TY  - JOUR
AU  - Krivokapic, Jovana
AU  - Ivanovic, Jasna
AU  - Krkobabic, Mirjana
AU  - Arsenijevic, Jelena
AU  - Ibric, Svetlana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4921
AB  - The present study was aimed to investigate the feasibility of loading microcrystalline cellulose derived from the agricultural waste with poorly water-soluble drug by using supercritical carbon dioxide as impregnation medium. Operating parameters of supercritical impregnation process (pressure, temperature and time) were varied to in order to maximize loading of ibuprofen used as a model drug into microcrystalline cellulose. The efficiency of ibuprofen loading using supercritical impregnation and release kinetics studies of microcrystalline cellulose in two pharmaceutical forms, powder and tablets, were investigated. The highest amount of ibuprofen was impregnated in microcrystalline cellulose powder by using supercritical impregnation at 25 MPa and 40 degrees C for 24 h (9.43%). Increasing pressure in the range of 10 MPa-25 MPa and time from 2 h to 24 h favours loading of ibuprofen into microcrystalline cellulose. A higher loading efficiency at the same impregnation conditions was observed for powdered microcrystalline cellulose. Temperature change in range of 40-60 degrees C had negligible influence on loading efficiency. FT-IR spectroscopy analysis showed no evidence of chemical modification of microcrystalline cellulose after processing. In vitro drug release study showed that impregnated powder formulations released the total amount of ibuprofen immediately, while the impregnation of microcrystalline cellulose powder in the form of tablets led to the achievement of the sustained release profile.
T2  - Sustainable Chemistry and Pharmacy
T1  - Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen
VL  - 21
DO  - 10.1016/j.scp.2021.100447
ER  - 

@article{
author = "Krivokapic, Jovana and Ivanovic, Jasna and Krkobabic, Mirjana and Arsenijevic, Jelena and Ibric, Svetlana",
year = "2021",
abstract = "The present study was aimed to investigate the feasibility of loading microcrystalline cellulose derived from the agricultural waste with poorly water-soluble drug by using supercritical carbon dioxide as impregnation medium. Operating parameters of supercritical impregnation process (pressure, temperature and time) were varied to in order to maximize loading of ibuprofen used as a model drug into microcrystalline cellulose. The efficiency of ibuprofen loading using supercritical impregnation and release kinetics studies of microcrystalline cellulose in two pharmaceutical forms, powder and tablets, were investigated. The highest amount of ibuprofen was impregnated in microcrystalline cellulose powder by using supercritical impregnation at 25 MPa and 40 degrees C for 24 h (9.43%). Increasing pressure in the range of 10 MPa-25 MPa and time from 2 h to 24 h favours loading of ibuprofen into microcrystalline cellulose. A higher loading efficiency at the same impregnation conditions was observed for powdered microcrystalline cellulose. Temperature change in range of 40-60 degrees C had negligible influence on loading efficiency. FT-IR spectroscopy analysis showed no evidence of chemical modification of microcrystalline cellulose after processing. In vitro drug release study showed that impregnated powder formulations released the total amount of ibuprofen immediately, while the impregnation of microcrystalline cellulose powder in the form of tablets led to the achievement of the sustained release profile.",
journal = "Sustainable Chemistry and Pharmacy",
title = "Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen",
volume = "21",
doi = "10.1016/j.scp.2021.100447"
}

Krivokapic, J., Ivanovic, J., Krkobabic, M., Arsenijevic, J.,& Ibric, S.. (2021). Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen. in Sustainable Chemistry and Pharmacy, 21.
https://doi.org/10.1016/j.scp.2021.100447

Krivokapic J, Ivanovic J, Krkobabic M, Arsenijevic J, Ibric S. Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen. in Sustainable Chemistry and Pharmacy. 2021;21.
doi:10.1016/j.scp.2021.100447 .

Krivokapic, Jovana, Ivanovic, Jasna, Krkobabic, Mirjana, Arsenijevic, Jelena, Ibric, Svetlana, "Supercritical fluid impregnation of microcrystalline cellulose derived from the agricultural waste with ibuprofen" in Sustainable Chemistry and Pharmacy, 21 (2021),
https://doi.org/10.1016/j.scp.2021.100447 . .

TY  - JOUR
AU  - Lukić, Ivana
AU  - Vulic, Jelena
AU  - Ivanovic, Jasna
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4736
AB  - Present study was aimed to produce biodegradable films with antioxidant activity for active food packaging. Films of poly(lactic acid) (PLA) with 5 wt% of poly(epsilon-caprolactone) (PCL), denoted as PLA-5, were loaded with thymol, carvacrol and their mixture using supercritical CO2 at 40 degrees C and 10 MPa for 5 h, with 27.53, 21.18, and 21.49 % of loading achieved, respectively. Morphological, structural and mechanical properties of the obtained PLA-5 films were analyzed. The highest total polyphenol content and the best antioxidant activity as well as good storage stability, acceptable physical properties and the lowest release rate (44.51 mg/L released after 6 weeks) were observed for PLA-5 film loaded with thymol and carvacrol mixture. Mixture of thymol and carvacrol loaded into PLA-5 film showed synergy and low percentage of migration into distilled water, revealing great potential for application as a food packaging material with aim to decrease requirements for amount of the active ingredients.
T2  - Food Packaging and Shelf Life
T1  - Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO(2) for active food packaging
VL  - 26
DO  - 10.1016/j.fpsl.2020.100578
ER  - 

@article{
author = "Lukić, Ivana and Vulic, Jelena and Ivanovic, Jasna",
year = "2020",
abstract = "Present study was aimed to produce biodegradable films with antioxidant activity for active food packaging. Films of poly(lactic acid) (PLA) with 5 wt% of poly(epsilon-caprolactone) (PCL), denoted as PLA-5, were loaded with thymol, carvacrol and their mixture using supercritical CO2 at 40 degrees C and 10 MPa for 5 h, with 27.53, 21.18, and 21.49 % of loading achieved, respectively. Morphological, structural and mechanical properties of the obtained PLA-5 films were analyzed. The highest total polyphenol content and the best antioxidant activity as well as good storage stability, acceptable physical properties and the lowest release rate (44.51 mg/L released after 6 weeks) were observed for PLA-5 film loaded with thymol and carvacrol mixture. Mixture of thymol and carvacrol loaded into PLA-5 film showed synergy and low percentage of migration into distilled water, revealing great potential for application as a food packaging material with aim to decrease requirements for amount of the active ingredients.",
journal = "Food Packaging and Shelf Life",
title = "Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO(2) for active food packaging",
volume = "26",
doi = "10.1016/j.fpsl.2020.100578"
}

Lukić, I., Vulic, J.,& Ivanovic, J.. (2020). Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO(2) for active food packaging. in Food Packaging and Shelf Life, 26.
https://doi.org/10.1016/j.fpsl.2020.100578

Lukić I, Vulic J, Ivanovic J. Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO(2) for active food packaging. in Food Packaging and Shelf Life. 2020;26.
doi:10.1016/j.fpsl.2020.100578 .

Lukić, Ivana, Vulic, Jelena, Ivanovic, Jasna, "Antioxidant activity of PLA/PCL films loaded with thymol and/or carvacrol using scCO(2) for active food packaging" in Food Packaging and Shelf Life, 26 (2020),
https://doi.org/10.1016/j.fpsl.2020.100578 . .