
Trišović N, Božić B, Lović J, Vitnik V, Vitnik Ž, Petrović S, Avramov-Ivić M. Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta. 2015;161:378-387.
doi:10.1016/j.electacta.2015.02.114 .
Trišović, Nemanja, Božić, Bojan, Lović, Jelena, Vitnik, Vesna, Vitnik, Željko, Petrović, Slobodan, Avramov-Ivić, Milka, "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode" in Electrochimica Acta, 161 (2015):378-387,
https://doi.org/10.1016/j.electacta.2015.02.114 . .
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Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products

Mladenović, Aleksandar R.; Jadranin, Milka; Pavlović, Aleksandar D.; Petrović, Slobodan; Drmanić, Saša; Avramov-Ivić, Milka; Mijin, Dušan

(Association of the Chemical Engineers of Serbia, 2015)

TY  - JOUR
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Pavlović, Aleksandar D.
AU  - Petrović, Slobodan
AU  - Drmanić, Saša
AU  - Avramov-Ivić, Milka
AU  - Mijin, Dušan
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2927
AB  - This study describes the investigation of degradation products of donepezil (DP) using a stability-indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetyl cholinesterase inhibitor. In order to investigate the stability of the drug and formed degradation products, a forced degradation study of the drug sample and finished product under different forced degradation conditions was conducted. Donepezil hydrochloride and donepezil tablets were subjected to stress degradation conditions recommended by the International Conference on Harmonization (ICH). Donepezil hydrochloride solutions were subjected to acid and alkali hydrolysis, chemical oxidation and thermal degradation. Significant degradation was observed under alkali hydrolysis and oxidative degradation conditions. Additional degradation products were observed under the conditions of oxidative degradation. The degradation products observed during forced degradation studies were monitored using the developed high performance liquid chromatography (HPLC) method. The parent method was modified in order to obtain LC-MS compatible method, which was used to identify the degradation products from forced degradation samples using high resolution mass spectrometry. The mass spectrum provided the precise mass from which the molecular formula of the drug substance and formed degradation products was derived, and proved the specificity of the method unambiguously.
AB  - Proučavanje degradacionih proizvoda donepezila je izvršeno korišćenjem RP-HPLC metode za određivanje stabilnosti donepezila, leka koji pripada grupi reverzibilnih inhibitora acetilholinesteraze. U cilju ispitivanja stabilnosti leka i njegovih degradacionih proizvoda sprovedena je studija forsirane degradacije čiste supstance kao i farmaceutskog proizvoda pod različitim uslovima. Donepezil-hidrohlorid i donepezil tablete su podvrgnuti različitim uslovima degradacije prema preporukama Internacionalne konferencije za harmonizaciju. Rastvori donepezil-hidrohlorida su podvrgnuti kiseloj i baznoj hidrolizi, hemijskoj oksidaciji i termalnoj degradaciji. Pri baznoj hidrolizi i hemijskoj oksidaciji uočena je značajna degradacija polaznog molekula. Oksidativnom degradacijom nastaju i proizvodi koji nisu uočeni kod ostalih postupaka forsirane degradacije. Nastali proizvodi analizirani su novorazvijenom HPLC metodom. Osnovna metoda je modifikovana u cilju dobijanja LC-MS kompatibilne metode kako bi se identifikovali nastali degradacioni proizvodi. Na osnovu resultata dobijenih masenom spektrometrijom dobijene su tačne mase proizvoda degradacije, čime je omogućeno određivanje njihovih molekulskih formula.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry & Chemical Engineering Quarterly
T1  - Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products
T1  - Analiza degradacionih proizvoda donepezila primenom tečne hromatografije i tečne hromatografije-masene spektrometrije
EP  - 455
IS  - 3
SP  - 447
VL  - 21
DO  - 10.2298/CICEQ141023047M
ER  - 
@article{
author = "Mladenović, Aleksandar R. and Jadranin, Milka and Pavlović, Aleksandar D. and Petrović, Slobodan and Drmanić, Saša and Avramov-Ivić, Milka and Mijin, Dušan",
year = "2015",
abstract = "This study describes the investigation of degradation products of donepezil (DP) using a stability-indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetyl cholinesterase inhibitor. In order to investigate the stability of the drug and formed degradation products, a forced degradation study of the drug sample and finished product under different forced degradation conditions was conducted. Donepezil hydrochloride and donepezil tablets were subjected to stress degradation conditions recommended by the International Conference on Harmonization (ICH). Donepezil hydrochloride solutions were subjected to acid and alkali hydrolysis, chemical oxidation and thermal degradation. Significant degradation was observed under alkali hydrolysis and oxidative degradation conditions. Additional degradation products were observed under the conditions of oxidative degradation. The degradation products observed during forced degradation studies were monitored using the developed high performance liquid chromatography (HPLC) method. The parent method was modified in order to obtain LC-MS compatible method, which was used to identify the degradation products from forced degradation samples using high resolution mass spectrometry. The mass spectrum provided the precise mass from which the molecular formula of the drug substance and formed degradation products was derived, and proved the specificity of the method unambiguously., Proučavanje degradacionih proizvoda donepezila je izvršeno korišćenjem RP-HPLC metode za određivanje stabilnosti donepezila, leka koji pripada grupi reverzibilnih inhibitora acetilholinesteraze. U cilju ispitivanja stabilnosti leka i njegovih degradacionih proizvoda sprovedena je studija forsirane degradacije čiste supstance kao i farmaceutskog proizvoda pod različitim uslovima. Donepezil-hidrohlorid i donepezil tablete su podvrgnuti različitim uslovima degradacije prema preporukama Internacionalne konferencije za harmonizaciju. Rastvori donepezil-hidrohlorida su podvrgnuti kiseloj i baznoj hidrolizi, hemijskoj oksidaciji i termalnoj degradaciji. Pri baznoj hidrolizi i hemijskoj oksidaciji uočena je značajna degradacija polaznog molekula. Oksidativnom degradacijom nastaju i proizvodi koji nisu uočeni kod ostalih postupaka forsirane degradacije. Nastali proizvodi analizirani su novorazvijenom HPLC metodom. Osnovna metoda je modifikovana u cilju dobijanja LC-MS kompatibilne metode kako bi se identifikovali nastali degradacioni proizvodi. Na osnovu resultata dobijenih masenom spektrometrijom dobijene su tačne mase proizvoda degradacije, čime je omogućeno određivanje njihovih molekulskih formula.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry & Chemical Engineering Quarterly",
title = "Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products, Analiza degradacionih proizvoda donepezila primenom tečne hromatografije i tečne hromatografije-masene spektrometrije",
pages = "455-447",
number = "3",
volume = "21",
doi = "10.2298/CICEQ141023047M"
}
Mladenović, A. R., Jadranin, M., Pavlović, A. D., Petrović, S., Drmanić, S., Avramov-Ivić, M.,& Mijin, D.. (2015). Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products. in Chemical Industry & Chemical Engineering Quarterly
Association of the Chemical Engineers of Serbia., 21(3), 447-455.
https://doi.org/10.2298/CICEQ141023047M
Mladenović AR, Jadranin M, Pavlović AD, Petrović S, Drmanić S, Avramov-Ivić M, Mijin D. Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products. in Chemical Industry & Chemical Engineering Quarterly. 2015;21(3):447-455.
doi:10.2298/CICEQ141023047M .
Mladenović, Aleksandar R., Jadranin, Milka, Pavlović, Aleksandar D., Petrović, Slobodan, Drmanić, Saša, Avramov-Ivić, Milka, Mijin, Dušan, "Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products" in Chemical Industry & Chemical Engineering Quarterly, 21, no. 3 (2015):447-455,
https://doi.org/10.2298/CICEQ141023047M . .
1
1
1

Electrical and morphological characterization of multiwalled carbon nanotubes functionalized via the Bingel reaction

Brković, Danijela V; Avramov-Ivić, Milka; Rakić, Vesna M.; Valentini, Luca; Uskoković, Petar; Marinković, Aleksandar

(Pergamon-Elsevier Science Ltd, Oxford, 2015)

TY  - JOUR
AU  - Brković, Danijela V
AU  - Avramov-Ivić, Milka
AU  - Rakić, Vesna M.
AU  - Valentini, Luca
AU  - Uskoković, Petar
AU  - Marinković, Aleksandar
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2982
AB  - Covalent sidewall functionalization of multiwalled carbon nanotubes (MWCNTs) has been performed using two approaches, direct and indirect cycloaddition through diethyl malonate, based on the Bingel reaction. The results revealed that functionalized MWCNTs demonstrated enhanced electrical properties and significantly lower sheet resistance, especially after electric field thermal assisted annealing at 80 degrees C was performed. The presence of 1,3-dicarbonyl compounds caused the surface of MWCNTs to be more hydrophilic, approachable for the electrolyte and improved the capacitance performance of Au/MWCNTs electrodes. The modified MWCNTs have been incorporated into nanocomposites by using solution mixing method with polyaniline and drop-casting resulting mixture on the paper substrate. The reduction in the sheet resistance with increasing the content of MWCNTs in the prepared nanocomposite films has been achieved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Physics and Chemistry of Solids
T1  - Electrical and morphological characterization of multiwalled carbon nanotubes functionalized via the Bingel reaction
EP  - 134
SP  - 121
VL  - 83
DO  - 10.1016/j.jpcs.2015.04.004
ER  - 
@article{
author = "Brković, Danijela V and Avramov-Ivić, Milka and Rakić, Vesna M. and Valentini, Luca and Uskoković, Petar and Marinković, Aleksandar",
year = "2015",
abstract = "Covalent sidewall functionalization of multiwalled carbon nanotubes (MWCNTs) has been performed using two approaches, direct and indirect cycloaddition through diethyl malonate, based on the Bingel reaction. The results revealed that functionalized MWCNTs demonstrated enhanced electrical properties and significantly lower sheet resistance, especially after electric field thermal assisted annealing at 80 degrees C was performed. The presence of 1,3-dicarbonyl compounds caused the surface of MWCNTs to be more hydrophilic, approachable for the electrolyte and improved the capacitance performance of Au/MWCNTs electrodes. The modified MWCNTs have been incorporated into nanocomposites by using solution mixing method with polyaniline and drop-casting resulting mixture on the paper substrate. The reduction in the sheet resistance with increasing the content of MWCNTs in the prepared nanocomposite films has been achieved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Physics and Chemistry of Solids",
title = "Electrical and morphological characterization of multiwalled carbon nanotubes functionalized via the Bingel reaction",
pages = "134-121",
volume = "83",
doi = "10.1016/j.jpcs.2015.04.004"
}
Brković, D. V., Avramov-Ivić, M., Rakić, V. M., Valentini, L., Uskoković, P.,& Marinković, A.. (2015). Electrical and morphological characterization of multiwalled carbon nanotubes functionalized via the Bingel reaction. in Journal of Physics and Chemistry of Solids
Pergamon-Elsevier Science Ltd, Oxford., 83, 121-134.
https://doi.org/10.1016/j.jpcs.2015.04.004
Brković DV, Avramov-Ivić M, Rakić VM, Valentini L, Uskoković P, Marinković A. Electrical and morphological characterization of multiwalled carbon nanotubes functionalized via the Bingel reaction. in Journal of Physics and Chemistry of Solids. 2015;83:121-134.
doi:10.1016/j.jpcs.2015.04.004 .
Brković, Danijela V, Avramov-Ivić, Milka, Rakić, Vesna M., Valentini, Luca, Uskoković, Petar, Marinković, Aleksandar, "Electrical and morphological characterization of multiwalled carbon nanotubes functionalized via the Bingel reaction" in Journal of Physics and Chemistry of Solids, 83 (2015):121-134,
https://doi.org/10.1016/j.jpcs.2015.04.004 . .
5
4
6

Electrooxidative Behavior of Arylazo Pyridone Dyes and Their Inclusion Complexes on Gold Electrode in 0.1 M NaOH

Mirković, Jelena; Lović, Jelena; Avramov-Ivić, Milka; Mijin, Dušan

(Pergamon-Elsevier Science Ltd, Oxford, 2014)

TY  - JOUR
AU  - Mirković, Jelena
AU  - Lović, Jelena
AU  - Avramov-Ivić, Milka
AU  - Mijin, Dušan
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2658
AB  - The electrochemical behavior of six arylazo pyridone dyes classified to the substituents present at the phenylazo and 2-pyridone moiety and their 1:1 inclusion complexes with (2-hydroxypropyl)-beta-cyclodextrin was studied using cyclic and square wave voltammetry in 0.1 M NaOH on a gold electrode. The formation of the inclusion complexes of the dyes was confirmed using UV-Vis and FTIR spectroscopy measurements. Among the studied dyes, according to potentiodynamic measurements, the most active is the dye 1. The inclusion complexes of the dyes exhibited improved electrochemical activity in comparison to the pure dyes. The results obtained by square wave voltammetry show the apparent activity of the dyes with a methoxy group as a substituent at the phenylazo moiety and ethyl and hydroxyethyl groups in the 2-pyridone moiety, and their inclusion complexes. The electrooxidation mechanism of the investigated arylazo pyridone dyes was also proposed.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Electrooxidative Behavior of Arylazo Pyridone Dyes and Their Inclusion Complexes on Gold Electrode in 0.1 M NaOH
EP  - 713
SP  - 705
VL  - 137
DO  - 10.1016/j.electacta.2014.06.048
ER  - 
@article{
author = "Mirković, Jelena and Lović, Jelena and Avramov-Ivić, Milka and Mijin, Dušan",
year = "2014",
abstract = "The electrochemical behavior of six arylazo pyridone dyes classified to the substituents present at the phenylazo and 2-pyridone moiety and their 1:1 inclusion complexes with (2-hydroxypropyl)-beta-cyclodextrin was studied using cyclic and square wave voltammetry in 0.1 M NaOH on a gold electrode. The formation of the inclusion complexes of the dyes was confirmed using UV-Vis and FTIR spectroscopy measurements. Among the studied dyes, according to potentiodynamic measurements, the most active is the dye 1. The inclusion complexes of the dyes exhibited improved electrochemical activity in comparison to the pure dyes. The results obtained by square wave voltammetry show the apparent activity of the dyes with a methoxy group as a substituent at the phenylazo moiety and ethyl and hydroxyethyl groups in the 2-pyridone moiety, and their inclusion complexes. The electrooxidation mechanism of the investigated arylazo pyridone dyes was also proposed.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Electrooxidative Behavior of Arylazo Pyridone Dyes and Their Inclusion Complexes on Gold Electrode in 0.1 M NaOH",
pages = "713-705",
volume = "137",
doi = "10.1016/j.electacta.2014.06.048"
}
Mirković, J., Lović, J., Avramov-Ivić, M.,& Mijin, D.. (2014). Electrooxidative Behavior of Arylazo Pyridone Dyes and Their Inclusion Complexes on Gold Electrode in 0.1 M NaOH. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 137, 705-713.
https://doi.org/10.1016/j.electacta.2014.06.048
Mirković J, Lović J, Avramov-Ivić M, Mijin D. Electrooxidative Behavior of Arylazo Pyridone Dyes and Their Inclusion Complexes on Gold Electrode in 0.1 M NaOH. in Electrochimica Acta. 2014;137:705-713.
doi:10.1016/j.electacta.2014.06.048 .
Mirković, Jelena, Lović, Jelena, Avramov-Ivić, Milka, Mijin, Dušan, "Electrooxidative Behavior of Arylazo Pyridone Dyes and Their Inclusion Complexes on Gold Electrode in 0.1 M NaOH" in Electrochimica Acta, 137 (2014):705-713,
https://doi.org/10.1016/j.electacta.2014.06.048 . .
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