TY  - CONF
AU  - Marković, Maja D.
AU  - Miladinović, Nina N.
AU  - Savić, Sanja I.
AU  - Panić, Vesna V.
AU  - Pantić, Olga J.
AU  - Spasojević, Pavle M.
AU  - Pjanović, Rada V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7300
AB  - Controlled release of drugs is a promising tool for improvement of therapy for many 
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as 
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for 
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate 
if the encapsulation of poorly water-soluble active substance (caffeine) during the 
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels 
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of 
crosslinker are prepared by free radical polymerisation in aqueous solution and 
ambient conditions by using novel initiation system based on hydrogen peroxide and 
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of 
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human 
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount 
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released 
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.
PB  - Leskovac : Faculty of Technology
C3  - Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023
T1  - POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE
SP  - 97
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7300
ER  - 

@conference{
author = "Marković, Maja D. and Miladinović, Nina N. and Savić, Sanja I. and Panić, Vesna V. and Pantić, Olga J. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "Controlled release of drugs is a promising tool for improvement of therapy for many 
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as 
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for 
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate 
if the encapsulation of poorly water-soluble active substance (caffeine) during the 
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels 
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of 
crosslinker are prepared by free radical polymerisation in aqueous solution and 
ambient conditions by using novel initiation system based on hydrogen peroxide and 
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of 
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human 
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount 
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released 
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.",
publisher = "Leskovac : Faculty of Technology",
journal = "Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023",
title = "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE",
pages = "97",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7300"
}

Marković, M. D., Miladinović, N. N., Savić, S. I., Panić, V. V., Pantić, O. J., Spasojević, P. M.,& Pjanović, R. V.. (2023). POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE. in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023
Leskovac : Faculty of Technology., 97.
https://hdl.handle.net/21.15107/rcub_technorep_7300

Marković MD, Miladinović NN, Savić SI, Panić VV, Pantić OJ, Spasojević PM, Pjanović RV. POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE. in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023. 2023;:97.
https://hdl.handle.net/21.15107/rcub_technorep_7300 .

Marković, Maja D., Miladinović, Nina N., Savić, Sanja I., Panić, Vesna V., Pantić, Olga J., Spasojević, Pavle M., Pjanović, Rada V., "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN”  METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF  CAFFEINE" in Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023 (2023):97,
https://hdl.handle.net/21.15107/rcub_technorep_7300 .

TY  - CONF
AU  - Miladinović, Nina N.
AU  - Marković, Maja
AU  - Pjanović, Rada
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5228
AB  - Several million tons of orange peel are generated annually as a result of the industrial
processing of this fruit. Orange peels are rich in polyphenols, that show antioxidant
activity. Hence, converting orange peels into antioxidant extract by using green eutectic
solvents (GES) would be a good solution. GES represent a mixture of organic substances
that are not harmful to human health, environmentally friendly and highly selective
towards the targeted active substance. The aim of this work was the extraction of
polyphenols from orange peel waste using a GES based on urea and glycerol, their
encapsulation into hydrogels based on poly(methacrylic acid) (PMAA), and controlled
release from these hydrogels. PMAA are non-toxic, biocompatible and pH sensitive, so
they are widely used for the targeted delivery of active substances. Swelling of PMAA
and the controlled release of polyphenols from PMAA were monitored in two mediums
with different pH values: 0.1 M hydrochloric acid (pH=1) and phosphate buffer
(pH=6.8) at 37 °C. The influence of the crosslinker amount and neutralization degree of
methacrylic acid (ND) on the PMAA swelling and the release of polyphenols was
examined. The kinetics of PMAA swelling and polyphenol release were analyzed using
the Peppas model. It was concluded that the swelling degree of PMAA increased with
an increase in pH value of medium and ND, and decreased with an increase in crosslinker
amount. As a consequence, the cumulative release of polyphenols was around three
times higher in pH=6.8 than in pH=1 for both series of the samples. Peppas model
showed that diffusion was the primary mechanism of polyphenols release for most
samples. Based on the analysis of the results, it is concluded that the sample with optimal
characteristics for the controlled release of polyphenols is the sample with 0%
neutralized methacrylic acid and 0.4 mol% MBA.
PB  - Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia
C3  - 8th Conference of Young Chemists of Serbia Book of Abstract
T1  - Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels
SP  - 88
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5228
ER  - 

@conference{
author = "Miladinović, Nina N. and Marković, Maja and Pjanović, Rada",
year = "2022",
abstract = "Several million tons of orange peel are generated annually as a result of the industrial
processing of this fruit. Orange peels are rich in polyphenols, that show antioxidant
activity. Hence, converting orange peels into antioxidant extract by using green eutectic
solvents (GES) would be a good solution. GES represent a mixture of organic substances
that are not harmful to human health, environmentally friendly and highly selective
towards the targeted active substance. The aim of this work was the extraction of
polyphenols from orange peel waste using a GES based on urea and glycerol, their
encapsulation into hydrogels based on poly(methacrylic acid) (PMAA), and controlled
release from these hydrogels. PMAA are non-toxic, biocompatible and pH sensitive, so
they are widely used for the targeted delivery of active substances. Swelling of PMAA
and the controlled release of polyphenols from PMAA were monitored in two mediums
with different pH values: 0.1 M hydrochloric acid (pH=1) and phosphate buffer
(pH=6.8) at 37 °C. The influence of the crosslinker amount and neutralization degree of
methacrylic acid (ND) on the PMAA swelling and the release of polyphenols was
examined. The kinetics of PMAA swelling and polyphenol release were analyzed using
the Peppas model. It was concluded that the swelling degree of PMAA increased with
an increase in pH value of medium and ND, and decreased with an increase in crosslinker
amount. As a consequence, the cumulative release of polyphenols was around three
times higher in pH=6.8 than in pH=1 for both series of the samples. Peppas model
showed that diffusion was the primary mechanism of polyphenols release for most
samples. Based on the analysis of the results, it is concluded that the sample with optimal
characteristics for the controlled release of polyphenols is the sample with 0%
neutralized methacrylic acid and 0.4 mol% MBA.",
publisher = "Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia",
journal = "8th Conference of Young Chemists of Serbia Book of Abstract",
title = "Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels",
pages = "88",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5228"
}

Miladinović, N. N., Marković, M.,& Pjanović, R.. (2022). Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels. in 8th Conference of Young Chemists of Serbia Book of Abstract
Serbian Chemical Society and Serbian Young Chemists’ Club, Belgrade, Serbia., 88.
https://hdl.handle.net/21.15107/rcub_technorep_5228

Miladinović NN, Marković M, Pjanović R. Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels. in 8th Conference of Young Chemists of Serbia Book of Abstract. 2022;:88.
https://hdl.handle.net/21.15107/rcub_technorep_5228 .

Miladinović, Nina N., Marković, Maja, Pjanović, Rada, "Extraction of polyphenols from orange peel and their controlled release from pH-sensitive hydrogels" in 8th Conference of Young Chemists of Serbia Book of Abstract (2022):88,
https://hdl.handle.net/21.15107/rcub_technorep_5228 .