TY  - JOUR
AU  - Veljović, Đorđe
AU  - Čolić, Miodrag
AU  - Kojić, Vesna
AU  - Bogdanović, Gordana
AU  - Kojić, Zvezdana
AU  - Banjac, Andrijana
AU  - Palcevskis, Eriks
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2174
AB  - The effect of decreasing the grain size on the biocompatibility, cellmaterial interface, and mechanical properties of microwave-sintered monophase hydroxyapatite bioceramics was investigated in this study. A nanosized stoichiometric hydroxyapatite powder was isostatically pressed at high pressure and sintered in a microwave furnace in order to obtain fine grained dense bioceramics. The samples sintered at 1200 degrees C, with a density near the theoretical one, were composed of micron-sized grains, while the grain size decreased to 130 nm on decreasing the sintering temperature to 900 degrees C. This decrease in the grain size certainly led to increases in the fracture toughness by much as 54%. An in vitro investigation of biocompatibility with L929 and human MRC-5 fibroblast cells showed noncytotoxic effects for both types of bioceramics, while the relative cell proliferation rate, cell attachment and metabolic activity of the fibroblasts were improved with decreasing of grain size. An initial in vivo investigation of biocompatibility by the primary cutaneous irritation test showed that both materials exhibited no irritation properties.
PB  - Wiley, Hoboken
T2  - Journal of Biomedical Materials Research Part A
T1  - The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics
EP  - 3070
IS  - 11
SP  - 3059
VL  - 100A
DO  - 10.1002/jbm.a.34225
ER  - 

@article{
author = "Veljović, Đorđe and Čolić, Miodrag and Kojić, Vesna and Bogdanović, Gordana and Kojić, Zvezdana and Banjac, Andrijana and Palcevskis, Eriks and Petrović, Rada and Janaćković, Đorđe",
year = "2012",
abstract = "The effect of decreasing the grain size on the biocompatibility, cellmaterial interface, and mechanical properties of microwave-sintered monophase hydroxyapatite bioceramics was investigated in this study. A nanosized stoichiometric hydroxyapatite powder was isostatically pressed at high pressure and sintered in a microwave furnace in order to obtain fine grained dense bioceramics. The samples sintered at 1200 degrees C, with a density near the theoretical one, were composed of micron-sized grains, while the grain size decreased to 130 nm on decreasing the sintering temperature to 900 degrees C. This decrease in the grain size certainly led to increases in the fracture toughness by much as 54%. An in vitro investigation of biocompatibility with L929 and human MRC-5 fibroblast cells showed noncytotoxic effects for both types of bioceramics, while the relative cell proliferation rate, cell attachment and metabolic activity of the fibroblasts were improved with decreasing of grain size. An initial in vivo investigation of biocompatibility by the primary cutaneous irritation test showed that both materials exhibited no irritation properties.",
publisher = "Wiley, Hoboken",
journal = "Journal of Biomedical Materials Research Part A",
title = "The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics",
pages = "3070-3059",
number = "11",
volume = "100A",
doi = "10.1002/jbm.a.34225"
}

Veljović, Đ., Čolić, M., Kojić, V., Bogdanović, G., Kojić, Z., Banjac, A., Palcevskis, E., Petrović, R.,& Janaćković, Đ.. (2012). The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics. in Journal of Biomedical Materials Research Part A
Wiley, Hoboken., 100A(11), 3059-3070.
https://doi.org/10.1002/jbm.a.34225

Veljović Đ, Čolić M, Kojić V, Bogdanović G, Kojić Z, Banjac A, Palcevskis E, Petrović R, Janaćković Đ. The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics. in Journal of Biomedical Materials Research Part A. 2012;100A(11):3059-3070.
doi:10.1002/jbm.a.34225 .

Veljović, Đorđe, Čolić, Miodrag, Kojić, Vesna, Bogdanović, Gordana, Kojić, Zvezdana, Banjac, Andrijana, Palcevskis, Eriks, Petrović, Rada, Janaćković, Đorđe, "The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics" in Journal of Biomedical Materials Research Part A, 100A, no. 11 (2012):3059-3070,
https://doi.org/10.1002/jbm.a.34225 . .