TY  - JOUR
AU  - Tolić, Ljiljana
AU  - Grujić, Svetlana
AU  - Mojović, Miloš
AU  - Jovanović, Miloš
AU  - Lubec, Gert
AU  - Bacić, Goran
AU  - Laušević, Mila
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3367
AB  - A selective, sensitive and fast method for extraction, identification and quantification of multifunctional drug anisomycin in various tissues and serum, based on liquid chromatography-tandem mass spectrometry, was developed, optimized and validated. The method was validated according to the FDA guidelines and generally demonstrated good selectivity, accuracy, precision, and stability of the analyte. In the optimized method, high extraction efficiency was achieved for tested tissues (heart, brain, spleen, kidney, liver and femoral muscle) and serum. The obtained values of lower limits of quantification (LLOQ, 1.0-11.0 ng g(-1)) and limits of detection (0.3-3.3 ng g(-1)) indicated that the method was suitable for determination of trace levels of anisomycin in the complex matrices. The method was linear (R-2  gt = 0.990) in the tested concentration range (LLOQ-2500 ng g-1). The developed method was successfully applied in the first study on in vivo pharmacokinetics and distribution of anisomycin in tissues and serum of Wistar albino rats following subcutaneous injection (150 mg kg(-1)). The peak concentration in most tissues was achieved within 3 h after injection. The highest anisomycin concentration was found in the brain and the lowest concentration was found in the serum.
PB  - Royal Society of Chemistry
T2  - RSC Advances
T1  - Determination of anisomycin in tissues and serum by LC-MS/MS: application to pharmacokinetic and distribution studies in rats
EP  - 92489
IS  - 95
SP  - 92479
VL  - 6
DO  - 10.1039/c6ra16083b
ER  - 

@article{
author = "Tolić, Ljiljana and Grujić, Svetlana and Mojović, Miloš and Jovanović, Miloš and Lubec, Gert and Bacić, Goran and Laušević, Mila",
year = "2016",
abstract = "A selective, sensitive and fast method for extraction, identification and quantification of multifunctional drug anisomycin in various tissues and serum, based on liquid chromatography-tandem mass spectrometry, was developed, optimized and validated. The method was validated according to the FDA guidelines and generally demonstrated good selectivity, accuracy, precision, and stability of the analyte. In the optimized method, high extraction efficiency was achieved for tested tissues (heart, brain, spleen, kidney, liver and femoral muscle) and serum. The obtained values of lower limits of quantification (LLOQ, 1.0-11.0 ng g(-1)) and limits of detection (0.3-3.3 ng g(-1)) indicated that the method was suitable for determination of trace levels of anisomycin in the complex matrices. The method was linear (R-2  gt = 0.990) in the tested concentration range (LLOQ-2500 ng g-1). The developed method was successfully applied in the first study on in vivo pharmacokinetics and distribution of anisomycin in tissues and serum of Wistar albino rats following subcutaneous injection (150 mg kg(-1)). The peak concentration in most tissues was achieved within 3 h after injection. The highest anisomycin concentration was found in the brain and the lowest concentration was found in the serum.",
publisher = "Royal Society of Chemistry",
journal = "RSC Advances",
title = "Determination of anisomycin in tissues and serum by LC-MS/MS: application to pharmacokinetic and distribution studies in rats",
pages = "92489-92479",
number = "95",
volume = "6",
doi = "10.1039/c6ra16083b"
}

Tolić, L., Grujić, S., Mojović, M., Jovanović, M., Lubec, G., Bacić, G.,& Laušević, M.. (2016). Determination of anisomycin in tissues and serum by LC-MS/MS: application to pharmacokinetic and distribution studies in rats. in RSC Advances
Royal Society of Chemistry., 6(95), 92479-92489.
https://doi.org/10.1039/c6ra16083b

Tolić L, Grujić S, Mojović M, Jovanović M, Lubec G, Bacić G, Laušević M. Determination of anisomycin in tissues and serum by LC-MS/MS: application to pharmacokinetic and distribution studies in rats. in RSC Advances. 2016;6(95):92479-92489.
doi:10.1039/c6ra16083b .

Tolić, Ljiljana, Grujić, Svetlana, Mojović, Miloš, Jovanović, Miloš, Lubec, Gert, Bacić, Goran, Laušević, Mila, "Determination of anisomycin in tissues and serum by LC-MS/MS: application to pharmacokinetic and distribution studies in rats" in RSC Advances, 6, no. 95 (2016):92479-92489,
https://doi.org/10.1039/c6ra16083b . .

TY  - JOUR
AU  - Janković-Mandić, Ljiljana
AU  - Dragović, Ranko M.
AU  - Đorđević, Milan M.
AU  - Đolić, Maja
AU  - Onjia, Antonije
AU  - Dragović, Snežana D.
AU  - Bacić, Goran G.
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2728
AB  - Among radionuclides in the soil deposited after Chernobyl accident, Cs-137 poses considerable environmental and radiological problemdue to its relatively long half-life (30.17 gamma), its abundance in the fallout, high mobility and similarity to potassium as the major plant nutrient. In this study the samples of undisturbed surface soil (n = 250) were taken from 70 regions in Belgrade, during 2006-2010. The specific activities of Cs-137 were measured by gamma-ray spectrometry. Based on obtained results, the external effective dose rates were calculated according to the internationally accepted activity to dose rate conversion equations. The specific activities of Cs-137 were geographically mapped. The presence of Cs-137 has been detected in all soil samples, with high variability of its specific activity, ranging from 3 to 87 Bq kg(-1).The mean specific activity of Cs-137 was 23 Bq kg(-1) and the corresponding absorbed dose was 1.5 nSv h(-1). The observed range reflects the inhomogeneity of the deposition process following the Chernobyl accident. It could also be attributed to topographic differences and spatial differences in physicochemical and biological soil properties, soil type and vegetation cover. The results of the present study could be valuable database for future estimations of the impact of radioactive pollution.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Spatial variability of cs-137 in the soil of Belgrade region (Serbia)
EP  - 455
IS  - 4
SP  - 449
VL  - 68
DO  - 10.2298/HEMIND130124069J
ER  - 

@article{
author = "Janković-Mandić, Ljiljana and Dragović, Ranko M. and Đorđević, Milan M. and Đolić, Maja and Onjia, Antonije and Dragović, Snežana D. and Bacić, Goran G.",
year = "2014",
abstract = "Among radionuclides in the soil deposited after Chernobyl accident, Cs-137 poses considerable environmental and radiological problemdue to its relatively long half-life (30.17 gamma), its abundance in the fallout, high mobility and similarity to potassium as the major plant nutrient. In this study the samples of undisturbed surface soil (n = 250) were taken from 70 regions in Belgrade, during 2006-2010. The specific activities of Cs-137 were measured by gamma-ray spectrometry. Based on obtained results, the external effective dose rates were calculated according to the internationally accepted activity to dose rate conversion equations. The specific activities of Cs-137 were geographically mapped. The presence of Cs-137 has been detected in all soil samples, with high variability of its specific activity, ranging from 3 to 87 Bq kg(-1).The mean specific activity of Cs-137 was 23 Bq kg(-1) and the corresponding absorbed dose was 1.5 nSv h(-1). The observed range reflects the inhomogeneity of the deposition process following the Chernobyl accident. It could also be attributed to topographic differences and spatial differences in physicochemical and biological soil properties, soil type and vegetation cover. The results of the present study could be valuable database for future estimations of the impact of radioactive pollution.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Spatial variability of cs-137 in the soil of Belgrade region (Serbia)",
pages = "455-449",
number = "4",
volume = "68",
doi = "10.2298/HEMIND130124069J"
}

Janković-Mandić, L., Dragović, R. M., Đorđević, M. M., Đolić, M., Onjia, A., Dragović, S. D.,& Bacić, G. G.. (2014). Spatial variability of cs-137 in the soil of Belgrade region (Serbia). in Hemijska industrija
Savez hemijskih inženjera, Beograd., 68(4), 449-455.
https://doi.org/10.2298/HEMIND130124069J

Janković-Mandić L, Dragović RM, Đorđević MM, Đolić M, Onjia A, Dragović SD, Bacić GG. Spatial variability of cs-137 in the soil of Belgrade region (Serbia). in Hemijska industrija. 2014;68(4):449-455.
doi:10.2298/HEMIND130124069J .

Janković-Mandić, Ljiljana, Dragović, Ranko M., Đorđević, Milan M., Đolić, Maja, Onjia, Antonije, Dragović, Snežana D., Bacić, Goran G., "Spatial variability of cs-137 in the soil of Belgrade region (Serbia)" in Hemijska industrija, 68, no. 4 (2014):449-455,
https://doi.org/10.2298/HEMIND130124069J . .